Andre J Ouellette, PhD
Andre J Ouellette, PhD
Professor of Pathology
NRT 7505 Health Sciences Campus Los Angeles

Correction for Cobo et al, "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". Infect Immun. 2018 10; 86(10). . View in PubMed

Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency Infect Immun. 2018 07; 86(7). . View in PubMed

Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. . View in PubMed

A novel role for lipid droplets in the organismal antibacterial response Elife. 2012 Nov 13; 1:e00003. . View in PubMed

ImmunologyHD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. . View in PubMed

Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins Biochemistry. 2011 Dec 06; 50(48):10508-19. . View in PubMed

Paneth cell a-defensins in enteric innate immunity Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. . View in PubMed

Paneth cells and innate mucosal immunity Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. . View in PubMed

Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue Biochemistry. 2008 Nov 25; 47(47):12626-34. . View in PubMed

Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers J Pept Sci. 2008 Apr; 14(4):503-9. . View in PubMed

Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. . View in PubMed

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion J Immunol. 2007 Jul 15; 179(2):1245-53. . View in PubMed

The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood Vet Immunol Immunopathol. 2007 Apr 15; 116(3-4):182-9. . View in PubMed

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity J Biol Chem. 2006 Sep 29; 281(39):28932-42. . View in PubMed

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4 J Biol Chem. 2006 Sep 22; 281(38):28068-78. . View in PubMed

Paneth cell alpha-defensin synthesis and function Curr Top Microbiol Immunol. 2006; 306:1-25. . View in PubMed

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. . View in PubMed

Mammalian defensins in the antimicrobial immune response Nat Immunol. 2005 Jun; 6(6):551-7. . View in PubMed

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides Mol Microbiol. 2005 May; 56(3):789-99. . View in PubMed

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria Infect Immun. 2005 Apr; 73(4):2312-20. . View in PubMed

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin Biochemistry. 2004 Dec 21; 43(50):15759-66. . View in PubMed

Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities J Virol. 2004 Nov; 78(21):11622-31. . View in PubMed

Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4 J Biol Chem. 2004 Oct 15; 279(42):44188-96. . View in PubMed

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. . View in PubMed

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response J Biol Chem. 2004 May 07; 279(19):19902-7. . View in PubMed

Defensin-mediated innate immunity in the small intestine Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. . View in PubMed

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions J Biol Chem. 2004 Mar 19; 279(12):11976-83. . View in PubMed

Paneth cell alpha-defensins from rhesus macaque small intestine Infect Immun. 2004 Mar; 72(3):1470-8. . View in PubMed

Quantitative interactions between cryptdin-4 amino terminal variants and membranes Peptides. 2003 Nov; 24(11):1795-805. . View in PubMed

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranesProsegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. . View in PubMed

Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7 J Biol Chem. 2003 Mar 07; 278(10):7910-9. . View in PubMed

Activation of Paneth cell alpha-defensins in mouse small intestine J Biol Chem. 2002 Feb 15; 277(7):5219-28. . View in PubMed

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel J Biol Chem. 2002 Feb 01; 277(5):3793-800. . View in PubMed

Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of Tspiralis-infected mice. Clin Exp Immunol. 2001 Oct; 126(1):117-25. . View in PubMed

Paneth cell defensins and innate immunity of the small bowel Inflamm Bowel Dis. 2001 Feb; 7(1):43-50. . View in PubMed

Characterization of luminal paneth cell alpha-defensins in mouse small intestineAttenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73. . View in PubMed

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria Nat Immunol. 2000 Aug; 1(2):113-8. . View in PubMed

Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin Infect Immun. 1999 Dec; 67(12):6643-51. . View in PubMed

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Science. 1999 Oct 15; 286(5439):498-502. . View in PubMed

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense Science. 1999 Oct 01; 286(5437):113-7. . View in PubMed

IVPaneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol. 1999 08; 277(2):G257-61. . View in PubMed

Peptide mediators of innate immunity in the small intestine J Med Microbiol. 1998 Nov; 47(11):941-2. . View in PubMed

Paneth cells and innate immunity in the crypt microenvironment Gastroenterology. 1997 Nov; 113(5):1779-84. . View in PubMed

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3 Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9. . View in PubMed

Cryptdin gene expression in developing mouse small intestine Am J Physiol. 1997 Jan; 272(1 Pt 1):G197-206. . View in PubMed

Paneth cell defensins: endogenous peptide components of intestinal host defense FASEB J. 1996 Sep; 10(11):1280-9. . View in PubMed

Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine Am J Physiol. 1996 Jul; 271(1 Pt 1):G68-74. . View in PubMed

Rat neutrophil defensinsPrecursor structures and expression during neutrophilic myelopoiesis. J Immunol. 1995 Nov 01; 155(9):4476-84. . View in PubMed

Defensins in granules of phagocytic and non-phagocytic cells Trends Cell Biol. 1995 Mar; 5(3):114-9. . View in PubMed

A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells Genomics. 1994 Nov 01; 24(1):99-109. . View in PubMed

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms Infect Immun. 1994 Nov; 62(11):5040-7. . View in PubMed

Paneth cell differentiation in the developing intestine of normal and transgenic mice Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10335-9. . View in PubMed

A novel gene family coding for cationic, cysteine-rich peptidesRegulation in mouse small intestine and cells of myeloid origin. J Biol Chem. 1994 Jul 15; 269(28):18702. . View in PubMed

Structure and diversity of the murine cryptdin gene family Genomics. 1994 Feb; 19(3):448-53. . View in PubMed

In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis Exp Cell Res. 1993 Oct; 208(2):344-9. . View in PubMed

Ontogeny of Ia messenger RNA in the mouse small intestinal epithelium is modulated by age of weaning and diet Gastroenterology. 1993 Oct; 105(4):974-80. . View in PubMed

Differential regulation of B7 mRNA in enterocytes and lymphoid cells Immunology. 1993 Jul; 79(3):434-8. . View in PubMed

Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury Mol Cell Biol. 1993 Mar; 13(3):1933-42. . View in PubMed

Ontogeny of class II MHC mRNA in the mouse small intestinal epithelium Mol Immunol. 1992 Oct; 29(10):1257-63. . View in PubMed

The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus Genomics. 1992 Oct; 14(2):363-8. . View in PubMed

Enteric defensins: antibiotic peptide components of intestinal host defense J Cell Biol. 1992 Aug; 118(4):929-36. . View in PubMed

Purification and primary structure of murine cryptdin-1, a Paneth cell defensin FEBS Lett. 1992 Jun 15; 304(2-3):146-8. . View in PubMed

Class II antigen-associated invariant chain mRNA in mouse small intestine Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1642-8. . View in PubMed

A novel mouse gene family coding for cationic, cysteine-rich peptidesRegulation in small intestine and cells of myeloid origin. J Biol Chem. 1990 Jun 15; 265(17):9831-7. . View in PubMed

Localization of the cryptdin locus on mouse chromosome 8 Genomics. 1989 Aug; 5(2):233-9. . View in PubMed

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium J Cell Biol. 1989 May; 108(5):1687-95. . View in PubMed

Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine Gastroenterology. 1988 Jan; 94(1):114-21. . View in PubMed

Association of poly(adenylate)-deficient messenger ribonucleic acid with membranes in mouse kidney Biochemistry. 1981 Jun 09; 20(12):3561-7. . View in PubMed

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