Faculty

Carrie Breton, ScD
Carrie Breton, ScD
Associate Professor of Preventive Medicine
Environmental Health
SSB 2nd floor 2001 N. Soto Street Health Sciences Campus Los Angeles
The overarching goals of my research program are to understand how environmental exposures early in life contribute to the increased risk of disease later in life, as well as the role genetic and epigenetic mechanisms play in driving observed associations.

Despite evidence from animal models supporting a developmental origins of adult disease hypothesis (DOHad), which proposes that adverse events during early life program an increased risk for numerous adult diseases, human studies of in utero or childhood environmental exposures have not been a primary focus until recently. My work in evaluating prenatal air pollution and prenatal tobacco smoke exposures provides evidence that early life exposures are important risk factors for cardio-respiratory health in children and young adults.

The Dynamic Relationship between Asthma and Obesity in School Children Am J Epidemiol. 2019 Nov 12. . View in PubMed

Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program Int J Obes (Lond). 2019 Oct 24. . View in PubMed

Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium Diabetes Care. 2019 Oct 10. . View in PubMed

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity Environ Int. 2019 Sep; 130:104935. . View in PubMed

Epigenome-wide meta-analysis of DNA methylation and childhood asthma J Allergy Clin Immunol. 2019 Jun; 143(6):2062-2074. . View in PubMed

Study Design, Protocol and Profile of the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) Pregnancy Cohort: a Prospective Cohort Study in Predominantly Low-Income Hispanic Women in Urban Los Angeles BMC Pregnancy Childbirth. 2019 May 30; 19(1):189. . View in PubMed

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis Environ Health Perspect. 2019 May; 127(5):57012. . View in PubMed

Associations between Maternal Tobacco Smoke Exposure and the Cord Blood [Formula: see text] DNA Methylome Environ Health Perspect. 2019 Apr; 127(4):47009. . View in PubMed

Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course Eur Respir J. 2019 Apr; 53(4). . View in PubMed

Within-subject effects of environmental and social stressors on pre- and post-partum obesity-related biobehavioral responses in low-income Hispanic women: protocol of an intensive longitudinal study BMC Public Health. 2019 Feb 28; 19(1):253. . View in PubMed

Cluster-based bagging of constrained mixed-effects models for high spatiotemporal resolution nitrogen oxides prediction over large regions Environ Int. 2019 07; 128:310-323. . View in PubMed

Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression Mitochondrion. 2019 05; 46:22-29. . View in PubMed

Exposure measurement error in air pollution studies: A framework for assessing shared, multiplicative measurement error in ensemble learning estimates of nitrogen oxides Environ Int. 2019 04; 125:97-106. . View in PubMed

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight Nat Commun. 2019 04 23; 10(1):1893. . View in PubMed

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes Curr Epidemiol Rep. 2018 Jun; 5(2):79-91. . View in PubMed

Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight Pediatr Obes. 2018 06; 13(6):348-356. . View in PubMed

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium Int J Epidemiol. 2018 02 01; 47(1):22-23u. . View in PubMed

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 07 20; 10(1):98. . View in PubMed

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2018; 83(3):130-152. . View in PubMed

Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018; 13(10-11):1027-1038. . View in PubMed

Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function: Findings From the Children's Health Study JAMA Netw Open. 2018 09 07; 1(5):e182172. . View in PubMed

Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group Environ Health Perspect. 2017 04; 125(4):511-526. . View in PubMed

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure Environ Health Perspect. 2017 01; 125(1):104-110. . View in PubMed

Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis Am J Hum Genet. 2016 Apr 07; 98(4):680-96. . View in PubMed

Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood Environ Epigenet. 2016 Apr; 2(2):dvw005. . View in PubMed

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study Environ Health Perspect. 2016 12; 124(12):1905-1912. . View in PubMed

cit: hypothesis testing software for mediation analysis in genomic applications Bioinformatics. 2016 08 01; 32(15):2364-5. . View in PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed

Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults PLoS One. 2016; 11(3):e0150825. . View in PubMed

Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study J Thorac Dis. 2015 Jan; 7(1):46-58. . View in PubMed

NOS1 methylation and carotid artery intima-media thickness in children Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22. . View in PubMed

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation PLoS One. 2014; 9(6):e99716. . View in PubMed

HDL anti-oxidant function associates with LDL level in young adults Atherosclerosis. 2014 Jan; 232(1):165-70. . View in PubMed

Response to letter regarding article, “Childhood air pollutant exposure and carotid artery intima–media thickness in young adults” Circulation. 2013 Jun 04; 127(22):e659. . View in PubMed

Birth weight and carotid artery intima-media thicknessJ Pediatr. 2013 May; 162(5):906-11. e1-2. . View in PubMed

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships Hum Genet. 2012 Oct; 131(10):1565-89. . View in PubMed

Childhood air pollutant exposure and carotid artery intima-media thickness in young adults Circulation. 2012 Sep 25; 126(13):1614-20. . View in PubMed

Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease Environ Health Perspect. 2012 Sep; 120(9):1320-6. . View in PubMed

Air pollution and health: emerging information on susceptible populations Air Qual Atmos Health. 2012 Jun 01; 5(2):189-201. . View in PubMed

Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in childrenJ Allergy Clin Immunol. 2012 Jan; 129(1):232-9. e1-7. . View in PubMed

Carotid artery intima-media thickness in college students: race/ethnicity matters Atherosclerosis. 2011 Aug; 217(2):441-6. . View in PubMed

Maternal perinatal undernutrition has long-term consequences on morphology, function and gene expression of the adrenal medulla in the adult male rat J Neuroendocrinol. 2011 Aug; 23(8):711-24. . View in PubMed

DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. . View in PubMed

Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinase Epigenetics. 2011 Jul; 6(7):895-8. . View in PubMed

A pathway-based analysis of urinary arsenic metabolites and skin lesions Am J Epidemiol. 2011 Apr 01; 173(7):778-86. . View in PubMed

Investigating air pollution and atherosclerosis in humans: concepts and outlook Prog Cardiovasc Dis. 2011 Mar-Apr; 53(5):334-43. . View in PubMed

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. . View in PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence Thorax. 2010 Feb; 65(2):139-45. . View in PubMed

Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation Am J Respir Crit Care Med. 2009 Sep 01; 180(5):462-7. . View in PubMed

Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function Am J Respir Crit Care Med. 2009 Apr 01; 179(7):601-7. . View in PubMed

GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study Environ Health. 2007 Dec 04; 6:39. . View in PubMed

Association between total ingested arsenic and toenail arsenic concentrations J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Oct; 42(12):1827-34. . View in PubMed

Maternal arsenic exposure associated with low birth weight in Bangladesh J Occup Environ Med. 2007 Oct; 49(10):1097-104. . View in PubMed

Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes Carcinogenesis. 2007 Jul; 28(7):1520-5. . View in PubMed

Dietary arsenic exposure in bangladesh Environ Health Perspect. 2007 Jun; 115(6):889-93. . View in PubMed

Characteristics of work related asthma: results from a population based survey Occup Environ Med. 2006 Jun; 63(6):411-5. . View in PubMed

Gender-specific protective effect of hemoglobin on arsenic-induced skin lesions Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):902-7. . View in PubMed

Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia Circulation. 2000 Apr 04; 101(13):1594-7. . View in PubMed

[Epidemiological profile of patients with myocardial infarction and normal coronary arteriography] Arch Mal Coeur Vaiss. 1979 Jan; 72(1):26-31. . View in PubMed

[Allergic reaction of a variety of Nicotiana tabacum to tobacco mosaic] Ann Inst Pasteur (Paris). 1951 Sep; 81(3):300-5. . View in PubMed

Powered by SC CTSI