Peter Kuhn, PhD

Peter Kuhn joined the USC Dana and David Dornsife College of Letters, Arts and Sciences as Dean’s Professor of Biological Sciences in July 2014. Dr. Kuhn also has appointments as Professor of Medicine, Professor of Biomedical Engineering and Professor of Aerospace & Mechanical Engineering, a founding member of the Michelson Center for Convergent Biosciences at USC and is leading CSI-Cancer at USC. He is a scientist, educator and entrepreneur with a career long commitment in personalized medicine and individualized cancer patient care. He is focused on the redesign of cancer care. The first product from technology developed by Dr. Kuhn became available for prostate cancer care in June 2016. Dr. Kuhn’s strategy is to advance our understanding of the human body to improve the human condition for those affected by cancer. His research is shedding new light at how cancer spreads through the body and evolves over time. This new science will lead to a personalized care strategy that is biologically informed and clinically actionable. He is a physicist who trained initially at the Julius Maximilians Universität Würzburg, Germany, before receiving his Masters in Physics at the University of Albany, Albany, NY in 1993 and his Ph.D. in 1995. He then moved to Stanford University where he joined the faculties of Medicine and Accelerator Physics as tenure track Assistant Professor. From 2002 to 2014 he established the Physics Oncology program at The Scripps Research in La Jolla, CA as tenured Associate Professor before joining USC in 2014. He has published over 200 peer scientific articles and patents resulting from his research.

• A Systematic Approach toward Enabling Maximal Targeting Efficiency of Cell Surface Proteins with Actively Targeted SERS Nanoparticles ACS Appl Mater Interfaces. 2024 Mar 20. . View in PubMed
• Blood-based liquid biopsy: A promising noninvasive test in diagnosis, surveillance, and prognosis of patients with upper tract urothelial carcinoma Urol Oncol. 2024 Feb 20. . View in PubMed
• Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery NPJ Precis Oncol. 2024 Feb 15; 8(1):36. . View in PubMed
• Liquid biopsy approach to monitor the efficacy and response to CAR-T cell therapy J Immunother Cancer. 2024 Feb 12; 12(2). . View in PubMed
• Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial Clin Cancer Res. 2023 Dec 15; 29(24):5087-5103. . View in PubMed
• Aqueous Humor Liquid Biopsy as a Companion Diagnostic for Retinoblastoma: implications for diagnosis, prognosis and therapeutic optionsFive years of Progress. Am J Ophthalmol. 2023 Nov 29. . View in PubMed
• Targeted single-cell proteomic analysis identifies new liquid biopsy biomarkers associated with multiple myeloma NPJ Precis Oncol. 2023 Sep 18; 7(1):95. . View in PubMed
• Cell State and Cell Type: Deconvoluting Circulating Tumor Cell Populations in Liquid Biopsies by Multi-Omics Cancers (Basel). 2023 Aug 03; 15(15). . View in PubMed
• Simultaneous Copy Number Alteration and Single-Nucleotide Variation Analysis in Matched Aqueous Humor and Tumor Samples in Children with Retinoblastoma Int J Mol Sci. 2023 May 11; 24(10). . View in PubMed
• Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform Eur J Epidemiol. 2023 May; 38(5):573-586. . View in PubMed
• Investigation of liquid biopsy analytes in peripheral blood of individuals after SARS-CoV-2 infection EBioMedicine. 2023 Apr; 90:104519. . View in PubMed
• BLOODPAC: Collaborating to chart a path towards blood-based screening for early cancer detection Clin Transl Sci. 2023 01; 16(1):5-9. . View in PubMed
• Single cell clonotypic and transcriptional evolution of multiple myeloma precursor diseaseCancer Cell. 2023 06 12; 41(6):1032-1047. e4. . View in PubMed
• Plasticity of circulating tumor cells in small cell lung cancer Sci Rep. 2023 07 21; 13(1):11775. . View in PubMed
• Characterization of BCMA Expression in Circulating Rare Single Cells of Patients with Plasma Cell Neoplasms Int J Mol Sci. 2022 Nov 03; 23(21). . View in PubMed
• Defining A Liquid Biopsy Profile of Circulating Tumor Cells and Oncosomes in Metastatic Colorectal Cancer for Clinical Utility Cancers (Basel). 2022 Oct 06; 14(19). . View in PubMed
• Multianalyte liquid biopsy to aid the diagnostic workup of breast cancer NPJ Breast Cancer. 2022 Sep 27; 8(1):112. . View in PubMed
• Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer case NPJ Precis Oncol. 2022 Jun 21; 6(1):41. . View in PubMed
• Liquid Biopsy Landscape in Patients with Primary Upper Tract Urothelial Carcinoma Cancers (Basel). 2022 Jun 18; 14(12). . View in PubMed
• Potential of Aqueous Humor as a Liquid Biopsy for Uveal Melanoma Int J Mol Sci. 2022 Jun 02; 23(11). . View in PubMed
• Disease characterization in liquid biopsy from HER2-mutated, non-amplified metastatic breast cancer patients treated with neratinib NPJ Breast Cancer. 2022 Feb 18; 8(1):22. . View in PubMed
• Characterization of Cellular and Acellular Analytes from Pre-Cystectomy Liquid Biopsies in Patients Newly Diagnosed with Primary Bladder Cancer Cancers (Basel). 2022 Feb 01; 14(3). . View in PubMed
• Circulating Tumor Cell Kinetics and Morphology from the Liquid Biopsy Predict Disease Progression in Patients with Metastatic Colorectal Cancer Following Resection Cancers (Basel). 2022 Jan 27; 14(3). . View in PubMed
• Chromosome 6p amplification detected in blood cell-free DNA in advanced intraocular retinoblastoma Ophthalmic Genet. 2022 12; 43(6):866-870. . View in PubMed
• Early detection of cancer Science. 2022 03 18; 375(6586):eaay9040. . View in PubMed
• Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphoma Blood Adv. 2022 08 23; 6(16):4675-4690. . View in PubMed
• Enrichment-Free Single-Cell Detection and Morphogenomic Profiling of Myeloma Patient Samples to Delineate Circulating Rare Plasma Cell Clones Curr Oncol. 2022 04 21; 29(5):2954-2972. . View in PubMed
• A Randomized Trial of Fulvestrant, Everolimus, and Anastrozole for the Front-line Treatment of Patients with Advanced Hormone Receptor-positive Breast Cancer, SWOG S1222 Clin Cancer Res. 2022 02 15; 28(4):611-617. . View in PubMed
• Early Breast Cancer Evolution by Autosomal Broad Copy Number Alterations Int J Genomics. 2022; 2022:9332922. . View in PubMed
• Prediction of Metastatic Patterns in Bladder Cancer: Spatiotemporal Progression and Development of a Novel, Web-based Platform for Clinical Utility Eur Urol Open Sci. 2021 Oct; 32:8-18. . View in PubMed
• Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy NPJ Precis Oncol. 2021 Jul 27; 5(1):73. . View in PubMed
• Comprehensive Somatic Copy Number Analysis Using Aqueous Humor Liquid Biopsy for Retinoblastoma Cancers (Basel). 2021 Jul 03; 13(13). . View in PubMed
• Health Economic Evidence for Liquid- and Tissue-based Molecular Tests that Inform Decisions on Prostate Biopsies and Treatment of Localised Prostate Cancer: A Systematic Review Eur Urol Open Sci. 2021 May; 27:77-87. . View in PubMed
• Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy Cancers (Basel). 2021 Mar 13; 13(6). . View in PubMed
• Large Extracellular Vesicle Characterization and Association with Circulating Tumor Cells in Metastatic Castrate Resistant Prostate Cancer Cancers (Basel). 2021 Mar 02; 13(5). . View in PubMed
• Platelet-Coated Circulating Tumor Cells Are a Predictive Biomarker in Patients with Metastatic Castrate-Resistant Prostate Cancer Mol Cancer Res. 2021 12; 19(12):2036-2045. . View in PubMed
• Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant PLoS Comput Biol. 2021 12; 17(12):e1009629. . View in PubMed
• Model Development of CDK4/6 Predicted Efficacy in Patients With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced or Metastatic Breast Cancer JCO Clin Cancer Inform. 2021 06; 5:758-767. . View in PubMed
• Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic Analysis J Vis Exp. 2021 09 07; (175). . View in PubMed
• Patient Empowerment During the COVID-19 Pandemic by Ensuring Safe and Fast Communication of Test Results: Implementation and Performance of a Tracking System J Med Internet Res. 2021 06 07; 23(6):e27348. . View in PubMed
• Liquid Biopsy in Colorectal Carcinoma: Clinical Applications and Challenges Cancers (Basel). 2020 May 27; 12(6). . View in PubMed
• Phase Ib Study of Enzalutamide with or Without Sorafenib in Patients with Advanced Hepatocellular Carcinoma Oncologist. 2020 12; 25(12):e1825-e1836. . View in PubMed
• Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes Ophthalmic Genet. 2020 12; 41(6):526-532. . View in PubMed
• Treatment response and tumor evolution: lessons from an extended series of multianalyte liquid biopsies in a metastatic breast cancer patient Cold Spring Harb Mol Case Stud. 2020 12; 6(6). . View in PubMed
• Variability in retinoblastoma genome stability is driven by age and not heritability Genes Chromosomes Cancer. 2020 10; 59(10):584-590. . View in PubMed
• Use of Wearable Activity Tracker in Patients With Cancer Undergoing Chemotherapy: Toward Evaluating Risk of Unplanned Health Care Encounters JCO Clin Cancer Inform. 2020 09; 4:839-853. . View in PubMed
• Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Transl Vis Sci Technol. 2020 09; 9(10):30. . View in PubMed
• Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Mol Cancer Res. 2020 08; 18(8):1166-1175. . View in PubMed
• Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic JCO Clin Cancer Inform. 2020 06; 4:583-601. . View in PubMed
• Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed
• Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases Clin Pharmacol Ther. 2020 04; 107(4):730-734. . View in PubMed
• Preanalytical Variables for the Genomic Assessment of the Cellular and Acellular Fractions of the Liquid Biopsy in a Cohort of Breast Cancer Patients J Mol Diagn. 2020 03; 22(3):319-337. . View in PubMed
• Feasibility of a large multi-center translational research project for newly diagnosed breast and ovarian cancer patients with affiliated biobank: the BRandO biology and outcome (BiO)-project Arch Gynecol Obstet. 2020 01; 301(1):273-281. . View in PubMed
• Modeling the Onset of Symptoms of COVID-19 Front Public Health. 2020; 8:473. . View in PubMed
• Single-Cell Circulating Tumor Cell Analysis Reveals Genomic Instability as a Distinctive Feature of Aggressive Prostate Cancer Clin Cancer Res. 2020 08 01; 26(15):4143-4153. . View in PubMed
• Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes J Am Chem Soc. 2020 09 30; 142(39):16704-16715. . View in PubMed
• Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis Recent Results Cancer Res. 2020; 215:89-104. . View in PubMed
• Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer Oncotarget. 2019 Dec 17; 10(66):7016-7030. . View in PubMed
• Patient reported outcomes can improve performance status assessment: a pilot study J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. . View in PubMed
• Prediction of Bone Metastasis in Inflammatory Breast Cancer Using a Markov Chain Model Oncologist. 2019 10; 24(10):1322-1330. . View in PubMed
• Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)Clin Genitourin Cancer. 2019 08; 17(4):241-247. e1. . View in PubMed
• Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed
• A new anion exchange purification method for Cu stable isotopes in blood samples Anal Bioanal Chem. 2019 Jan; 411(3):765-776. . View in PubMed
• Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer J Transl Med. 2019 08 28; 17(1):294. . View in PubMed
• Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients PLoS One. 2019; 14(2):e0210976. . View in PubMed
• Single-Cell Analysis of Circulating Tumor Cells Methods Mol Biol. 2019; 1908:243-264. . View in PubMed
• Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosis Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed
• Multiplex protein detection on circulating tumor cells from liquid biopsies using imaging mass cytometry Converg Sci Phys Oncol. 2018 Mar; 4(1). . View in PubMed
• Effect of Blood Collection Tube Type and Time to Processing on the Enumeration and High-Content Characterization of Circulating Tumor Cells Using the High-Definition Single-Cell Assay Arch Pathol Lab Med. 2018 Feb; 142(2):198-207. . View in PubMed
• Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed
• Low-dimensional dynamical characterization of human performance of cancer patients using motion data Clin Biomech (BristolAvon). 2018 07; 56:61-69. . View in PubMed
• Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms J Urol. 2018 06; 199(6):1494-1501. . View in PubMed
• Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation Clin Transl Sci. 2018 05; 11(3):267-276. . View in PubMed
• Development of metastatic brain disease involves progression through lung metastases in EGFR mutated non-small cell lung cancer Converg Sci Phys Oncol. 2017 Sep; 3(3). . View in PubMed
• Robotic salvage retroperitoneal and pelvic lymph node dissection for ‘node-only’ recurrent prostate cancer: technique and initial series BJU Int. 2017 09; 120(3):401-408. . View in PubMed
• Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters Clin Cancer Res. 2017 04 01; 23(7):1722-1732. . View in PubMed
• Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma JAMA Ophthalmol. 2017 11 01; 135(11):1221-1230. . View in PubMed
• The prothrombotic activity of cancer cells in the circulation Blood Rev. 2016 Jan; 30(1):11-9. . View in PubMed
• A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma Clin Cancer Res. 2016 Jan 01; 22(1):61-8. . View in PubMed
• Vasculogenic mimicry in small cell lung cancer Nat Commun. 2016 11 09; 7:13322. . View in PubMed
• A physical sciences network characterization of circulating tumor cell aggregate transport Am J Physiol Cell Physiol. 2015 May 15; 308(10):C792-802. . View in PubMed
• Fourier-ring descriptor to characterize rare circulating cells from images generated using immunofluorescence microscopy Comput Med Imaging Graph. 2015 Mar; 40:70-87. . View in PubMed
• The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation Am J Physiol Cell Physiol. 2015 Feb 01; 308(3):C229-36. . View in PubMed
• Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients Phys Biol. 2015 Jan 09; 12(1):016008. . View in PubMed
• Spatiotemporal progression of metastatic breast cancer: a Markov chain model highlighting the role of early metastatic sites NPJ Breast Cancer. 2015; 1:15018. . View in PubMed
• Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5 PLoS One. 2015; 10(5):e0127081. . View in PubMed
• Entropy, complexity, and Markov diagrams for random walk cancer models Sci Rep. 2014 Dec 19; 4:7558. . View in PubMed
• Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer Drug Dev Res. 2014 Sep; 75(6):384-92. . View in PubMed
• Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer J Thorac Oncol. 2014 Aug; 9(8):1111-9. . View in PubMed
• Adrenal metastases in lung cancer: clinical implications of a mathematical model J Thorac Oncol. 2014 Apr; 9(4):442-6. . View in PubMed
• Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction Phys Biol. 2014 Feb; 11(1):016002. . View in PubMed
• Physical biology in cancer2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C80-8. . View in PubMed
• Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells PLoS One. 2014; 9(8):e101777. . View in PubMed
• Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model Cancer Res. 2013 May 01; 73(9):2760-9. . View in PubMed
• The GPCR Network: a large-scale collaboration to determine human GPCR structure and function Nat Rev Drug Discov. 2013 01; 12(1):25-34. . View in PubMed
• A physical sciences network characterization of non-tumorigenic and metastatic cells Sci Rep. 2013; 3:1449. . View in PubMed
• An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer PLoS One. 2013; 8(7):e67733. . View in PubMed
• Circulating tumor cells in non-small cell lung carcinoma J Thorac Dis. 2012 Oct; 4(5):456-8. . View in PubMed
• Fluid biopsy for solid tumors: a patient’s companion for lifelong characterization of their disease Future Oncol. 2012 Aug; 8(8):989-98. . View in PubMed
• Characterization of circulating endothelial cells in acute myocardial infarction Sci Transl Med. 2012 Mar 21; 4(126):126ra33. . View in PubMed
• Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3731-6. . View in PubMed
• Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line Phys Biol. 2012 Feb; 9(1):016002. . View in PubMed
• Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers Phys Biol. 2012 Feb; 9(1):016003. . View in PubMed
• High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis Phys Biol. 2012 Feb; 9(1):016004. . View in PubMed
• Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology Phys Biol. 2012 Feb; 9(1):016005. . View in PubMed
• Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors Phys Biol. 2012 Feb; 9(1):016001. . View in PubMed
• A fluid biopsy as investigating technology for the fluid phase of solid tumors Phys Biol. 2012 Feb; 9(1):010301. . View in PubMed
• A stochastic Markov chain model to describe lung cancer growth and metastasis PLoS One. 2012; 7(4):e34637. . View in PubMed
• Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient Front Oncol. 2012; 2:96. . View in PubMed
• Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient Front Oncol. 2012; 2:72. . View in PubMed
• Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science. 2010 Nov 19; 330(6007):1066-71. . View in PubMed
• Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10708-12. . View in PubMed
• Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family J Virol. 2010 Mar; 84(6):3059-67. . View in PubMed
• Cytomorphology of circulating colorectal tumor cells:a small case series J Oncol. 2010; 2010:861341. . View in PubMed
• Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3 J Virol. 2009 Dec; 83(24):12998-3008. . View in PubMed
• Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. . View in PubMed
• Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling J Virol. 2009 Oct; 83(19):10314-8. . View in PubMed
• Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. . View in PubMed
• Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans Am J Hum Genet. 2009 Sep; 85(3):328-37. . View in PubMed
• A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5252-7. . View in PubMed
• Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold J Virol. 2009 Feb; 83(4):1823-36. . View in PubMed
• Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1 J Mol Biol. 2008 Jul 25; 380(5):828-43. . View in PubMed
• A specific cholesterol binding site is established by the 28 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. . View in PubMed
• Enthalpy array analysis of enzymatic and binding reactions Anal Biochem. 2008 Jun 01; 377(1):33-9. . View in PubMed
• Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3 J Virol. 2008 Jun; 82(11):5279-94. . View in PubMed
• C-ME: a 3D community-based, real-time collaboration tool for scientific research and training PLoS One. 2008 Feb 20; 3(2):e1621. . View in PubMed
• In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. . View in PubMed
• Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition J Biol Chem. 2007 Dec 14; 282(50):36505-13. . View in PubMed
• High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science. 2007 Nov 23; 318(5854):1258-65. . View in PubMed
• Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus J Virol. 2007 Nov; 81(21):12049-60. . View in PubMed
• Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression Protein Expr Purif. 2007 Nov; 56(1):85-92. . View in PubMed
• Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol. 2007 Jun; 81(12):6700-8. . View in PubMed
• Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models J Virol. 2007 Jun; 81(11):5637-48. . View in PubMed
• Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex Protein Expr Purif. 2007 May; 53(1):51-62. . View in PubMed
• Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein J Virol. 2007 Apr; 81(8):3913-21. . View in PubMed
• Case study of the morphologic variation of circulating tumor cells Hum Pathol. 2007 Mar; 38(3):514-9. . View in PubMed
• Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity J Biol Chem. 2006 Sep 22; 281(38):28185-92. . View in PubMed
• Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 206 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. . View in PubMed
• Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol. 2006 Aug; 80(16):7894-901. . View in PubMed
• Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy J Virol. 2006 Aug; 80(16):7918-28. . View in PubMed
• Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 215 A resolution. Proteins. 2006 Jun 01; 63(4):1106-11. . View in PubMed
• Crystal structure of TM1367 from Thermotoga maritima at 190 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. . View in PubMed
• High speed detection of circulating tumor cells Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. . View in PubMed
• Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity Structure. 2006 Feb; 14(2):321-30. . View in PubMed
• In situ data collection and structure refinement from microcapillary protein crystallization J Appl Crystallogr. 2005 Dec; 38(6):900-905. . View in PubMed
• Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1”-phosphate dephosphorylation by a conserved domain of nsP3 Structure. 2005 Nov; 13(11):1665-75. . View in PubMed
• Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7 J Virol. 2005 Oct; 79(20):12905-13. . View in PubMed
• Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers J Virol. 2005 Aug; 79(15):9665-76. . View in PubMed
• Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena spat 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. . View in PubMed
• Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 280 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. . View in PubMed
• Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 185 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. . View in PubMed
• Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 165 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. . View in PubMed
• Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 200-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. . View in PubMed
• Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 24 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. . View in PubMed
• Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 210 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. . View in PubMed
• Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 19 A resolution. Proteins. 2004 Aug 01; 56(2):396-400. . View in PubMed
• Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 190 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. . View in PubMed
• Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 18 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. . View in PubMed
• Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 160 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. . View in PubMed
• Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 250 A resolution. Proteins. 2004 May 15; 55(3):768-71. . View in PubMed
• Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 175 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. . View in PubMed
• Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 20 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. . View in PubMed
• Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. . View in PubMed
• Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein Structure. 2003 Jun; 11(6):677-90. . View in PubMed
• A low-dimensional deformation model for cancer cells in flow Phys Fluids (1994). 2012 Aug; 24(8):81903. . View in PubMed

• Berry, Jesse
• Goldkorn, Amir
• Lenz, Heinz-Josef
• Daneshmand, Siamak
• Quinn, David
• Nieva, Jorge