Austin K Mircheff, PhD
Austin K Mircheff, PhD
Professor of Physiology & Neuroscience
Physiology and Biophysics
BMT 11-A, 1333 San Pablo Street Health Sciences Campus Los Angeles

Molecular Evidence for Precursors of Sjögren's Foci in Histologically Normal Lacrimal Glands Int J Mol Sci. 2019 Jan 08; 20(1). . View in PubMed

A randomized, controlled study to evaluate the efficacy of intra-articular, autologous adipose tissue injections for the treatment of mild-to-moderate knee osteoarthritis compared to hyaluronic acid: a study protocol BMC Musculoskelet Disord. 2018 Oct 24; 19(1):383. . View in PubMed

Pregnancy probabilistically augments potential precursors to chronic, immune-mediated or autoimmune lacrimal gland infiltrates Ocul Surf. 2018 01; 16(1):120-131. . View in PubMed

Dry eye in postmenopausal women: a hormonal disorder Menopause. 2016 Mar; 23(3):343-51. . View in PubMed

Multiple Natural and Experimental Inflammatory Rabbit Lacrimal Gland PhenotypesOcul Surf. 2016 10; 14(4):460-483. e3. . View in PubMed

Potentially pathogenic immune cells and networks in apparently healthy lacrimal glands Ocul Surf. 2015 Jan; 13(1):47-81. . View in PubMed

Diverse mediators modulate the chloride ion fluxes that drive lacrimal fluid production Invest Ophthalmol Vis Sci. 2013 Apr 26; 54(4):2927-33. . View in PubMed

Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens Cornea. 2012 Jun; 31(6):693-701. . View in PubMed

A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. . View in PubMed

Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5137-44. . View in PubMed

Distinct dacryoadenitides autoadoptively transferred to rabbits by different subpopulations of lymphocytes activated ex vivo Cornea. 2010 Oct; 29(10):1153-62. . View in PubMed

A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human Ocul Surf. 2010 Jul; 8(3):111-34. . View in PubMed

Microporous poly(L-lactic acid) membranes fabricated by polyethylene glycol solvent-cast/particulate leaching technique Tissue Eng Part C Methods. 2009 Sep; 15(3):463-74. . View in PubMed

Cytopathology and exocrine dysfunction induced in ex vivo rabbit lacrimal gland acinar cell models by chronic exposure to histamine or serotonin Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3164-75. . View in PubMed

Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis J Ocul Pharmacol Ther. 2009 Jun; 25(3):285-92. . View in PubMed

Autoimmune dacryoadenitis and keratoconjunctivitis induced in rabbits by subcutaneous injection of autologous lymphocytes activated ex vivo against lacrimal antigens J Autoimmun. 2008 Sep; 31(2):116-22. . View in PubMed

Animal models of dry eye Dev Ophthalmol. 2008; 41:298-312. . View in PubMed

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib Mol Cancer Ther. 2007 Apr; 6(4):1262-75. . View in PubMed

Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. . View in PubMed

Current status of gene delivery and gene therapy in lacrimal gland using viral vectors Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. . View in PubMed

Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland Exp Eye Res. 2006 Nov; 83(5):1081-8. . View in PubMed

Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and function Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1368-75. . View in PubMed

Mucosal immunity and self-tolerance in the ocular surface system Ocul Surf. 2005 Oct; 3(4):182-92. . View in PubMed

Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis J Autoimmune Dis. 2005 Jun 28; 2:6. . View in PubMed

Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation Scand J Immunol. 2005 Jan; 61(1):36-50. . View in PubMed

Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation Exp Eye Res. 2004 Nov; 79(5):665-75. . View in PubMed

Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells J Cell Physiol. 2004 Apr; 199(1):108-25. . View in PubMed

Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells Mol Biol Cell. 2003 Nov; 14(11):4397-413. . View in PubMed

Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist Scand J Immunol. 2003 Nov; 58(5):550-65. . View in PubMed

Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. . View in PubMed

Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis Cornea. 2003 Jan; 22(1):25-32. . View in PubMed

Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. . View in PubMed

Growth of purified lacrimal acinar cells in Matrigel raft cultures Exp Eye Res. 2002 Mar; 74(3):349-60. . View in PubMed

Expression of IL-10 and TNF-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes Cornea. 2002 Mar; 21(2):210-4. . View in PubMed

A new model system for studying lacrimal physiology using cultured lacrimal gland acinar cells on Matrigel rafts Adv Exp Med Biol. 2002; 506(Pt A):159-63. . View in PubMed

IL-2 immunoreactive proteins in lacrimal acinar cells Adv Exp Med Biol. 2002; 506(Pt B):795-9. . View in PubMed

Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction Adv Exp Med Biol. 2002; 506(Pt B):789-94. . View in PubMed

Epidermal growth factor traffic in lacrimal acinar cells Adv Exp Med Biol. 2002; 506(Pt A):213-7. . View in PubMed

Glycolipid-rich membrane microdomains in lacrimal acinar cell endomembrane compartments Adv Exp Med Biol. 2002; 506(Pt A):207-11. . View in PubMed

Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system Exp Eye Res. 2002 Jan; 74(1):7-22. . View in PubMed

M3 receptor autoimmunity: losing tolerance to a familiar protein Adv Exp Med Biol. 2002; 506(Pt A):51-8. . View in PubMed

Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations Exp Eye Res. 2000 Jul; 71(1):11-22. . View in PubMed

Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits Exp Eye Res. 2000 Jul; 71(1):23-31. . View in PubMed

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein Virology. 1999 Oct 10; 263(1):30-41. . View in PubMed

Androgen influence on lacrimal gland apoptosis, necrosis, and lymphocytic infiltration Invest Ophthalmol Vis Sci. 1999 Mar; 40(3):592-602. . View in PubMed

MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes Am J Physiol. 1999 11; 277(5):C994-C1007. . View in PubMed

In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition Am J Physiol. 1999 05; 276(5):F711-9. . View in PubMed

Androgen support of lacrimal gland function in the female rabbit Adv Exp Med Biol. 1998; 438:89-93. . View in PubMed

A method to study induction of autoimmunity in vitro: co-culture of lacrimal cells and autologous immune system cells Adv Exp Med Biol. 1998; 438:583-9. . View in PubMed

Kinesin activation drives the retrieval of secretory membranes following secretion in rabbit lacrimal acinar cells Adv Exp Med Biol. 1998; 438:177-80. . View in PubMed

A unified theory of the role of the ocular surface in dry eye Adv Exp Med Biol. 1998; 438:643-51. . View in PubMed

Acinar cell basal-lateral membrane-endomembrane traffic may mediate interactions with both T cells and B cells Adv Exp Med Biol. 1998; 438:63-8. . View in PubMed

Adenovirus infection of the cornea causes histopathologic changes in the lacrimal gland Curr Eye Res. 1997 May; 16(5):459-66. . View in PubMed

Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity Exp Eye Res. 1997 Feb; 64(2):141-56. . View in PubMed

Androgen support of lacrimal gland function Endocrine. 1997 Feb; 6(1):39-45. . View in PubMed

Na-K-ATPase in lacrimal gland acinar cell endosomal system: correcting a case of mistaken identity Am J Physiol. 1996 Nov; 271(5 Pt 1):C1685-98. . View in PubMed

Endothelin protein expression in tear glands of the rabbit Curr Eye Res. 1996 Jul; 15(7):768-73. . View in PubMed

Evidence of sodium-dependent glucose transport in human erythroleukemia cells Life Sci. 1996; 58(17):1445-52. . View in PubMed

Hormonal support of lacrimal function, primary lacrimal deficiency, autoimmunity, and peripheral tolerance in the lacrimal gland Ocul Immunol Inflamm. 1996; 4(3):145-72. . View in PubMed

Fluid phase endocytosis by isolated rabbit lacrimal gland acinar cells Exp Eye Res. 1995 May; 60(5):511-25. . View in PubMed

Hypophysectomy-induced regression of female rat lacrimal glands: partial restoration and maintenance by dihydrotestosterone and prolactin Invest Ophthalmol Vis Sci. 1995 Jan; 36(1):216-26. . View in PubMed

Autoimmunity of the lacrimal gland Int Ophthalmol Clin. 1994; 34(1):1-18. . View in PubMed

Hypothesis for autoantigen presentation and T cell activation Adv Exp Med Biol. 1994; 350:651-4. . View in PubMed

Effects of dihydrotestosterone and prolactin on lacrimal gland function Adv Exp Med Biol. 1994; 350:99-104. . View in PubMed

Isolation and identification of plasma membrane populations Methods Enzymol. 1994; 228:432-48. . View in PubMed

Endocytosis and exocytosis in rabbit lacrimal gland acinar cells Adv Exp Med Biol. 1994; 350:111-4. . View in PubMed

Complex subcellular distribution of sodium-dependent amino acid transport systems in kidney cortex and LLC-PK1/Cl4 cells Kidney Int. 1994 Jan; 45(1):110-22. . View in PubMed

Immunogold localization of prolactin in acinar cells of lacrimal gland Adv Exp Med Biol. 1994; 350:75-7. . View in PubMed

Carbachol-induced increase of Na+/H+ antiport and recruitment of Na+,K(+)-ATPase in rabbit lacrimal acini Curr Eye Res. 1993 Jun; 12(6):539-51. . View in PubMed

Plasma membrane internalization and recycling in rabbit lacrimal acinar cells Invest Ophthalmol Vis Sci. 1993 Feb; 34(2):305-16. . View in PubMed

Isolation and subcellular fractionation analysis of acini from rabbit lacrimal glands Invest Ophthalmol Vis Sci. 1992 Sep; 33(10):2951-65. . View in PubMed

Class II antigen expression by lacrimal epithelial cellsAn updated working hypothesis for antigen presentation by epithelial cells. Invest Ophthalmol Vis Sci. 1991 Jul; 32(8):2302-10. . View in PubMed

pH-sensitive anion exchanger in rat lacrimal acinar cells Am J Physiol. 1991 Mar; 260(3 Pt 1):G517-23. . View in PubMed

Analytic subcellular fractionation of acini from rat lacrimal gland Invest Ophthalmol Vis Sci. 1990 Nov; 31(11):2437-47. . View in PubMed

Isolation and provisional identification of plasma membrane populations from cultured human retinal pigment epithelium Invest Ophthalmol Vis Sci. 1990 May; 31(5):863-78. . View in PubMed

Isolation of enterocyte membranes Methods Enzymol. 1990; 192:341-54. . View in PubMed

Parathyroid hormone-induced translocation of Na-H antiporters in rat proximal tubules Am J Physiol. 1989 Oct; 257(4 Pt 1):C637-45. . View in PubMed

Lacrimal fluid and electrolyte secretion: a review Curr Eye Res. 1989 Jun; 8(6):607-17. . View in PubMed

Isolation of plasma membranes from polar cells and tissues: apical/basolateral separation, purity, function Methods Enzymol. 1989; 172:18-34. . View in PubMed

Cl(-)-HCO3- antiport in rat lacrimal gland Am J Physiol. 1988 Sep; 255(3 Pt 1):G367-73. . View in PubMed

Ca2+ - and cAMP-induced protein phosphorylation in lacrimal gland basolateral membranes Am J Physiol. 1988 Apr; 254(4 Pt 1):G543-51. . View in PubMed

Characterization of intracellular Ca2+-stores in rat duodenal epithelium Prog Clin Biol Res. 1988; 252:127-32. . View in PubMed

Na+/H+ antiporter in lacrimal acinar cell basal-lateral membranes Invest Ophthalmol Vis Sci. 1987 Oct; 28(10):1726-9. . View in PubMed

Laterobasal membranes from intestinal epithelial cells: isolation free of intracellular membrane contaminants J Membr Biol. 1987; 98(3):197-205. . View in PubMed

Apical and basal-lateral Na/K-ATPase in rat lacrimal gland acinar cells Invest Ophthalmol Vis Sci. 1986 Aug; 27(8):1293-6. . View in PubMed

Mapping subcellular distribution of Na+-K+-ATPase in rat parotid gland Am J Physiol. 1986 Mar; 250(3 Pt 1):C430-41. . View in PubMed

Complex subcellular distributions of enzymatic markers in intestinal epithelial cells J Membr Biol. 1985; 83(1-2):95-107. . View in PubMed

A map of membrane populations isolated from rat exorbital gland Am J Physiol. 1984 Dec; 247(6 Pt 1):G651-61. . View in PubMed

Na+/H+ antiporter in membrane populations resolved from a renal brush border vesicle preparation Am J Physiol. 1984 Jun; 246(6 Pt 2):F853-8. . View in PubMed

Basal-lateral and intracellular membrane populations of rat exorbital lacrimal gland Am J Physiol. 1983 Jul; 245(1):G133-42. . View in PubMed

Intestinal surface aminooligopeptidaseDistinct molecular forms during assembly on intracellular membranes in vivo. J Biol Chem. 1983 May 10; 258(9):5960-6. . View in PubMed

Empirical strategy for analytical fractionation of epithelial cells Am J Physiol. 1983 Apr; 244(4):G347-56. . View in PubMed

Delineation of sodium-stimulated amino acid transport pathways in rabbit kidney brush border vesicles J Membr Biol. 1982; 64(1-2):113-22. . View in PubMed

Pathways for alanine transport in intestinal basal lateral membrane vesicles J Membr Biol. 1980 Jan 31; 52(1):83-92. . View in PubMed

Highly purified basal lateral plasma membranes from rat duodenumPhysical criteria for purity. J Membr Biol. 1979 Nov 30; 50(3-4):343-63. . View in PubMed

Large scale, analytical method for isolating basal lateral plasma membranes from rat duodenum Prep Biochem. 1979; 9(2):133-48. . View in PubMed

Alkaline phosphatase of basal lateral and brush border plasma membranes from intestinal epithelium J Supramol Struct. 1979; 11(4):451-66. . View in PubMed

Preparative scale isolation of basal-lateral plasma membranes from rat intestinal epithelial cells Membr Biochem. 1978; 1(3-4):177-85. . View in PubMed

Distribution of bicarbonate-stimulated ATPase in rat intestinal epithelium J Cell Biol. 1977 Apr; 73(1):257-60. . View in PubMed

Analytical isolation of plasma membranes of intestinal epithelial cells: identification of Na, K-ATPase rich membranes and the distribution of enzyme activities J Membr Biol. 1976 Sep 17; 28(4):309-33. . View in PubMed

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Affiliated Faculty at UPC