Faculty

Andre J Ouellette

Andre J Ouellette

Professor of Pathology
Pathology
NRT 7505 Health Sciences Campus Los Angeles

Rapamycin rejuvenates oral health in aging mice Elife. 2020 Apr 28; 9. . View in PubMed

Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. . View in PubMed

A novel role for lipid droplets in the organismal antibacterial response Elife. 2012 Nov 13; 1:e00003. . View in PubMed

ImmunologyHD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. . View in PubMed

Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins Biochemistry. 2011 Dec 06; 50(48):10508-19. . View in PubMed

Paneth cell a-defensins in enteric innate immunity Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. . View in PubMed

Paneth cells and innate mucosal immunity Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. . View in PubMed

Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue Biochemistry. 2008 Nov 25; 47(47):12626-34. . View in PubMed

Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers J Pept Sci. 2008 Apr; 14(4):503-9. . View in PubMed

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion J Immunol. 2007 Jul 15; 179(2):1245-53. . View in PubMed

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity J Biol Chem. 2006 Sep 29; 281(39):28932-42. . View in PubMed

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4 J Biol Chem. 2006 Sep 22; 281(38):28068-78. . View in PubMed

Paneth cell alpha-defensin synthesis and function Curr Top Microbiol Immunol. 2006; 306:1-25. . View in PubMed

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. . View in PubMed

Mammalian defensins in the antimicrobial immune response Nat Immunol. 2005 Jun; 6(6):551-7. . View in PubMed

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides Mol Microbiol. 2005 May; 56(3):789-99. . View in PubMed

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria Infect Immun. 2005 Apr; 73(4):2312-20. . View in PubMed

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin Biochemistry. 2004 Dec 21; 43(50):15759-66. . View in PubMed

Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities J Virol. 2004 Nov; 78(21):11622-31. . View in PubMed

Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4 J Biol Chem. 2004 Oct 15; 279(42):44188-96. . View in PubMed

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. . View in PubMed

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response J Biol Chem. 2004 May 07; 279(19):19902-7. . View in PubMed

Defensin-mediated innate immunity in the small intestine Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. . View in PubMed

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions J Biol Chem. 2004 Mar 19; 279(12):11976-83. . View in PubMed

Paneth cell alpha-defensins from rhesus macaque small intestine Infect Immun. 2004 Mar; 72(3):1470-8. . View in PubMed

Quantitative interactions between cryptdin-4 amino terminal variants and membranes Peptides. 2003 Nov; 24(11):1795-805. . View in PubMed

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranesProsegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. . View in PubMed

Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7 J Biol Chem. 2003 Mar 07; 278(10):7910-9. . View in PubMed

Activation of Paneth cell alpha-defensins in mouse small intestine J Biol Chem. 2002 Feb 15; 277(7):5219-28. . View in PubMed

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel J Biol Chem. 2002 Feb 01; 277(5):3793-800. . View in PubMed

Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of Tspiralis-infected mice. Clin Exp Immunol. 2001 Oct; 126(1):117-25. . View in PubMed

Paneth cell defensins and innate immunity of the small bowel Inflamm Bowel Dis. 2001 Feb; 7(1):43-50. . View in PubMed

Characterization of luminal paneth cell alpha-defensins in mouse small intestineAttenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73. . View in PubMed

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria Nat Immunol. 2000 Aug; 1(2):113-8. . View in PubMed

Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin Infect Immun. 1999 Dec; 67(12):6643-51. . View in PubMed

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Science. 1999 Oct 15; 286(5439):498-502. . View in PubMed

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense Science. 1999 Oct 01; 286(5437):113-7. . View in PubMed

IVPaneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol. 1999 08; 277(2):G257-61. . View in PubMed

Peptide mediators of innate immunity in the small intestine J Med Microbiol. 1998 Nov; 47(11):941-2. . View in PubMed

Paneth cells and innate immunity in the crypt microenvironment Gastroenterology. 1997 Nov; 113(5):1779-84. . View in PubMed

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3 Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9. . View in PubMed

Cryptdin gene expression in developing mouse small intestine Am J Physiol. 1997 Jan; 272(1 Pt 1):G197-206. . View in PubMed

Paneth cell defensins: endogenous peptide components of intestinal host defense FASEB J. 1996 Sep; 10(11):1280-9. . View in PubMed

Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine Am J Physiol. 1996 Jul; 271(1 Pt 1):G68-74. . View in PubMed

Rat neutrophil defensinsPrecursor structures and expression during neutrophilic myelopoiesis. J Immunol. 1995 Nov 01; 155(9):4476-84. . View in PubMed

Defensins in granules of phagocytic and non-phagocytic cells Trends Cell Biol. 1995 Mar; 5(3):114-9. . View in PubMed

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms Infect Immun. 1994 Nov; 62(11):5040-7. . View in PubMed

A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells Genomics. 1994 Nov 01; 24(1):99-109. . View in PubMed

A novel gene family coding for cationic, cysteine-rich peptidesRegulation in mouse small intestine and cells of myeloid origin. J Biol Chem. 1994 Jul 15; 269(28):18702. . View in PubMed

Structure and diversity of the murine cryptdin gene family Genomics. 1994 Feb; 19(3):448-53. . View in PubMed

In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis Exp Cell Res. 1993 Oct; 208(2):344-9. . View in PubMed

Ontogeny of Ia messenger RNA in the mouse small intestinal epithelium is modulated by age of weaning and diet Gastroenterology. 1993 Oct; 105(4):974-80. . View in PubMed

Differential regulation of B7 mRNA in enterocytes and lymphoid cells Immunology. 1993 Jul; 79(3):434-8. . View in PubMed

Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury Mol Cell Biol. 1993 Mar; 13(3):1933-42. . View in PubMed

Ontogeny of class II MHC mRNA in the mouse small intestinal epithelium Mol Immunol. 1992 Oct; 29(10):1257-63. . View in PubMed

The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus Genomics. 1992 Oct; 14(2):363-8. . View in PubMed

Enteric defensins: antibiotic peptide components of intestinal host defense J Cell Biol. 1992 Aug; 118(4):929-36. . View in PubMed

Purification and primary structure of murine cryptdin-1, a Paneth cell defensin FEBS Lett. 1992 Jun 15; 304(2-3):146-8. . View in PubMed

Class II antigen-associated invariant chain mRNA in mouse small intestine Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1642-8. . View in PubMed

A novel mouse gene family coding for cationic, cysteine-rich peptidesRegulation in small intestine and cells of myeloid origin. J Biol Chem. 1990 Jun 15; 265(17):9831-7. . View in PubMed

Localization of the cryptdin locus on mouse chromosome 8 Genomics. 1989 Aug; 5(2):233-9. . View in PubMed

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium J Cell Biol. 1989 May; 108(5):1687-95. . View in PubMed

Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine Gastroenterology. 1988 Jan; 94(1):114-21. . View in PubMed

Association of poly(adenylate)-deficient messenger ribonucleic acid with membranes in mouse kidney Biochemistry. 1981 Jun 09; 20(12):3561-7. . View in PubMed

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Affiliated Faculty at UPC