Faculty

Pat R. Levitt, PhD
Pat R. Levitt, PhD
Professor of Pediatrics;W.M. Keck Chair in Neurogenetics;Chief Scientific Officer, Vice President, and Director of The Saban Research Institute;Director of the Program in Developmental Neurogenetics at The Saban Research Institute
Pediatrics
4640 West Sunset Boulevard Off Campus Los Angeles
Dr. Levitt received his BA in Biological Sciences from the University of Chicago, PhD in Neuroscience at the University of California, San Diego. He completed a postdoctoral fellowship in Neuroscience at Yale University. Dr. Levitt has held leadership positions at University of Pittsburgh, Vanderbilt University and University of Southern California. Dr. Levitt was elected as a member into the prestigious Institute of Medicine (IOM), part of the National Academy of Sciences. Named a McKnight Foundation Scholar in 2002, Dr. Levitt also was a MERIT awardee from the National Institute of Mental Health and served as a member of the National Advisory Mental Health Council for the National Institute of Mental Health. He is an elected Fellow of the American Association for the Advancement of Science (AAAS), Chair-elect of the Neuroscience Division of the AAAS, and an elected member of the Dana Alliance for Brain Initiatives. He is a Senior Fellow at the Center for the Developing Child at Harvard University, and serves as Scientific Director of the National Scientific Council on the Developing Child, a policy council that brings the best research from child development and neuroscience to assist policy makers and business leaders in making wise program investment decisions. He is a member of a number of scientific advisory boards for foundations and university programs, served as Senior Editor for Journal of Neuroscience, and currently serves on the editorial boards of eLife, Neuron, Cerebral Cortex, Autism Research, Journal of Neurodevelopmental Disorders and Disease Models and Mechanisms. Dr. Levitt’s research focuses on the development of brain architecture that controls learning, emotional and social behavior. His research focuses on genetic and environment factors that increase risk for neurodevelopmental and neuropsychiatric disorders, such as autism and schizophrenia. His clinical research studies address autism heterogeneity by studying children with autism who also have co-occurring medical conditions, such as gastrointestinal disorders, with the goal of developing better diagnostic criteria and personalized treatments. He has published over 250 papers.

FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis Elife. 2019 May 17; 8. . View in PubMed

Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors Autism Res. 2019 May; 12(5):700-714. . View in PubMed

Association of Perceived Maternal Stress During the Perinatal Period With Electroencephalography Patterns in 2-Month-Old Infants JAMA Pediatr. 2019 Apr 08. . View in PubMed

Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase Cereb Cortex. 2019 Jan 01; 29(1):189-201. . View in PubMed

Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice Neurobiol Stress. 2018 Feb; 8:10-20. . View in PubMed

Analysis of shared heritability in common disorders of the brain Science. 2018 06 22; 360(6395). . View in PubMed

Distinct projection targets define subpopulations of mouse brainstem vagal neurons that express the autism-associated MET receptor tyrosine kinase J Comp Neurol. 2017 Dec 15; 525(18):3787-3808. . View in PubMed

Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase Cereb Cortex. 2017 Nov 28; 1-13. . View in PubMed

Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2017 Jun; 13(6):e1006831. . View in PubMed

Beyond Hat in Hand: Science Advocacy Is Foundational for Policy Decisions Neuron. 2017 May 17; 94(4):708-712. . View in PubMed

Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2017 06; 13(6):e1006831. . View in PubMed

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder J Autism Dev Disord. 2017 06; 47(6):1673-1681. . View in PubMed

EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development J Comp Neurol. 2016 Jul 01; 524(10):2080-92. . View in PubMed

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder J Autism Dev Disord. 2016 Mar; 46(3):1124-30. . View in PubMed

Brief Report: Recruitment and Retention of Minority Children for Autism Research J Autism Dev Disord. 2016 Feb; 46(2):698-703. . View in PubMed

Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis Dev Neurobiol. 2016 10; 76(10):1160-81. . View in PubMed

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse Placenta. 2016 06; 42:74-83. . View in PubMed

Early-Life Stress Paradigm Transiently Alters Maternal Behavior, Dam-Pup Interactions, and Offspring Vocalizations in Mice Front Behav Neurosci. 2016; 10:142. . View in PubMed

EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development J Comp Neurol. 2016 07 01; 524(10):2080-92. . View in PubMed

Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior J Neurodev Disord. 2015; 7:35. . View in PubMed

Comparative DNA methylation among females with neurodevelopmental disorders and seizures identifies TAC1 as a MeCP2 target gene J Neurodev Disord. 2013 Jun 11; 5(1):15. . View in PubMed

EphA signaling impacts development of topographic connectivity in auditory corticofugal systems Cereb Cortex. 2013 Apr; 23(4):775-85. . View in PubMed

Enrichment of elevated plasma F2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction PLoS One. 2013; 8(7):e68444. . View in PubMed

Autism-associated promoter variant in MET impacts functional and structural brain networks Neuron. 2012 Sep 06; 75(5):904-15. . View in PubMed

Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors Autism Res. 2012 Apr; 5(2):101-8. . View in PubMed

Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain Neuroscience. 2011 Dec 01; 197:1-7. . View in PubMed

A new synaptic player leading to autism risk: Met receptor tyrosine kinase J Neurodev Disord. 2011 Sep; 3(3):282-92. . View in PubMed

Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET Cereb Cortex. 2011 Jul; 21(7):1613-26. . View in PubMed

Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder J Neurodev Disord. 2011 Jun; 3(2):101-12. . View in PubMed

A transient placental source of serotonin for the fetal forebrain Nature. 2011 Apr 21; 472(7343):347-50. . View in PubMed

Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase J Neurosci. 2011 Apr 13; 31(15):5855-64. . View in PubMed

Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1) Dev Neurosci. 2011; 33(1):64-74. . View in PubMed

Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain J Comp Neurol. 2010 Nov 01; 518(21):4463-78. . View in PubMed

Association of MET with social and communication phenotypes in individuals with autism spectrum disorder Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):438-446. . View in PubMed

Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. . View in PubMed

Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain J Comp Neurol. 2009 Apr 10; 513(5):511-31. . View in PubMed

Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions Pediatrics. 2009 Mar; 123(3):1018-24. . View in PubMed

Adaptive changes in gene expression patterns in the somatosensory cortex after deletion of ephrinA5 Mol Cell Neurosci. 2008 Sep; 39(1):21-31. . View in PubMed

Future of individualized psychiatric treatment Pharmacogenomics. 2008 May; 9(5):493-5. . View in PubMed

Association of RGS2 and RGS5 variants with schizophrenia symptom severity Schizophr Res. 2008 Apr; 101(1-3):67-75. . View in PubMed

Fetal mechanisms in neurodevelopmental disorders Pediatr Neurol. 2008 Mar; 38(3):163-76. . View in PubMed

Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia Biol Psychiatry. 2008 Jan 01; 63(1):32-41. . View in PubMed

Bootstrap classification and point-based feature selection from age-staged mouse cerebellum tissues of matrix assisted laser desorption/ionization mass spectra using a fuzzy rule-building expert system Anal Chim Acta. 2007 Sep 19; 599(2):219-31. . View in PubMed

Disruption of cerebral cortex MET signaling in autism spectrum disorder Ann Neurol. 2007 Sep; 62(3):243-50. . View in PubMed

Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon Neuroscience. 2007 Aug 24; 148(2):385-99. . View in PubMed

DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia Genes Brain Behav. 2007 Apr; 6(3):229-39. . View in PubMed

Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation J Neurosci. 2007 Mar 21; 27(12):3295-304. . View in PubMed

Autism spectrum disorders: developmental disconnection syndromes Curr Opin Neurobiol. 2007 Feb; 17(1):103-11. . View in PubMed

A genetic variant that disrupts MET transcription is associated with autism Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16834-9. . View in PubMed

Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during developmentI. Cerebral cortex. Neuroscience. 2006 Nov 03; 142(4):1145-61. . View in PubMed

Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during developmentII. Subcortical regions. Neuroscience. 2006 Nov 03; 142(4):1163-81. . View in PubMed

Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development Neuroscience. 2006 Aug 25; 141(2):781-94. . View in PubMed

Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry. 2006 Jul 15; 60(2):163-76. . View in PubMed

Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples Biol Psychiatry. 2006 Jul 15; 60(2):152-62. . View in PubMed

DNA self-polymers as microarray probes improve assay sensitivity J Neurosci Methods. 2006 Mar 15; 151(2):216-23. . View in PubMed

Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism Neuron. 2005 Nov 23; 48(4):563-75. . View in PubMed

Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats J Neurosci. 2005 Oct 05; 25(40):9102-11. . View in PubMed

Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: A methodological study in postnatal and adult mouse J Neurosci Res. 2005 Sep 01; 81(5):613-21. . View in PubMed

Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice J Comp Neurol. 2005 Jul 04; 487(3):270-82. . View in PubMed

Developmental neurobiology and clinical disorders: lost in translation? Neuron. 2005 May 05; 46(3):407-12.. View in PubMed

Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia Neuropsychopharmacology. 2005 May; 30(5):974-83. . View in PubMed

Applications of gene targeting technology to mental retardation and developmental disability research Ment Retard Dev Disabil Res Rev. 2005; 11(4):295-302. . View in PubMed

Disruption of interneuron development Epilepsia. 2005; 46 Suppl 7:22-8. . View in PubMed

Autism as a disorder of neural information processing: directions for research and targets for therapy Mol Psychiatry. 2004 Jul; 9(7):646-63. . View in PubMed

Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene Genomics. 2004 May; 83(5):790-801. . View in PubMed

Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development Curr Opin Pharmacol. 2004 Feb; 4(1):65-71. . View in PubMed

Autism and 15q11-q13 disorders: behavioral, genetic, and pathophysiological issues Ment Retard Dev Disabil Res Rev. 2004; 10(4):284-91. . View in PubMed

DNA microarray analysis of postmortem brain tissue Int Rev Neurobiol. 2004; 60:153-81. . View in PubMed

Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth Mol Cell Neurosci. 2003 Nov; 24(3):725-40. . View in PubMed

Differential regulation of thalamic and cortical axonal growth by hepatocyte growth factor/scatter factor Dev Neurosci. 2003 Mar-Aug; 25(2-4):197-206. . View in PubMed

Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders Neurochem Res. 2002 Oct; 27(10):1049-63. . View in PubMed

Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP J Neurobiol. 2002 Jun 05; 51(3):190-204. . View in PubMed

Association and linkage analyses of RGS4 polymorphisms in schizophrenia Hum Mol Genet. 2002 Jun 01; 11(12):1373-80. . View in PubMed

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J Neurosci. 2002 Apr 01; 22(7):2718-29. . View in PubMed

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse Trends Neurosci. 2001 Aug; 24(8):479-86. . View in PubMed

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia Mol Psychiatry. 2001 May; 6(3):293-301. . View in PubMed

Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays ScientificWorldJournal. 2001 Apr 04; 1:114-6. . View in PubMed

Complex signaling responsible for molecular regionalization of the cerebral cortex Cereb Cortex. 1999 Sep; 9(6):562-8. . View in PubMed

Assignment of the gene encoding the limbic system-associated membrane protein (LAMP) to mouse chromosome 16B5 and human chromosome 3q132-q21. Genomics. 1998 May 01; 49(3):472-4. . View in PubMed

Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis Brain Res Mol Brain Res. 1997 Jul; 47(1-2):202-14. . View in PubMed

Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures Exp Brain Res. 1997 May; 114(3):433-41. . View in PubMed

Expression of the mRNAs encoding the limbic system-associated membrane protein (LAMP): IAdult rat brain. J Comp Neurol. 1996 Nov 11; 375(2):274-88. . View in PubMed

Expression of the mRNAs encoding the limbic system-associated membrane protein (LAMP): IIFetal rat brain. J Comp Neurol. 1996 Nov 11; 375(2):289-302. . View in PubMed

Complementary distribution of collagen type IV and the epidermal growth factor receptor in the rat embryonic telencephalon Cereb Cortex. 1996 May-Jun; 6(3):540-9. . View in PubMed

Environmental signals influence expression of a cortical areal phenotype in vitro independent of effects on progenitor cell proliferation Dev Biol. 1996 Apr 10; 175(1):184-90. . View in PubMed

Dopamine receptors mediate differential morphological effects on cerebral cortical neurons in vitro J Neurosci Res. 1996 Feb 15; 43(4):439-53. . View in PubMed

Distribution of limbic system-associated membrane protein immunoreactivity in primate basal ganglia Neuroscience. 1995 Nov; 69(1):71-81. . View in PubMed

Age-dependent specification of the corticocortical connections of cerebral grafts J Neurosci. 1995 Mar; 15(3 Pt 1):1819-34. . View in PubMed

Cerebral cortical progenitors are fated to produce region-specific neuronal populations Cereb Cortex. 1993 May-Jun; 3(3):187-98. . View in PubMed

Attraction of specific thalamic input by cerebral grafts depends on the molecular identity of the implant Proc Natl Acad Sci U S A. 1992 May 01; 89(9):3706-10. . View in PubMed

Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain J Comp Neurol. 1991 Dec 01; 314(1):125-35. . View in PubMed

Brain macrophages and microglia respond differently to lesions of the developing and adult visual system J Comp Neurol. 1991 Dec 01; 314(1):136-46. . View in PubMed

Access to gastric tissue promotes the survival of axotomized neurons in the dorsal motor nucleus of the vagus in neonatal rats J Comp Neurol. 1991 Nov 08; 313(2):213-26. . View in PubMed

A membrane glycoprotein associated with the limbic system mediates the formation of the septo-hippocampal pathway in vitro Neuron. 1989 Nov; 3(5):551-61. . View in PubMed

Developmental and regeneration-associated regulation of the limbic system associated membrane protein in explant cultures of the rat brain Neuroscience. 1989; 28(2):455-74. . View in PubMed

A unique membrane protein is expressed on early developing limbic system axons and cortical targets J Neurosci. 1988 Dec; 8(12):4653-61. . View in PubMed

Central adrenergic receptor changes in the inherited noradrenergic hyperinnervated mutant mouse tottering Brain Res. 1987 Aug 18; 418(1):174-7. . View in PubMed

Emergence of cyclic guanosine 3':5'-monophosphate-dependent protein kinase immunoreactivity in developing rhesus monkey cerebellum: correlative immunocytochemical and electron microscopic analysis J Neurosci. 1984 Oct; 4(10):2553-64. . View in PubMed

Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker Neuroscience. 1984 Apr; 11(4):761-817. . View in PubMed

Central monoamine neuron systems: their organization in the developing and mature primate brain and the genetic regulation of their terminal fields Adv Neurol. 1982; 35:49-59. . View in PubMed

Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis J Neurosci. 1981 Jan; 1(1):27-39. . View in PubMed

Development of the noradrenergic innervation of neocortex Brain Res. 1979 Feb 23; 162(2):243-59. . View in PubMed

Developmental organization of raphe serotonin neuron groups in the rat Anat Embryol (Berl). 1978 Sep 27; 154(3):241-51. . View in PubMed

Powered by SC CTSI

Affiliated Faculty at UPC