Faculty

Hidekazu Tsukamoto

Hidekazu Tsukamoto

Professor of Pathology
Pathology
MMR 1333 San Pablo St Health Sciences Campus Los Angeles

Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation Birth Defects Res. 2022 02; 114(3-4):105-115. . View in PubMed

Cell-to-Cell Communications in Alcohol-Associated Liver Disease Front Physiol. 2022; 13:831004. . View in PubMed

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles Hepatol Commun. 2020 Apr; 4(4):606-626. . View in PubMed

Stearoyl-CoA desaturase and tumorigenesis Chem Biol Interact. 2020 Jan 25; 316:108917. . View in PubMed

The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC) Clin Mol Hepatol. 2020 10; 26(4):584-585. . View in PubMed

Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1ß and IL-17 upregulation in alcoholic hepatitis mice J Mol Med (Berl). 2020 07; 98(7):1021-1034. . View in PubMed

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease J Hepatol. 2020 05; 72(5):946-959. . View in PubMed

Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. . View in PubMed

Fate and functional roles of Prominin 1+ cells in liver injury and cancer Sci Rep. 2020 11 10; 10(1):19412. . View in PubMed

Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice JCI Insight. 2020 02 13; 5(3). . View in PubMed

Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis J Clin Invest. 2020 04 01; 130(4):2129-2145. . View in PubMed

Cell Death and Liver Disease Gut Liver. 2020 01 15; 14(1):20-29. . View in PubMed

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs Nat Commun. 2020 06 17; 11(1):3084. . View in PubMed

Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276. . View in PubMed

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science J Gastroenterol. 2019 Mar; 54(3):218-225. . View in PubMed

Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol. 2019 06; 77:11-18. . View in PubMed

Inflammatory pathways in alcoholic steatohepatitis J Hepatol. 2019 02; 70(2):249-259. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients Hepatology. 2018 05; 67(5):1737-1753. . View in PubMed

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 04; 14:164-177. . View in PubMed

Publisher Correction: Alcoholic liver disease Nat Rev Dis Primers. 2018 08 28; 4(1):18. . View in PubMed

Alcoholic liver disease Nat Rev Dis Primers. 2018 08 16; 4(1):16. . View in PubMed

Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases Am J Pathol. 2017 Apr; 187(4):781-797. . View in PubMed

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6 Gastroenterology. 2017 05; 152(6):1477-1491. . View in PubMed

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood Hepatology. 2017 02; 65(2):475-490. . View in PubMed

Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability Hepatology. 2017 02; 65(2):678-693. . View in PubMed

The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury J Biol Chem. 2017 07 07; 292(27):11336-11347. . View in PubMed

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1 PLoS One. 2017; 12(8):e0181052. . View in PubMed

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Mol Ther. 2017 01 04; 25(1):218-231. . View in PubMed

Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the 'D-shuttle' project J Radiol Prot. 2016 Mar; 36(1):49-66. . View in PubMed

The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. . View in PubMed

TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome J Clin Invest. 2016 Feb; 126(2):527-42. . View in PubMed

Uncovering the liver's role in immunity through RNA co-expression networks Mamm Genome. 2016 10; 27(9-10):469-84. . View in PubMed

Alcoholic hepatitis: Translational approaches to develop targeted therapies Hepatology. 2016 10; 64(4):1343-55. . View in PubMed

Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-? 1. Cancer Gene Ther. 2016 08; 23(8):266-77.. View in PubMed

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9.. View in PubMed

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese J Lipid Res. 2016 06; 57(6):1017-28. . View in PubMed

PLoS One. 2016; 11(5):e0156111. . View in PubMed

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models Front Physiol. 2016; 7:498. . View in PubMed

A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution Front Physiol. 2016; 7:579. . View in PubMed

Notch signaling and M1 macrophage activation in obesity-alcohol synergism Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. . View in PubMed

ALPD 2015, Preface Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. . View in PubMed

Morphogen-related therapeutic targets for liver fibrosis Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. . View in PubMed

Notch, metabolism and macrophages Oncotarget. 2015 Aug 21; 6(24):19942-3. . View in PubMed

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice J Neuroimmunol. 2015 Aug 15; 285:169-79. . View in PubMed

Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Pancreas. 2015 Aug; 44(6):882-7. . View in PubMed

Metabolic reprogramming and cell fate regulation in alcoholic liver disease Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. . View in PubMed

Reply: To PMID 25132354 Hepatology. 2015 Jul; 62(1):324. . View in PubMed

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation J Clin Invest. 2015 Apr; 125(4):1579-90. . View in PubMed

Low intracellular iron increases the stability of matriptase-2 J Biol Chem. 2015 Feb 13; 290(7):4432-46. . View in PubMed

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells J Hepatol. 2015 Feb; 62(2):388-97. . View in PubMed

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis Adv Exp Med Biol. 2015; 815:131-44. . View in PubMed

Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in miceGastroenterology. 2015 Jan; 148(1):203-214. e16. . View in PubMed

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice Hepatology. 2015 Jan; 61(1):129-40. . View in PubMed

New Approaches for Studying Alcoholic Liver Disease Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. . View in PubMed

Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity Hepatol Int. 2014 Jul; 8(3):330-8. . View in PubMed

Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. . View in PubMed

Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells J Gastroenterol. 2014 May; 49(5):890-9. . View in PubMed

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells Hepatology. 2014 Mar; 59(3):1118-29. . View in PubMed

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice Hepatology. 2013 Jul; 58(1):108-19. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed

Kenji Fujiwara, MD, PhD Gastroenterology. 2013 Apr; 144(4):661-3. . View in PubMed

Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process Oral Dis. 2013 Mar; 19(2):144-50. . View in PubMed

Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway PLoS One. 2013; 8(4):e60534. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Epigenetic regulation of miR-34a expression in alcoholic liver injury Am J Pathol. 2012 Sep; 181(3):804-17. . View in PubMed

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation Hepatology. 2012 Sep; 56(3):1129-39. . View in PubMed

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. . View in PubMed

Hepatology. 2012 Apr; 55(4):1271-81. . View in PubMed

Mouse intragastric infusion (iG) model Nat Protoc. 2012 Mar 29; 7(4):771-81. . View in PubMed

Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration J Biol Chem. 2012 Mar 23; 287(13):10355-10367. . View in PubMed

Morphogens and hepatic stellate cell fate regulation in chronic liver disease J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

StellaTUM: current consensus and discussion on pancreatic stellate cell research Gut. 2012 Feb; 61(2):172-8. . View in PubMed

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed

Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK J Hepatol. 2011 Sep; 55(3):673-682. . View in PubMed

Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. . View in PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed

Epigenetic cell fate regulation of hepatic stellate cells Hepatol Res. 2011 Jul; 41(7):675-82. . View in PubMed

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease Gastroenterology. 2011 Mar; 140(3):1052-62. . View in PubMed

Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver Hepatology. 2011 Mar; 53(3):983-95. . View in PubMed

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein Blood. 2011 Feb 03; 117(5):1687-99. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology. 2011 Jan; 53(1):96-105. . View in PubMed

The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells J Biol Chem. 2010 Oct 01; 285(40):30463-71. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. . View in PubMed

Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 2010 Mar; 51(3):932-41. . View in PubMed

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology. 2010 Mar; 51(3):986-95. . View in PubMed

TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I J Hepatol. 2010 Mar; 52(3):407-16. . View in PubMed

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosisGastroenterology. 2010 Feb; 138(2):705-14714. e1-4. . View in PubMed

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed

Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol. 2009 Oct 15; 183(8):5232-43. . View in PubMed

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression J Biol Chem. 2009 Aug 21; 284(34):22580-9. . View in PubMed

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model Hepatology. 2009 Aug; 50(2):462-71. . View in PubMed

"Second hit" models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed

Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1Gastroenterology. 2009 May; 136(5):1783-95. e10. . View in PubMed

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression Cell Metab. 2009 Mar; 9(3):217-27. . View in PubMed

Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas. 2009 Mar; 38(2):e47-52. . View in PubMed

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development Hepatology. 2009 Mar; 49(3):998-1011. . View in PubMed

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. . View in PubMed

C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene Oncogene. 2008 Dec 04; 27(53):6749-60. . View in PubMed

Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. . View in PubMed

Expression of carboxylesterase and lipase genes in rat liver cell-types Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. . View in PubMed

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. . View in PubMed

Fat paradox of steatohepatitis J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. . View in PubMed

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. . View in PubMed

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. . View in PubMed

Intragastric ethanol infusion model in rodents Methods Mol Biol. 2008; 447:33-48. . View in PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed

Conceptual importance of identifying alcoholic liver disease as a lifestyle disease J Gastroenterol. 2007 Aug; 42(8):603-9. . View in PubMed

A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem. 2007 Apr 27; 282(17):12928-39. . View in PubMed

Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages J Biol Chem. 2007 Feb 23; 282(8):5582-8. . View in PubMed

Epigenetic mechanism of stellate cell trans-differentiation J Hepatol. 2007 Feb; 46(2):352-3. . View in PubMed

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. . View in PubMed

Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. . View in PubMed

A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease Ann Rheum Dis. 2006 Apr; 65(4):508-14. . View in PubMed

Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells J Biol Chem. 2005 Dec 09; 280(49):40650-9. . View in PubMed

Fat paradox in liver disease Keio J Med. 2005 Dec; 54(4):190-2. . View in PubMed

Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. . View in PubMed

Steatohepatitis induced by intragastric overfeeding in mice Hepatology. 2005 Oct; 42(4):905-14. . View in PubMed

Hepatoprotective mechanisms of Yan-gan-wan Hepatol Res. 2005 Aug; 32(4):202-12. . View in PubMed

A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease Addict Behav. 2005 Mar; 30(3):465-73. . View in PubMed

Adipogenic transcriptional regulation of hepatic stellate cells J Biol Chem. 2005 Feb 11; 280(6):4959-67. . View in PubMed

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. . View in PubMed

Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption Gastroenterology. 2004 May; 126(5):1387-99. . View in PubMed

Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. . View in PubMed

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells J Biol Chem. 2004 Mar 19; 279(12):11392-401. . View in PubMed

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes Blood. 2004 Feb 15; 103(4):1509-14. . View in PubMed

Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed

PPAR Gamma and Hepatic Stellate Cells Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. . View in PubMed

Signaling role of iron in NF-kappa B activation in hepatic macrophages Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. . View in PubMed

Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. . View in PubMed

Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease Alcohol. 2003 Jun; 30(2):107-13. . View in PubMed

Signaling role of intracellular iron in NF-kappaB activation J Biol Chem. 2003 May 16; 278(20):17646-54. . View in PubMed

Aberrant HS1 molecule in a patient with systemic lupus erythematosus Genes Immun. 2003 Mar; 4(2):122-31. . View in PubMed

Redox regulation of cytokine expression in Kupffer cells Antioxid Redox Signal. 2002 Oct; 4(5):741-8. . View in PubMed

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001 Alcohol. 2002 Oct; 28(2):117-28. . View in PubMed

Iron activates NF-kappaB in Kupffer cells Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. . View in PubMed

Role of abnormal methionine metabolism in alcoholic liver injury Alcohol. 2002 Jul; 27(3):155-62. . View in PubMed

IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. . View in PubMed

Iron regulation of hepatic macrophage TNFalpha expression Free Radic Biol Med. 2002 Feb 15; 32(4):309-13. . View in PubMed

Alcoholic liver disease (ALD): a new domain for prevention efforts Subst Use Misuse. 2002; 37(14):1887-904. . View in PubMed

Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis Arthritis Rheum. 2001 Dec; 44(12):2819-27. . View in PubMed

Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications Prostaglandins Leukot Essent Fatty Acids. 2001 Oct; 65(4):191-6. . View in PubMed

Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E420-9. . View in PubMed

Wnt signaling regulates hemopoiesis through stromal cells J Immunol. 2001 Jul 15; 167(2):765-72. . View in PubMed

Defect of lck in a patient with common variable immunodeficiency Int J Mol Med. 2001 Jun; 7(6):609-14. . View in PubMed

Current concepts in the pathogenesis of alcoholic liver injury FASEB J. 2001 Jun; 15(8):1335-49. . View in PubMed

Alcohol and retinoids Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):207S-217S. . View in PubMed

How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S.. View in PubMed

Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha Toxicol Appl Pharmacol. 2001 Jan 01; 170(1):39-45. . View in PubMed

Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells J Immunol. 2001 Jan 01; 166(1):130-6. . View in PubMed

Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. . View in PubMed

Peroxisome proliferator-activated receptors and hepatic stellate cell activation J Biol Chem. 2000 Nov 17; 275(46):35715-22. . View in PubMed

Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology. 2000 Nov; 32(5):1008-17. . View in PubMed

Cyp2e1 and ALD Hepatology. 2000 Jul; 32(1):154-6. . View in PubMed

Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. . View in PubMed

Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. . View in PubMed

RAR and RXR expression by Kupffer cells Exp Mol Pathol. 2000 Feb; 68(1):13-20. . View in PubMed

Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. . View in PubMed

Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology. 1999 Sep; 117(3):706-16. . View in PubMed

Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat Hepatology. 1999 Jul; 30(1):209-14. . View in PubMed

Cytokine regulation of hepatic stellate cells in liver fibrosis Alcohol Clin Exp Res. 1999 May; 23(5):911-6. . View in PubMed

Relationship between serum levels of anti-low-density lipoprotein-acetaldehyde-adduct antibody and aldehyde dehydrogenase 2 heterozygotes in patients with alcoholic liver injury Alcohol Clin Exp Res. 1999 Apr; 23(4 Suppl):24S-28S. . View in PubMed

Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury Am J Physiol. 1999 12; 277(6):G1240-50. . View in PubMed

Is interleukin-10 antifibrogenic in chronic liver injury? Hepatology. 1998 Dec; 28(6):1707-9.. View in PubMed

Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS J Pharm Sci. 1998 Nov; 87(11):1308-15. . View in PubMed

Molecular mechanism of induced hepatic macrophage cytokine gene expression in experimental alcoholic liver injury Alcohol Clin Exp Res. 1998 Aug; 22(5 Suppl):253S-254S. . View in PubMed

Identification of the 150-kDa surface antigen of Entamoeba histolytica as a galactose- and N-acetyl-D-galactosamine-inhibitable lectin Parasitol Res. 1998 Aug; 84(8):632-9. . View in PubMed

GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):170-7. . View in PubMed

WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes Carcinogenesis. 1998 Jul; 19(7):1217-22. . View in PubMed

Polymorphism in the Ialpha1 germ-line transcript regulatory region and IgA productivity in patients with IgA nephropathy J Immunol. 1998 May 15; 160(10):4936-42. . View in PubMed

The carboxyl-terminal region of protein C is essential for its secretion Blood. 1998 May 15; 91(10):3784-91. . View in PubMed

Molecular mechanisms of type II factor XIII deficiency: novel Gly562-Arg mutation and C-terminal truncation of the A subunit cause factor XIII deficiency as characterized in a mammalian expression system Blood. 1998 Apr 15; 91(8):2830-8. . View in PubMed

Results of resection of gastric cancer with distant metastases Hepatogastroenterology. 1998 Mar-Apr; 45(20):592-6. . View in PubMed

Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells J Biol Chem. 1998 Jan 02; 273(1):302-8. . View in PubMed

Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages Am J Physiol. 1997 Jun; 272(6 Pt 1):G1355-64. . View in PubMed

Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression J Neurochem. 1997 Jun; 68(6):2587-92. . View in PubMed

Iron overload in the rat pancreas following portacaval shunting and dietary iron supplementation Exp Mol Pathol. 1997 Apr; 64(2):90-102. . View in PubMed

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis Am J Physiol. 1997 Mar; 272(3 Pt 1):G589-96. . View in PubMed

A new type of major aminopeptidase in bovine brain Biochem Mol Med. 1996 Dec; 59(2):161-8. . View in PubMed

Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA J Neurochem. 1996 Oct; 67(4):1335-43. . View in PubMed

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells Hepatology. 1996 Sep; 24(3):670-6. . View in PubMed

Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA J Immunol. 1996 Jun 15; 156(12):4901-8. . View in PubMed

Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA J Clin Invest. 1996 Jun 15; 97(12):2823-32. . View in PubMed

Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart Free Radic Res. 1996 May; 24(5):361-7. . View in PubMed

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Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report Hepatology. 1990 Sep; 12(3 Pt 1):599-608. . View in PubMed

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Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis Hepatology. 1990 Feb; 11(2):173-82. . View in PubMed

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Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease Exp Mol Pathol. 1989 Oct; 51(2):141-8. . View in PubMed

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Hyperthermia with simultaneous administration of interferon using established human renal carcinoma heterotransplanted in nude mice Br J Urol. 1989 Mar; 63(3):227-32. . View in PubMed

Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis Hepatology. 1989 Feb; 9(2):302-6. . View in PubMed

[Abnormal cholecystokinin-acinar function coupling in atrophied pancreatic acini from rats fed ethanol and a high-fat diet] Arukoru Kenkyuto Yakubutsu Ison. 1988 Dec; 23(4):332-50. . View in PubMed

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Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat Alcohol Clin Exp Res. 1986; 10(6 Suppl):13S-19S. . View in PubMed

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Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet Hepatology. 1985 Mar-Apr; 5(2):224-32. . View in PubMed

Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats Alcohol Clin Exp Res. 1985 Jan-Feb; 9(1):31-7. . View in PubMed

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Hepatic origin of triglycerides in fatty livers produced by the continuous intragastric infusion of an ethanol diet Lipids. 1984 Jun; 19(6):419-22. . View in PubMed

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