Faculty

Anna H Wu, PhD
Anna H Wu, PhD
Professor of Preventive Medicine
Preventive Medicine
NOR 4443 1441 Eastlake Avenue Health Sciences Campus Los Angeles
Dr. Wu's research focuses on the epidemiology of cancer with emphasis on understanding the increase of various (e.g., breast, ovarian, prostate, colon ) cancers among Asian migrants to the US. A second area of research interest relates to the study of tobacco-related cancers (e.g., lung, stomach/esophagus) and genes that may be important in the metabolism of tobacco constituents.

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer Hum Genet. 2019 Jul; 138(7):789-791. . View in PubMed

Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study Int J Epidemiol. 2019 Jun 01; 48(3):822-830. . View in PubMed

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women Cancer Med. 2019 May; 8(5):2503-2513. . View in PubMed

Association between ambient air pollution and breast cancer risk: The multiethnic cohort study Int J Cancer. 2019 Mar 28. . View in PubMed

Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort Neuro Oncol. 2019 Mar 18; 21(4):498-507. . View in PubMed

A Pooled Analysis of Breastfeeding and Breast Cancer Risk by Hormone Receptor Status in Parous Hispanic Women Epidemiology. 2019 05; 30(3):449-457. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Evaluation of Medicare Claims Data as a Tool to Identify Dementia J Alzheimers Dis. 2019; 67(2):769-778. . View in PubMed

A comprehensive gene-environment interaction analysis in Ovarian Cancer using genome-wide significant common variants Int J Cancer. 2019 05 01; 144(9):2192-2205. . View in PubMed

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study Br J Cancer. 2018 04; 118(8):1123-1129. . View in PubMed

Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic VariantsGastroenterology. 2018 04; 154(5):1273-1281. e3. . View in PubMed

Determinants of prolactin in postmenopausal Chinese women in Singapore Cancer Causes Control. 2018 01; 29(1):51-62. . View in PubMed

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk Cancer Res. 2018 09 15; 78(18):5419-5430. . View in PubMed

A Randomized Controlled Trial of Green Tea Extract Supplementation and Mammographic Density in Postmenopausal Women at Increased Risk of Breast Cancer Cancer Prev Res (Phila). 2017 Dec; 10(12):710-718. . View in PubMed

Effect of Green Tea Supplements on Liver Enzyme Elevation: Results from a Randomized Intervention Study in the United States Cancer Prev Res (Phila). 2017 Oct; 10(10):571-579. . View in PubMed

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci Br J Cancer. 2017 Feb 14; 116(4):524-535. . View in PubMed

Estrogen receptor-beta genetic variations and overall survival in patients with locally advanced gastric cancer Pharmacogenomics J. 2017 01; 17(1):36-41. . View in PubMed

A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA Int J Epidemiol. 2017 12 01; 46(6):1836-1846. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians Carcinogenesis. 2017 05 01; 38(5):511-518. . View in PubMed

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res. 2017 06 01; 77(11):2789-2799. . View in PubMed

Cigarette smoking is associated with adverse survival among women with ovarian cancer: Results from a pooled analysis of 19 studies Int J Cancer. 2017 06 01; 140(11):2422-2435. . View in PubMed

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer Int J Cancer. 2016 Dec 15; 139(12):2646-2654. . View in PubMed

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation Am J Hum Genet. 2016 Oct 06; 99(4):903-911. . View in PubMed

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer Int J Cancer. 2016 Sep 15; 139(6):1303-1317. . View in PubMed

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet. 2016 Apr; 48(4):374-86. . View in PubMed

A targeted genetic association study of epithelial ovarian cancer susceptibility Oncotarget. 2016 Feb 16; 7(7):7381-9. . View in PubMed

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial Am J Clin Nutr. 2016 12; 104(6):1671-1682. . View in PubMed

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study Int J Epidemiol. 2016 10; 45(5):1619-1630. . View in PubMed

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes Hum Genet. 2016 07; 135(7):741-56. . View in PubMed

Chronic Recreational Physical Inactivity and Epithelial Ovarian Cancer Risk: Evidence from the Ovarian Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2016 07; 25(7):1114-24. . View in PubMed

Environmental Determinants of Aggression in Adolescents: Role of Urban Neighborhood Greenspace J Am Acad Child Adolesc Psychiatry. 2016 07; 55(7):591-601. . View in PubMed

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study Int J Epidemiol. 2016 06; 45(3):884-95. . View in PubMed

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk Obstet Gynecol. 2016 05; 127(5):828-36. . View in PubMed

Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors Cancer Epidemiol Biomarkers Prev. 2016 05; 25(5):780-90. . View in PubMed

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer Oncotarget. 2016 10 25; 7(43):69097-69110. . View in PubMed

Age-specific risk factor profiles of adenocarcinomas of the esophagus: A pooled analysis from the international BEACON consortium Int J Cancer. 2016 Jan 01; 138(1):55-64. . View in PubMed

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression Hum Mol Genet. 2016 09 01; 25(17):3863-3876. . View in PubMed

Fine-Mapping of the 1p112 Breast Cancer Susceptibility Locus. PLoS One. 2016; 11(8):e0160316. . View in PubMed

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) Sci Rep. 2016 09 07; 6:32512. . View in PubMed

Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk Hum Mol Genet. 2016 08 15; 25(16):3600-3612. . View in PubMed

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk Genet Epidemiol. 2015 Dec; 39(8):689-97. . View in PubMed

A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1739-47. . View in PubMed

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer Carcinogenesis. 2015 Nov; 36(11):1341-53. . View in PubMed

Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density Cancer Prev Res (Phila). 2015 Oct; 8(10):942-51. . View in PubMed

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer Nat Commun. 2015 Sep 22; 6:8234. . View in PubMed

Contribution of the neighborhood environment and obesity to breast cancer survival: the California Breast Cancer Survivorship Consortium Cancer Epidemiol Biomarkers Prev. 2015 Aug; 24(8):1282-90. . View in PubMed

African Americans and Hispanics Remain at Lower Risk of Ovarian Cancer Than Non-Hispanic Whites after Considering Nongenetic Risk Factors and Oophorectomy Rates Cancer Epidemiol Biomarkers Prev. 2015 Jul; 24(7):1094-100. . View in PubMed

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition Mol Cancer Ther. 2015 Jun; 14(6):1495-503. . View in PubMed

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q312. Hum Mol Genet. 2015 May 15; 24(10):2966-84. . View in PubMed

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study Gynecol Oncol. 2015 Mar; 136(3):542-8. . View in PubMed

Diabetes and other comorbidities in breast cancer survival by race/ethnicity: the California Breast Cancer Survivorship Consortium (CBCSC) Cancer Epidemiol Biomarkers Prev. 2015 Feb; 24(2):361-8. . View in PubMed

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk PLoS One. 2015; 10(6):e0128106. . View in PubMed

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC) J Genet Genome Res. 2015; 2(2). . View in PubMed

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium Hum Mol Genet. 2014 Nov 15; 23(22):6096-111. . View in PubMed

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun. 2014 Sep 23; 4:4999. . View in PubMed

Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study BMC Cancer. 2014 Feb 04; 14:60. . View in PubMed

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):880-90. . View in PubMed

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer Nat Commun. 2013; 4:1628. . View in PubMed

Biological effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients Front Oncol. 2013; 3:298. . View in PubMed

Diabetes and risk of esophageal and gastric adenocarcinomas Int J Cancer. 2012 Sep 15; 131(6):1417-22. . View in PubMed

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies Lancet Oncol. 2012 Apr; 13(4):385-94. . View in PubMed

Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. . View in PubMed

Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women Cancer Prev Res (Phila). 2012 Mar; 5(3):393-402. . View in PubMed

Birth weight and other prenatal factors and risk of breast cancer in Asian-Americans Breast Cancer Res Treat. 2011 Dec; 130(3):917-25. . View in PubMed

Anthropometric, dietary, and hormonal correlates of serum adiponectin in Asian American women Nutr Cancer. 2011; 63(4):549-57. . View in PubMed

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors PLoS One. 2011; 6(10):e25985. . View in PubMed

Dietary patterns and breast cancer risk in Asian American women Am J Clin Nutr. 2009 Apr; 89(4):1145-54. . View in PubMed

Consortium analysis of 7 candidate SNPs for ovarian cancer Int J Cancer. 2008 Jul 15; 123(2):380-388. . View in PubMed

Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations Hum Mol Genet. 2008 Mar 15; 17(6):825-34. . View in PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. . View in PubMed

Epidemiology of soy exposures and breast cancer risk Br J Cancer. 2008 Jan 15; 98(1):9-14. . View in PubMed

Fiber intake and risk of adenocarcinomas of the esophagus and stomach Cancer Causes Control. 2007 Sep; 18(7):713-22. . View in PubMed

A common genetic risk factor for colorectal and prostate cancer Nat Genet. 2007 Aug; 39(8):954-6. . View in PubMed

Diabetes and risk of breast cancer in Asian-American women Carcinogenesis. 2007 Jul; 28(7):1561-6. . View in PubMed

Body size, hormone therapy and risk of breast cancer in Asian-American women Int J Cancer. 2007 Feb 15; 120(4):844-52. . View in PubMed

Estrogens, progestins, and risk of breast cancer Ernst Schering Found Symp Proc. 2007; (1):127-50. . View in PubMed

Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity Breast Cancer Res. 2006; 8(2):R24. . View in PubMed

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women Nutr Cancer. 2006; 56(2):128-35. . View in PubMed

Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancers Cancer Causes Control. 2005 Nov; 16(9):1065-74. . View in PubMed

A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women Am J Clin Nutr. 2005 May; 81(5):1133-41. . View in PubMed

Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis J Natl Cancer Inst. 2005 Jan 05; 97(1):51-9. . View in PubMed

Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol. 2004 Jan 15; 159(2):140-7.. View in PubMed

Adolescent and adult soy intake and risk of breast cancer in Asian-Americans Carcinogenesis. 2002 Sep; 23(9):1491-6. . View in PubMed

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States) Cancer Causes Control. 2001 Oct; 12(8):721-32. . View in PubMed

Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis. 2001 Oct; 22(10):1681-4. . View in PubMed

A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity Am J Hum Genet. 2001 Jul; 69(1):148-58. . View in PubMed

A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders Cancer Epidemiol Biomarkers Prev. 2000 Oct; 9(10):1051-8. . View in PubMed

Effects of soy foods on ovarian function in premenopausal women Br J Cancer. 2000 Jun; 82(11):1879-86. . View in PubMed

Diet and breast carcinoma in multiethnic populations Cancer. 2000 Mar 01; 88(5 Suppl):1239-44. . View in PubMed

Exposure misclassification bias in studies of environmental tobacco smoke and lung cancer Environ Health Perspect. 1999 Dec; 107 Suppl 6:873-7. . View in PubMed

Breast cancer and oral contraceptive use in Asian-American women Am J Epidemiol. 1999 Sep 15; 150(6):561-7. . View in PubMed

Breast Cancer among Asian Americans and Pacific Islanders Asian Am Pac Isl J Health. 1998; 6(2):327-343. . View in PubMed

Colon and Rectal Cancer among Asian Americans and Pacific Islanders Asian Am Pac Isl J Health. 1998; 6(2):184-200. . View in PubMed

Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States Am J Epidemiol. 1996 Mar 15; 143(6):535-42. . View in PubMed

Comparison of dietary habits, physical activity and body size among Chinese in North America and China Int J Epidemiol. 1994 Oct; 23(5):984-90. . View in PubMed

Environmental tobacco smoke and lung cancer in nonsmoking womenA multicenter study. JAMA. 1994 Jun 08; 271(22):1752-9. . View in PubMed

Diet, physical activity, and colorectal cancer among Chinese in North America and China J Natl Cancer Inst. 1990 Jun 06; 82(11):915-26. . View in PubMed

Environmental tobacco smoke: exposure-response relationships in epidemiologic studies Risk Anal. 1990 Mar; 10(1):39-48. . View in PubMed

Ethnic distribution of amyloidosis: an autopsy study Mod Pathol. 1989 Jul; 2(4):372-7. . View in PubMed

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