Kimberly Gokoffski

Kimberly Gokoffski

Assistant Professor of Clinical Ophthalmology;Associate Director of Research, Institute for Technology and Medical Systems (ITEMS)
HC4 4900 1450 San Pablo Street Health Sciences Campus Los Angeles

North American Neuro-Ophthalmology Society: Thomas Carlow Young Investigator Award, 2017

Department of Ophthalmology, UC Davis: 1st Place Resident Research Presentation, Alumni Day, 2012

UC Irvine: Graduated with Distinction in Research, 2009

UC Irvine: Graduated with Distinction in Community Service, 2009

UC Irvine: Developmental and Systems Biology Training Grant, 2008

Center for Complex Biological Systems: Student Project Grant, 2007

International Conference in Systems Biology: Travel Award, 2006

UC Irvine: Paul H. Silverman Award for Research in Stem Cells, 2005-2007

UC Irvine: School of Biological Sciences Travel Award, 2002

UC Irvine: Alpha Omega Alpha Honors Society Community Service Award, 2001

UC Irvine: Center for Complex Biological Systems Student Project Grant, 2001

NIH: NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship, 2001

UC Irvine: NIH Neurosciences Training Grant, 2001

UC Irvine: MSTP 2nd Place Oral Presentation Award, 2001

University of Kansas: Research Experience for Undergraduates (REU) Fellowship, 2001

University of Pittsburgh: Summer Undergraduate Research Program (SURP) Fellowship, 2001

Re: "Correlation of Automated Computed Tomography Volumetric Analysis Metrics With Motility Disturbances in Thyroid Eye Disease" Ophthalmic Plast Reconstr Surg. 2023 Mar-Apr 01; 39(2):194. . View in PubMed

AxonQuantifier: A semi-automated program for quantifying axonal density from whole-mounted optic nerves J Neurosci Methods. 2023 07 01; 394:109895. . View in PubMed

The Influence of Electrode Properties on Induced Voltage Gradient Along the Rat Optic Nerve IEEE J Electromagn RF Microw Med Biol. 2022 Sep; 6(3):321-330. . View in PubMed

Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis Am J Ophthalmol Case Rep. 2022 Jun; 26:101485. . View in PubMed

Metastatic neuroendocrine tumors mimicking as primary ocular disease Am J Ophthalmol Case Rep. 2022 Jun; 26:101425. . View in PubMed

Electrical devices for visual restoration Surv Ophthalmol. 2022 May-Jun; 67(3):793-800. . View in PubMed

Miller Fisher Syndrome With Acetylcholine Receptor Antibody: A Case Series J Neuroophthalmol. 2022 Feb 25. . View in PubMed

Internuclear Ophthalmoplegia Characterizes Multiple Sclerosis Rather Than Neuromyelitis Optica Spectrum Disease J Neuroophthalmol. 2022 06 01; 42(2):239-245. . View in PubMed

Surgical Outcomes of Transposition Surgery for the Correction of Large-Angle Strabismus J Neuroophthalmol. 2021 Dec 01; 41(4):e806-e814. . View in PubMed

Clinical correlation recommended: accuracy of clinician versus radiologic interpretation of the imaging of orbital lesions Orbit. 2021 Apr; 40(2):133-137. . View in PubMed

Glaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study Am J Ophthalmol. 2021 06; 226:100-107. . View in PubMed

A case of reversible toxic optic neuropathy from tacrolimus (FK506) Am J Ophthalmol Case Rep. 2020 Dec; 20:100932. . View in PubMed

Optic Nerve Regeneration: How Will We Get There? J Neuroophthalmol. 2020 06; 40(2):234-242.. View in PubMed

Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions Curr Opin Neurol. 2020 02; 33(1):93-105. . View in PubMed

Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):90-97. . View in PubMed

Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro Invest Ophthalmol Vis Sci. 2019 08 01; 60(10):3659-3668. . View in PubMed

Ophthalmic Artery Occlusion after Cocaine Use J Emerg Med. 2015 Jul; 49(1):61-2. . View in PubMed

Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate Development. 2011 Oct; 138(19):4131-42. . View in PubMed

Spatial dynamics of multistage cell lineages in tissue stratification Biophys J. 2010 Nov 17; 99(10):3145-54. . View in PubMed

Cell lineages and the logic of proliferative control PLoS Biol. 2009 Jan 20; 7(1):e15. . View in PubMed

Feedback regulation in multistage cell lineages Math Biosci Eng. 2009 Jan; 6(1):59-82. . View in PubMed

My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.

The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.
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