Leonardo Morsut

Morsut Lab Website

• Programming Juxtacrine-Based Synthetic Signaling Networks in a Cellular Potts Framework Methods Mol Biol. 2024; 2760:283-307. . View in PubMed
• Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs bioRxiv. 2023 May 20. . View in PubMed
• The living interface between synthetic biology and biomaterial design Nat Mater. 2022 04; 21(4):390-397. . View in PubMed
• The evolution of synthetic receptor systems Nat Chem Biol. 2022 03; 18(3):244-255. . View in PubMed
• Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion ACS Synth Biol. 2022 04 15; 11(4):1417-1439. . View in PubMed
• The sound of silence: Transgene silencing in mammalian cell engineering Cell Syst. 2022 12 21; 13(12):950-973. . View in PubMed
• Novel synthetic biology approaches for developmental systems Stem Cell Reports. 2021 05 11; 16(5):1051-1064. . View in PubMed
• How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future? Cell Syst. 2020 12 16; 11(6):550-554.. View in PubMed
• Synthetic development: building mammalian multicellular structures with artificial genetic programs Curr Opin Biotechnol. 2019 10; 59:130-140. . View in PubMed
• Guiding human development in a dish Nat Methods. 2019 07; 16(7):585-586. . View in PubMed
• Tissue Patterning: The Winner Takes It All, the Losers Standing Small Curr Biol. 2019 05 06; 29(9):R334-R337. . View in PubMed
• Simple Rules Determine Distinct Patterns of Branching Morphogenesis Cell Syst. 2019 09 25; 9(3):221-227. . View in PubMed
• Programming self-organizing multicellular structures with synthetic cell-cell signaling Science. 2018 07 13; 361(6398):156-162. . View in PubMed
• Engineering multicellular systems: using synthetic biology to control tissue self-organization Curr Opin Biomed Eng. 2017 Dec; 4:163-173. . View in PubMed
• Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch ReceptorsCell. 2016 Oct 06; 167(2):419-432. e16. . View in PubMed
• Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors Cell. 2016 Feb 11; 164(4):780-91. . View in PubMed
• Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits Cell. 2016 Feb 11; 164(4):770-9. . View in PubMed
• CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes Cell. 2013 Jul 18; 154(2):442-51. . View in PubMed
• USP15 is a deubiquitylating enzyme for receptor-activated SMADs Nat Cell Biol. 2011 Sep 25; 13(11):1368-75. . View in PubMed
• Role of YAP/TAZ in mechanotransduction Nature. 2011 Jun 08; 474(7350):179-83. . View in PubMed
• Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo Development. 2010 Aug 01; 137(15):2571-8. . View in PubMed
• FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Cell. 2009 Jan 09; 136(1):123-35. . View in PubMed
• MicroRNA control of Nodal signalling Nature. 2007 Sep 13; 449(7159):183-8. . View in PubMed
• Microvascular patterns in human medullary tegmentum at the level of the area postrema J Anat. 2005 Apr; 206(4):405-10. . View in PubMed

• McMahon, Andrew
• Chuong, Cheng-Ming
• Chai, Yang
• Crump, Gage