Faculty

Aaron Nagiel

Aaron Nagiel

Assistant Professor of Ophthalmology
Pediatrics
4640 West Sunset Blvd Off Campus Los Angeles

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Research to Prevent Blindness: RPB Career Development Award, 2021-2023

Donald E. and Delia B. Baxter Foundation: Baxter Foundation Fellowship, 2019-2020

: Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship, 2016-2019

: Ronald G. Michels Fellowship Foundation Award, 2016-2017

Michels Fellowship Foundation: Ronald G. Michels Fellowship, 2016-2017

Jules Stein Eye Institute: Excellence in Research Award, 2016

: Heed Ophthalmic Foundation Fellowship, 2015-2016

Jules Stein Eye Institute: Pepose-Saltzman Young Investigator ARVO Award, 2014-2015

Jules Stein Eye Institute: Excellence in Research Award, 2014

: Heed Foundation Residents Retreat Participant, 2014

: ARVO National Eye Institute Travel Grant, 2014

Jules Stein Eye Institute: Robert E. Christensen Research Award, 2013

The Rockefeller University: Sumi Koide Travel Fellowship, 2010

: Finalist, Paul and Daisy Soros Fellowship for New Americans, 2006

: John Harvard Scholarship, 2001-2003

Harvard University: Detur Prize, 2001

Subretinal deposits in young patients treated with voretigene neparvovec-rzyl for RPE65-mediated retinal dystrophy Br J Ophthalmol. 2022 Jul 14. . View in PubMed

VITREOUS HEMORRHAGE IN TYPE 3 GAUCHER DISEASE: AN ANGIOGRAPHIC AND PATHOLOGIC ANALYSIS Retin Cases Brief Rep. 2022 Jul 01; 16(4):414-418. . View in PubMed

Neovascularization of the optic disc and peripheral retinal ischemia in a child with a novel variant in ALMS1 (Alström syndrome) Am J Ophthalmol Case Rep. 2022 Jun; 26:101506. . View in PubMed

Variability in Plus Disease Diagnosis using Single and Serial Images Ophthalmol Retina. 2022 May 31. . View in PubMed

Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis Ophthalmol Retina. 2022 01; 6(1):58-64. . View in PubMed

Inherited Retinal Disease Panels-Caveat Emptor-Truly Know Your Inherited Retinal Disease Panel Retina. 2022 01 01; 42(1):1-3. . View in PubMed

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2206113119. . View in PubMed

Endoscopic vitreoretinal surgery: Review of current applications and future trends Surv Ophthalmol. 2021 Mar-Apr; 66(2):198-212. . View in PubMed

Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome J Mol Med (Berl). 2021 11; 99(11):1623-1638. . View in PubMed

Traumatic Retinal Detachment in Patients with Self-Injurious Behavior: An International Multicenter Study Ophthalmol Retina. 2021 08; 5(8):805-814. . View in PubMed

Characterization and staging of outer plexiform layer development in human retina and retinal organoids Development. 2021 12 01; 148(23). . View in PubMed

Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome Invest Ophthalmol Vis Sci. 2021 06 01; 62(7):27. . View in PubMed

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues Nat Commun. 2021 05 25; 12(1):3100. . View in PubMed

Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes Sci Rep. 2021 03 02; 11(1):4966. . View in PubMed

VISUAL AND ANATOMIC OUTCOMES OF PEDIATRIC ENDOSCOPIC VITRECTOMY IN 326 CASES Retina. 2020 Nov; 40(11):2083-2090. . View in PubMed

Diagnostic and Therapeutic Challenges Retina. 2020 Aug; 40(8):1641-1643. . View in PubMed

Focal Scleral Nodule: A New Name for Solitary Idiopathic Choroiditis and Unifocal Helioid Choroiditis Ophthalmology. 2020 11; 127(11):1567-1577. . View in PubMed

Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity Ophthalmol Retina. 2020 06; 4(6):602-612. . View in PubMed

Precision Therapy for Inherited Retinal Disease: At the Forefront of Genomic Medicine Clin Lab Med. 2020 06; 40(2):189-204. . View in PubMed

Surgical Techniques for the Subretinal Delivery of Pediatric Gene Therapy Ophthalmol Retina. 2020 06; 4(6):644-645. . View in PubMed

Voretigene neparvovec-rzyl for treatment of RPE65-mediated inherited retinal diseases: a model for ocular gene therapy development Expert Opin Biol Ther. 2020 06; 20(6):565-578. . View in PubMed

Retinal stem cell transplantation: Balancing safety and potential Prog Retin Eye Res. 2020 03; 75:100779. . View in PubMed

Ocular Trauma From Toy Guns With Foam Projectiles in 4 Children Clin Pediatr (Phila). 2020 01; 59(1):92-94. . View in PubMed

Bilateral retinal detachment after chimeric antigen receptor T-cell therapy Blood Adv. 2020 05 26; 4(10):2158-2162. . View in PubMed

Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy Invest Ophthalmol Vis Sci. 2020 11 02; 61(13):2. . View in PubMed

Correspondence Retina. 2019 01; 39(1):e4. . View in PubMed

Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy JAMA Ophthalmol. 2019 12 01; 137(12):1381-1388. . View in PubMed

Endoscopy for Pediatric Retinal Disease Asia Pac J Ophthalmol (Phila). 2018 May-Jun; 7(3):200-207. . View in PubMed

Gene therapy for RPE65-mediated retinal dystrophies Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. . View in PubMed

EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY Retina. 2018 Apr; 38(4):748-754. . View in PubMed

PERIPAPILLARY PACHYCHOROID SYNDROME Retina. 2018 09; 38(9):1652-1667. . View in PubMed

Practice Patterns of Endophthalmitis Treatment: An International Survey of Retina Specialists Ophthalmol Retina. 2018 09; 2(9):979-980. . View in PubMed

SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S87-S91. . View in PubMed

VITRECTOMY-ASSISTED BIOPSY FOR MOLECULAR PROGNOSTICATION OF CHOROIDAL MELANOMA 2 MM OR LESS IN THICKNESS WITH A 27-GAUGE CUTTER Retina. 2017 Jul; 37(7):1377-1382. . View in PubMed

Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction Am J Ophthalmol. 2017 Feb; 174:85-94. . View in PubMed

THE SPECTRUM OF AMALRIC TRIANGULAR CHOROIDAL INFARCTION Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. . View in PubMed

PARANEOPLASTIC VITELLIFORM MACULOPATHY IN THE SETTING OF CHOROIDAL MELANOMA: EVOLUTION OVER ONE YEAR Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. . View in PubMed

ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends Retina. 2016 Apr; 36(4):660-78. . View in PubMed

Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. . View in PubMed

Isolated Zygomycetes Endophthalmitis: A Case Report Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. . View in PubMed

A Promising Future for Optical Coherence Tomography Angiography JAMA Ophthalmol. 2015 Jun; 133(6):629-30. . View in PubMed

Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography Retina. 2015 Apr; 35(4):638-47. . View in PubMed

RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT Retin Cases Brief Rep. 2015; 9(4):269-72. . View in PubMed

Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomographyAm J Ophthalmol. 2013 Nov; 156(5):981-988. e2. . View in PubMed

Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery Arch Ophthalmol. 2012 Dec; 130(12):1605-8. . View in PubMed

Retinopathy of prematurity residency trainingOphthalmology. 2012 Dec; 119(12):2644-5. e1-2. . View in PubMed

Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. . View in PubMed

The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. . View in PubMed

Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish J Neurosci. 2008 Aug 20; 28(34):8442-53. . View in PubMed

Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells J Biol Chem. 2004 Sep 24; 279(39):40659-69. . View in PubMed

The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

Visit our lab website: nagiellab.org
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Affiliated Faculty at UPC