Laurie D. De Leve, MD, PhD

Dr. DeLeve’s clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.

• USC: Mellon Mentoring Award for Faculty Mentoring Faculty, 2015
• Western Society for Clinical Investigation: Outstanding Investigator Award, 2008
• Alpha Omega Alpha: Teaching Award, 2005

• Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition Hepatology. 2020 11; 72(5):1771-1785. . View in PubMed
• Sinusoids as Drivers of Liver Development: More Than Simple Chemistry Hepatology. 2019 08; 70(2):737-739. . View in PubMed
• Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program Clin Trials. 2019 06; 16(3):253-262. . View in PubMed
• Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat Hepatology. 2019 03; 69(3):1259-1272. . View in PubMed
• Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin) Hepatology. 2019 02; 69(2):831-844. . View in PubMed
• Liver-Selective MMP-9 Inhibition in the Rat Eliminates Ischemia-Reperfusion Injury and Accelerates Liver Regeneration Hepatology. 2019 01; 69(1):314-328. . View in PubMed
• Liver Sinusoidal Endothelial Cell: An Update Semin Liver Dis. 2017 11; 37(4):377-387. . View in PubMed
• VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration Am J Physiol Gastrointest Liver Physiol. 2016 05 01; 310(9):G739-46. . View in PubMed
• Liver sinusoidal endothelial cells in hepatic fibrosis Hepatology. 2015 May; 61(5):1740-6. . View in PubMed
• An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles J Control Release. 2014 Oct 10; 191:15-23. . View in PubMed
• Liver sinusoidal endothelial cells and liver regeneration J Clin Invest. 2013 May; 123(5):1861-6. . View in PubMed
• Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice Int J Hematol. 2013 Apr; 97(4):456-64. . View in PubMed
• Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cellsGastroenterology. 2012 Dec; 143(6):1555-1563. e2. . View in PubMed
• Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in ratsGastroenterology. 2012 Apr; 142(4):918-927. e6. . View in PubMed
• Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats J Clin Invest. 2012 Apr; 122(4):1567-73. . View in PubMed
• 15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed
• The effects of old age on hepatic stellate cells Curr Gerontol Geriatr Res. 2011; 2011:439835. . View in PubMed
• Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. . View in PubMed
• Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations J Struct Biol. 2010 Sep; 171(3):382-8. . View in PubMed
• Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury Gastroenterology. 2009 Aug; 137(2):704-12. . View in PubMed
• Vascular disorders of the liver Hepatology. 2009 May; 49(5):1729-64. . View in PubMed
• Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis Am J Pathol. 2008 Oct; 173(4):993-1001. . View in PubMed
• Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence Hepatology. 2008 Sep; 48(3):920-30. . View in PubMed
• Sinusoidal obstruction syndrome Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. . View in PubMed
• Hepatic microvasculature in liver injury Semin Liver Dis. 2007 Nov; 27(4):390-400. . View in PubMed
• Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. . View in PubMed
• Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen J Hepatol. 2005 Mar; 42(3):371-7. . View in PubMed
• Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. . View in PubMed
• Screening in liver disease: report of an AASLD clinical workshop Hepatology. 2004 May; 39(5):1204-12. . View in PubMed
• Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome Hepatology. 2003 Oct; 38(4):900-8. . View in PubMed
• Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition Gastroenterology. 2003 Sep; 125(3):882-90. . View in PubMed
• Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. . View in PubMed
• Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation Mayo Clin Proc. 2003 May; 78(5):589-98. . View in PubMed
• Vascular liver diseases Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. . View in PubMed
• Hepatic circulatory diseases associated with chronic myeloid disorders Clin Liver Dis. 2002 Nov; 6(4):909-31. . View in PubMed
• Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease) Semin Liver Dis. 2002 Feb; 22(1):27-42. . View in PubMed
• Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes Pharmacology. 2000 Apr; 60(3):143-54. . View in PubMed
• Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat Hepatology. 2000 Feb; 31(2):428-34. . View in PubMed
• Characterization of a reproducible rat model of hepatic veno-occlusive disease Hepatology. 1999 Jun; 29(6):1779-91. . View in PubMed
• Glutathione defense in non-parenchymal cells Semin Liver Dis. 1998; 18(4):403-13. . View in PubMed
• Sinusoidal endothelial cells as a target for acetaminophen toxicityDirect action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. . View in PubMed
• Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethane-induced genotoxicity in human fibroblasts Mutat Res. 1997 Mar 17; 389(2-3):291-7. . View in PubMed
• Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts Mutat Res. 1996 Nov 04; 371(1-2):105-8. . View in PubMed
• Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation Hepatology. 1996 Oct; 24(4):830-7. . View in PubMed
• Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease Hepatology. 1996 Mar; 23(3):589-99. . View in PubMed
• Mechanisms of drug-induced liver disease Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. . View in PubMed
• Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A J Pharmacol Exp Ther. 1995 Apr; 273(1):545-53. . View in PubMed
• Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense J Pharmacol Exp Ther. 1994 Mar; 268(3):1261-70. . View in PubMed
• Glutathione metabolism and its role in hepatotoxicity Pharmacol Ther. 1991 Dec; 52(3):287-305. . View in PubMed
• Importance and regulation of hepatic glutathione Semin Liver Dis. 1990 Nov; 10(4):251-66. . View in PubMed
• Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity Clin Pharmacol Ther. 1989 Sep; 46(3):279-90. . View in PubMed
• Plasma concentration-response relationships of two formulations of propranolol J Clin Pharmacol. 1985 Apr; 25(3):182-6. . View in PubMed
• Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man Clin Pharmacol Ther. 1984 Apr; 35(4):461-6. . View in PubMed
• Nonselective beta-receptor stimulation and blockade and left ventricular function Clin Pharmacol Ther. 1983 Nov; 34(5):570-5. . View in PubMed

• Kaplowitz, Neil
• Tsukamoto, Hidekazu