Nicholas Mancuso, PhD
Nicholas Mancuso, PhD
Assistant Professor of Preventive Medicine
Center for Genetic Epidemiology
2001 N. Soto Street Health Sciences Campus Los Angeles
My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease MechanismsCell. 2019 Oct 17; 179(3):750-771. e22. . View in PubMed

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI Genet Epidemiol. 2019 09; 43(6):629-645. . View in PubMed

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture Nat Genet. 2019 08; 51(8):1244-1251. . View in PubMed

Probabilistic fine-mapping of transcriptome-wide association studies Nat Genet. 2019 04; 51(4):675-682. . View in PubMed

Opportunities and challenges for transcriptome-wide association studies Nat Genet. 2019 04; 51(4):592-599. . View in PubMed

Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women Cancer Prev Res (Phila). 2019 01; 12(1):31-42. . View in PubMed

Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization PLoS One. 2019; 14(6):e0218917. . View in PubMed

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights Nat Genet. 2018 04; 50(4):538-548. . View in PubMed

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions Nat Commun. 2018 10 04; 9(1):4079. . View in PubMed

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Nat Commun. 2018 03 21; 9(1):1178. . View in PubMed

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits Am J Hum Genet. 2018 10 04; 103(4):535-552. . View in PubMed

Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits Am J Hum Genet. 2017 Nov 02; 101(5):737-751. . View in PubMed

Targeted mutagenesis in a human-parasitic nematode PLoS Pathog. 2017 Oct; 13(10):e1006675. . View in PubMed

Enhanced methods to detect haplotypic effects on gene expression Bioinformatics. 2017 Aug 01; 33(15):2307-2313. . View in PubMed

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits Am J Hum Genet. 2017 Mar 02; 100(3):473-487. . View in PubMed

A multi-stage genome-wide association study of uterine fibroids in African Americans Hum Genet. 2017 10; 136(10):1363-1373. . View in PubMed

The contribution of rare variation to prostate cancer heritability Nat Genet. 2016 Jan; 48(1):30-5. . View in PubMed

Accurate viral population assembly from ultra-deep sequencing data Bioinformatics. 2014 Jun 15; 30(12):i329-37. . View in PubMed

Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows BMC Bioinformatics. 2013; 14 Suppl 9:S2. . View in PubMed

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