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Omid Akbari, PhD

Professor of Molecular Microbiology & Immunology

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Phone +1 323 442 7930
Email akbari@usc.edu
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Publications

  • Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity J Exp Med. 2024 May 06; 221(5). . View in PubMed
  • Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages PLoS Pathog. 2024 Mar 11; 20(3):e1012079. . View in PubMed
  • Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity J Allergy Clin Immunol. 2024 Jan 19. . View in PubMed
  • Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease Sci Rep. 2024 02 13; 14(1):3612. . View in PubMed
  • Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models Nat Commun. 2023 Sep 26; 14(1):5989. . View in PubMed
  • Spatially resolved immune exhaustion within the alloreactive microenvironment predicts liver transplant rejection Res Sq. 2023 Jul 03. . View in PubMed
  • LAIR-1 limits macrophage activation in acute inflammatory lung injury Mucosal Immunol. 2023 12; 16(6):788-800. . View in PubMed
  • Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cellsJ Allergy Clin Immunol. 2023 02; 151(2):526-538. e8. . View in PubMed
  • Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation Nat Commun. 2023 04 11; 14(1):2045. . View in PubMed
  • Multiple chemical sensitivity scoping review protocol: overview of research and MCS construct BMJ Open. 2023 09 22; 13(9):e072098. . View in PubMed
  • Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome Cell Rep. 2023 08 29; 42(8):112990. . View in PubMed
  • Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivityJ Allergy Clin Immunol. 2022 05; 149(5):1628-1642. e10. . View in PubMed
  • LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivityJ Allergy Clin Immunol. 2022 01; 149(1):223-236. e6. . View in PubMed
  • Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23 Nat Commun. 2022 03 17; 13(1):1440. . View in PubMed
  • Near-roadway air pollution, immune cells and adipokines among obese young adults Environ Health. 2022 03 19; 21(1):36. . View in PubMed
  • Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection Front Immunol. 2022; 13:831103. . View in PubMed
  • Analysis of the interplay between hepatitis B virus-positive hepatocytes and Kupffer cells ex vivo using mice as a model STAR Protoc. 2022 06 17; 3(2):101364. . View in PubMed
  • PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability Nat Commun. 2022 08 31; 13(1):5118. . View in PubMed
  • Correction for Hirose et al, “Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells”. J Virol. 2021 Apr 12; 95(9). . View in PubMed
  • CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation Mucosal Immunol. 2021 07; 14(4):899-911. . View in PubMed
  • IL-10 production by ILC2s requires Blimp-1 and cMaf, modulates cellular metabolism, and ameliorates airway hyperreactivityJ Allergy Clin Immunol. 2021 04; 147(4):1281-1295. e5. . View in PubMed
  • Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes Front Immunol. 2021; 12:727008. . View in PubMed
  • Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation mBio. 2021 08 31; 12(4):e0117621. . View in PubMed
  • Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis Front Immunol. 2021; 12:679521. . View in PubMed
  • PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-a Production and Restricts Progression of Metastatic Melanoma Front Immunol. 2021; 12:733136. . View in PubMed
  • AMPK induces regulatory innate lymphoid cells after traumatic brain injury JCI Insight. 2021 01 11; 6(1). . View in PubMed
  • Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells J Virol. 2021 01 28; 95(4). . View in PubMed
  • CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma Nat Commun. 2021 05 05; 12(1):2526. . View in PubMed
  • Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis iScience. 2020 Oct 23; 23(10):101549. . View in PubMed
  • Repopulation of T, B, and NK cells following alemtuzumab treatment in relapsing-remitting multiple sclerosis J Neuroinflammation. 2020 Jun 15; 17(1):189. . View in PubMed
  • Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation FASEB J. 2020 09; 34(9):11444-11459. . View in PubMed
  • Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector functionJ Allergy Clin Immunol. 2020 02; 145(2):502-517. e5. . View in PubMed
  • Role of Autophagy in Lung Inflammation Front Immunol. 2020; 11:1337. . View in PubMed
  • PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity Nat Commun. 2020 08 10; 11(1):3998. . View in PubMed
  • Feasibility of quantifying change in immune white cells in abdominal adipose tissue in response to an immune modulator in clinical obesity PLoS One. 2020; 15(9):e0237496. . View in PubMed
  • Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity Front Immunol. 2020; 11:542818. . View in PubMed
  • DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus Nat Commun. 2020 09 18; 11(1):4718. . View in PubMed
  • Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed
  • A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity PLoS Genet. 2019 12; 15(12):e1008528. . View in PubMed
  • Immunologic benefit of maternal donors in pediatric living donor liver transplantation Pediatr Transplant. 2019 11; 23(7):e13560. . View in PubMed
  • Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance Nat Commun. 2019 04 12; 10(1):1693. . View in PubMed
  • Roles of Type 1, 2, and 3 Innate Lymphoid Cells in Herpes Simplex Virus 1 Infection In Vitro and In Vivo J Virol. 2019 07 01; 93(13). . View in PubMed
  • Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes Nat Commun. 2019 02 12; 10(1):713. . View in PubMed
  • Dietary Fiber-Induced Microbial Short Chain Fatty Acids Suppress ILC2-Dependent Airway Inflammation Front Immunol. 2019; 10:2051. . View in PubMed
  • TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway HyperreactivityCell Rep. 2019 12 24; 29(13):4509-4524. e5. . View in PubMed
  • Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Sci Rep. 2019 02 12; 9(1):1816. . View in PubMed
  • A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice Nat Commun. 2019 12 12; 10(1):5681. . View in PubMed
  • Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentationJ Allergy Clin Immunol. 2018 12; 142(6):1894-1908. e7. . View in PubMed
  • Activated plasmacytoid dendritic cells regulate type 2 innate lymphoid cell-mediated airway hyperreactivityJ Allergy Clin Immunol. 2018 03; 141(3):893-905. e6. . View in PubMed
  • IL-10, TGF-ß, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cellsJ Allergy Clin Immunol. 2018 03; 141(3):1147-1151. e8. . View in PubMed
  • Herpes Simplex Virus 1 Specifically Targets Human CD1d Antigen Presentation To Enhance Its Pathogenicity J Virol. 2018 11 15; 92(22). . View in PubMed
  • Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma Front Immunol. 2018; 9:2694. . View in PubMed
  • Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interactionJ Allergy Clin Immunol. 2017 May; 139(5):1468-1477. e2. . View in PubMed
  • Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps Immun Inflamm Dis. 2017 09; 5(3):233-243. . View in PubMed
  • Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation Antimicrob Agents Chemother. 2017 08; 61(8). . View in PubMed
  • Type two innate lymphoid cells: the Janus cells in health and disease Immunol Rev. 2017 07; 278(1):192-206. . View in PubMed
  • Reply J Allergy Clin Immunol. 2017 02; 139(2):712-713. . View in PubMed
  • Increased Innate Lymphoid Cells in Periodontal Tissue of the Murine Model of Periodontitis: The Role of AMP-Activated Protein Kinase and Relevance for the Human Condition Front Immunol. 2017; 8:922. . View in PubMed
  • Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. . View in PubMed
  • Innate lymphoid cells: a paradigm for low SSI in cleft lip repair J Surg Res. 2016 10; 205(2):312-317. . View in PubMed
  • Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity Obesity (Silver Spring). 2016 06; 24(6):1274-82. . View in PubMed
  • Lack of autophagy induces steroid-resistant airway inflammationJ Allergy Clin Immunol. 2016 05; 137(5):1382-1389. e9. . View in PubMed
  • Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4 J Neuroimmunol. 2016 10 15; 299:70-78. . View in PubMed
  • Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity Nat Commun. 2016 10 18; 7:13202. . View in PubMed
  • Cell Rep. 2016 07 12; 16(2):405-418. . View in PubMed
  • Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission Immunity. 2016 05 17; 44(5):1204-14. . View in PubMed
  • ICOS regulates ILC2s in asthma Oncotarget. 2015 Sep 22; 6(28):24584-5. . View in PubMed
  • A Subset of CD8aß+ Invariant NKT Cells in a Humanized Mouse Model J Immunol. 2015 Aug 15; 195(4):1459-69. . View in PubMed
  • Batf3 deficiency is not critical for the generation of CD8a? dendritic cells. Immunobiology. 2015 Apr; 220(4):518-24.. View in PubMed
  • ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity Immunity. 2015 Mar 17; 42(3):538-51. . View in PubMed
  • Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses PLoS One. 2014; 9(1):e87617. . View in PubMed
  • Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivityJ Allergy Clin Immunol. 2013 Apr; 131(4):1048-571057. e1-2. . View in PubMed
  • Sex-specific perinatal nicotine-induced asthma in rat offspring Am J Respir Cell Mol Biol. 2013 Jan; 48(1):53-62. . View in PubMed
  • Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection PLoS One. 2013; 8(3):e59599. . View in PubMed
  • Perinatal nicotine exposure induces asthma in second generation offspring BMC Med. 2012 Oct 30; 10:129. . View in PubMed
  • Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties J Immunol. 2012 Mar 01; 188(5):2254-65. . View in PubMed
  • Effects of systemic versus local administration of corticosteroids on mucosal tolerance J Immunol. 2012 Jan 01; 188(1):470-6. . View in PubMed
  • Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis J Clin Invest. 2011 Jan; 121(1):277-87. . View in PubMed
  • TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells J Immunol. 2010 Dec 01; 185(11):6839-49. . View in PubMed
  • A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity J Immunol. 2010 Feb 15; 184(4):2107-15. . View in PubMed
  • PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions Mucosal Immunol. 2010 Jan; 3(1):81-91. . View in PubMed
  • The role of costimulatory molecules in allergic disease and asthma Int Arch Allergy Immunol. 2010; 151(3):179-89. . View in PubMed
  • Dendritic cell modulation as a new interventional approach for the treatment of asthma Drug News Perspect. 2009 Oct; 22(8):445-51. . View in PubMed
  • Natural killer T cells in the lungs of patients with asthma J Allergy Clin Immunol. 2009 May; 123(5):1181-5. . View in PubMed
  • Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB J Immunol. 2009 Apr 15; 182(8):5116-22. . View in PubMed
  • Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice J Immunol. 2008 Oct 01; 181(7):4560-4569. . View in PubMed
  • Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop Eur J Immunol. 2008 Jun; 38(6):1756-66. . View in PubMed
  • ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival J Immunol. 2008 Apr 15; 180(8):5448-56. . View in PubMed
  • Recent advances in the role of NKT cells in allergic diseases and asthma Curr Allergy Asthma Rep. 2008 Apr; 8(2):165-70. . View in PubMed
  • Invariant natural killer T cells in obstructive pulmonary diseases N Engl J Med. 2007 Jul 12; 357(2):193-4; author reply 194-5. . View in PubMed
  • CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma N Engl J Med. 2006 Mar 16; 354(11):1117-29. . View in PubMed
  • Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2782-7. . View in PubMed
  • Respiratory tolerance is inhibited by the administration of corticosteroids J Immunol. 2005 Dec 01; 175(11):7380-7. . View in PubMed
  • TIM-1 induces T cell activation and inhibits the development of peripheral tolerance Nat Immunol. 2005 May; 6(5):447-54. . View in PubMed
  • Role of regulatory dendritic cells in allergy and asthma Curr Allergy Asthma Rep. 2005 Jan; 5(1):56-61. . View in PubMed
  • Role of regulatory dendritic cells in allergy and asthma Curr Opin Allergy Clin Immunol. 2004 Dec; 4(6):533-8. . View in PubMed
  • Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity Nat Immunol. 2004 Nov; 5(11):1149-56. . View in PubMed
  • CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation Eur J Immunol. 2004 Jul; 34(7):1817-27. . View in PubMed
  • Role of regulatory T cells in allergy and asthma Curr Opin Immunol. 2003 Dec; 15(6):627-33. . View in PubMed
  • Regulatory T cells control the development of allergic disease and asthma J Allergy Clin Immunol. 2003 Sep; 112(3):480-7; quiz 488. . View in PubMed
  • Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity Nat Med. 2003 May; 9(5):582-8. . View in PubMed
  • Mucosal tolerance and immunity: regulating the development of allergic disease and asthma Int Arch Allergy Immunol. 2003 Feb; 130(2):108-18. . View in PubMed
  • Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity Nat Med. 2002 Sep; 8(9):1024-32. . View in PubMed
  • CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation J Allergy Clin Immunol. 2002 Sep; 110(3):460-8. . View in PubMed
  • Asthma: an epidemic of dysregulated immunity Nat Immunol. 2002 Aug; 3(8):715-20. . View in PubMed

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