Faculty

Pat R. Levitt

Pat R. Levitt

Professor of Pediatrics;W.M. Keck Chair in Neurogenetics;Chief Scientific Officer, Vice President, and Director of The Saban Research Institute;Director of the Program in Developmental Neurogenetics at The Saban Research Institute
Pediatrics
4640 West Sunset Blvd Off Campus Los Angeles

Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences Environ Health Perspect. 2022 01; 130(1):17008. . View in PubMed

Disrupted Timing of MET Signaling Derails the Developmental Maturation of Cortical Circuits and Leads to Altered Behavior in Mice Cereb Cortex. 2022 04 05; 32(8):1769-1786. . View in PubMed

Translating the Biology of Adversity and Resilience Into New Measures for Pediatric Practice Pediatrics. 2022 06 01; 149(6). . View in PubMed

Neurologic complications of Down syndrome: a systematic review J Neurol. 2021 Dec; 268(12):4495-4509. . View in PubMed

Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling J Pineal Res. 2021 Mar; 70(2):e12705. . View in PubMed

Time-delimited signaling of MET receptor tyrosine kinase regulates cortical circuit development and critical period plasticity Mol Psychiatry. 2021 08; 26(8):3723-3736. . View in PubMed

Leveraging the Biology of Adversity and Resilience to Transform Pediatric Practice Pediatrics. 2021 02; 147(2). . View in PubMed

Genes, Environments, and Time: The Biology of Adversity and Resilience Pediatrics. 2021 02; 147(2). . View in PubMed

MET Receptor Tyrosine Kinase Regulates Lifespan Ultrasonic Vocalization and Vagal Motor Neuron Development Front Neurosci. 2021; 15:768577. . View in PubMed

Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone J Neurosci. 2021 04 14; 41(15):3301-3306. . View in PubMed

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults Neurobiol Stress. 2020 Nov; 13:100251. . View in PubMed

An exploratory study of predictors of cognition in two low-income samples of infants across the first year of life PLoS One. 2020; 15(9):e0238507. . View in PubMed

Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems Sci Rep. 2020 09 22; 10(1):15437. . View in PubMed

Transcriptome data of temporal and cingulate cortex in the Rett syndrome brain Sci Data. 2020 06 19; 7(1):192. . View in PubMed

Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors Autism Res. 2019 05; 12(5):700-714. . View in PubMed

Precision in the development of neocortical architecture: From progenitors to cortical networks Prog Neurobiol. 2019 04; 175:77-95. . View in PubMed

FOXP2 exhibits projection neuron class specific expression, but is not required for multiple aspects of cortical histogenesis Elife. 2019 05 17; 8. . View in PubMed

Association of Perceived Maternal Stress During the Perinatal Period With Electroencephalography Patterns in 2-Month-Old Infants JAMA Pediatr. 2019 06 01; 173(6):561-570. . View in PubMed

Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase Cereb Cortex. 2019 01 01; 29(1):189-201. . View in PubMed

Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice Neurobiol Stress. 2018 Feb; 8:10-20. . View in PubMed

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits Genes Brain Behav. 2018 06; 17(5):e12431. . View in PubMed

Analysis of shared heritability in common disorders of the brain Science. 2018 06 22; 360(6395). . View in PubMed

Integrative functional genomic analysis of human brain development and neuropsychiatric risks Science. 2018 12 14; 362(6420). . View in PubMed

Distinct projection targets define subpopulations of mouse brainstem vagal neurons that express the autism-associated MET receptor tyrosine kinase J Comp Neurol. 2017 Dec 15; 525(18):3787-3808. . View in PubMed

Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2017 Jun; 13(6):e1006831. . View in PubMed

Beyond Hat in Hand: Science Advocacy Is Foundational for Policy Decisions Neuron. 2017 May 17; 94(4):708-712. . View in PubMed

MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic VocalizationsNeuron. 2017 May 03; 94(3):465-485. e5. . View in PubMed

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder J Autism Dev Disord. 2017 06; 47(6):1673-1681. . View in PubMed

Social Origins of Developmental Risk for Mental and Physical Illness J Neurosci. 2017 11 08; 37(45):10783-10791. . View in PubMed

The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism Biol Psychiatry. 2017 03 01; 81(5):424-433. . View in PubMed

Specific Connectivity and Unique Molecular Identity of MET Receptor Tyrosine Kinase Expressing Serotonergic Neurons in the Caudal Dorsal Raphe Nuclei ACS Chem Neurosci. 2017 05 17; 8(5):1053-1064. . View in PubMed

Hepatocyte Growth Factor Modulates MET Receptor Tyrosine Kinase and ß-Catenin Functional Interactions to Enhance Synapse Formation eNeuro. 2016 Jul-Aug; 3(4). . View in PubMed

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder J Autism Dev Disord. 2016 Mar; 46(3):1124-30. . View in PubMed

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine Neuropsychopharmacology. 2016 Mar; 41(4):949-59. . View in PubMed

Brief Report: Recruitment and Retention of Minority Children for Autism Research J Autism Dev Disord. 2016 Feb; 46(2):698-703. . View in PubMed

Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2016 11; 12(11):e1006425. . View in PubMed

Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis Dev Neurobiol. 2016 10; 76(10):1160-81. . View in PubMed

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse Placenta. 2016 06; 42:74-83. . View in PubMed

EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development J Comp Neurol. 2016 07 01; 524(10):2080-92. . View in PubMed

Early-Life Stress Paradigm Transiently Alters Maternal Behavior, Dam-Pup Interactions, and Offspring Vocalizations in Mice Front Behav Neurosci. 2016; 10:142. . View in PubMed

Receptor Tyrosine Kinase MET Interactome and Neurodevelopmental Disorder Partners at the Developing Synapse Biol Psychiatry. 2016 12 15; 80(12):933-942. . View in PubMed

Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing J Neurosci. 2016 08 03; 36(31):8200-9. . View in PubMed

The Genetic Intersection of Neurodevelopmental Disorders and Shared Medical Comorbidities - Relations that Translate from Bench to Bedside Front Psychiatry. 2016; 7:142. . View in PubMed

Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning J Neurosci. 2016 06 08; 36(23):6258-68. . View in PubMed

Patterns of Risk for Multiple Co-Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum Disorder Autism Res. 2015 Dec; 8(6):771-81. . View in PubMed

Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice Physiol Behav. 2015 Nov 01; 151:469-77. . View in PubMed

Positive regulation of neocortical synapse formation by the Plexin-D1 receptor Brain Res. 2015 Aug 07; 1616:157-165. . View in PubMed

Neurodevelopment and the origins of brain disorders Neuropsychopharmacology. 2015 Jan; 40(1):1-3. . View in PubMed

Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior J Neurodev Disord. 2015; 7:35. . View in PubMed

Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters Front Synaptic Neurosci. 2015; 7:20. . View in PubMed

MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus J Neurosci. 2014 Dec 03; 34(49):16166-79. . View in PubMed

The psychologist as an interlocutor in autism spectrum disorder assessment: insights from a study of spontaneous prosody J Speech Lang Hear Res. 2014 Aug; 57(4):1162-77. . View in PubMed

Rigid-compulsive behaviors are associated with mixed bowel symptoms in autism spectrum disorder J Autism Dev Disord. 2014 Jun; 44(6):1425-32. . View in PubMed

Transcriptional landscape of the prenatal human brain Nature. 2014 Apr 10; 508(7495):199-206. . View in PubMed

Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome Transl Psychiatry. 2013 Oct 22; 3:e316. . View in PubMed

Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus J Comp Neurol. 2013 Oct 01; 521(14):3241-59. . View in PubMed

Neurobiology of secure infant attachment and attachment despite adversity: a mouse model Genes Brain Behav. 2013 Oct; 12(7):673-80. . View in PubMed

Comparative DNA methylation among females with neurodevelopmental disorders and seizures identifies TAC1 as a MeCP2 target gene J Neurodev Disord. 2013 Jun 11; 5(1):15. . View in PubMed

EphA signaling impacts development of topographic connectivity in auditory corticofugal systems Cereb Cortex. 2013 Apr; 23(4):775-85. . View in PubMed

Role of EphA/ephrin--a signaling in the development of topographic maps in mouse corticothalamic projections J Comp Neurol. 2013 Feb 15; 521(3):626-37. . View in PubMed

Vasopressin eliminates the expression of familiar odor bias in neonatal female mice through V1aR Horm Behav. 2013 Feb; 63(2):352-60. . View in PubMed

Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem Dev Neurosci. 2013; 35(1):1-16. . View in PubMed

Enrichment of elevated plasma F2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction PLoS One. 2013; 8(7):e68444. . View in PubMed

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse Front Behav Neurosci. 2013; 7:195. . View in PubMed

Modulation of parvalbumin interneuron number by developmentally transient neocortical vasopressin receptor 1a (V1aR) Neuroscience. 2012 Oct 11; 222:20-8. . View in PubMed

Autism-associated promoter variant in MET impacts functional and structural brain networks Neuron. 2012 Sep 06; 75(5):904-15. . View in PubMed

The SSRI citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of SERT antagonism Neuropsychopharmacology. 2012 Jul; 37(8):1879-84. . View in PubMed

Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors Autism Res. 2012 Apr; 5(2):101-8. . View in PubMed

Single-neuron RNA-Seq: technical feasibility and reproducibility Front Genet. 2012; 3:124. . View in PubMed

Placental source for 5-HT that tunes fetal brain development Neuropsychopharmacology. 2012 Jan; 37(1):299-300. . View in PubMed

Modeling of autism genetic variations in mice: focusing on synaptic and microcircuit dysfunctions Dev Neurosci. 2012; 34(2-3):88-100. . View in PubMed

Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain Neuroscience. 2011 Dec 01; 197:1-7. . View in PubMed

Serotonin and the autisms: a red flag or a red herring? Arch Gen Psychiatry. 2011 Nov; 68(11):1093-4.. View in PubMed

The conundrums of understanding genetic risks for autism spectrum disorders Nat Neurosci. 2011 Oct 30; 14(12):1499-506. . View in PubMed

SnapShot: genetics of autismNeuron. 2011 Oct 20; 72(2):418-8. e1. . View in PubMed

A new synaptic player leading to autism risk: Met receptor tyrosine kinase J Neurodev Disord. 2011 Sep; 3(3):282-92. . View in PubMed

One-month-old human infants learn about the social world while they sleep Dev Sci. 2011 Sep; 14(5):1134-41. . View in PubMed

Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk J Neurosci. 2011 Aug 10; 31(32):11437-42. . View in PubMed

Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET Cereb Cortex. 2011 Jul; 21(7):1613-26. . View in PubMed

Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder J Neurodev Disord. 2011 Jun; 3(2):101-12. . View in PubMed

A transient placental source of serotonin for the fetal forebrain Nature. 2011 Apr 21; 472(7343):347-50. . View in PubMed

Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase J Neurosci. 2011 Apr 13; 31(15):5855-64. . View in PubMed

The autism risk genes MET and PLAUR differentially impact cortical development Autism Res. 2011 Feb; 4(1):68-83. . View in PubMed

Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1) Dev Neurosci. 2011; 33(1):64-74. . View in PubMed

Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET Toxicol Sci. 2010 Dec; 118(2):625-34. . View in PubMed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain Neural Dev. 2010 Dec 01; 5:32. . View in PubMed

Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain J Comp Neurol. 2010 Nov 01; 518(21):4463-78. . View in PubMed

Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression Mol Psychiatry. 2010 Oct; 15(10):987-95. . View in PubMed

The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin Neuron. 2010 Sep 09; 67(5):702-12. . View in PubMed

Neuroscience and the future of early childhood policy: moving from why to what and how Neuron. 2010 Sep 09; 67(5):689-91. . View in PubMed

Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit Biol Psychiatry. 2010 Jul 15; 68(2):197-204. . View in PubMed

Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes Neuroscience. 2010 Jul 14; 168(3):797-810. . View in PubMed

Specificity of prenatal cocaine exposure effects on cortical interneurons is independent from dopamine D1 receptor co-localization J Chem Neuroanat. 2010 Jul; 39(4):228-34. . View in PubMed

RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7999-8004. . View in PubMed

Association of MET with social and communication phenotypes in individuals with autism spectrum disorder Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):438-446. . View in PubMed

Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders Neuron. 2010 Feb 25; 65(4):437-9. . View in PubMed

Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. . View in PubMed

Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling Nature. 2009 Sep 24; 461(7263):524-8. . View in PubMed

Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain J Comp Neurol. 2009 Apr 10; 513(5):511-31. . View in PubMed

Prenatal exposure to drugs: effects on brain development and implications for policy and education Nat Rev Neurosci. 2009 Apr; 10(4):303-12. . View in PubMed

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders J Clin Invest. 2009 Apr; 119(4):747-54. . View in PubMed

Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions Pediatrics. 2009 Mar; 123(3):1018-24. . View in PubMed

The organization of the transcriptional network in specific neuronal classes Mol Syst Biol. 2009; 5:291. . View in PubMed

Adaptive changes in gene expression patterns in the somatosensory cortex after deletion of ephrinA5 Mol Cell Neurosci. 2008 Sep; 39(1):21-31. . View in PubMed

Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder Autism Res. 2008 Jun; 1(3):159-68. . View in PubMed

Future of individualized psychiatric treatment Pharmacogenomics. 2008 May; 9(5):493-5. . View in PubMed

It is time to take a stand for medical research and against terrorism targeting medical scientists Biol Psychiatry. 2008 Apr 15; 63(8):725-7. . View in PubMed

Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments Behav Brain Res. 2008 Apr 09; 188(2):380-90. . View in PubMed

Association of RGS2 and RGS5 variants with schizophrenia symptom severity Schizophr Res. 2008 Apr; 101(1-3):67-75. . View in PubMed

Fetal mechanisms in neurodevelopmental disorders Pediatr Neurol. 2008 Mar; 38(3):163-76. . View in PubMed

Gene x environment effects: stress and memory dysfunctions caused by stress and gonadal factor irregularities during puberty in control and TGF-alpha hypomorphic mice Neuropsychopharmacology. 2008 Feb; 33(3):557-65. . View in PubMed

Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brain Dev Neurosci. 2008; 30(4):262-75. . View in PubMed

Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia Biol Psychiatry. 2008 Jan 01; 63(1):32-41. . View in PubMed

Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia Schizophr Bull. 2008 Jan; 34(1):118-26. . View in PubMed

Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia Biol Psychiatry. 2007 Oct 01; 62(7):711-21. . View in PubMed

Bootstrap classification and point-based feature selection from age-staged mouse cerebellum tissues of matrix assisted laser desorption/ionization mass spectra using a fuzzy rule-building expert system Anal Chim Acta. 2007 Sep 19; 599(2):219-31. . View in PubMed

Disruption of cerebral cortex MET signaling in autism spectrum disorder Ann Neurol. 2007 Sep; 62(3):243-50. . View in PubMed

Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain Cereb Cortex. 2007 Sep; 17(9):2108-22. . View in PubMed

Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalon Neuroscience. 2007 Aug 24; 148(2):385-99. . View in PubMed

Pharmacokinetic profile of cocaine following intravenous administration in the female rabbit Eur J Pharmacol. 2007 Jun 01; 563(1-3):124-9. . View in PubMed

Serotonin modulates the response of embryonic thalamocortical axons to netrin-1 Nat Neurosci. 2007 May; 10(5):588-97. . View in PubMed

DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia Genes Brain Behav. 2007 Apr; 6(3):229-39. . View in PubMed

Waved-1 mutant mice are hypersensitive to the locomotor actions of cocaine Synapse. 2007 Apr; 61(4):259-62. . View in PubMed

Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation J Neurosci. 2007 Mar 21; 27(12):3295-304. . View in PubMed

Autism spectrum disorders: developmental disconnection syndromes Curr Opin Neurobiol. 2007 Feb; 17(1):103-11. . View in PubMed

Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution J Neurosci. 2007 Jan 03; 27(1):152-7. . View in PubMed

A genetic variant that disrupts MET transcription is associated with autism Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16834-9. . View in PubMed

Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during developmentII. Subcortical regions. Neuroscience. 2006 Nov 03; 142(4):1163-81. . View in PubMed

Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during developmentI. Cerebral cortex. Neuroscience. 2006 Nov 03; 142(4):1145-61. . View in PubMed

Polymorphic GGC repeat differentially regulates human reelin gene expression levels J Neural Transm (Vienna). 2006 Oct; 113(10):1373-82. . View in PubMed

Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4) Biol Psychiatry. 2006 Sep 15; 60(6):534-7. . View in PubMed

Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development Neuroscience. 2006 Aug 25; 141(2):781-794. . View in PubMed

Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts Eur J Neurosci. 2006 Aug; 24(3):806-18. . View in PubMed

Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry. 2006 Jul 15; 60(2):163-76. . View in PubMed

Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples Biol Psychiatry. 2006 Jul 15; 60(2):152-62. . View in PubMed

Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro Brain Res. 2006 Jun 20; 1095(1):17-25. . View in PubMed

RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion Nat Neurosci. 2006 Jun; 9(6):832-42. . View in PubMed

DNA self-polymers as microarray probes improve assay sensitivity J Neurosci Methods. 2006 Mar 15; 151(2):216-23. . View in PubMed

Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism Neuron. 2005 Nov 23; 48(4):563-75. . View in PubMed

Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain Brain Res Mol Brain Res. 2005 Oct 31; 140(1-2):1-9. . View in PubMed

Prenatal cocaine exposure specifically alters spontaneous alternation behavior Behav Brain Res. 2005 Oct 14; 164(1):107-16. . View in PubMed

Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats J Neurosci. 2005 Oct 05; 25(40):9102-11. . View in PubMed

Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouse J Comp Neurol. 2005 Sep 05; 489(4):449-66. . View in PubMed

Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: A methodological study in postnatal and adult mouse J Neurosci Res. 2005 Sep 01; 81(5):613-21. . View in PubMed

Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice J Comp Neurol. 2005 Jul 04; 487(3):270-82. . View in PubMed

Developmental neurobiology and clinical disorders: lost in translation? Neuron. 2005 May 05; 46(3):407-12.. View in PubMed

Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia Neuropsychopharmacology. 2005 May; 30(5):974-83. . View in PubMed

Postpubertal sex differentiation of forebrain structures and functions depend on transforming growth factor-alpha J Neurosci. 2005 Apr 13; 25(15):3870-80. . View in PubMed

Applications of gene targeting technology to mental retardation and developmental disability research Ment Retard Dev Disabil Res Rev. 2005; 11(4):295-302. . View in PubMed

Disruption of interneuron development Epilepsia. 2005; 46 Suppl 7:22-8. . View in PubMed

Sex differences in expression of transforming growth factor-alpha and epidermal growth factor receptor mRNA in Waved-1 and C57Bl6 mice Neuroscience. 2005; 134(3):877-87. . View in PubMed

Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia Biol Psychiatry. 2004 Dec 15; 56(12):943-50. . View in PubMed

Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders Trends Neurosci. 2004 Jul; 27(7):400-6. . View in PubMed

Autism as a disorder of neural information processing: directions for research and targets for therapy Mol Psychiatry. 2004 Jul; 9(7):646-63. . View in PubMed

Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene Genomics. 2004 May; 83(5):790-801. . View in PubMed

Multiple roles of ephrins during the formation of thalamocortical projections: maps and more J Neurobiol. 2004 Apr; 59(1):82-94. . View in PubMed

Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development Curr Opin Pharmacol. 2004 Feb; 4(1):65-71. . View in PubMed

NeuroscienceSealing cortical cell fate. Science. 2004 Jan 02; 303(5654):48-9. . View in PubMed

Autism and 15q11-q13 disorders: behavioral, genetic, and pathophysiological issues Ment Retard Dev Disabil Res Rev. 2004; 10(4):284-91. . View in PubMed

DNA microarray analysis of postmortem brain tissue Int Rev Neurobiol. 2004; 60:153-81. . View in PubMed

Regionally restricted expression of the transcription factor c-myc intron 1 binding protein during brain development J Comp Neurol. 2003 Dec 22; 467(4):581-92. . View in PubMed

Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth Mol Cell Neurosci. 2003 Nov; 24(3):725-40. . View in PubMed

Structural and functional maturation of the developing primate brain J Pediatr. 2003 Oct; 143(4 Suppl):S35-45. . View in PubMed

Differential regulation of thalamic and cortical axonal growth by hepatocyte growth factor/scatter factor Dev Neurosci. 2003 Mar-Aug; 25(2-4):197-206. . View in PubMed

Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction J Neurosci. 2003 Jan 15; 23(2):622-31. . View in PubMed

Repeated iv. cocaine exposure produces long-lasting behavioral sensitization in pregnant adults, but behavioral tolerance in their offspring. Neuroscience. 2003; 122(3):579-83. . View in PubMed

Miswiring of limbic thalamocortical projections in the absence of ephrin-A5 J Neurosci. 2002 Nov 01; 22(21):9352-7. . View in PubMed

Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders Neurochem Res. 2002 Oct; 27(10):1049-63. . View in PubMed

Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP J Neurobiol. 2002 Jun 05; 51(3):190-204. . View in PubMed

Association and linkage analyses of RGS4 polymorphisms in schizophrenia Hum Mol Genet. 2002 Jun 01; 11(12):1373-80. . View in PubMed

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J Neurosci. 2002 Apr 01; 22(7):2718-29. . View in PubMed

Schizophrenia as a disorder of neurodevelopment Annu Rev Neurosci. 2002; 25:409-32. . View in PubMed

Regional differences in neurotrophin availability regulate selective expression of VGF in the developing limbic cortex J Neurosci. 2001 Dec 01; 21(23):9315-24. . View in PubMed

The human genome: gene expression profiling and schizophrenia Am J Psychiatry. 2001 Sep; 158(9):1384. . View in PubMed

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse Trends Neurosci. 2001 Aug; 24(8):479-86. . View in PubMed

Prenatal cocaine exposure as a risk factor for later developmental outcomes JAMA. 2001 Jul 04; 286(1):45; author reply 46-7. . View in PubMed

Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex Cereb Cortex. 2001 May; 11(5):430-40. . View in PubMed

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia Mol Psychiatry. 2001 May; 6(3):293-301. . View in PubMed

Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays ScientificWorldJournal. 2001 Apr 04; 1:114-6. . View in PubMed

Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon Neuron. 2001 Apr; 30(1):79-89. . View in PubMed

Novel proteoglycan epitope expressed in functionally discrete patterns in primate cortical and subcortical regions J Comp Neurol. 2001 Feb 12; 430(3):369-88. . View in PubMed

Prenatal cocaine exposure produces consistent developmental alterations in dopamine-rich regions of the cerebral cortex Neuroscience. 2001; 106(1):5-14. . View in PubMed

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex Neuron. 2000 Oct; 28(1):53-67. . View in PubMed

In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons J Neurosci. 2000 Jun 15; 20(12):4606-14. . View in PubMed

Progressive postnatal assembly of limbic-autonomic circuits revealed by central transneuronal transport of pseudorabies virus J Neurosci. 2000 Apr 01; 20(7):2731-41. . View in PubMed

Postnatal decrease in transforming growth factor alpha is associated with enlarged ventricles, deficient amygdaloid vasculature and performance deficits Neuroscience. 2000; 96(4):825-36. . View in PubMed

Mechanisms of progenitor maturation are conserved in the striatum and cortex Dev Neurosci. 2000; 22(1-2):7-15. . View in PubMed

Regionalization of the cerebral cortex: developmental mechanisms and models Novartis Found Symp. 2000; 228:173-81; discussion 181-7. . View in PubMed

Complex signaling responsible for molecular regionalization of the cerebral cortex Cereb Cortex. 1999 Sep; 9(6):562-8. . View in PubMed

The role of ErbB receptor signaling in cell fate decisions by cortical progenitors: evidence for a biased, lineage-based responsiveness to different ligands Mol Cell Neurosci. 1998 Dec; 12(6):349-62. . View in PubMed

Membrane-associated molecules guide limbic and nonlimbic thalamocortical projections J Neurosci. 1998 Nov 15; 18(22):9409-19. . View in PubMed

Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin J Neurosci. 1998 Sep 15; 18(18):7047-60. . View in PubMed

Prenatal effects of drugs of abuse on brain development Drug Alcohol Depend. 1998 Jun-Jul; 51(1-2):109-25. . View in PubMed

Assignment of the gene encoding the limbic system-associated membrane protein (LAMP) to mouse chromosome 16B5 and human chromosome 3q132-q21. Genomics. 1998 May 01; 49(3):472-4. . View in PubMed

Regulation of thalamic neurite outgrowth by the Eph ligand ephrin-A5: implications in the development of thalamocortical projections Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5329-34. . View in PubMed

The critical impact of early cellular environment on neuronal development Prev Med. 1998 Mar-Apr; 27(2):180-3. . View in PubMed

Induction of presynaptic reexpression of an adhesion protein in lamina II after dorsal root deafferentation in adult rat spinal cord Exp Neurol. 1998 Feb; 149(2):468-72. . View in PubMed

Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex Neuron. 1997 Aug; 19(2):251-67. . View in PubMed

Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis Brain Res Mol Brain Res. 1997 Jul; 47(1-2):202-14. . View in PubMed

New evidence for neurotransmitter influences on brain development Trends Neurosci. 1997 Jun; 20(6):269-74. . View in PubMed

Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures Exp Brain Res. 1997 May; 114(3):433-41. . View in PubMed

Mechanisms specifying area fate in cortex include cell-cycle-dependent decisions and the capacity of progenitors to express phenotype memory Development. 1997 Apr; 124(8):1623-30. . View in PubMed

Limbic system-associated membrane protein (LAMP) induces neurite outgrowth and intracellular Ca2+ increase in primary fetal neurons Mol Cell Neurosci. 1997; 10(1-2):43-55. . View in PubMed

Signaling pathways that regulate specification of neurons in developing cerebral cortex Dev Neurosci. 1997; 19(1):6-8. . View in PubMed

Patterning and specification of the cerebral cortex Annu Rev Neurosci. 1997; 20:1-24. . View in PubMed

Expression of the mRNAs encoding the limbic system-associated membrane protein (LAMP): IAdult rat brain. J Comp Neurol. 1996 Nov 11; 375(2):274-88. . View in PubMed

Expression of the mRNAs encoding the limbic system-associated membrane protein (LAMP): IIFetal rat brain. J Comp Neurol. 1996 Nov 11; 375(2):289-302. . View in PubMed

Short exposure to methylazoxymethanol causes a long-term inhibition of axonal outgrowth from cultured embryonic rat hippocampal neurons J Neurosci Res. 1996 Nov 01; 46(3):349-59. . View in PubMed

Restricted expression of the actin-regulatory protein, tropomyosin, defines distinct boundaries, evaginating neuroepithelium, and choroid plexus forerunners during early CNS development J Neurosci. 1996 Nov 01; 16(21):6853-63. . View in PubMed

Complementary distribution of collagen type IV and the epidermal growth factor receptor in the rat embryonic telencephalon Cereb Cortex. 1996 May-Jun; 6(3):540-9. . View in PubMed

Nonuniform alteration of dendritic development in the cerebral cortex following prenatal cocaine exposure Cereb Cortex. 1996 May-Jun; 6(3):431-45. . View in PubMed

Requirement of a corepressor for Dr1-mediated repression of transcription Genes Dev. 1996 Apr 15; 10(8):1033-48. . View in PubMed

Environmental signals influence expression of a cortical areal phenotype in vitro independent of effects on progenitor cell proliferation Dev Biol. 1996 Apr 10; 175(1):184-90. . View in PubMed

Normal development of tyrosine hydroxylase and serotonin immunoreactive fibers innervating anterior cingulate cortex and visual cortex in rabbits exposed prenatally to cocaine Brain Res. 1996 Apr 09; 715(1-2):221-4. . View in PubMed

Dopamine receptors mediate differential morphological effects on cerebral cortical neurons in vitro J Neurosci Res. 1996 Feb 15; 43(4):439-53. . View in PubMed

Limbic system-associated membrane protein (LAMP) in primate amygdala and hippocampus Hippocampus. 1996; 6(5):483-94. . View in PubMed

Distribution of limbic system-associated membrane protein immunoreactivity in primate basal ganglia Neuroscience. 1995 Nov; 69(1):71-81. . View in PubMed

Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex Brain Res. 1995 Aug 14; 689(1):32-46. . View in PubMed

The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting Neuron. 1995 Aug; 15(2):287-97. . View in PubMed

Age-dependent specification of the corticocortical connections of cerebral grafts J Neurosci. 1995 Mar; 15(3 Pt 1):1819-34. . View in PubMed

Molecular contributions to cerebral cortical specification Ciba Found Symp. 1995; 193:200-13; discussion 251-7. . View in PubMed

Partial deafferentation of cat spinal neurons results in permanent changes in cell surface molecular expression and metabolic activity Exp Neurol. 1993 Sep; 123(1):74-80. . View in PubMed

Immunocytochemical analysis of a novel carbohydrate differentiation antigen (CDA-3C2) associated with olfactory and otic systems during embryogenesis in the rat J Comp Neurol. 1993 Jun 22; 332(4):444-70. . View in PubMed

Immunoelectron microscopic analysis of a novel carbohydrate differentiation antigen (CDA-3C2) in the developing rat olfactory and otic systems J Comp Neurol. 1993 Jun 22; 332(4):471-86. . View in PubMed

Cerebral cortical progenitors are fated to produce region-specific neuronal populations Cereb Cortex. 1993 May-Jun; 3(3):187-98. . View in PubMed

Immunocytochemical demonstration of early appearing astroglial structures that form boundaries and pathways along axon tracts in the fetal brain J Comp Neurol. 1993 Feb 15; 328(3):415-36. . View in PubMed

Attraction of specific thalamic input by cerebral grafts depends on the molecular identity of the implant Proc Natl Acad Sci U S A. 1992 May 01; 89(9):3706-10. . View in PubMed

Target-derived astroglia regulate axonal outgrowth in a region-specific manner Dev Biol. 1992 Feb; 149(2):278-94. . View in PubMed

Myosin II distribution in neurons is consistent with a role in growth cone motility but not synaptic vesicle mobilization Neuron. 1992 Jan; 8(1):25-44. . View in PubMed

Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain J Comp Neurol. 1991 Dec 01; 314(1):125-35. . View in PubMed

Brain macrophages and microglia respond differently to lesions of the developing and adult visual system J Comp Neurol. 1991 Dec 01; 314(1):136-46. . View in PubMed

Access to gastric tissue promotes the survival of axotomized neurons in the dorsal motor nucleus of the vagus in neonatal rats J Comp Neurol. 1991 Nov 08; 313(2):213-26. . View in PubMed

The early commitment of fetal neurons to the limbic cortex J Neurosci. 1991 Feb; 11(2):519-33. . View in PubMed

Heterogeneous distribution of the limbic system-associated membrane protein in the caudate nucleus and substantia nigra of the cat Neuroscience. 1991; 40(3):725-33. . View in PubMed

Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages Neuroscience. 1991; 44(3):765-76. . View in PubMed

Isolation, biochemical characterization and ultrastructural analysis of the limbic system-associated membrane protein (LAMP), a protein expressed by neurons comprising functional neural circuits J Neurosci. 1990 Jan; 10(1):73-90. . View in PubMed

A membrane glycoprotein associated with the limbic system mediates the formation of the septo-hippocampal pathway in vitro Neuron. 1989 Nov; 3(5):551-61. . View in PubMed

Developmental and regeneration-associated regulation of the limbic system associated membrane protein in explant cultures of the rat brain Neuroscience. 1989; 28(2):455-74. . View in PubMed

A unique membrane protein is expressed on early developing limbic system axons and cortical targets J Neurosci. 1988 Dec; 8(12):4653-61. . View in PubMed

Normal pharmacological and morphometric parameters in the noradrenergic hyperinnervated mutant mouse, "tottering" Cell Tissue Res. 1988 Apr; 252(1):175-80. . View in PubMed

Central adrenergic receptor changes in the inherited noradrenergic hyperinnervated mutant mouse tottering Brain Res. 1987 Aug 18; 418(1):174-7. . View in PubMed

Emergence of cyclic guanosine 3':5'-monophosphate-dependent protein kinase immunoreactivity in developing rhesus monkey cerebellum: correlative immunocytochemical and electron microscopic analysis J Neurosci. 1984 Oct; 4(10):2553-64. . View in PubMed

Region-specific distribution of catecholamine afferents in primate cerebral cortex: a fluorescence histochemical analysis J Comp Neurol. 1984 Jul 20; 227(1):23-36. . View in PubMed

Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker Neuroscience. 1984 Apr; 11(4):761-817. . View in PubMed

Specificity of antisera prepared against pure bovine MAO-B Brain Res. 1983 Oct 03; 276(1):127-39. . View in PubMed

Early divergence and changing proportions of neuronal and glial precursor cells in the primate cerebral ventricular zone Dev Biol. 1983 Apr; 96(2):472-84. . View in PubMed

Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons Proc Natl Acad Sci U S A. 1982 Oct; 79(20):6385-9. . View in PubMed

The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey Brain Res. 1982 May; 256(1):35-57. . View in PubMed

Central monoamine neuron systems: their organization in the developing and mature primate brain and the genetic regulation of their terminal fields Adv Neurol. 1982; 35:49-59. . View in PubMed

Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4630-4. . View in PubMed

Coexistence of neuronal and glial precursor cells in the cerebral ventricular zone of the fetal monkey: an ultrastructural immunoperoxidase analysis J Neurosci. 1981 Jan; 1(1):27-39. . View in PubMed

Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain J Comp Neurol. 1980 Oct 01; 193(3):815-40. . View in PubMed

Origin and organization of brainstem catecholamine innervation in the rat J Comp Neurol. 1979 Aug 15; 186(4):505-28. . View in PubMed

Development of the noradrenergic innervation of neocortex Brain Res. 1979 Feb 23; 162(2):243-59. . View in PubMed

Developmental organization of raphe serotonin neuron groups in the rat Anat Embryol (Berl). 1978 Sep 27; 154(3):241-51. . View in PubMed

Noradrenaline neuron innervation of the neocortex in the rat Brain Res. 1978 Jan 13; 139(2):219-31. . View in PubMed

Selective cell association of catecholamine neurons in brain aggregates in vitro Brain Res. 1976 Jul 30; 111(2):311-20. . View in PubMed

Dr. Levitt received his BA in Biological Sciences from the University of Chicago, PhD in Neuroscience at the University of California, San Diego. He completed a postdoctoral fellowship in Neuroscience at Yale University. Dr. Levitt has held leadership positions at University of Pittsburgh, Vanderbilt University and University of Southern California. Dr. Levitt was elected as a member into the prestigious Institute of Medicine (IOM), part of the National Academy of Sciences. Named a McKnight Foundation Scholar in 2002, Dr. Levitt also was a MERIT awardee from the National Institute of Mental Health and served as a member of the National Advisory Mental Health Council for the National Institute of Mental Health. He is an elected Fellow of the American Association for the Advancement of Science (AAAS), Chair-elect of the Neuroscience Division of the AAAS, and an elected member of the Dana Alliance for Brain Initiatives. He is a Senior Fellow at the Center for the Developing Child at Harvard University, and serves as Scientific Director of the National Scientific Council on the Developing Child, a policy council that brings the best research from child development and neuroscience to assist policy makers and business leaders in making wise program investment decisions. He is a member of a number of scientific advisory boards for foundations and university programs, served as Senior Editor for Journal of Neuroscience, and currently serves on the editorial boards of eLife, Neuron, Cerebral Cortex, Autism Research, Journal of Neurodevelopmental Disorders and Disease Models and Mechanisms. Dr. Levitt’s research focuses on the development of brain architecture that controls learning, emotional and social behavior. His research focuses on genetic and environment factors that increase risk for neurodevelopmental and neuropsychiatric disorders, such as autism and schizophrenia. His clinical research studies address autism heterogeneity by studying children with autism who also have co-occurring medical conditions, such as gastrointestinal disorders, with the goal of developing better diagnostic criteria and personalized treatments. He has published over 250 papers.
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