Paul M. Thompson, PhD

Paul Thompson is a Professor in the Keck School of Medicine of USC. His team’s research projects focus on the neuroscience, mathematics, computer science, software engineering and clinical aspects of neuroimaging and brain mapping.

Honored with the 2023 Pioneer in Medicine Award of the Society of Brain Mapping and Therapeutics, and the U.S. Alzheimer Association’s Zenith Award, Paul Thompson directs the ENIGMA Consortium, a global alliance of 2500 scientists in 47 countries who conduct the largest studies of 30 major brain diseases – ranging from Parkinson’s disease, anorexia, schizophrenia, depression, ADHD, bipolar illness and OCD, to HIV and addictions and their effects in the brain. ENIGMA’s genomic screens of over 70,000 people’s brain scans and genome-wide data (published in Nature Genetics, 2012; Nature, 2015; Science, 2020) have brought together experts from 300 institutions to unearth over 500 genetic variants that affect brain structure, disease risk, and brain connectivity. At USC, Dr. Thompson is a Professor of Neurology, Psychiatry, Radiology, Pediatrics, Engineering, and Ophthalmology, and Director of the ENIGMA Center for Worldwide Medicine, Imaging & Genomics – a $11M NIH Center of Excellence in Big Data Computing. Using worldwide medication screens, ENIGMA discovers factors that affect progression of Alzheimer’s disease and other dementias, schizophrenia, depression and childhood brain disorders. Dr. Thompson also directs AI4AD – an $18M NIH Initiative on AI methods to accelerate Alzheimer’s disease research, discovering novel treatment targets; he directs the India ENIGMA Initiative – large-scale study of brain aging in India. He directs the USC Imaging Genetics Center – a group of 50 scientists in Marina del Rey. His team created the first maps of Alzheimer’s disease and schizophrenia spreading in the living brain, and a method to track brain growth in children. Dr. Thompson has an M.A. in mathematics and Greek and Latin Languages from Oxford University, and a PhD in neuroscience from UCLA.

Collaborating with imaging labs around the world, Dr. Thompson and his students have published over 1,500 publications (h-index: 206) describing novel mathematical and computational strategies for analyzing brain image databases, for detecting pathology in individual patients and groups, and for creating disease-specific atlases of the human brain.

Recent work has discovered new structural and functional brain changes during brain development and degeneration, Alzheimer’s Disease and other dementias, schizophrenia and bipolar illness, HIV/AIDS, methamphetamine abuse, and autism. For many of these illnesses, Dr. Thompson’s Center is creating population-based tools to understand factors that resist them. New computational tools, developed in the lab, are used to map how these diseases spread in the living brain, and in drug trials and basic research studies.

• Society for Brain Mapping and Therapeutics: Pioneer in Medicine Award, 2023
• U.S. Alzheimer Association: Zenith Award, 2021
• Kent Innovations in Academia Award, 2015
• Di Chiro Outstanding Scientific Paper Award, 1998
• Eiduson Award for Neuroscience Research, 1998
• Outstanding Graduate Student of the Year, UCLA, UCLA Chancellor’s Service Award, 1998
• SPIE Medical Imaging Award, Best Paper, 1997

• Using rare genetic mutations to revisit structural brain asymmetry Nat Commun. 2024 Mar 26; 15(1):2639. . View in PubMed
• The genetic architecture of multimodal human brain age Nat Commun. 2024 Mar 23; 15(1):2604. . View in PubMed
• Cannabis Dependence is Associated with Reduced Hippocampal Subregion Volumes Independently of Sex: Findings from an ENIGMA Addiction Working Group Multi-Country Study Cannabis Cannabinoid Res. 2024 Mar 18. . View in PubMed
• Distance-weighted Sinkhorn loss for Alzheimer’s disease classification iScience. 2024 Mar 15; 27(3):109212. . View in PubMed
• Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Mol Psychiatry. 2024 Mar 07. . View in PubMed
• The power of many brains: Catalyzing neuropsychiatric discovery through open neuroimaging data and large-scale collaboration Sci Bull (Beijing). 2024 Mar 06. . View in PubMed
• A WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN bioRxiv. 2024 Mar 06. . View in PubMed
• Mapping Brain Structure Variability in Chronic Pain: The Role of Widespreadness and Pain Type and Its Mediating Relationship With Suicide Attempt Biol Psychiatry. 2024 Mar 01; 95(5):473-481. . View in PubMed
• Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation Lancet Digit Health. 2024 Mar; 6(3):e211-e221. . View in PubMed
• Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study Epilepsia. 2024 Feb 27. . View in PubMed
• Genotype-specific spinal cord damage in spinocerebellar ataxias: an ENIGMA-Ataxia study J Neurol Neurosurg Psychiatry. 2024 Feb 21. . View in PubMed
• Pervasive alterations of intra-axonal volume and network organization in young children with a 16p112 deletion. Transl Psychiatry. 2024 Feb 14; 14(1):95. . View in PubMed
• Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk Mol Psychiatry. 2024 Feb 09. . View in PubMed
• Counterfactual MRI Generation with Denoising Diffusion Models for Interpretable Alzheimer’s Disease Effect Detection bioRxiv. 2024 Feb 08. . View in PubMed
• White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group Mol Psychiatry. 2024 Feb 07. . View in PubMed
• Deep Normative Tractometry for Identifying Joint White Matter Macro- and Micro-structural Abnormalities in Alzheimer’s Disease bioRxiv. 2024 Feb 06. . View in PubMed
• Brain Age Analysis and Dementia Classification using Convolutional Neural Networks trained on Diffusion MRI: Tests in Indian and North American Cohorts bioRxiv. 2024 Feb 06. . View in PubMed
• Autism-related dietary preferences mediate autism-gut microbiome associations Cell. 2024 Jan 18; 187(2):495-510. . View in PubMed
• Beyond the Global Brain Differences: Intraindividual Variability Differences in 1q211 Distal and 15q11. 2 BP1-BP2 Deletion Carriers. Biol Psychiatry. 2024 Jan 15; 95(2):147-160. . View in PubMed
• A global multicohort study to map subcortical brain development and cognition in infancy and early childhood Nat Neurosci. 2024 Jan; 27(1):176-186. . View in PubMed
• Source-based morphometry reveals structural brain pattern abnormalities in 22q112 deletion syndrome. Hum Brain Mapp. 2024 Jan; 45(1):e26553. . View in PubMed
• Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures Sci Rep. 2024 01 11; 14(1):1084. . View in PubMed
• The Genetic Architecture of Amygdala Nuclei Biol Psychiatry. 2024 Jan 01; 95(1):72-84. . View in PubMed
• Genomic loci influence patterns of structural covariance in the human brain Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52):e2300842120. . View in PubMed
• Cortical microstructural associations with CSF amyloid and pTau Mol Psychiatry. 2023 Dec 13. . View in PubMed
• Normative Modeling of Brain Morphometry Across the Lifespan Using CentileBrain: Algorithm Benchmarking and Model Optimization bioRxiv. 2023 Dec 02. . View in PubMed
• Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium Neuroimage. 2023 Dec 01; 283:120412. . View in PubMed
• Alzheimer’s Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy medRxiv. 2023 Nov 29. . View in PubMed
• Association between late-life air pollution exposure and medial temporal lobe atrophy in older women medRxiv. 2023 Nov 29. . View in PubMed
• Longitudinal change in memory performance as a strong endophenotype for Alzheimer’s disease Alzheimers Dement. 2023 Nov 20. . View in PubMed
• Sex-specific genetic architecture of late-life memory performance Alzheimers Dement. 2023 Nov 20. . View in PubMed
• Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals Mol Psychiatry. 2023 Nov; 28(11):4915-4923. . View in PubMed
• APOE4 poses opposite effects of plasma LDL on white matter integrity in older adults bioRxiv. 2023 Oct 28. . View in PubMed
• Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry bioRxiv. 2023 Oct 25. . View in PubMed
• Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study bioRxiv. 2023 Oct 23. . View in PubMed
• Childhood trauma moderates schizotypy-related brain morphology: analyses of 1182 healthy individuals from the ENIGMA schizotypy working group Psychol Med. 2023 Oct 20; 1-13. . View in PubMed
• Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium Mol Psychiatry. 2023 Oct; 28(10):4320. . View in PubMed
• The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium Mol Psychiatry. 2023 Oct; 28(10):4307-4319. . View in PubMed
• Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses Mol Psychiatry. 2023 Oct; 28(10):4363-4373. . View in PubMed
• The Genetic Architecture of Multimodal Human Brain Age bioRxiv. 2023 Sep 30. . View in PubMed
• Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes bioRxiv. 2023 Sep 01. . View in PubMed
• BundleCleaner: Unsupervised Denoising and Subsampling of Diffusion MRI-Derived Tractography Data bioRxiv. 2023 Aug 21. . View in PubMed
• Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification Mol Psychiatry. 2023 Aug 04. . View in PubMed
• A systematic review of neuroimaging epigenetic research: calling for an increased focus on development Mol Psychiatry. 2023 Jul; 28(7):2839-2847. . View in PubMed
• Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence Nat Hum Behav. 2023 Jun; 7(6):1001-1017. . View in PubMed
• Variational Autoencoders for Generating Synthetic Tractography-Based Bundle Templates in a Low-Data Setting bioRxiv. 2023 May 09. . View in PubMed
• Comparison of Anatomical and Diffusion MRI for detecting Parkinson’s Disease using Deep Convolutional Neural Network bioRxiv. 2023 May 01. . View in PubMed
• A Comprehensive Corpus Callosum Segmentation Tool for Detecting Callosal Abnormalities and Genetic Associations from Multi Contrast MRIs ArXiv. 2023 May 01. . View in PubMed
• The Influence of Brain MRI Defacing Algorithms on Brain-Age Predictions via 3D Convolutional Neural Networks bioRxiv. 2023 Apr 29. . View in PubMed
• Using rare genetic mutations to revisit structural brain asymmetry bioRxiv. 2023 Apr 18. . View in PubMed
• Cortical microstructural associations with CSF amyloid and pTau medRxiv. 2023 Apr 11. . View in PubMed
• Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium bioRxiv. 2023 Apr 07. . View in PubMed
• Efficiently Training Vision Transformers on Structural MRI Scans for Alzheimer’s Disease Detection ArXiv. 2023 Mar 14. . View in PubMed
• Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study bioRxiv. 2023 Mar 10. . View in PubMed
• Curriculum Based Multi-Task Learning for Parkinson’s Disease Detection ArXiv. 2023 Feb 27. . View in PubMed
• Predicting Brain Amyloid Positivity from T1 weighted brain MRI and MRI-derived Gray Matter, White Matter and CSF maps using Transfer Learning on 3D CNNs bioRxiv. 2023 Feb 16. . View in PubMed
• Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers Obesity (Silver Spring). 2023 11; 31(11):2699-2708. . View in PubMed
• White Matter Integrity and Chronic Poststroke Upper Limb Function: An ENIGMA Stroke Recovery Analysis Stroke. 2023 09; 54(9):2438-2441. . View in PubMed
• Variational Autoencoders for Generating Synthetic Tractography-Based Bundle Templates in a Low-Data Setting Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• The Influence of Brain MRI Defacing Algorithms on Brain-Age Predictions via 3D Convolutional Neural Networks Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-7. . View in PubMed
• Few-Shot Classification of Autism Spectrum Disorder using Site-Agnostic Meta-Learning and Brain MRI Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• Evaluating Fiber Orientation Dispersion Measures Computed From Single-Shell Diffusion MRI Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• A Comprehensive Corpus Callosum Segmentation Tool for Detecting Callosal Abnormalities and Genetic Associations from Multi Contrast MRIs Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-4. . View in PubMed
• Comparison of Anatomical and Diffusion MRI for detecting Parkinson’s Disease using Deep Convolutional Neural Network Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis Hum Brain Mapp. 2023 07; 44(10):4165-4182. . View in PubMed
• Predictive Modeling Of Alzheimer’s Disease Prognosis Using Anatomical & Diffusion MRI Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-5. . View in PubMed
• Efficiently Training Vision Transformers on Structural MRI Scans for Alzheimer’s Disease Detection Annu Int Conf IEEE Eng Med Biol Soc. 2023 07; 2023:1-6. . View in PubMed
• Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study Brain Connect. 2023 05; 13(4):211-225. . View in PubMed
• Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder J Am Acad Child Adolesc Psychiatry. 2023 04; 62(4):403-414. . View in PubMed
• Interactions between the lipidome and genetic and environmental factors in autism Nat Med. 2023 04; 29(4):936-949. . View in PubMed
• Multisite test-retest reliability and compatibility of brain metrics derived from FreeSurfer versions 71, 6. 0, and 5. 3. Hum Brain Mapp. 2023 03; 44(4):1515-1532. . View in PubMed
• Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium Mol Psychiatry. 2023 03; 28(3):1201-1209. . View in PubMed
• Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia Psychiatry Res Neuroimaging. 2023 03; 329:111597. . View in PubMed
• Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group Mol Psychiatry. 2023 03; 28(3):1079-1089. . View in PubMed
• Association between brain similarity to severe mental illnesses and comorbid cerebral, physical, and cognitive impairments Neuroimage. 2023 01; 265:119786. . View in PubMed
• Progressive Spinal Cord Degeneration in Friedreich’s Ataxia: Results from ENIGMA-Ataxia Mov Disord. 2023 01; 38(1):45-56. . View in PubMed
• Poorer sleep health is associated with altered brain activation during cognitive control processing in healthy adults Cereb Cortex. 2023 05 24; 33(11):7100-7119. . View in PubMed
• Addressing Global Environmental Challenges to Mental Health Using Population Neuroscience: A Review JAMA Psychiatry. 2023 10 01; 80(10):1066-1074. . View in PubMed
• Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214634120. . View in PubMed
• Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry Biol Psychiatry. 2023 01 01; 93(1):45-58. . View in PubMed
• Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions Brain. 2023 04 19; 146(4):1686-1696. . View in PubMed
• An interpretable Alzheimer’s disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification Front Aging Neurosci. 2023; 15:1281748. . View in PubMed
• The Queensland Twin Adolescent Brain Project, a longitudinal study of adolescent brain development Sci Data. 2023 04 08; 10(1):195. . View in PubMed
• Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults JAMA Neurol. 2023 09 01; 80(9):929-939. . View in PubMed
• Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium Proc Natl Acad Sci U S A. 2023 04 04; 120(14):e2213880120. . View in PubMed
• Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children’s Brain (Dis)similarity to Schizophrenia Biol Psychiatry. 2023 08 15; 94(4):332-340. . View in PubMed
• Erratum: Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot Product Pac Symp Biocomput. 2023; 28:555. . View in PubMed
• Preliminary validation of a structural magnetic resonance imaging metric for tracking dementia-related neurodegeneration and future decline Neuroimage Clin. 2023; 39:103458. . View in PubMed
• Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease Hum Brain Mapp. 2023 04 15; 44(6):2636-2653. . View in PubMed
• Maternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study BMC Med. 2023 02 14; 21(1):57. . View in PubMed
• White matter microstructure shows sex differences in late childhood: Evidence from 6797 children Hum Brain Mapp. 2023 02 01; 44(2):535-548. . View in PubMed
• Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants Am J Psychiatry. 2023 09 01; 180(9):685-698. . View in PubMed
• Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders Biol Psychiatry. 2023 05 15; 93(10):905-920. . View in PubMed
• Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke Neurology. 2023 05 16; 100(20):e2103-e2113. . View in PubMed
• Relationships between physical activity, healthy eating and cortical thickness in children and young adults Brain Imaging Behav. 2022 Dec; 16(6):2690-2704. . View in PubMed
• Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data BMC Bioinformatics. 2022 Sep 28; 23(Suppl 3):398. . View in PubMed
• The role of educational attainment and brain morphology in major depressive disorder: Findings from the ENIGMA major depressive disorder consortium J Psychopathol Clin Sci. 2022 Aug; 131(6):664-673. . View in PubMed
• Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q112 deletion syndrome: A review of ENIGMA findings. Psychiatry Clin Neurosci. 2022 May; 76(5):140-161. . View in PubMed
• Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses Hum Brain Mapp. 2022 11; 43(16):4970-4983. . View in PubMed
• Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium Brain Behav. 2022 10; 12(10):e2755. . View in PubMed
• Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis J Am Acad Child Adolesc Psychiatry. 2022 09; 61(9):1182-1188. . View in PubMed
• Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 09; 7(9):935-948. . View in PubMed
• Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data Epilepsia. 2022 08; 63(8):2081-2095. . View in PubMed
• FiberNeat: Unsupervised White Matter Tract Filtering Annu Int Conf IEEE Eng Med Biol Soc. 2022 07; 2022:5055-5061. . View in PubMed
• Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans Obesity (Silver Spring). 2022 07; 30(7):1462-1471. . View in PubMed
• SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility Acta Neuropathol. 2022 07; 144(1):107-127. . View in PubMed
• Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings Twin Res Hum Genet. 2022 06; 25(3):129-139. . View in PubMed
• Persistence of Anxiety/Depression Symptoms in Early Adolescence: A Prospective Study of Daily Life Stress, Rumination, and Daytime Sleepiness in a Genetically Informative Cohort Twin Res Hum Genet. 2022 06; 25(3):115-128. . View in PubMed
• Reply to: “Parkinson’s Disease, Premature Mortality, and Amygdala” Mov Disord. 2022 05; 37(5):1111-1112. . View in PubMed
• Disparities in Breastfeeding Initiation Among African American and Black Immigrant WIC Recipients in the District of Columbia, 2007-2019 Am J Public Health. 2022 04; 112(4):671-674. . View in PubMed
• Neuroinformatics. 2022 04; 20(2):507-512. . View in PubMed
• Genetic variants associated with longitudinal changes in brain structure across the lifespan Nat Neurosci. 2022 04; 25(4):421-432. . View in PubMed
• Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium Mol Psychiatry. 2022 04; 27(4):2114-2125. . View in PubMed
• Fetal programming of human energy homeostasis brain networks: Issues and considerations Obes Rev. 2022 03; 23(3):e13392. . View in PubMed
• Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study Mol Psychiatry. 2022 02; 27(2):1167-1176. . View in PubMed
• Hum Brain Mapp. 2022 01; 43(1):399-413. . View in PubMed
• ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders Hum Brain Mapp. 2022 01; 43(1):83-112. . View in PubMed
• Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory Hum Brain Mapp. 2022 01; 43(1):566-575. . View in PubMed
• Mapping brain asymmetry in health and disease through the ENIGMA consortium Hum Brain Mapp. 2022 01; 43(1):167-181. . View in PubMed
• Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups Brain Behav. 2022 01; 12(1):e2413. . View in PubMed
• The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke Hum Brain Mapp. 2022 01; 43(1):129-148. . View in PubMed
• ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research Hum Brain Mapp. 2022 01; 43(1):194-206. . View in PubMed
• Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group Hum Brain Mapp. 2022 01; 43(1):341-351. . View in PubMed
• Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group Hum Brain Mapp. 2022 01; 43(1):292-299. . View in PubMed
• Hum Brain Mapp. 2022 01; 43(1):23-36. . View in PubMed
• A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium Hum Brain Mapp. 2022 01; 43(1):352-372. . View in PubMed
• Neuroinformatics. 2022 01; 20(1):261-275. . View in PubMed
• Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90? years. Hum Brain Mapp. 2022 01; 43(1):431-451.. View in PubMed
• Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90? years. Hum Brain Mapp. 2022 01; 43(1):452-469.. View in PubMed
• FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts Hum Brain Mapp. 2022 01; 43(1):207-233. . View in PubMed
• Greater male than female variability in regional brain structure across the lifespan Hum Brain Mapp. 2022 01; 43(1):470-499. . View in PubMed
• Hum Brain Mapp. 2022 01; 43(1):15-22. . View in PubMed
• Sex is a defining feature of neuroimaging phenotypes in major brain disorders Hum Brain Mapp. 2022 01; 43(1):500-542. . View in PubMed
• Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs Hum Brain Mapp. 2022 01; 43(1):300-328. . View in PubMed
• In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group Hum Brain Mapp. 2022 01; 43(1):385-398. . View in PubMed
• Testing a convolutional neural network-based hippocampal segmentation method in a stroke population Hum Brain Mapp. 2022 01; 43(1):234-243. . View in PubMed
• Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium Hum Brain Mapp. 2022 01; 43(1):373-384. . View in PubMed
• What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group Hum Brain Mapp. 2022 01; 43(1):56-82. . View in PubMed
• A comparison of methods to harmonize cortical thickness measurements across scanners and sites Neuroimage. 2022 11 01; 261:119509. . View in PubMed
• Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot Product Pac Symp Biocomput. 2022; 27:133-143. . View in PubMed
• Session Introduction: Big Data Imaging Genomics Pac Symp Biocomput. 2022; 27:68-72. . View in PubMed
• Identifying imaging genetic associations via regional morphometricity estimation Pac Symp Biocomput. 2022; 27:97-108. . View in PubMed
• Identifying highly heritable brain amyloid phenotypes through mining Alzheimer’s imaging and sequencing biobank data Pac Symp Biocomput. 2022; 27:109-120. . View in PubMed
• Effects of ApoE4 and ApoE2 genotypes on subcortical magnetic susceptibility and microstructure in 27,535 participants from the UK Biobank Pac Symp Biocomput. 2022; 27:121-132. . View in PubMed
• Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use Cereb Cortex. 2022 02 08; 32(4):796-807. . View in PubMed
• Genetic map of regional sulcal morphology in the human brain from UK biobank data Nat Commun. 2022 10 14; 13(1):6071. . View in PubMed
• Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group Biol Psychiatry. 2022 03 15; 91(6):582-592. . View in PubMed
• Systematic evaluation of machine learning algorithms for neuroanatomically-based age prediction in youth Hum Brain Mapp. 2022 12 01; 43(17):5126-5140. . View in PubMed
• Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group Biol Psychiatry. 2022 11 01; 92(9):730-738. . View in PubMed
• Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis J Am Heart Assoc. 2022 05 17; 11(10):e025109. . View in PubMed
• Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology Commun Biol. 2022 09 27; 5(1):1024. . View in PubMed
• Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity Neuroimage. 2022 11 15; 262:119555. . View in PubMed
• ENIGMA HALFpipe: Interactive, reproducible, and efficient analysis for resting-state and task-based fMRI data Hum Brain Mapp. 2022 06 15; 43(9):2727-2742. . View in PubMed
• Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy Brain. 2022 05 24; 145(4):1285-1298. . View in PubMed
• Age-dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury Hum Brain Mapp. 2022 06 01; 43(8):2653-2667. . View in PubMed
• Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis Transl Psychiatry. 2022 07 26; 12(1):297. . View in PubMed
• The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging Hum Brain Mapp. 2022 04 15; 43(6):1997-2010. . View in PubMed
• The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder Transl Psychiatry. 2022 02 21; 12(1):70. . View in PubMed
• Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression Nat Commun. 2022 07 27; 13(1):4320. . View in PubMed
• Site effects how-to and when: An overview of retrospective techniques to accommodate site effects in multi-site neuroimaging analyses Front Neurol. 2022; 13:923988. . View in PubMed
• Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium J Affect Disord. 2022 12 01; 318:204-216. . View in PubMed
• Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study Brain Imaging Behav. 2021 Dec; 15(6):2813-2823. . View in PubMed
• The role of maternal BMI on brain food cue reactivity in children: a preliminary study Brain Imaging Behav. 2021 Dec; 15(6):2746-2755. . View in PubMed
• Alzheimer’s Disease Classification Accuracy is Improved by MRI Harmonization based on Attention-Guided Generative Adversarial Networks Proc SPIE Int Soc Opt Eng. 2021 Nov; 12088. . View in PubMed
• Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy Proc SPIE Int Soc Opt Eng. 2021 Nov; 12088. . View in PubMed
• Corrigendum to: Heritability of regional brain volumes in large-scale neuroimaging and genetic studies Cereb Cortex. 2021 Aug 26; 31(10):4865. . View in PubMed
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• Toga, Arthur
• Peterson, Bradley
• Jahanshad, Neda
• Aisen, Paul
• Leahy, Richard