Peter Stephen Conti

Peter Stephen Conti

Professor of Radiology;Director, Molecular Imaging Center;PET Imaging Center Director
CSC 103 Health Sciences Campus Los Angeles

Associations between vascular function and tau PET are associated with global cognition and amyloid J Neurosci. 2020 Oct 12. . View in PubMed

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline Nature. 2020 05; 581(7806):71-76. . View in PubMed

A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema Sci Rep. 2019 12 04; 9(1):18264. . View in PubMed

Developing Effective Alzheimer's Disease Therapies: Clinical Experience and Future Directions J Alzheimers Dis. 2019; 71(3):715-732. . View in PubMed

64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging Nanoscale. 2018 Mar 29; 10(13):6113-6124. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

Effect of Androgen on Normal Biodistribution of [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice Anticancer Res. 2017 02; 37(2):475-479. . View in PubMed

A Nanoscale Tool for Photoacoustic-Based Measurements of Clotting Time and Therapeutic Drug Monitoring of Heparin . 2016 Oct 12; 16(10):6265-6271. . View in PubMed

A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice Int J Cancer. 2016 Feb 15; 138(4):1013-23. . View in PubMed

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan Cell Metab. 2015 Jul 07; 22(1):86-99. . View in PubMed

Improved metabolic stability for 18F PET probes rapidly constructed via tetrazine trans-cyclooctene ligation Bioconjug Chem. 2015 Mar 18; 26(3):435-42. . View in PubMed

Development of PET probes for cancer imaging Curr Top Med Chem. 2015; 15(8):795-819. . View in PubMed

Design, synthesis, and validation of Axl-targeted monoclonal antibody probe for microPET imaging in human lung cancer xenograft Mol Pharm. 2014 Nov 03; 11(11):3974-9. . View in PubMed

Characterization and evaluation of (64)Cu-labeled A20FMDV2 conjugates for imaging the integrin avß 6 Mol Imaging Biol. 2014 Aug; 16(4):567-77. . View in PubMed

Axl-targeted cancer imaging with humanized antibody h173 Mol Imaging Biol. 2014 Aug; 16(4):511-8. . View in PubMed

Efficient synthesis of fluorescent-PET probes based on [¹8F]BODIPY dye Chem Commun (Camb). 2014 Jul 14; 50(55):7371-3. . View in PubMed

Facile Preparation of a Thiol-Reactive (18)F-Labeling Agent and Synthesis of (18)F-DEG-VS-NT for PET Imaging of a Neurotensin Receptor-Positive Tumor J Nucl Med. 2014 Jul; 55(7):1178-84. . View in PubMed

Development of multi-functional chelators based on sarcophagine cages Molecules. 2014 Apr 03; 19(4):4246-55. . View in PubMed

A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody ACS Nano. 2014 Mar 25; 8(3):2064-76. . View in PubMed

Evaluation of ¹8F-labeled BODIPY dye as potential PET agents for myocardial perfusion imaging Nucl Med Biol. 2014 Jan; 41(1):120-6. . View in PubMed

Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET J Nucl Med. 2014 Jan; 55(1):23-9. . View in PubMed

(64)Cu labeled sarcophagine exendin-4 for microPET imaging of glucagon like peptide-1 receptor expression Theranostics. 2014; 4(8):770-7. . View in PubMed

EphB4-targeted imaging with antibody h131, h131-F(ab')2 and h131-Fab Mol Pharm. 2013 Dec 02; 10(12):4527-33. . View in PubMed

Cytoreductive chemotherapy improves the biodistribution of antibodies directed against tumor necrosis in murine solid tumor models . 2013 Dec; 12(12):2827-36. . View in PubMed

Baseline 18F-FDG PET/CT parameters as imaging biomarkers of overall survival in castrate-resistant metastatic prostate cancer J Nucl Med. 2013 Aug; 54(8):1195-201. . View in PubMed

Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs Biomaterials. 2013 Apr; 34(12):3098-109. . View in PubMed

Efficient 18F labeling of cysteine-containing peptides and proteins using tetrazine-trans-cyclooctene ligation Mol Imaging. 2013 Mar-Apr; 12(2):121-8. . View in PubMed

Development and evaluation of 18F-TTCO-Cys40-Exendin-4: a PET probe for imaging transplanted islets J Nucl Med. 2013 Feb; 54(2):244-51. . View in PubMed

"Kit like" (18)F labeling method for synthesis of RGD peptide-based PET probes Am J Nucl Med Mol Imaging. 2013; 3(1):97-101. . View in PubMed

Efficient construction of PET/fluorescence probe based on sarcophagine cage: an opportunity to integrate diagnosis with treatment Mol Imaging Biol. 2012 Dec; 14(6):718-24. . View in PubMed

[18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations Mol Imaging. 2012 Sep-Oct; 11(5):426-32. . View in PubMed

A Cy55-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice. Amino Acids. 2012 Apr; 42(4):1329-37. . View in PubMed

A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors Mol Biol Cell. 2012 Feb; 23(4):602-13. . View in PubMed

Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature Mol Imaging Biol. 2012 Feb; 14(1):96-105. . View in PubMed

Fasting enhances the response of glioma to chemo- and radiotherapy PLoS One. 2012; 7(9):e44603. . View in PubMed

Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for 64Cu radiopharmaceuticals Chemistry. 2011 Sep 05; 17(37):10222-5. . View in PubMed

Design, synthesis and validation of integrin a2ß1-targeted probe for microPET imaging of prostate cancer Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1313-22. . View in PubMed

18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal metastases Nucl Med Commun. 2011 May; 32(5):343-7. . View in PubMed

Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer Eur J Nucl Med Mol Imaging. 2011 Apr; 38(4):642-50. . View in PubMed

Biological stability evaluation of the a2ß1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide Bioconjug Chem. 2011 Feb 16; 22(2):256-63. . View in PubMed

Automated synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-ß-D-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module Nucl Med Biol. 2011 Feb; 38(2):201-6. . View in PubMed

(64)Cu labeled AmBaSar-RGD2 for micro-PET imaging of integrin avß3 expression Curr Radiopharm. 2011 Jan; 4(1):68-74. . View in PubMed

Improved synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-ß-D-arabinofuranosyluracil ([18F]FMAU) Curr Radiopharm. 2011 Jan; 4(1):24-30. . View in PubMed

Clinical trials network strives for standardization J Nucl Med. 2010 Nov; 51(11):15N. . View in PubMed

Evaluation of copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved microPET imaging of integrin alphavbeta3 expression Bioconjug Chem. 2010 Aug 18; 21(8):1417-24. . View in PubMed

In vivo effect of propranolol dose and timing on cerebral perfusion after traumatic brain injury J Trauma. 2010 Feb; 68(2):353-6. . View in PubMed

An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[66. 6]icosane-1-ylamino)methyl)benzoic acid, for 64Cu radiopharmaceuticals. Nucl Med Biol. 2010 Jan; 37(1):57-65. . View in PubMed

Controlling familywise error rate for matched subspace detection in dynamic FDG PET IEEE Trans Med Imaging. 2009 Oct; 28(10):1623-31. . View in PubMed

Expert opinions on positron emission tomography and computed tomography imaging in lymphoma Oncologist. 2009; 14 Suppl 2:30-40. . View in PubMed

A one-session circumferential reconstruction in thoracic and lumbar spine fractures using a small expandable cage J Neurosurg Sci. 2008 Dec; 52(4):101-6; discussion 106. . View in PubMed

[F-18]-fluorodeoxyglucose PET-CT of the normal prostate gland Ann Nucl Med. 2008 Nov; 22(9):787-93. . View in PubMed

Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine Brain Res. 2008 Oct 09; 1234:32-43. . View in PubMed

Biglycan overexpression on tooth enamel formation in transgenic mice Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53. . View in PubMed

Choline autoradiography of human prostate cancer xenograft: effect of castration Mol Imaging. 2008 May-Jun; 7(3):147-52. . View in PubMed

A new diagnostic approach to better identify antiphospholipid syndrome Int J Immunopathol Pharmacol. 2008 Apr-Jun; 21(2):387-92. . View in PubMed

B-cell non-Hodgkin lymphoma: PET/CT evaluation after 90Y-ibritumomab tiuxetan radioimmunotherapy--initial experience Radiology. 2008 Mar; 246(3):895-902. . View in PubMed

[F-18]-Fluorodeoxyglucose PET and PET-CT in diagnostic imaging evaluation of locally recurrent and metastatic bladder transitional cell carcinoma Int J Clin Oncol. 2008 Feb; 13(1):42-7. . View in PubMed

How do rat cortical cells cultured with aluminum die: necrosis or apoptosis? Int J Immunopathol Pharmacol. 2008 Jan-Mar; 21(1):107-15.. View in PubMed

F-18 FDG PET and PET/CT evaluation of response to chemotherapy in bone and soft tissue sarcomas Clin Nucl Med. 2008 Jan; 33(1):8-13. . View in PubMed

Biodistribution and PET imaging of [(18)F]-fluoroadenosine derivatives Nucl Med Biol. 2007 Apr; 34(3):267-72. . View in PubMed

Detection of occult medullary thyroid cancer recurrence with 2-deoxy-2-[F-18]fluoro-D-glucose-PET and PET/CT Mol Imaging Biol. 2007 Mar-Apr; 9(2):72-7. . View in PubMed

[F-18]fluorodeoxyglucose positron emission tomography and positron emission tomography: computed tomography in recurrent and metastatic cholangiocarcinoma J Comput Assist Tomogr. 2007 Mar-Apr; 31(2):223-8. . View in PubMed

Breast MRI and 18F FDG PET/CT in the management of breast cancer Ann Nucl Med. 2007 Jan; 21(1):33-8. . View in PubMed

Assessment of three year experience of a strategy for patient selection and timing of operation in the management of acute thoracic and lumbar spine fractures: a prospective study Acta Neurochir (Wien). 2006 Nov; 148(11):1181-7; discussion 1187. . View in PubMed

18F-FDG PET and PET/CT for detection of pulmonary metastases from musculoskeletal sarcomas Nucl Med Commun. 2006 Oct; 27(10):795-802. . View in PubMed

2-Deoxy-2-[18F]fluoro-D-glucose-positron emission tomography and positron emission tomography/computed tomography diagnosis of patients with recurrent papillary thyroid cancer Mol Imaging Biol. 2006 Sep-Oct; 8(5):309-14. . View in PubMed

2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography/computed tomography imaging evaluation of esophageal cancer Mol Imaging Biol. 2006 May-Jun; 8(3):193-200. . View in PubMed

Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging Phys Med Biol. 2005 Dec 07; 50(23):5421-41. . View in PubMed

Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the joint working group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance J Nucl Med. 2005 Jul; 46(7):1225-39. . View in PubMed

Concurrent PET/CT with an integrated imaging system: intersociety dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance J Am Coll Radiol. 2005 Jul; 2(7):568-84. . View in PubMed

Glucose metabolism of human prostate cancer mouse xenografts Mol Imaging. 2005 Apr-Jun; 4(2):91-7. . View in PubMed

Direct comparison of radiolabeled probes FMAU, FHBG, and FHPG as PET imaging agents for HSV1-tk expression in a human breast cancer model Mol Imaging. 2004 Apr; 3(2):76-84. . View in PubMed

18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis Nucl Med Biol. 2004 Feb; 31(2):179-89. . View in PubMed

Diagnostic role of [F-18]-FDG positron emission tomography in restaging renal cell carcinoma Clin Nephrol. 2003 Dec; 60(6):395-400. . View in PubMed

FDG PET in suspected recurrent and metastatic prostate cancer Oncol Rep. 2003 Sep-Oct; 10(5):1485-8. . View in PubMed

Evaluation of recurrent gastric malignancy with [F-18]-FDG positron emission tomography Clin Radiol. 2003 Mar; 58(3):215-21. . View in PubMed

Diagnostic utility of FDG PET in multiple myeloma Skeletal Radiol. 2002 Dec; 31(12):690-4. . View in PubMed

Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression J Nucl Med. 2002 Aug; 43(8):1072-83. . View in PubMed

Evaluation of 2'-deoxy-2'-flouro-5-methyl-1-beta-D-arabinofuranosyluracil as a potential gene imaging agent for HSV-tk expression in vivo Mol Imaging. 2002 Apr-Jun; 1(2):74-81. . View in PubMed

Administration guidelines for radioimmunotherapy of non-Hodgkin's lymphoma with (90)Y-labeled anti-CD20 monoclonal antibody J Nucl Med. 2002 Feb; 43(2):267-72. . View in PubMed

Gastric and colonic bypass grafts: FDG positron emission tomographic patterns Clin Nucl Med. 2001 Nov; 26(11):955-6. . View in PubMed

A cost analysis of positron emission tomography AJR Am J Roentgenol. 2001 Jul; 177(1):31-40. . View in PubMed

A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents Bioorg Med Chem Lett. 2000 Dec 18; 10(24):2741-3. . View in PubMed

Blocking catabolism with eniluracil enhances PET studies of 5-[18F]fluorouracil pharmacokinetics J Nucl Med. 2000 Oct; 41(10):1714-24. . View in PubMed

Impact of extremely low frequency electromagnetic fields on CD4 expression in peripheral blood mononuclear cells Mol Cell Biochem. 1999 Nov; 201(1-2):49-55. . View in PubMed

Imaging of locally recurrent and metastatic thyroid cancer with positron emission tomography Thyroid. 1999 Aug; 9(8):797-804. . View in PubMed

Evaluation of 9-[(3-18F-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG) in vitro and in vivo as a probe for PET imaging of gene incorporation and expression in tumors Nucl Med Biol. 1999 May; 26(4):371-6. . View in PubMed

Cerebral vasculopathy in sickle cell anemia: diagnostic contribution of positron emission tomography Blood. 1999 Jan 01; 93(1):71-9. . View in PubMed

Alpha-alkylation of amino acid derivatives: synthesis and chiral resolution of [11C]beta-aminoisobutyric acid Nucl Med Biol. 1997 Nov; 24(8):771-5. . View in PubMed

9-[(3-[18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]-FHPG): a potential imaging agent of viral infection and gene therapy using PET Nucl Med Biol. 1996 Aug; 23(6):787-92. . View in PubMed

High performance liquid chromatography of carbon-11 labeled thymidine and its major catabolites for clinical PET studies Nucl Med Biol. 1994 Nov; 21(8):1045-51. . View in PubMed

Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen Neurosurgery. 1993 Mar; 32(3):485-9; discussion 489-90. . View in PubMed

Effects of vasopressin on blood-brain transfer of methionine in dogs J Neurochem. 1992 Oct; 59(4):1421-9. . View in PubMed

Advances in medical imaging for cancer diagnosis and treatment Cancer. 1991 Feb 15; 67(4 Suppl):1121-8. . View in PubMed

Bowel obstruction caused by gastric balloons AJR Am J Roentgenol. 1988 Aug; 151(2):313-4. . View in PubMed

Altered peripheral amino acid uptake in obstructive jaundice J Surg Res. 1987 Apr; 42(4):383-93. . View in PubMed

Imaging studies of patients with malignant fibrous histiocytoma using C-11-alpha-aminoisobutyric acid (AIB) Clin Nucl Med. 1987 Jan; 12(1):22-6. . View in PubMed

Evaluation of [1-11C]-alpha-aminoisobutyric acid for tumor detection and amino acid transport measurement: spontaneous canine tumor studies Eur J Nucl Med. 1985; 10(1-2):48-55. . View in PubMed

Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice Cancer Res. 1984 Oct; 44(10):4382-5. . View in PubMed

4-[125I] iodophenyltrimethylammonium ion, an iodinated acetylcholinesterase inhibitor with potential as a myocardial imaging agent J Nucl Med. 1980 Sep; 21(9):875-9. . View in PubMed

Dr. Conti is a tenured Professor at the University of Southern California with academic appointments in the Departments of Radiology, Biomedical Engineering, and Pharmaceutical Sciences. He received his undergraduate degree from Johns Hopkins University and medical degree from Cornell University. His Ph.D. in Biophysics was completed at Memorial Sloan-Kettering Cancer Center. He is board certified in Nuclear Medicine (ABNM) and Diagnostic Radiology (ABR). Dr. Conti has been the Director of the USC PET Imaging Science Center since its inception in 1991. His research activities have focused on the development of novel PET and hybrid imaging agents for diagnostic and theranostic applications in cancer and other diseases. Dr. Conti has published over 300 peer-reviewed papers in the field of molecular imaging. He is the 2016 recipient of the Paul C Aebersold Award from the Society of Nuclear Medicine and Molecular Imaging for his achievements in the basic science of nuclear medicine, and was the 2018 Peter Valk Award recipient for his pioneering work in clinical Positron Emission Tomography. In 2019 he received a Lifetime Achievement Award from the American College of Nuclear Medicine and in January of 2020, the President’s Award for his service to the College. In June 2020, Dr. Conti received the Benedict Cassen Prize from the Education and Research Foundation for his pioneering work in the development of novel radiopharmaceuticals and clinical PET applications for cancer imaging, and his volunteerism and service to the molecular imaging community. The Prize honors the memory of Benedict Cassen, the inventor of the rectilinear radioisotope scanner—the first instrument capable of making an image of radiotracer distribution in body organs of living patients, and was seminal to the development of clinical nuclear medicine.
Powered by SC CTSI

Affiliated Faculty at UPC