Amy L. Ryan

Amy L. Ryan

Assistant Professor of Medicine
HMR 712 2011 Zonal Avenue Off Campus Los Angeles

American Thoracic Society: ATS Assembly on Respiratory Cell and Molecular Biology Carol Basbaum Award , 2017

British Council: British Councils Alumni Award for Professional Achievement in the USA Finalist, 2017

American Physiology Society: Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award, 2014

American Heart Association : Finalist, Cournand and Comroe Young Investigator Award, 2009

House of Commons: Finalist, Britain's Top Young Researcher in Biosciences and Medicine, 2005

Stem Cells and Lung Regeneration Am J Physiol Cell Physiol. 2020 Aug 12. . View in PubMed

The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner bioRxiv. 2020 Jul 22. . View in PubMed

Technological advances in study of lung regenerative medicine: perspective from the 2019 Vermont lung stem cell conference Cytotherapy. 2020 Jun 02. . View in PubMed

Correcting CFTR: New Gene Editing Strategies for Rescuing CFTR Function Ex Vivo Cell Stem Cell. 2020 Apr 02; 26(4):476-478. . View in PubMed

Derivation of induced pluripotent stem cells from ferret somatic cells Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L671-L683. . View in PubMed

Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 10; 61(4):429-439. . View in PubMed

The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. . View in PubMed

Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration Cell Stem Cell. 2017 12 07; 21(6):712-714. . View in PubMed

Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells J Biosci. 2016 Dec; 41(4):659-666. . View in PubMed

The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. . View in PubMed

Alterations of voltage-dependent K(+) channels in the mesenteric artery during the early and chronic phases of diabetes Clin Exp Pharmacol Physiol. 2016 09; 43(9):808-17. . View in PubMed

The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle Vascul Pharmacol. 2016 09; 84:38-46. . View in PubMed

Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells Pharmacology. 2016; 98(5-6):220-227. . View in PubMed

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs Cell Rep. 2015 Sep 01; 12(9):1385-90. . View in PubMed

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs Cell Stem Cell. 2015 Apr 02; 16(4):367-72. . View in PubMed

W-7 inhibits voltage-dependent K(+) channels independent of calmodulin activity in rabbit coronary arterial smooth muscle cells Eur J Pharmacol. 2015 Mar 05; 750:14-9. . View in PubMed

The Effects of the Selective Serotonin Reuptake Inhibitor Fluvoxamine on Voltage-Dependent K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells Biol Pharm Bull. 2015; 38(8):1208-13. . View in PubMed

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. . View in PubMed

Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension Physiol Rep. 2013 Dec 01; 1(7):e00190. . View in PubMed

Side-effects of protein kinase inhibitors on ion channels J Biosci. 2013 Dec; 38(5):937-49. . View in PubMed

Human models for smooth muscle cell differentiationFocus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". . 2013 Feb 15; 304(4):C287-8. . View in PubMed

Regulation of ca(2+) signaling in pulmonary hypertension Korean J Physiol Pharmacol. 2013 Feb; 17(1):1-8. . View in PubMed

Animal models of pulmonary hypertension: Rho kinase inhibition Prog Biophys Mol Biol. 2012 Aug; 109(3):67-75. . View in PubMed

"Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cellsFocus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". . 2012 Jul 15; 303(2):C113-4. . View in PubMed

PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells . 2012 Jan 15; 302(2):C405-11. . View in PubMed

Identification of functional progenitor cells in the pulmonary vasculature Pulm Circ. 2012 Jan-Mar; 2(1):84-100. . View in PubMed

Direct effect of protein kinase C inhibitors on cardiovascular ion channels BMB Rep. 2011 Sep; 44(9):559-65. . View in PubMed

Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling Compr Physiol. 2011 Jul; 1(3):1555-602. . View in PubMed

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines Stem Cells. 2011 Jul; 29(7):1158-64. . View in PubMed

Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant Mol Pharmacol. 2011 Mar; 79(3):381-8. . View in PubMed

Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels Pulm Circ. 2011 Jan 01; 1(1):48-71. . View in PubMed

Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101. . View in PubMed

Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats Prog Biophys Mol Biol. 2010 Sep; 103(1):88-94. . View in PubMed

Idiopathic pulmonary arterial hypertension Dis Model Mech. 2010 May-Jun; 3(5-6):268-73. . View in PubMed

Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension . 2010 May; 298(5):C1217-25. . View in PubMed

Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension . 2010 Apr; 298(4):L548-57. . View in PubMed

Patho-, physiological roles of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells J Smooth Muscle Res. 2010; 46(2):89-105. . View in PubMed

Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension . 2009 Oct; 297(4):L666-76. . View in PubMed

Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells Ann N Y Acad Sci. 2009 Oct; 1177:101-11. . View in PubMed

Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells . 2009 Jun; 296(6):L979-86. . View in PubMed

Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension . 2009 Jun; 296(6):L870-8. . View in PubMed

Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation . 2009 Mar; 296(3):L347-60. . View in PubMed

Fine tuning I(CRAC): the interactions of STIM-1 and Orai J Physiol. 2009 Jan 15; 587(1):15-6. . View in PubMed

Bringing down the ROS: a new therapeutic approach for PPHN . 2008 Dec; 295(6):L976-8. . View in PubMed

Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells . 2008 Dec; 295(6):L1048-55. . View in PubMed

Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells . 2008 Oct; 295(4):L648-57. . View in PubMed

Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells . 2008 Jul; 295(1):L61-70. . View in PubMed

Regulation of pulmonary vasoconstriction by agonists and caveolae Exp Lung Res. 2008 May; 34(4):195-208. . View in PubMed

Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling Circulation. 2008 Jan 01; 117(1):61-9. . View in PubMed

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells . 2007 Oct; 293(4):L952-9. . View in PubMed

Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells . 2007 Sep; 293(3):C928-37. . View in PubMed

Many of us take our lungs for granted yet they perform a function that is critical for life, respiration. Unfortunately millions of Americans suffer from one of a number of debilitating lung diseases making the subconscious action of breathing a very conscious and difficult activity. Studying human lung disease and, in particular, the way in which a lung disease develops in humans is exceptionally difficult in a dish. For me this was the challenge that became the focus of my postdoctoral research at The Salk Institute for Biological Studies – to create a reproducible and effective way to study human lung development and disease in a dish.

My laboratory will focus on utilizing patient derived induced pluripotent stem cells (iPSC) and state-of-the-art gene editing technologies, such as CRISPR, to a) model and study mechanisms of lung disease development and b) investigate approaches for tissue regeneration and stem cell mediated repair of the airway epithelium.
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Affiliated Faculty at UPC