Sarah Hamm-Alvarez

Sarah Hamm-Alvarez

Professor of Ophthalmology and Pharmacology and Pharmaceutical Sciences;Associate Dean for Basic and Translational Research
MCA 346A 1333 San Pablo Street Health Sciences Campus Los Angeles

American Association of Pharmaceutical Scientists: Fellow, 2014

: Higher Education Resource Services (HERS) Representative, 2010-2011

USC School of Pharmacy: Gavin S. Herbert Professor of Pharmaceutical Sciences, 2004-2015

USC School of Pharmacy: John A. Biles Professor of Pharmaceutical Sciences, 2003

Linneaus University, Kalmar Sweden: Doctor of Philosophy, honoris causa, 2003

American Heart Association: Initial Investigatorship, 1994-1996

Duke University: Muscular Dystrophy Association Postdoctoral Fellow, 1991-1993

Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium Int J Mol Sci. 2020 Aug 26; 21(17). . View in PubMed

Application of advances in endocytosis and membrane trafficking to drug delivery Adv Drug Deliv Rev. 2020 Aug 03. . View in PubMed

Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption Transl Vis Sci Technol. 2020 Jul; 9(8):23. . View in PubMed

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye Int J Mol Sci. 2020 Apr 15; 21(8). . View in PubMed

Caveolin elastin-like polypeptide fusions mediate temperature-dependent assembly of caveolar microdomains ACS Biomater Sci Eng. 2020 Jan 13; 6(1):198-204. . View in PubMed

Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model Sci Rep. 2020 01 29; 10(1):1455. . View in PubMed

PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease Am J Respir Crit Care Med. 2019 Jul 01; 200(1):6-8. . View in PubMed

Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome Biomarkers. 2019 Feb; 24(1):91-102. . View in PubMed

Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls Biomark Med. 2019 12; 13(17):1447-1457. . View in PubMed

Oligomeric a-synuclein is increased in basal tears of Parkinson's patients Biomark Med. 2019 08; 13(11):941-952. . View in PubMed

Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease Mol Pharm. 2019 07 01; 16(7):3024-3039. . View in PubMed

Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide Bioconjug Chem. 2019 09 18; 30(9):2358-2372. . View in PubMed

Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome Sci Rep. 2019 07 02; 9(1):9559. . View in PubMed

Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells Int J Mol Sci. 2018 Nov 09; 19(11). . View in PubMed

NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis Exp Eye Res. 2018 11; 176:243-251. . View in PubMed

Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients Sci Rep. 2018 07 23; 8(1):11044. . View in PubMed

A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome J Control Release. 2018 12 28; 292:183-195. . View in PubMed

Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models Sci Rep. 2018 07 02; 8(1):9919. . View in PubMed

Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome Stem Cells Int. 2017; 2017:3134543. . View in PubMed

PLoS One. 2017; 12(9):e0184781. . View in PubMed

Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. . View in PubMed

Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome Am J Physiol Cell Physiol. 2016 06 01; 310(11):C942-54. . View in PubMed

Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines J Control Release. 2016 10 28; 240:93-108. . View in PubMed

Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification J Proteomics Bioinform. 2015 Nov; 8(11):260-265. . View in PubMed

A thermo-responsive protein treatment for dry eyes J Control Release. 2015 Feb 10; 199:156-67. . View in PubMed

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. . View in PubMed

Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. . View in PubMed

A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome J Control Release. 2013 Nov 10; 171(3):269-79. . View in PubMed

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms Nanomedicine. 2013 Aug; 9(6):786-94. . View in PubMed

Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. . View in PubMed

Analyzing live cellularity in the human trabecular meshwork Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. . View in PubMed

A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains Biomacromolecules. 2012 Nov 12; 13(11):3439-44. . View in PubMed

In situ autofluorescence visualization of human trabecular meshwork structure Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. . View in PubMed

Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site PLoS One. 2012; 7(2):e31789. . View in PubMed

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways J Control Release. 2011 Oct 30; 155(2):134-43. . View in PubMed

Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain J Control Release. 2011 Oct 30; 155(2):218-26. . View in PubMed

A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. . View in PubMed

Polystyrene nanoparticle trafficking across MDCK-II Nanomedicine. 2011 Oct; 7(5):588-94. . View in PubMed

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland . 2011 Aug; 301(2):C507-21. . View in PubMed

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. . View in PubMed

Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. . View in PubMed

Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells ACS Nano. 2010 May 25; 4(5):2735-47. . View in PubMed

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. . View in PubMed

Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy Exp Eye Res. 2010 Feb; 90(2):223-37. . View in PubMed

Mitochondrial medicine and therapeutics, Part IIPreface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. . View in PubMed

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland Exp Eye Res. 2009 Sep; 89(3):319-32. . View in PubMed

Quantitative second harmonic generation imaging of cartilage damage Cell Tissue Bank. 2008 Dec; 9(4):299-307. . View in PubMed

Mitochondrial medicine and mitochondrion-based therapeutics Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. . View in PubMed

Polystyrene nanoparticle trafficking across alveolar epithelium Nanomedicine. 2008 Jun; 4(2):139-45. . View in PubMed

Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells . 2008 Mar; 294(3):C662-74. . View in PubMed

Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome Matrix Biol. 2008 Jan; 27(1):53-66. . View in PubMed

Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability Ann Thorac Surg. 2007 May; 83(5):1641-50. . View in PubMed

Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. . View in PubMed

Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini J Virol. 2006 Dec; 80(23):11833-51. . View in PubMed

Current status of gene delivery and gene therapy in lacrimal gland using viral vectors Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. . View in PubMed

Integrin adhesion in regulation of lacrimal gland acinar cell secretion Exp Eye Res. 2006 Sep; 83(3):543-53. . View in PubMed

Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis Exp Eye Res. 2006 Jul; 83(1):84-96. . View in PubMed

Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development Exp Eye Res. 2006 Jan; 82(1):33-45. . View in PubMed

Intracellular trafficking of nonviral vectors Gene Ther. 2005 Dec; 12(24):1734-51. . View in PubMed

Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. . View in PubMed

Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini . 2005 Oct; 289(4):C1052-68. . View in PubMed

Mucosal immunity and self-tolerance in the ocular surface system Ocul Surf. 2005 Oct; 3(4):182-92. . View in PubMed

Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation Scand J Immunol. 2005 Jan; 61(1):36-50. . View in PubMed

Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation Exp Eye Res. 2004 Nov; 79(5):665-75. . View in PubMed

Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland Gene Ther. 2004 Jun; 11(12):970-81. . View in PubMed

Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells J Cell Physiol. 2004 Apr; 199(1):108-25. . View in PubMed

Modulation of secretory functions in epithelia by adenovirus capsid proteins J Control Release. 2003 Dec 05; 93(2):129-40. . View in PubMed

Actin microfilaments et al--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. . View in PubMed

Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist Scand J Immunol. 2003 Nov; 58(5):550-65. . View in PubMed

Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells Mol Biol Cell. 2003 Nov; 14(11):4397-413. . View in PubMed

Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. . View in PubMed

Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. . View in PubMed

Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. . View in PubMed

Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain" . 2002 Mar; 282(3):C417-9. . View in PubMed

Epidermal growth factor traffic in lacrimal acinar cells Adv Exp Med Biol. 2002; 506(Pt A):213-7. . View in PubMed

Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system Exp Eye Res. 2002 Jan; 74(1):7-22. . View in PubMed

Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells Adv Exp Med Biol. 2002; 506(Pt A):199-205. . View in PubMed

M3 receptor autoimmunity: losing tolerance to a familiar protein Adv Exp Med Biol. 2002; 506(Pt A):51-8. . View in PubMed

Etk/Bmx activation modulates barrier function in epithelial cells . 2001 Jun; 280(6):C1657-68. . View in PubMed

Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression Pharm Res. 2001 Feb; 18(2):246-9. . View in PubMed

Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases Cell Motil Cytoskeleton. 2000 Dec; 47(4):253-68. . View in PubMed

Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton Biochem Biophys Res Commun. 2000 Nov 02; 277(3):525-30. . View in PubMed

Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini Curr Eye Res. 2000 May; 20(5):373-83. . View in PubMed

Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1 J Control Release. 1999 Nov 01; 62(1-2):129-40. . View in PubMed

Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function Biochem J. 1999 Aug 15; 342 ( Pt 1):1-6. . View in PubMed

Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney Physiol Rev. 1998 Oct; 78(4):1109-29. . View in PubMed

Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1) Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. . View in PubMed

A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments J Cell Sci. 1998 Jul; 111 ( Pt 13):1841-52. . View in PubMed

Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells J Cell Sci. 1998 May; 111 ( Pt 9):1267-76. . View in PubMed

Kinesin activation drives the retrieval of secretory membranes following secretion in rabbit lacrimal acinar cells Adv Exp Med Biol. 1998; 438:177-80. . View in PubMed

Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity Exp Eye Res. 1997 Feb; 64(2):141-56. . View in PubMed

Involvement of phosphorylation in doxorubicin-mediated myofibril degenerationAn immunofluorescence microscopy analysis. Circ Res. 1997 Jan; 80(1):52-61. . View in PubMed

Paclitaxel and nocodazole differentially alter endocytosis in cultured cells Pharm Res. 1996 Nov; 13(11):1647-56. . View in PubMed

Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes Am J Physiol. 1996 Sep; 271(3 Pt 1):C929-43. . View in PubMed

Microtubule-based motor proteins: new targets for enhancing drug delivery? Pharm Res. 1996 Apr; 13(4):489-96.. View in PubMed

Coordinate depression of bradykinin receptor recycling and microtubule-dependent transport by taxol Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7812-6. . View in PubMed

Regulation of kinesin activity by phosphorylation of kinesin-associated proteins J Biol Chem. 1994 Jul 22; 269(29):19176-82. . View in PubMed

Regulation of vesicle transport in CV-1 cells and extracts J Cell Sci. 1993 Nov; 106 ( Pt 3):955-66. . View in PubMed

Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase J Biol Chem. 1989 Jun 05; 264(16):9649-56. . View in PubMed

Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2046-50. . View in PubMed

Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.
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