Peggy Farnham, PhD

Dr. Farnham is the William M. Keck Professor of Biochemistry and the Chair of the Department of Biochemistry and Molecular Biology at the Keck School of Medicine at the University of Southern California in Los Angeles, California. Dr. Farnham received her bachelor’s degree from Rice University, her Ph.D. from Yale University, and performed her post-doctoral training at Stanford University. Dr. Farnham previously held Professorships at the McArdle Laboratory for Cancer Research at the University of Wisconsin-Madison and at the University of California-Davis where she was the Associate Director of the UC Davis Genome Center. Dr. Farnham is an international leader in the study of chromatin regulation and its control of transcription factor binding and function. She is a member of an international consortia of genomic scientists working on the ENCODE (Encyclopedia of DNA elements) Project and a member of an NIH Roadmap Reference Epigenome Mapping Center. Based on her contributions to biomedical research, she was elected as a fellow of AAAS in 2010 and in 2012 she received the ASBMB Herbert A Sober Award, which recognizes outstanding biochemical and molecular biological research with particular emphasis on the development of methods and techniques to aid in research.

Research Interests: transcriptional genomics, genomic technologies
Diseases Models: cancer cells and tissues, cultured neuroepithelial cells
Consortia: ENCODE, Roadmap Epigenome Mapping Centers, PsychENCODE

• ASBMB Herbert A. Sober Award, 2012
• AAAS Fellow, 2010

• m6A epitranscriptome analysis reveals differentially methylated transcripts that drive early chemoresistance in bladder cancer NAR Cancer. 2023 Dec; 5(4):zcad054. . View in PubMed
• Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes Nature. 2022 May; 605(7909):E3. . View in PubMed
• FOXC1 Binds Enhancers and Promotes Cisplatin Resistance in Bladder Cancer Cancers (Basel). 2022 Mar 28; 14(7). . View in PubMed
• Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability Genome Biol. 2022 07 26; 23(1):163. . View in PubMed
• TENET 20: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023. . View in PubMed
• Expanded encyclopaedias of DNA elements in the human and mouse genomes Nature. 2020 07; 583(7818):699-710. . View in PubMed
• Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells PLoS One. 2020; 15(2):e0228590. . View in PubMed
• Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters Nucleic Acids Res. 2020 06 19; 48(11):5986-6000. . View in PubMed
• Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner Epigenetics Chromatin. 2019 May 03; 12(1):26. . View in PubMed
• The Enigmatic HOX Genes: Can We Crack Their Code? Cancers (Basel). 2019 Mar 07; 11(3).. View in PubMed
• The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression Sci Adv. 2019 07; 5(7):eaaw6710. . View in PubMed
• Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature J Cell Biochem. 2019 03; 120(3):3056-3070. . View in PubMed
• A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome Nat Commun. 2019 09 12; 10(1):4154. . View in PubMed
• ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters Genome Res. 2018 Feb 02. . View in PubMed
• Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation Sci Adv. 2018 12; 4(12):eaav8550. . View in PubMed
• CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops Genome Biol. 2018 10 08; 19(1):160. . View in PubMed
• Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq) Methods Mol Biol. 2018; 1766:209-229. . View in PubMed
• A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13 Cell Rep. 2017 Nov 07; 21(6):1411-1417. . View in PubMed
• dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression Nucleic Acids Res. 2017 Sep 29; 45(17):9901-9916. . View in PubMed
• 4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus Sci Rep. 2016 Mar 03; 6:22462. . View in PubMed
• Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells Nucleic Acids Res. 2016 05 19; 44(9):4123-33. . View in PubMed
• Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits Epigenetics Chromatin. 2016; 9:50. . View in PubMed
• The PsychENCODE project Nat Neurosci. 2015 Dec; 18(12):1707-12. . View in PubMed
• Inferring regulatory element landscapes and transcription factor networks from cancer methylomes Genome Biol. 2015 May 21; 16:105. . View in PubMed
• The role of DNA methylation in directing the functional organization of the cancer epigenome Genome Res. 2015 Apr; 25(4):467-77. . View in PubMed
• Integrative analysis of 111 reference human epigenomes Nature. 2015 Feb 19; 518(7539):317-30. . View in PubMed
• Intermediate DNA methylation is a conserved signature of genome regulation Nat Commun. 2015 Feb 18; 6:6363. . View in PubMed
• Epigenetic and transcriptional determinants of the human breast Nat Commun. 2015 Feb 18; 6:6351. . View in PubMed
• Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome Epigenetics Chromatin. 2015; 8:57. . View in PubMed
• Altering cancer transcriptomes using epigenomic inhibitors Epigenetics Chromatin. 2015; 8:9. . View in PubMed
• Demystifying the secret mission of enhancers: linking distal regulatory elements to target genes Crit Rev Biochem Mol Biol. 2015; 50(6):550-73. . View in PubMed
• Regulatory network decoded from epigenomes of surface ectoderm-derived cell types Nat Commun. 2014 Nov 25; 5:5442. . View in PubMed
• Functional annotation of colon cancer risk SNPs Nat Commun. 2014 Sep 30; 5:5114. . View in PubMed
• Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes Genome Biol. 2014 Sep 20; 15(9):469. . View in PubMed
• Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3366. . View in PubMed
• Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha BMC Genomics. 2014 Jun 24; 15:520. . View in PubMed
• Defining functional DNA elements in the human genome Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6131-8. . View in PubMed
• Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation Nucleic Acids Res. 2014; 42(16):10856-68. . View in PubMed
• Can genome engineering be used to target cancer-associated enhancers? Epigenomics. 2014; 6(5):493-501.. View in PubMed
• Comprehensive functional annotation of 77 prostate cancer risk loci PLoS Genet. 2014 Jan; 10(1):e1004102. . View in PubMed
• Cross-talk between site-specific transcription factors and DNA methylation states J Biol Chem. 2013 Nov 29; 288(48):34287-94. . View in PubMed
• Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Nat Immunol. 2013 Oct; 14(10):1073-83. . View in PubMed
• Recombinant antibodies to histone post-translational modifications Nat Methods. 2013 Oct; 10(10):992-5. . View in PubMed
• Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm Genome Res. 2013 Sep; 23(9):1522-40. . View in PubMed
• DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape Nat Genet. 2013 Jul; 45(7):836-41. . View in PubMed
• ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes Epigenetics Chromatin. 2013 May 21; 6(1):13. . View in PubMed
• LOcating non-unique matched tags (LONUT) to improve the detection of the enriched regions for ChIP-seq data PLoS One. 2013; 8(6):e67788. . View in PubMed
• Spark: a navigational paradigm for genomic data exploration Genome Res. 2012 Nov; 22(11):2262-9. . View in PubMed
• Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3 Genome Biol. 2012 Sep 26; 13(9):R52. . View in PubMed
• Uncovering transcription factor modules using one- and three-dimensional analyses J Biol Chem. 2012 Sep 07; 287(37):30914-21. . View in PubMed
• Thematic minireview series on results from the ENCODE Project: Integrative global analyses of regulatory regions in the human genome J Biol Chem. 2012 Sep 07; 287(37):30885-7. . View in PubMed
• An integrated encyclopedia of DNA elements in the human genome Nature. 2012 Sep 06; 489(7414):57-74. . View in PubMed
• Architecture of the human regulatory network derived from ENCODE data Nature. 2012 Sep 06; 489(7414):91-100. . View in PubMed
• Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages Nucleic Acids Res. 2012 Sep; 40(16):7690-704. . View in PubMed
• ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia Genome Res. 2012 Sep; 22(9):1813-31. . View in PubMed
• Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFß tumor suppressor signaling pathways Mol Cancer Res. 2012 Jul; 10(7):979-91. . View in PubMed
• The transcription factor encyclopedia Genome Biol. 2012; 13(3):R24. . View in PubMed
• Using ChIPMotifs for de novo motif discovery of OCT4 and ZNF263 based on ChIP-based high-throughput experiments Methods Mol Biol. 2012; 802:323-34. . View in PubMed
• Autophagy driven by a master regulator of hematopoiesis Mol Cell Biol. 2012 Jan; 32(1):226-39. . View in PubMed
• The Human Epigenome Browser at Washington University Nat Methods. 2011 Nov 29; 8(12):989-90. . View in PubMed
• Genetic framework for GATA factor function in vascular biology Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13641-6. . View in PubMed
• KAP1 protein: an enigmatic master regulator of the genome J Biol Chem. 2011 Jul 29; 286(30):26267-76. . View in PubMed
• L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure Mol Cell. 2011 May 20; 42(4):438-50. . View in PubMed
• Functional analysis of KAP1 genomic recruitment Mol Cell Biol. 2011 May; 31(9):1833-47. . View in PubMed
• Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome J Biol Chem. 2011 Apr 08; 286(14):11985-96. . View in PubMed
• A user’s guide to the encyclopedia of DNA elements (ENCODE) PLoS Biol. 2011 Apr; 9(4):e1001046. . View in PubMed
• Characterization of the contradictory chromatin signatures at the 3′ exons of zinc finger genes PLoS One. 2011 Feb 15; 6(2):e17121. . View in PubMed
• Using ChIP-seq technology to generate high-resolution profiles of histone modifications Methods Mol Biol. 2011; 791:265-86. . View in PubMed
• Transcription factor effector domains Subcell Biochem. 2011; 52:261-77. . View in PubMed
• Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation PLoS One. 2011; 6(11):e27740. . View in PubMed
• ZNF274 recruits the histone methyltransferase SETDB1 to the 3′ ends of ZNF genes PLoS One. 2010 Dec 08; 5(12):e15082. . View in PubMed
• Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes BMC Genomics. 2010 Dec 02; 11:689. . View in PubMed
• ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells Oncogene. 2010 Oct 07; 29(40):5500-10. . View in PubMed
• The NIH Roadmap Epigenomics Mapping Consortium Nat Biotechnol. 2010 Oct; 28(10):1045-8. . View in PubMed
• Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications Nat Biotechnol. 2010 Oct; 28(10):1097-105. . View in PubMed
• 5-azacytidine treatment reorganizes genomic histone modification patterns Epigenetics. 2010 Apr; 5(3):229-40. . View in PubMed
• Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263 J Biol Chem. 2010 Jan 08; 285(2):1393-403. . View in PubMed
• Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data Nucleic Acids Res. 2010 Jan; 38(3):e13. . View in PubMed
• Using ChIP-seq technology to identify targets of zinc finger transcription factors Methods Mol Biol. 2010; 649:437-55. . View in PubMed
• W-ChIPMotifs: a web application tool for de novo motif discovery from ChIP-based high-throughput data Bioinformatics. 2009 Dec 01; 25(23):3191-3. . View in PubMed
• Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy Mol Cell. 2009 Nov 25; 36(4):667-81. . View in PubMed
• Insights from genomic profiling of transcription factors Nat Rev Genet. 2009 Sep; 10(9):605-16. . View in PubMed
• N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor Cancer Res. 2008 Dec 01; 68(23):9654-62. . View in PubMed
• E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites Genome Res. 2008 Nov; 18(11):1763-77. . View in PubMed
• Analysis of the mechanisms mediating tumor-specific changes in gene expression in human liver tumors Cancer Res. 2008 Apr 15; 68(8):2641-51. . View in PubMed
• Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells Genome Res. 2008 Apr; 18(4):521-32. . View in PubMed
• Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets Genome Res. 2008 Mar; 18(3):393-403. . View in PubMed
• Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes Proc Natl Acad Sci U S A. 2007 Dec 04; 104(49):19416-21. . View in PubMed
• Genome-scale ChIP-chip analysis using 10,000 human cells Biotechniques. 2007 Dec; 43(6):791-7. . View in PubMed
• A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members Genome Res. 2007 Nov; 17(11):1550-61. . View in PubMed
• Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs Cell. 2007 Jun 29; 129(7):1311-23. . View in PubMed
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project Nature. 2007 Jun 14; 447(7146):799-816. . View in PubMed
• Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches Genome Res. 2007 Jun; 17(6):807-17. . View in PubMed
• Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs PLoS Genet. 2007 Jun; 3(6):e89. . View in PubMed
• Identification of genes directly regulated by the oncogene ZNF217 using chromatin immunoprecipitation (ChIP)-chip assays J Biol Chem. 2007 Mar 30; 282(13):9703-9712. . View in PubMed
• A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data–a case study using E2F1 Genome Res. 2006 Dec; 16(12):1585-95. . View in PubMed
• Locating mammalian transcription factor binding sites: a survey of computational and experimental techniques Genome Res. 2006 Dec; 16(12):1455-64. . View in PubMed
• Comparison of sample preparation methods for ChIP-chip assays Biotechniques. 2006 Nov; 41(5):577-80. . View in PubMed
• Suz12 binds to silenced regions of the genome in a cell-type-specific manner Genome Res. 2006 Jul; 16(7):890-900. . View in PubMed
• Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome Genome Res. 2006 May; 16(5):595-605. . View in PubMed
• Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):1859-64. . View in PubMed
• CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome Nucleic Acids Res. 2005; 33(9):2952-61. . View in PubMed
• The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation J Biol Chem. 2004 Oct 29; 279(44):46343-9. . View in PubMed
• Genomic approaches that aid in the identification of transcription factor target genes Exp Biol Med (Maywood). 2004 Sep; 229(8):705-21. . View in PubMed
• Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27 Genes Dev. 2004 Jul 01; 18(13):1592-605. . View in PubMed
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells Immunity. 2004 Apr; 20(4):477-94. . View in PubMed
• High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays Methods Enzymol. 2004; 376:315-34. . View in PubMed
• E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 J Biol Chem. 2003 Oct 24; 278(43):42466-76. . View in PubMed
• Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression Curr Biol. 2003 May 13; 13(10):882-6. . View in PubMed
• Identification and characterization of CRG-L2, a new marker for liver tumor development Oncogene. 2003 Mar 20; 22(11):1730-6. . View in PubMed
• Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase Oncogene. 2003 Mar 13; 22(10):1445-60. . View in PubMed
• Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy Mol Cancer Ther. 2003 Jan; 2(1):113-21. . View in PubMed
• Probing chromatin immunoprecipitates with CpG-island microarrays to identify genomic sites occupied by DNA-binding proteins Methods Enzymol. 2003; 371:577-96. . View in PubMed
• Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter J Biol Chem. 2002 Oct 18; 277(42):40156-62. . View in PubMed
• The identification of E2F1-specific target genes Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3890-5. . View in PubMed
• Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis Genes Dev. 2002 Jan 15; 16(2):235-44. . View in PubMed
• c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism J Biol Chem. 2001 Dec 21; 276(51):48562-71. . View in PubMed
• Use of chromatin immunoprecipitation to clone novel E2F target promoters Mol Cell Biol. 2001 Oct; 21(20):6820-32. . View in PubMed
• Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis Mol Cell Biol. 2001 Sep; 21(17):6006-16. . View in PubMed
• The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements J Biol Chem. 2001 Jun 08; 276(23):20482-90. . View in PubMed
• Computer-assisted identification of cell cycle-related genes: new targets for E2F transcription factors J Mol Biol. 2001 May 25; 309(1):99-120. . View in PubMed
• Expression profiling and identification of novel genes in hepatocellular carcinomas Oncogene. 2001 May 10; 20(21):2704-12. . View in PubMed
• Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation J Biol Chem. 2000 Oct 27; 275(43):33798-805. . View in PubMed
• Direct recruitment of N-myc to target gene promoters Mol Carcinog. 2000 Oct; 29(2):76-86. . View in PubMed
• Target gene specificity of E2F and pocket protein family members in living cells Mol Cell Biol. 2000 Aug; 20(16):5797-807. . View in PubMed
• Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation Oncogene. 2000 Apr 27; 19(18):2257-68. . View in PubMed
• CAD, a c-Myc target gene, is not deregulated in Burkitt’s lymphoma cell lines Mol Carcinog. 2000 Feb; 27(2):84-96. . View in PubMed
• Coexamination of site-specific transcription factor binding and promoter activity in living cells Mol Cell Biol. 1999 Dec; 19(12):8393-9. . View in PubMed
• Context-dependent transcriptional regulation J Biol Chem. 1999 Oct 15; 274(42):29583-6. . View in PubMed
• Identification of target genes of oncogenic transcription factors Proc Soc Exp Biol Med. 1999 Oct; 222(1):9-28. . View in PubMed
• No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice Mol Carcinog. 1999 Aug; 25(4):295-303. . View in PubMed
• Activation of the murine dihydrofolate reductase promoter by E2F1A requirement for CBP recruitment. J Biol Chem. 1999 May 28; 274(22):15883-91. . View in PubMed
• Characterization of the 3′ untranslated region of mouse E2F1 mRNA Gene. 1998 Nov 26; 223(1-2):355-60. . View in PubMed
• c-Myc target gene specificity is determined by a post-DNAbinding mechanism Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13887-92. . View in PubMed
• E2F-mediated growth regulation requires transcription factor cooperation J Biol Chem. 1997 Jul 18; 272(29):18367-74. . View in PubMed
• Myc versus USF: discrimination at the cad gene is determined by core promoter elements Mol Cell Biol. 1997 May; 17(5):2529-37. . View in PubMed
• Position-dependent transcriptional regulation of the murine dihydrofolate reductase promoter by the E2F transactivation domain Mol Cell Biol. 1997 Apr; 17(4):1966-76. . View in PubMed
• Transcriptional regulation of the dihydrofolate reductase gene Bioessays. 1996 Jan; 18(1):55-62. . View in PubMed
• Conclusions and future directions Curr Top Microbiol Immunol. 1996; 208:129-37. . View in PubMed
• Introduction to the E2F family: protein structure and gene regulation Curr Top Microbiol Immunol. 1996; 208:1-30. . View in PubMed
• Strain-dependent differences in DNA synthesis and gene expression in the regenerating livers of CB57BL/6J and C3H/HeJ mice Mol Carcinog. 1995 Sep; 14(1):46-52. . View in PubMed
• v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1 Cell Growth Differ. 1995 May; 6(5):549-56. . View in PubMed
• An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants Mol Cell Biol. 1995 May; 15(5):2527-35. . View in PubMed
• The bidirectionally transcribed dihydrofolate reductase and rep-3a promoters are growth regulated by distinct mechanisms Cell Growth Differ. 1995 May; 6(5):541-8. . View in PubMed
• Identification of cis-acting elements that can obviate a requirement for the C-terminal domain of RNA polymerase II J Biol Chem. 1995 Mar 24; 270(12):6798-807. . View in PubMed
• Inappropriate transcription from the 5′ end of the murine dihydrofolate reductase gene masks transcriptional regulation Nucleic Acids Res. 1994 Aug 11; 22(15):3061-8. . View in PubMed
• Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter Genes Dev. 1994 Jul 01; 8(13):1526-37. . View in PubMed
• Cloning, chromosomal location, and characterization of mouse E2F1 Mol Cell Biol. 1994 Mar; 14(3):1861-9. . View in PubMed
• Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter J Biol Chem. 1994 Jan 21; 269(3):2252-7. . View in PubMed
• Transcriptional regulation of the dihydrofolate reductase/rep-3 locus Crit Rev Eukaryot Gene Expr. 1994; 4(1):19-53. . View in PubMed
• The role of E2F in the mammalian cell cycle Biochim Biophys Acta. 1993 Aug 23; 1155(2):125-31. . View in PubMed
• An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes J Biol Chem. 1993 Jul 25; 268(21):15674-80. . View in PubMed
• Site-specific initiation of transcription by RNA polymerase II Proc Soc Exp Biol Med. 1993 Jun; 203(2):127-39. . View in PubMed
• A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter Mol Cell Biol. 1993 Mar; 13(3):1610-8. . View in PubMed
• Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties Cell. 1992 Jul 24; 70(2):351-64. . View in PubMed
• krox 20 messenger RNA and protein expression in the adult central nervous system Brain Res Mol Brain Res. 1992 Jun; 14(1-2):117-23. . View in PubMed
• The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II Mol Cell Biol. 1992 May; 12(5):2250-9. . View in PubMed
• The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter Mol Cell Biol. 1992 Mar; 12(3):1054-63. . View in PubMed
• Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter in vitro J Biol Chem. 1992 Jan 05; 267(1):385-91. . View in PubMed
• Cell cycle analysis of Krox-20, c-fos, and JE expression in proliferating NIH3T3 fibroblasts Cell Growth Differ. 1991 Sep; 2(9):465-73. . View in PubMed
• Sp1 activation of RNA polymerase II transcription complexes involves a heat-labile DNA-binding component Gene Expr. 1991 May; 1(2):137-48. . View in PubMed
• Identification of the serum-responsive transcription initiation site of the zinc finger gene Krox-20 Mol Cell Biol. 1990 Jul; 10(7):3788-91. . View in PubMed
• Characterization of the 5′ end of the growth-regulated Syrian hamster CAD gene Cell Growth Differ. 1990 Apr; 1(4):179-89. . View in PubMed
• Sequences downstream of the transcription initiation site modulate the activity of the murine dihydrofolate reductase promoter Mol Cell Biol. 1990 Apr; 10(4):1390-8. . View in PubMed
• Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site Mol Cell Biol. 1990 Feb; 10(2):653-61. . View in PubMed
• Identification of a new promoter upstream of the murine dihydrofolate reductase gene Mol Cell Biol. 1989 Oct; 9(10):4568-70. . View in PubMed
• In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene Mol Cell Biol. 1986 Jul; 6(7):2392-401. . View in PubMed
• Murine dihydrofolate reductase transcripts through the cell cycle Mol Cell Biol. 1986 Feb; 6(2):365-71. . View in PubMed
• Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle J Biol Chem. 1985 Jun 25; 260(12):7675-80. . View in PubMed
• Opposite-strand RNAs from the 5′ flanking region of the mouse dihydrofolate reductase gene Proc Natl Acad Sci U S A. 1985 Jun; 82(12):3978-82. . View in PubMed
• Heterogeneity at the 5′ termini of mouse dihydrofolate reductase mRNAsEvidence for multiple promoter regions. J Biol Chem. 1985 Feb 25; 260(4):2307-14. . View in PubMed
• Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1126-30. . View in PubMed
• Effects of NusA protein on transcription termination in the tryptophan operon of Escherichia coli Cell. 1982 Jul; 29(3):945-51. . View in PubMed
• Effects of DNA base analogs on transcription termination at the tryptophan operon attenuator of EScherichia coli Proc Natl Acad Sci U S A. 1982 Feb; 79(4):998-1002. . View in PubMed
• Synthetic sites for transcription termination and a functional comparison with tryptophan operon termination sites in vitro Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4180-4. . View in PubMed
• Rho-independent termination: dyad symmetry in DNA causes RNA polymerase to pause during transcription in vitro Nucleic Acids Res. 1981 Feb 11; 9(3):563-77. . View in PubMed
• A model for transcription termination suggested by studies on the trp attenuator in vitro using base analogs Cell. 1980 Jul; 20(3):739-48. . View in PubMed
• Effects of gentamicin on trypsin, chymotrypsin, and collagenase J Infect Dis. 1978 Aug; 138(2):257-9. . View in PubMed
• A re-examination of the distributions of octopamine and phenylethanolamine in the aplysia nervous system J Neurochem. 1978 May; 30(5):1173-6. . View in PubMed

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