The overall goal of my lab is to elucidate the factors that establish and maintain the "histone code" and how their concerted functions regulate essential chromatin-dependent events including transcription, DNA replication and DNA repair. This is accomplished using a combination of conventional biochemical approaches and state-of-the-art technologies. Our long term goal is to translate these fundamental biological insights into novel epigenetic therapies for the treatment of human diseases.
Ring around the genes Nat Cell Biol. 2007 Dec; 9(12):1343-4. . View in PubMed