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Gutian Xiao

Professor of Molecular Microbiology and Immunology

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Email Gutian.Xiao@med.usc.edu
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Publications

  • Critical and distinct roles of cell type-specific NF-? B2 in lung cancer. JCI Insight. 2024 Feb 22; 9(4).. View in PubMed
  • Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2 bioRxiv. 2024 Jan 09. . View in PubMed
  • Alveolar Macrophages Inherently Express Programmed Death-1 Ligand 1 for Optimal Protective Immunity and Tolerance J Immunol. 2021 07 01; 207(1):110-114. . View in PubMed
  • Methods Mol Biol. 2021; 2366:213-241. . View in PubMed
  • PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis JCI Insight. 2021 03 08; 6(5). . View in PubMed
  • Dual but not single PD-1 or TIM-3 blockade enhances oncolytic virotherapy in refractory lung cancer J Immunother Cancer. 2020 05; 8(1). . View in PubMed
  • Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance Nat Commun. 2019 11 22; 10(1):5324. . View in PubMed
  • Oncoimmunology. 2018; 7(6):e1435250. . View in PubMed
  • Murine Bronchoalveolar Lavage Bio Protoc. 2017 May 20; 7(10). . View in PubMed
  • Isolation of Murine Alveolar Type II Epithelial Cells Bio Protoc. 2017 May 20; 7(10). . View in PubMed
  • Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation Cancer Immunol Res. 2017 03; 5(3):257-268. . View in PubMed
  • Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer Cancer Res. 2015 Aug 15; 75(16):3209-15. . View in PubMed
  • Differential roles of STAT3 in the initiation and growth of lung cancer Oncogene. 2015 Jul; 34(29):3804-3814. . View in PubMed
  • Systematic detection of noncanonical NF-? B activation. Methods Mol Biol. 2015; 1280:121-54.. View in PubMed
  • NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? Retrovirology. 2012 Sep 25; 9:78.. View in PubMed
  • PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease Cell Biosci. 2012 Jun 25; 2(1):23. . View in PubMed
  • Human T-cell lymphotropic virus: a model of NF-? B-associated tumorigenesis. Viruses. 2011 Jun; 3(6):714-49.. View in PubMed
  • Blood. 2011 Feb 03; 117(5):1652-61. . View in PubMed
  • Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer J Biol Chem. 2010 Apr 16; 285(16):11786-92. . View in PubMed
  • DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target Cancer Res. 2010 Mar 01; 70(5):1766-72. . View in PubMed
  • Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax Neoplasia. 2009 Oct; 11(10):1036-41. . View in PubMed
  • PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation Blood. 2009 Apr 30; 113(18):4370-80. . View in PubMed
  • SUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processing EMBO Rep. 2008 Sep; 9(9):885-90. . View in PubMed
  • Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions Autophagy. 2007 Nov-Dec; 3(6):600-3. . View in PubMed
  • Autophagy and NF-kappaB: fight for fate Cytokine Growth Factor Rev. 2007 Jun-Aug; 18(3-4):233-43. . View in PubMed
  • Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation Cell Res. 2007 Jun; 17(6):520-30. . View in PubMed
  • Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5324-9. . View in PubMed
  • Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK) Cell Res. 2006 Nov; 16(11):895-901. . View in PubMed
  • Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease Cytokine Growth Factor Rev. 2006 Aug; 17(4):281-93. . View in PubMed
  • Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100 J Biol Chem. 2005 Dec 09; 280(49):40578-82. . View in PubMed
  • Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100 J Biol Chem. 2005 Mar 18; 280(11):9765-8. . View in PubMed
  • Regulation of NF-kappa B2 p100 processing by its cis-acting domain J Biol Chem. 2005 Jan 07; 280(1):18-27. . View in PubMed
  • Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms J Biol Chem. 2004 Oct 22; 279(43):44563-72. . View in PubMed
  • Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation J Biol Chem. 2004 Jul 16; 279(29):30099-105. . View in PubMed

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