Faculty

Common activation mechanism of class A GPCRs Elife. 2019 Dec 19; 8. . View in PubMed

Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor Anal Chem. 2019 Jul 02; 91(13):8162-8169. . View in PubMed

An online resource for GPCR structure determination and analysis Nat Methods. 2019 02; 16(2):151-162. . View in PubMed

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor Nat Chem Biol. 2019 01; 15(1):11-17. . View in PubMed

Crystal Structure of the Human Cannabinoid Receptor CB2Cell. 2019 01 24; 176(3):459-467. e13. . View in PubMed

Advancing Chemokine GPCR Structure Based Drug Discovery Structure. 2019 03 05; 27(3):405-408. . View in PubMed

A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure ACS Chem Biol. 2019 06 21; 14(6):1150-1153. . View in PubMed

Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors Sci Rep. 2018 Jul 24; 8(1):11380. . View in PubMed

Crystal structure of the Frizzled 4 receptor in a ligand-free state Nature. 2018 08; 560(7720):666-670. . View in PubMed

Chemical Diversity in the G Protein-Coupled Receptor Superfamily Trends Pharmacol Sci. 2018 05; 39(5):494-512. . View in PubMed

A2A adenosine receptor functional states characterized by 19F-NMR Proc Natl Acad Sci U S A. 2018 12 11; 115(50):12733-12738. . View in PubMed

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine ReceptorCell. 2018 01 11; 172(1-2):68-80. e12. . View in PubMed

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR PolypharmacologyCell. 2018 02 08; 172(4):719-730. e14. . View in PubMed

Computational design of thermostabilizing point mutations for G protein-coupled receptors Elife. 2018 06 21; 7. . View in PubMed

A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor Medchemcomm. 2017 Jun 01; 8(6):1332-1336. . View in PubMed

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Nat Commun. 2017 05 17; 8:15383. . View in PubMed

Crystal Structure of the Human Cannabinoid Receptor CB1Cell. 2016 Oct 20; 167(3):750-762. e14. . View in PubMed

An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels Nat Commun. 2016 Jan 12; 7:8770. . View in PubMed

Conformational states of the full-length glucagon receptor Nat Commun. 2015 Jul 31; 6:7859. . View in PubMed

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Nature. 2015 Jul 30; 523(7562):561-7. . View in PubMed

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 Cell. 2015 Jun 18; 161(7):1633-43. . View in PubMed

Constitutive phospholipid scramblase activity of a G protein-coupled receptor Nat Commun. 2014 Oct 08; 5:5115. . View in PubMed

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges Structure. 2014 Aug 05; 22(8):1120-1139. . View in PubMed

Agonist-bound structure of the human P2Y12 receptor Nature. 2014 May 01; 509(7498):119-22. . View in PubMed

Allosteric sodium in class A GPCR signaling Trends Biochem Sci. 2014 May; 39(5):233-44. . View in PubMed

J Biol Chem. 2013 Nov 29; 288(48):34470-83. . View in PubMed

Asia growth in membrane protein structure Curr Opin Struct Biol. 2013 Aug; 23(4):481-2. . View in PubMed

Coordinating the impact of structural genomics on the human a-helical transmembrane proteome Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. . View in PubMed

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer Methods Mol Biol. 2013; 1013:93-127. . View in PubMed

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes J Biol Chem. 2012 Dec 14; 287(51):43063-70. . View in PubMed

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity ACS Chem Biol. 2012 Jul 20; 7(7):1184-9. . View in PubMed

Biased signaling pathways in ß2-adrenergic receptor characterized by 19F-NMR Science. 2012 Mar 02; 335(6072):1106-10. . View in PubMed

Crystal structure of a lipid G protein-coupled receptor Science. 2012 Feb 17; 335(6070):851-5. . View in PubMed

Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? JIMD Rep. 2012; 5:59-70.. View in PubMed

A roadmap to membrane protein structures Methods. 2011 Dec; 55(4):271-2. . View in PubMed

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography J Am Chem Soc. 2010 Aug 25; 132(33):11443-5. . View in PubMed

Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation J Mol Biol. 2010 Jul 23; 400(4):743-54. . View in PubMed

Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding J Mol Biol. 2010 Apr 16; 397(5):1287-97. . View in PubMed

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region J Mol Biol. 2010 Apr 09; 397(4):1106-18. . View in PubMed

Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria Mol Genet Metab. 2010 Jan; 99(1):4-9. . View in PubMed

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures J Am Chem Soc. 2009 Aug 05; 131(30):10497-506. . View in PubMed

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008 Nat Rev Drug Discov. 2009 06; 8(6):455-63. . View in PubMed

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5847-50. . View in PubMed

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications Nature. 2008 Nov 06; 456(7218):121-4. . View in PubMed

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction PLoS Pathog. 2008 Aug 15; 4(8):e1000129. . View in PubMed

A specific cholesterol binding site is established by the 28 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. . View in PubMed

Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments J Membr Biol. 2008 May; 223(1):13-26. . View in PubMed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog J Mol Biol. 2008 Feb 22; 376(3):758-70. . View in PubMed

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 205 A resolution. Proteins. 2008 Feb 01; 70(2):603-8. . View in PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch J Virol. 2007 Jun; 81(12):6700-8. . View in PubMed

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 26 A resolution reveals a new fold with a novel active site. Proteins. 2006 Nov 15; 65(3):771-6. . View in PubMed

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 175 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 2006 Nov 15; 65(3):777-82. . View in PubMed

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 20 A resolution. Proteins. 2006 Nov 15; 65(3):527-37. . View in PubMed

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 190 A resolution. Proteins. 2006 Oct 01; 65(1):249-54. . View in PubMed

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 270 A resolution reveals a new fold. Proteins. 2006 Oct 01; 65(1):243-8. . View in PubMed

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4 J Mol Biol. 2006 Sep 29; 362(4):733-42. . View in PubMed

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 158 A resolution. Proteins. 2006 Sep 01; 64(4):1083-90. . View in PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 206 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. . View in PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs J Virol. 2006 Aug; 80(16):7894-901. . View in PubMed

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 215 A resolution. Proteins. 2006 Jun 01; 63(4):1106-11. . View in PubMed

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 260 A resolution. Proteins. 2006 Apr 01; 63(1):256-60. . View in PubMed

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 190 A resolution reveals a new fold. Proteins. 2005 Dec 01; 61(4):1132-6. . View in PubMed

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 220 A resolution. Proteins. 2005 Nov 15; 61(3):669-73. . View in PubMed

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 195 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):444-8. . View in PubMed

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 205 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):449-53. . View in PubMed

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 183 A resolution. Proteins. 2005 Sep 01; 60(4):797-802. . View in PubMed

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition Biochemistry. 2005 Jul 19; 44(28):9574-80. . View in PubMed

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 190 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):864-8. . View in PubMed

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 20 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):869-74. . View in PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena spat 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. . View in PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 280 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. . View in PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 185 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. . View in PubMed

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16903-8. . View in PubMed

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 187 A resolution. Proteins. 2004 Oct 01; 57(1):213-7. . View in PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 200-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. . View in PubMed

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 165 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. . View in PubMed

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 183 A resolution. Proteins. 2004 Aug 15; 56(3):615-8. . View in PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 24 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. . View in PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 210 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. . View in PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 18 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. . View in PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 190 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. . View in PubMed

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 19 A resolution. Proteins. 2004 Aug 01; 56(2):396-400. . View in PubMed

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 195 A resolution. Proteins. 2004 Aug 01; 56(2):392-5. . View in PubMed

A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform Chembiochem. 2004 Jul 05; 5(7):921-7. . View in PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 160 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. . View in PubMed

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 190 A resolution. Proteins. 2004 Jul 01; 56(1):171-5. . View in PubMed

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 23 A resolution. Proteins. 2004 Jun 01; 55(4):1078-81. . View in PubMed

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 190 A resolution. Proteins. 2004 May 15; 55(3):759-63. . View in PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 250 A resolution. Proteins. 2004 May 15; 55(3):768-71. . View in PubMed

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 177-A resolution. Proteins. 2004 May 01; 55(2):474-8. . View in PubMed

Automated sample mounting and alignment system for biological crystallography at a synchrotron source Structure. 2004 Apr; 12(4):537-45. . View in PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 175 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. . View in PubMed

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 17 A resolution. Proteins. 2004 Mar 01; 54(4):801-5. . View in PubMed

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 25 A resolution. Proteins. 2004 Mar 01; 54(4):810-3. . View in PubMed

Biopterin responsive phenylalanine hydroxylase deficiency Genet Med. 2004 Jan-Feb; 6(1):27-32. . View in PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 20 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. . View in PubMed

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 13 A resolution. Proteins. 2004 Jan 01; 54(1):174-7. . View in PubMed

A fully integrated protein crystallization platform for small-molecule drug discovery J Struct Biol. 2003 Apr; 142(1):207-17. . View in PubMed

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 15 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. . View in PubMed

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 225 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. . View in PubMed