Kasper S. Wang

Kasper S. Wang

Professor of Surgery (Clinical Scholar);Associate Chief for the Division of Pediatrics Surgery at CHLA
CHL MailStop72 Off Campus Los Angeles

Prominin-1-expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury Physiol Rep. 2020 07; 8(14):e14508. . View in PubMed

Optimizing Resources in Children's Surgical Care: An Update on the American College of Surgeons' Verification Program Pediatrics. 2020 05; 145(5). . View in PubMed

Neurodevelopmental Outcomes in Preschool and School Aged Children With Biliary Atresia and Their Native Liver J Pediatr Gastroenterol Nutr. 2020 01; 70(1):79-86. . View in PubMed

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome Hepatology. 2019 09; 70(3):899-910. . View in PubMed

Prominin-1 Promotes Biliary Fibrosis Associated With Biliary Atresia Hepatology. 2019 06; 69(6):2586-2597. . View in PubMed

Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized TrialJ Pediatr. 2018 11; 202:179-185. e4. . View in PubMed

Liquid chromatography-mass spectroscopy in the diagnosis of biliary atresia in children with hyperbilirubinemia J Surg Res. 2018 08; 228:228-237. . View in PubMed

Newborn screening for biliary atresia in the United States Pediatr Surg Int. 2017 Dec; 33(12):1315-1318. . View in PubMed

Notch signaling promotes ductular reactions in biliary atresia J Surg Res. 2017 07; 215:250-256. . View in PubMed

Hepatic Prominin-1 expression is associated with biliary fibrosis Surgery. 2017 05; 161(5):1266-1272. . View in PubMed

Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis Hepatology. 2017 05; 65(5):1645-1654. . View in PubMed

Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells Stem Cells Transl Med. 2017 01; 6(1):238-248. . View in PubMed

Toll-like receptor 3 mediates PROMININ-1 expressing cell expansion in biliary atresia via Transforming Growth Factor-Beta J Pediatr Surg. 2016 Jun; 51(6):917-22. . View in PubMed

Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers J Hepatol. 2016 May; 64(5):1137-1146. . View in PubMed

Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary AtresiaJ Pediatr. 2016 Mar; 170:211-7. e1-2. . View in PubMed

Newborn Screening for Biliary Atresia Pediatrics. 2015 Dec; 136(6):e1663-9. . View in PubMed

Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille SyndromeJ Pediatr. 2015 Aug; 167(2):390-6. e3. . View in PubMed

Recent advances in the pathogenesis and management of biliary atresia Curr Opin Pediatr. 2015 Jun; 27(3):389-94. . View in PubMed

Expansion of prominin-1-expressing cells in association with fibrosis of biliary atresia Hepatology. 2014 Sep; 60(3):941-53. . View in PubMed

Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury Hepatology. 2014 Jul; 60(1):311-22. . View in PubMed

Hypothermia and neonatal encephalopathy Pediatrics. 2014 Jun; 133(6):1146-50. . View in PubMed

Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial JAMA. 2014 May 07; 311(17):1750-9. . View in PubMed

Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent ß-catenin activation J Hepatol. 2014 May; 60(5):1002-9. . View in PubMed

Immersion in water during labor and delivery Pediatrics. 2014 Apr; 133(4):758-61. . View in PubMed

Persistent hyperbilirubinemia in a newborn J Pediatr Health Care. 2014 Mar-Apr; 28(2):172-6. . View in PubMed

Use of inhaled nitric oxide in preterm infants Pediatrics. 2014 Jan; 133(1):164-70. . View in PubMed

Surfactant replacement therapy for preterm and term neonates with respiratory distress Pediatrics. 2014 Jan; 133(1):156-63. . View in PubMed

Respiratory support in preterm infants at birth Pediatrics. 2014 Jan; 133(1):171-4. . View in PubMed

Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study Hepatology. 2013 Nov; 58(5):1724-31. . View in PubMed

Percutaneous liver biopsy: pathologic diagnosis and complications in children J Pediatr Gastroenterol Nutr. 2013 Nov; 57(5):644-8. . View in PubMed

Health related quality of life in patients with biliary atresia surviving with their native liverJ Pediatr. 2013 Oct; 163(4):1052-7. e2. . View in PubMed

Laparoscopic versus open treatment of congenital duodenal obstruction: multicenter short-term outcomes analysis J Laparoendosc Adv Surg Tech A. 2013 Oct; 23(10):876-80. . View in PubMed

Prenatal substance abuse: short- and long-term effects on the exposed fetus Pediatrics. 2013 Mar; 131(3):e1009-24. . View in PubMed

Guidance on management of asymptomatic neonates born to women with active genital herpes lesions Pediatrics. 2013 Feb; 131(2):383-6. . View in PubMed

Congenital heart disease and heterotaxy: upper gastrointestinal fluoroscopy can be misleading and surgery in an asymptomatic patient is not beneficial J Pediatr Surg. 2013 Jan; 48(1):164-9. . View in PubMed

Laparoscopic common bile duct exploration in children is associated with decreased cost and length of stay: results of a two-center analysis J Pediatr Surg. 2013 Jan; 48(1):215-20. . View in PubMed

Assessment and management of inguinal hernia in infants Pediatrics. 2012 Oct; 130(4):768-73. . View in PubMed

The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin Stem Cells. 2012 Sep; 30(9):1999-2009. . View in PubMed

Levels of neonatal care Pediatrics. 2012 Sep; 130(3):587-97. . View in PubMed

Management of neonates with suspected or proven early-onset bacterial sepsis Pediatrics. 2012 May; 129(5):1006-15. . View in PubMed

Neonatal drug withdrawal Pediatrics. 2012 Feb; 129(2):e540-60. . View in PubMed

Fibroblast growth factor receptor-mediated activation of AKT-ß-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells PLoS One. 2012; 7(11):e50401. . View in PubMed

The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival Ann Surg. 2011 Oct; 254(4):577-85. . View in PubMed

Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation Pediatrics. 2011 Oct; 128(4):e1046-52. . View in PubMed

Policy statement—Recommendations for the prevention of perinatal group B streptococcal (GBS) disease Pediatrics. 2011 Sep; 128(3):611-6. . View in PubMed

Postnatal glucose homeostasis in late-preterm and term infants Pediatrics. 2011 Mar; 127(3):575-9. . View in PubMed

ß-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis J Surg Res. 2010 Dec; 164(2):276-85. . View in PubMed

Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2 Gastroenterology. 2010 Dec; 139(6):2170-82. . View in PubMed

Policy statement--postnatal corticosteroids to prevent or treat bronchopulmonary dysplasia Pediatrics. 2010 Oct; 126(4):800-8. . View in PubMed

Inversion herniotomy: a laparoscopic technique for female inguinal hernia repair J Laparoendosc Adv Surg Tech A. 2010 Jun; 20(5):481-4. . View in PubMed

Subcutaneous fixation of gastrostomy tube is superior to temporary fixation J Laparoendosc Adv Surg Tech A. 2010 Mar; 20(2):207-9. . View in PubMed

Wnt5a knock-out mouse as a new model of anorectal malformation J Surg Res. 2009 Oct; 156(2):278-82. . View in PubMed

Advanced practice in neonatal nursing Pediatrics. 2009 Jun; 123(6):1606-7. . View in PubMed

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation Dev Dyn. 2009 Feb; 238(2):294-301. . View in PubMed

Abdominal involvement in pediatric heart and lung transplant recipients with posttransplant lymphoproliferative disease increases the risk of mortality J Pediatr Surg. 2008 Dec; 43(12):2174-7. . View in PubMed

Preservation of extracorporeal tissue in closing gastroschisis augments intestinal length J Pediatr Surg. 2008 Dec; 43(12):2213-5. . View in PubMed

Contemporary management of lipoblastoma J Pediatr Surg. 2008 Jul; 43(7):1295-300. . View in PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development Dev Biol. 2006 Nov 15; 299(2):373-85. . View in PubMed

Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung Dev Biol. 2006 May 01; 293(1):77-89. . View in PubMed

Molecular mechanisms of early lung specification and branching morphogenesis Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. . View in PubMed

Left-sided gastroschisis associated with situs inversus J Pediatr Surg. 2004 Dec; 39(12):1883-4. . View in PubMed

Omphalocele, colonic atresia, and Hirschsprung's disease: an unusual cluster of malformations in a single patient Pediatr Surg Int. 2001 Mar; 17(2-3):218-20. . View in PubMed

Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. . View in PubMed

Gastric acid secretion in aquaporin-4 knockout mice Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. . View in PubMed

Colon water transport in transgenic mice lacking aquaporin-4 water channels Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. . View in PubMed

Revenge of the conjoined twin: a giant presacral recurrence in a patient born with an attached, well-differentiated teratoma Surgery. 1999 11; 126(5):980-3. . View in PubMed

Papillary cystic neoplasm of the pancreas: a report of three pediatric cases and literature review J Pediatr Surg. 1998 Jun; 33(6):842-5. . View in PubMed

Posttranscriptional regulation of connexin 32 expression in liver during acute inflammation J Cell Physiol. 1996 Feb; 166(2):461-7. . View in PubMed

Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation Shock. 1995 Mar; 3(3):204-9. . View in PubMed

Dr. Wang's academic interest focuses on biliary atresia. Biliary atresia is a disease of infants where the bile ducts are damaged due to unclear causes. As a consequence of the damage, bile is unable to flow from the liver and progressive liver damage occurs. Biliary atresia is the most common indication for pediatric liver transplantation. Dr. Wang is the Principal Investigator for an NIH funded U01 grant for CHLA focusing on biliary atresia and other liver diseases of infants and children. The grant enables CHLA to participate in the Childhood Liver Disease Research and Education Network (ChiLDREN) which is a consortium of 15 of the top children's hospitals in the U.S. and Canada joined to studies rare but lethal pediatric liver diseases. To date, nearly 1500 patients with biliary atresia have been enrolled in number studies and clinical trials through ChiLDREN. Currently enrollment in a prospective randomized double blinded placebo controlled study on the efficacy of corticosteroids in the treatment of patients with biliary atresia after Kasai portoenterostomy is closed. Unblinding of data will occur in 2013 to be followed by publication of observations. In addition to involvement in ChiLDREN, Dr. Wang heads a research program focusing on the molecular events involved in biliary atresia. His research lab focuses on the signaling pathways regulating liver stem/progenitor cells during liver organogenesis and a variety of liver damage such as that incurred by biliary atresia.
Powered by SC CTSI

Affiliated Faculty at UPC