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W. Martin Kast, PhD

Professor of Molecular Microbiology & Immunology, Obstetrics & Gynecology, Urology, and Otolaryngology-Head & Neck Surgery

Walter A. Richter Cancer Research Chair

Director Medical Biology Graduate Program

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Overview

W. Martin Kast, PhD is a Professor of Molecular Microbiology & Immunology, Obstetrics & Gynecology, Urology and Otolaryngology at the Norris Comprehensive Cancer Center (NCCC) of the University of Southern California in Los Angeles, CA. He holds the Walter A. Richter Cancer Research Chair and is the Director of the NCCC Tumor Micro-environment program, the Director of the USC Medical Biology & Infectious Diseases Immunology and Pathogenesis Graduate Programs, the Director of the Beckman Center for Immune Monitoring, the Director of the K-12 Cancer Education Program and the Associate Dean of Academic Integrity. A native of the Netherlands, he earned his BS, MS, and PhD summa cum laude, from the University of Amsterdam in the Netherlands. He is serving on multiple Study Sections including the National Institute of Health and the Cancer Prevention and Research Institute of Texas. His research involves the design of therapeutic cancer vaccines directed against human papilloma virus (HPV) and prostate cancer. Several of his therapeutic HPV vaccines hare currently been tried out in clinical trials. He studies HPV cell entry and the interaction of HPV with the human immune system to find out how HPV escapes immune detection and how to reverse that. He has published 286 articles that have been quoted more than 27,500 times and led to a publication h-index of 85. He is also the inventor on 18 patents. His research is supported by NIH grants. He is an editor for the journal Cancers. He also served as the secretary/treasurer of the International Papillomavirus Society from 2012-2019 and serves on the advisory board of 6 biotechnology companies. In October 2022, he published a book entitled Oncology that is meant for Elementary Schools serving underrepresented minority students together with his daughter Dr. Dieuwertje J. Kast. In his free time he is a Scoutmaster and an actor.

Awards

  • USC Stevens Center for Innovation : Commercialization Award, 2021
  • University of Southern California: Graduate Student Mentoring Award, 2021
  • 10XGenomics: 10XGenomics Prize, 2021
  • Society of Immunotherapy of Cancer: Team Science Award, 2020
  • University of Southern California: Dornsife Award for Exceptional Service, 2019
  • Affymetrix: Affymetrix Prize, 2016
  • Rare Genomics Institute: BeHeard Ultimate Prize, 2015
  • STOP Cancer: STOP Cancer Award, 2015
  • University of Southern California: Mellon Award for Graduate Student Mentoring, 2014
  • University of Amsterdam: Landsteiner Prize, 2012
  • Royal Netherlands Academy of Arts and Sciences: Royal Netherlands Academy of Arts & Sciences Award, 1991-1995
  • Netherlands Cancer Institute: Antoni van Leeuwenhoek Prize, 1991

Publications

  • Understanding medical mistrust and HPV vaccine hesitancy among multiethnic parents in Los Angeles J Behav Med. 2023 04; 46(1-2):100-115. . View in PubMed
  • Heterozygote advantage at HLA class I and II loci and reduced risk of colorectal cancer Front Immunol. 2023; 14:1268117. . View in PubMed
  • Diversity of Anal HPV and Non-HPV Sexually Transmitted Infections and Concordance with Genital Infections in HIV-Infected and HIV-Uninfected Women in the Tapajós Region, Amazon, Brazil Viruses. 2023 06 06; 15(6). . View in PubMed
  • Examining multilevel influences on parental HPV vaccine hesitancy among multiethnic communities in Los Angeles: a qualitative analysis BMC Public Health. 2023 03 22; 23(1):545. . View in PubMed
  • Investigation of the Optimal Prime Boost Spacing Regimen for a Cancer Therapeutic Vaccine Targeting Human Papillomavirus Cancers (Basel). 2022 Sep 05; 14(17). . View in PubMed
  • Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy EBioMedicine. 2022 12; 86:104389. . View in PubMed
  • Integration of immunotherapy into treatment of cervical cancer: Recent data and ongoing trials Cancer Treat Rev. 2022 05; 106:102385. . View in PubMed
  • Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors Cancer Immunol Res. 2020 07; 8(7):856-868. . View in PubMed
  • The Essential Role of anxA2 in Langerhans Cell Birbeck Granules Formation Cells. 2020 04 15; 9(4). . View in PubMed
  • Immune Activation in Patients with Locally Advanced Cervical Cancer Treated with Ipilimumab Following Definitive Chemoradiation (GOG-9929) Clin Cancer Res. 2020 11 01; 26(21):5621-5630. . View in PubMed
  • Theta-Defensins Inhibit High-Risk Human Papillomavirus Infection Through Charge-Driven Capsid Clustering Front Immunol. 2020; 11:561843. . View in PubMed
  • Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapy Oncoimmunology. 2020 11 29; 9(1):1851539. . View in PubMed
  • TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy Front Immunol. 2020; 11:922. . View in PubMed
  • Therapeutic efficacy of a human papillomavirus type 16 E7 bacterial exotoxin fusion protein adjuvanted with CpG or GPI-0100 in a preclinical mouse model for HPV-associated disease Vaccine. 2019 05 16; 37(22):2915-2924. . View in PubMed
  • Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study BMC Cancer. 2018 Oct 11; 18(1):970. . View in PubMed
  • Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors Gynecol Oncol. 2018 10; 151(1):102-110. . View in PubMed
  • Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses Cancer Immunol Res. 2018 07; 6(7):870-880. . View in PubMed
  • Nano-Pulse Stimulation induces immunogenic cell death in human papillomavirus-transformed tumors and initiates an adaptive immune response PLoS One. 2018; 13(1):e0191311. . View in PubMed
  • Heterotetrameric annexin A2/S100A10 (A2t) is essential for oncogenic human papillomavirus trafficking and capsid disassembly, and protects virions from lysosomal degradation Sci Rep. 2018 08 03; 8(1):11642. . View in PubMed
  • Annexin A2 in Virus Infection Front Microbiol. 2018; 9:2954. . View in PubMed
  • Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy Oncotarget. 2017 Sep 26; 8(43):74378-74390. . View in PubMed
  • Syndemic synergy of HPV and other sexually transmitted pathogens in the development of high-grade anal squamous intraepithelial lesions Papillomavirus Res. 2017 12; 4:90-98. . View in PubMed
  • A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression Front Immunol. 2017; 8:563. . View in PubMed
  • The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis J Virol. 2016 Dec 01; 90(23):10629-10641. . View in PubMed
  • Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection J Gen Virol. 2016 Feb; 97(2):422-434. . View in PubMed
  • T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation Papillomavirus Res. 2016 12; 2:21-30. . View in PubMed
  • Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment AIDS Patient Care STDS. 2016 07; 30(7):291-306. . View in PubMed
  • Immunostimulatory Activity of the Cytokine-Based Biologic, IRX-2, on Human Papillomavirus-Exposed Langerhans Cells J Interferon Cytokine Res. 2016 05; 36(5):291-301. . View in PubMed
  • Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases Hum Vaccin Immunother. 2016 06 02; 12(6):1418-29. . View in PubMed
  • Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro Virol J. 2016 11 18; 13(1):187. . View in PubMed
  • Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients J Acquir Immune Defic Syndr. 2016 09 01; 73(1):27-33. . View in PubMed
  • Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4 J Neuroimmunol. 2016 10 15; 299:70-78. . View in PubMed
  • Langerhans cells from women with cervical precancerous lesions become functionally responsive against human papillomavirus after activation with stabilized Poly-I:C Clin Immunol. 2015 Dec; 161(2):197-208. . View in PubMed
  • Human papillomavirus-exposed Langerhans cells are activated by stabilized Poly-I:C Papillomavirus Res. 2015 Dec 01; 1:12-21. . View in PubMed
  • A novel murine model for evaluating bovine papillomavirus prophylactics/therapeutics for equine sarcoid-like tumours J Gen Virol. 2015 Sep; 96(9):2764-2768. . View in PubMed
  • Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes Prostate. 2015 Feb 15; 75(3):280-91. . View in PubMed
  • Functional analysis of HPV-like particle-activated Langerhans cells in vitro Methods Mol Biol. 2015; 1249:333-50. . View in PubMed
  • Small molecule inhibitors of the annexin A2 heterotetramer prevent human papillomavirus type 16 infection J Antimicrob Chemother. 2015; 70(6):1686-90. . View in PubMed
  • Molecular analysis of human papillomavirus virus-like particle activated Langerhans cells in vitro Methods Mol Biol. 2015; 1249:135-49. . View in PubMed
  • Inhibition of Langerhans cell maturation by human papillomavirus type 16: a novel role for the annexin A2 heterotetramer in immune suppression J Immunol. 2014 May 15; 192(10):4748-57. . View in PubMed
  • Suppression of Langerhans cell activation is conserved amongst human papillomavirus a and ß genotypes, but not a µ genotype Virology. 2014 Mar; 452-453:279-86. . View in PubMed
  • The evolving field of human papillomavirus receptor research: a review of binding and entry J Virol. 2013 Jun; 87(11):6062-72. . View in PubMed
  • Human papillomavirus infection in head and neck cancer: the role of the secretory leukocyte protease inhibitor Oncol Rep. 2013 May; 29(5):1962-8. . View in PubMed
  • A novel series of conferences tackling the hurdles confronting the translation of novel cancer immunotherapies J Transl Med. 2012 Nov 05; 10:218. . View in PubMed
  • Cancer testes antigens in breast cancer: biological role, regulation, and therapeutic applicability Int Rev Immunol. 2012 Oct; 31(5):302-20. . View in PubMed
  • Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia J Pathol. 2012 Apr; 226(5):713-22. . View in PubMed
  • Perspective for prophylaxis and treatment of cervical cancer: an immunological approach Int Rev Immunol. 2012 Feb; 31(1):3-21. . View in PubMed
  • In this issue: targeting Human Papilloma Virus-associated disease, from cervical to head and neck carcinoma…and more Int Rev Immunol. 2012 Feb; 31(1):1-2. . View in PubMed
  • Immunological treatment options for locoregionally advanced head and neck squamous cell carcinoma Int Rev Immunol. 2012 Feb; 31(1):22-42. . View in PubMed
  • The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection PLoS One. 2012; 7(8):e43519. . View in PubMed
  • Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer Prostate. 2012 Jan; 72(1):12-23. . View in PubMed
  • Notch-ing from T-cell to B-cell lymphoid malignancies Cancer Lett. 2011 Sep 01; 308(1):1-13. . View in PubMed
  • Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy J Immunother. 2011 Jul-Aug; 34(6):490-9. . View in PubMed
  • The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma Int J Oncol. 2011 Jul; 39(1):185-91. . View in PubMed
  • Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer Int Rev Immunol. 2011 Apr-Jun; 30(2-3):127-37. . View in PubMed
  • Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies Int Rev Immunol. 2011 Apr-Jun; 30(2-3):71-86. . View in PubMed
  • Bovine papillomavirus DNA can be detected in keratinocytes of equine sarcoid tumors Vet Microbiol. 2010 Dec 15; 146(3-4):269-75. . View in PubMed
  • Prevention is better than cure: the case for clinical trials of therapeutic cancer vaccines in the prophylactic setting Mol Interv. 2010 Aug; 10(4):197-203. . View in PubMed
  • Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression Cancer Res. 2010 May 15; 70(10):3955-64. . View in PubMed
  • Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer PLoS One. 2010 May 12; 5(5):e10471. . View in PubMed
  • Phase 2 trial of combination thalidomide plus temozolomide in patients with metastatic malignant melanoma: Southwest Oncology Group S0508 Cancer. 2010 Jan 15; 116(2):424-31. . View in PubMed
  • Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages Vaccine. 2009 Dec 30; 27 Suppl 6:G52-9. . View in PubMed
  • A major role for the minor capsid protein of human papillomavirus type 16 in immune escape J Immunol. 2009 Nov 15; 183(10):6151-6. . View in PubMed
  • Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, DC. Head Neck. 2009 Nov; 31(11):1393-422. . View in PubMed
  • Immunogenicity of an HPV-16 L2 DNA vaccine Vaccine. 2009 Oct 30; 27(46):6432-4. . View in PubMed
  • Lymph node-targeted immunotherapy mediates potent immunity resulting in regression of isolated or metastatic human papillomavirus-transformed tumors Clin Cancer Res. 2009 Oct 01; 15(19):6167-76. . View in PubMed
  • Sperm protein 17 is expressed in the sperm fibrous sheath J Transl Med. 2009 Jul 15; 7:61. . View in PubMed
  • Prostate stem cell antigen: a prospective therapeutic and diagnostic target Cancer Lett. 2009 May 18; 277(2):126-32. . View in PubMed
  • Androgen ablation augments prostate cancer vaccine immunogenicity only when applied after immunization Prostate. 2009 May 01; 69(6):571-84. . View in PubMed
  • Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer Gynecol Oncol. 2009 May; 113(2):256-63. . View in PubMed
  • Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition Cancer Immunol Immunother. 2009 May; 58(5):719-28. . View in PubMed
  • Reversal of human papillomavirus-specific T cell immune suppression through TLR agonist treatment of Langerhans cells exposed to human papillomavirus type 16 J Immunol. 2009 Mar 01; 182(5):2919-28. . View in PubMed
  • Peptide-based vaccines for cancer: realizing their potential Expert Rev Vaccines. 2008 Dec; 7(10):1533-45. . View in PubMed
  • rAAV/Her-2/neu loading of dendritic cells for a potent cellular-mediated MHC class I restricted immune response against ovarian cancer Viral Immunol. 2008 Dec; 21(4):435-42. . View in PubMed
  • Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells J Transl Med. 2008 Oct 05; 6:56. . View in PubMed
  • Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells Oncogene. 2008 Oct 02; 27(44):5833-44. . View in PubMed
  • Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer J Immunother. 2008 Oct; 31(8):693-703. . View in PubMed
  • Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells Cancer Immunol Immunother. 2008 Jun; 57(6):789-97. . View in PubMed
  • Sperm fibrous sheath proteins: a potential new class of target antigens for use in human therapeutic cancer vaccines Cancer Immun. 2008 Apr 24; 8:8. . View in PubMed
  • A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting Immunol Rev. 2008 Apr; 222:316-27. . View in PubMed
  • Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI) Cancer Immunol Immunother. 2008 Mar; 57(3):303-15. . View in PubMed
  • AKAP-4: a novel cancer testis antigen for multiple myeloma Br J Haematol. 2008 Feb; 140(4):465-8. . View in PubMed
  • Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity Cancer Res. 2008 Feb 01; 68(3):861-9. . View in PubMed
  • Recent advances in strategies for immunotherapy of human papillomavirus-induced lesions Int J Cancer. 2008 Jan 15; 122(2):247-59. . View in PubMed
  • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs Int Immunol. 2007 Oct; 19(10):1223-34. . View in PubMed
  • A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia Gynecol Oncol. 2007 Sep; 106(3):558-66. . View in PubMed
  • Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity J Immunol. 2007 Jun 15; 178(12):7587-97. . View in PubMed
  • Rejection of large HPV-16 expressing tumors in aged mice by a single immunization of VacciMax encapsulated CTL/T helper peptides J Transl Med. 2007 Jun 07; 5:26. . View in PubMed
  • Advances in immunotherapy of multiple myeloma: from the discovery of tumor-associated antigens to clinical trials Int Rev Immunol. 2007 May-Aug; 26(3-4):197-222. . View in PubMed
  • The efficacy of a DNA vaccine containing inserted and replicated regions of the E7 gene for treatment of HPV-16 induced tumors Vaccine. 2007 Apr 30; 25(17):3437-44. . View in PubMed
  • Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax J Transl Med. 2007 Apr 23; 5:20. . View in PubMed
  • Serum cytokine profiling as a diagnostic and prognostic tool in ovarian cancer: a potential role for interleukin 7 Clin Cancer Res. 2007 Apr 15; 13(8):2385-91. . View in PubMed
  • A NOD/SCID tumor model for human ovarian cancer that allows tracking of tumor progression through the biomarker Sp17 J Immunol Methods. 2007 Apr 10; 321(1-2):86-93. . View in PubMed
  • In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer Cancer Res. 2007 Feb 01; 67(3):1344-51. . View in PubMed
  • Mechanisms used by human papillomaviruses to escape the host immune response Curr Cancer Drug Targets. 2007 Feb; 7(1):79-89. . View in PubMed
  • Therapeutic vaccination for HPV induced cervical cancers Dis Markers. 2007; 23(4):337-52. . View in PubMed
  • Immunological consequences of using three different clinical/laboratory techniques of emulsifying peptide-based vaccines in incomplete Freund’s adjuvant J Transl Med. 2006 Oct 23; 4:42. . View in PubMed
  • T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells Cancer Immunol Immunother. 2006 Sep; 55(9):1142-50. . View in PubMed
  • Eradication of established HPV 16-expressing tumors by a single administration of a vaccine composed of a liposome-encapsulated CTL-T helper fusion peptide in a water-in-oil emulsion Vaccine. 2006 Jun 12; 24(24):5235-44. . View in PubMed
  • Gamma-radiation upregulates MHC class I/II and ICAM-I molecules in multiple myeloma cell lines and primary tumors In Vitro Cell Dev Biol Anim. 2006 Mar-Apr; 42(3-4):89-95. . View in PubMed
  • Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma Hum Pathol. 2005 Dec; 36(12):1289-93. . View in PubMed
  • Vaccination Against Cervical Cancer: Hopes and Realities Am J Cancer (Auckl). 2005 Jul; 4(4):207-219. . View in PubMed
  • Human papillomavirus L1L2-E7 virus-like particles partially mature human dendritic cells and elicit E7-specific T-helper responses from patients with cervical intraepithelial neoplasia or cervical cancer in vitro Hum Immunol. 2005 Jul; 66(7):762-72. . View in PubMed
  • Human papillomavirus can escape immune recognition through Langerhans cell phosphoinositide 3-kinase activation J Immunol. 2005 Jun 01; 174(11):7172-8. . View in PubMed
  • Heterologous papillomavirus virus-like particles and human papillomavirus virus-like particle immune complexes activate human Langerhans cells Vaccine. 2005 Feb 25; 23(14):1720-9. . View in PubMed
  • Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor Cancer Res. 2005 Feb 15; 65(4):1570-6. . View in PubMed
  • The impact of anti HPV vaccination on cervical cancer incidence and HPV induced cervical lesions: consequences for clinical management Eur J Gynaecol Oncol. 2005; 26(2):129-42. . View in PubMed
  • Synopsis of the 6th Walker’s Cay Colloquium on Cancer Vaccines and Immunotherapy J Transl Med. 2004 Jun 22; 2(1):20. . View in PubMed
  • Disease-stage variance in functional CD4(+) T-cell responses against novel pan-human leukocyte antigen-D region presented human papillomavirus-16 E7 epitopes Clin Cancer Res. 2004 May 15; 10(10):3301-8. . View in PubMed
  • Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors Oncogene. 2004 May 13; 23(22):3972-9. . View in PubMed
  • Sperm protein 17 is expressed in human somatic ciliated epithelia J Histochem Cytochem. 2004 Apr; 52(4):549-54. . View in PubMed
  • Peptide-based vaccines for cancer immunotherapy Expert Opin Biol Ther. 2004 Feb; 4(2):181-98. . View in PubMed
  • Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes Vaccine. 2004 Jan 02; 22(3-4):520-7. . View in PubMed
  • Cure of glioma: a space not yet occupied for the lesion Cancer Invest. 2004; 22(3):479-80. . View in PubMed
  • Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo Blood. 2004 Jan 01; 103(1):177-84. . View in PubMed
  • Progress in the development of immunotherapy of cancer using ex vivo-generated dendritic cells expressing multiple tumor antigen epitopes Cancer Invest. 2004; 22(3):417-34. . View in PubMed
  • Cancer immunotherapy: avoiding the road to perdition J Transl Med. 2004 07 29; 2(1):26. . View in PubMed
  • Synopsis of the 5th annual Cancer Vaccines and Immunotherapy Colloquium at Walker’s Cay Cancer Immunol Immunother. 2003 Oct; 52(10):655-60. . View in PubMed
  • Is sperm protein 17 a useful target for tumor immunotherapy? Blood. 2003 Sep 15; 102(6):2308-9.. View in PubMed
  • Advances in prophylactic cancer vaccine research Expert Rev Anticancer Ther. 2003 Aug; 3(4):537-45. . View in PubMed
  • Heterologous boosting increases immunogenicity of chimeric papillomavirus virus-like particle vaccines Vaccine. 2003 Jul 04; 21(23):3219-27. . View in PubMed
  • Differential uptake and cross-presentation of human papillomavirus virus-like particles by dendritic cells and Langerhans cells Cancer Res. 2003 Jul 01; 63(13):3478-82. . View in PubMed
  • Enhanced tumour growth after DNA vaccination against human papilloma virus E7 oncoprotein: evidence for tumour-induced immune deviation Vaccine. 2003 Jun 02; 21(19-20):2506-15. . View in PubMed
  • Recent progress in tumour vaccine development Expert Opin Investig Drugs. 2003 Jun; 12(6):971-81. . View in PubMed
  • CD4+ T cell matters in tumor immunity Int Rev Immunol. 2003 Mar-Apr; 22(2):113-40. . View in PubMed
  • HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation J Cell Physiol. 2003 Mar; 194(3):356-62. . View in PubMed
  • Advances in immunotherapy for prostate cancer Adv Cancer Res. 2003; 87:159-94. . View in PubMed
  • Cervical cancer vaccines: recent advances in HPV research Viral Immunol. 2003; 16(2):111-21. . View in PubMed
  • HPV protein/peptide vaccines: from animal models to clinical trials Front Biosci. 2003 Jan 01; 8:s81-91. . View in PubMed
  • Synopsis of the 4th Walker’s Cay Meeting on Cancer Vaccines, 7-10 March 2002 Cancer Immunol Immunother. 2002 Dec; 51(11-12):674-6. . View in PubMed
  • Emerging strategies in tumor vaccines Curr Opin Oncol. 2002 Nov; 14(6):641-8. . View in PubMed
  • Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice Cancer Res. 2002 Oct 15; 62(20):5792-9. . View in PubMed
  • The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells J Immunol. 2002 Oct 15; 169(8):4273-8. . View in PubMed
  • Human papillomavirus virus-like particles do not activate Langerhans cells: a possible immune escape mechanism used by human papillomaviruses J Immunol. 2002 Sep 15; 169(6):3242-9. . View in PubMed
  • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells Nat Med. 2002 Sep; 8(9):979-86. . View in PubMed
  • Ins and outs of clinical trials with peptide-based vaccines Front Biosci. 2002 May 01; 7:e204-13. . View in PubMed
  • Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy J Immunother. 2002 Mar-Apr; 25(2):97-138. . View in PubMed
  • Immunodominance and tumor escape Semin Cancer Biol. 2002 Feb; 12(1):25-31. . View in PubMed
  • Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells Am J Pathol. 2002 Feb; 160(2):521-8. . View in PubMed
  • The cell-mediated immune response to human papillomavirus-induced cervical cancer: implications for immunotherapy Adv Cancer Res. 2002; 86:113-48. . View in PubMed
  • Comparison of human papillomavirus type 16 L1 chimeric virus-like particles versus L1/L2 chimeric virus-like particles in tumor prevention Intervirology. 2002; 45(4-6):300-7. . View in PubMed
  • T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14565-70. . View in PubMed
  • Effect of preexisting neutralizing antibodies on the anti-tumor immune response induced by chimeric human papillomavirus virus-like particle vaccines Virology. 2001 Nov 25; 290(2):350-60. . View in PubMed
  • Eradication of established tumors by vaccination with Venezuelan equine encephalitis virus replicon particles delivering human papillomavirus 16 E7 RNA Cancer Res. 2001 Nov 01; 61(21):7861-7. . View in PubMed
  • Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice Cancer Res. 2001 Aug 01; 61(15):5857-60. . View in PubMed
  • Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo Cancer Res. 2001 Jul 15; 61(14):5499-504. . View in PubMed
  • Pharmacokinetic differences between a T cell-tolerizing and a T cell-activating peptide J Immunol. 2001 Jun 15; 166(12):7151-7. . View in PubMed
  • Human dendritic cells are activated by chimeric human papillomavirus type-16 virus-like particles and induce epitope-specific human T cell responses in vitro J Immunol. 2001 May 15; 166(10):5917-24. . View in PubMed
  • Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA vaccine J Immunol. 2001 May 01; 166(9):5366-73. . View in PubMed
  • Prospect for immunotherapy of acute lymphoblastic leukemia Leukemia. 2001 May; 15(5):701-6. . View in PubMed
  • Physical interaction of human papillomavirus virus-like particles with immune cells Int Immunol. 2001 May; 13(5):633-41. . View in PubMed
  • Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells J Immunol. 2001 May 01; 166(9):5398-406. . View in PubMed
  • Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of Simian virus 40 large T antigen J Cell Biochem. 2001 Apr 2-27; 82(1):155-62. . View in PubMed
  • A murine model for the effects of pelvic radiation and cisplatin chemotherapy on human papillomavirus vaccine efficacy Clin Cancer Res. 2001 Mar; 7(3 Suppl):876s-881s. . View in PubMed
  • Human T-cell responses to HLA-A-restricted high binding affinity peptides of human papillomavirus type 18 proteins E6 and E7 Clin Cancer Res. 2001 Mar; 7(3 Suppl):788s-795s. . View in PubMed
  • Tracking the common ancestry of antigenically distinct cancer variants Clin Cancer Res. 2001 Mar; 7(3 Suppl):871s-875s. . View in PubMed
  • Cervical cancer vaccines: emerging concepts and developments J Cell Physiol. 2001 Feb; 186(2):169-82. . View in PubMed
  • Mucosal vaccination with a recombinant Salmonella typhimurium expressing human papillomavirus type 16 (HPV16) L1 virus-like particles (VLPs) or HPV16 VLPs purified from insect cells inhibits the growth of HPV16-expressing tumor cells in mice Virology. 2001 Jan 05; 279(1):354-60. . View in PubMed
  • A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive Clin Cancer Res. 2000 Sep; 6(9):3406-16. . View in PubMed
  • Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma J Immunother. 2000 Mar-Apr; 23(2):255-66. . View in PubMed
  • Notch signaling as a target in multimodality cancer therapy Curr Opin Mol Ther. 2000 Feb; 2(1):55-65. . View in PubMed
  • Successful immunotherapy of an intraocular tumor in mice Cancer Res. 1999 Oct 15; 59(20):5250-4. . View in PubMed
  • Effects of TGF-beta on the immune system: implications for cancer immunotherapy Leukemia. 1999 Aug; 13(8):1188-99. . View in PubMed
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