Faculty

William Gauderman, PhD
William Gauderman, PhD
Professor of Preventive Medicine
Preventive Medicine
SSB 202K 2001 N. Soto Street Health Sciences Campus Los Angeles
Dr. Gauderman's research falls into two distinct areas:

1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children's Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity Hum Mol Genet. 2019 Oct 01; 28(19):3327-3338. . View in PubMed

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure Hum Mol Genet. 2019 Apr 10. . View in PubMed

A Unified Model for the Analysis of Gene-Environment Interaction Am J Epidemiol. 2019 Apr 01; 188(4):760-767. . View in PubMed

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos J Allergy Clin Immunol. 2019 Mar; 143(3):957-969. . View in PubMed

Discovery of common and rare genetic risk variants for colorectal cancer Nat Genet. 2019 01; 51(1):76-87. . View in PubMed

Factors Associated with Prevalent Diabetic Retinopathy in Chinese Americans: The Chinese American Eye Study Ophthalmol Retina. 2018 Feb; 2(2):96-105. . View in PubMed

Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma Obesity (Silver Spring). 2018 12; 26(12):1938-1948. . View in PubMed

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 09; 50(9):1343. . View in PubMed

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis Nat Genet. 2018 08; 50(8):1072-1080. . View in PubMed

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures Pediatr Obes. 2018 05; 13(5):312-320. . View in PubMed

Factors Associated with Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study (CHES) Ophthalmol Retina. 2018 03; 2(3):209-216. . View in PubMed

Dietary Nutrient Intake, Ethnicity, and Epigenetic Silencing of Lung Cancer Genes Detected in Sputum in New Mexican Smokers Cancer Prev Res (Phila). 2018 02; 11(2):93-102. . View in PubMed

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure Am J Hum Genet. 2018 03 01; 102(3):375-400. . View in PubMed

Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search Hum Hered. 2018; 83(3):130-152. . View in PubMed

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases Am J Epidemiol. 2017 Oct 01; 186(7):753-761. . View in PubMed

Dietary nutrients associated with preservation of lung function in Hispanic and non-Hispanic white smokers from New Mexico Int J Chron Obstruct Pulmon Dis. 2017; 12:3171-3181. . View in PubMed

Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control Am J Respir Crit Care Med. 2017 01 15; 195(2):179-188. . View in PubMed

Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012 JAMA. 2016 Apr 12; 315(14):1491-501. . View in PubMed

Adaptive Set-Based Methods for Association Testing Genet Epidemiol. 2016 Feb; 40(2):113-22. . View in PubMed

E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use Pediatrics. 2016 08; 138(2). . View in PubMed

Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study Genet Epidemiol. 2016 07; 40(5):394-403. . View in PubMed

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group Genet Epidemiol. 2016 07; 40(5):404-15. . View in PubMed

Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children PLoS One. 2016; 11(5):e0155567. . View in PubMed

Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies Am J Respir Crit Care Med. 2016 06 01; 193(11):1271-80. . View in PubMed

Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study JAMA Ophthalmol. 2016 06 01; 134(6):683-90. . View in PubMed

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos Hum Mol Genet. 2016 11 15; 25(22):5035-5045. . View in PubMed

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci Nat Commun. 2015 Oct 26; 6:8739. . View in PubMed

Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants JAMA. 2015 Mar 17; 313(11):1133-42. . View in PubMed

Association of improved air quality with lung development in children N Engl J Med. 2015 Mar 05; 372(10):905-13. . View in PubMed

15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers J Natl Cancer Inst. 2015 Feb 23; 107(5). . View in PubMed

Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma Nat Commun. 2015 Jan 16; 6:5965. . View in PubMed

Genetic ancestry influences asthma susceptibility and lung function among Latinos J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. . View in PubMed

Fraction of exhaled nitric oxide values in childhood are associated with 17q112-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55. . View in PubMed

Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants Thorax. 2014 Jun; 69(6):540-7. . View in PubMed

Finding novel genes by testing G × E interactions in a genome-wide association study Genet Epidemiol. 2013 Sep; 37(6):603-13. . View in PubMed

Childhood infections and adult height in monozygotic twin pairs Am J Epidemiol. 2013 Aug 15; 178(4):551-8. . View in PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies Genet Epidemiol. 2013 Jul; 37(5):440-51. . View in PubMed

A genome-wide association study of central corneal thickness in Latinos Invest Ophthalmol Vis Sci. 2013 Apr 01; 54(4):2435-43. . View in PubMed

A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. . View in PubMed

Confounding and heterogeneity in genetic association studies with admixed populations Am J Epidemiol. 2013 Feb 15; 177(4):351-60. . View in PubMed

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. . View in PubMed

Accuracy of a new time-resolved step counter in children Pediatr Exerc Sci. 2012 Nov; 24(4):622-33. . View in PubMed

A genome-wide association meta-analysis identifies new childhood obesity loci Nat Genet. 2012 May; 44(5):526-31. . View in PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California Am J Epidemiol. 2011 May 01; 173(9):1039-48. . View in PubMed

Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children Allergy. 2011 Mar; 66(3):412-9. . View in PubMed

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. . View in PubMed

Discovery of complex pathways from observational data Stat Med. 2010 Aug 30; 29(19):1998-2011. . View in PubMed

Efficient genome-wide association testing of gene-environment interaction in case-parent trios Am J Epidemiol. 2010 Jul 01; 172(1):116-22. . View in PubMed

Genetic Analysis Workshop 16: Strategies for genome-wide association study analyses BMC Proc. 2009 Dec 15; 3 Suppl 7:S1. . View in PubMed

Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene-environment interactions Am J Epidemiol. 2009 Dec 15; 170(12):1494-501. . View in PubMed

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene Am J Hum Genet. 2009 May; 84(5):581-93. . View in PubMed

Gene-environment interaction in genome-wide association studies Am J Epidemiol. 2009 Jan 15; 169(2):219-26. . View in PubMed

Detecting gene-environment interactions in genome-wide association data Genet Epidemiol. 2009; 33 Suppl 1:S68-73. . View in PubMed

Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing Pediatrics. 2008 Jul; 122(1):e107-14. . View in PubMed

Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins Neurology. 2007 Jul 24; 69(4):381-8. . View in PubMed

Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study Lancet. 2007 Feb 17; 369(9561):571-7. . View in PubMed

Exploiting gene-environment interaction to detect genetic associations Hum Hered. 2007; 63(2):111-9. . View in PubMed

Dog ownership enhances symptomatic responses to air pollution in children with asthma Environ Health Perspect. 2006 Dec; 114(12):1910-5. . View in PubMed

Air pollution and children--an unhealthy mix N Engl J Med. 2006 Jul 06; 355(1):78-9. . View in PubMed

Differential twin concordance for multiple sclerosis by latitude of birthplace Ann Neurol. 2006 Jul; 60(1):56-64. . View in PubMed

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis Am J Hum Genet. 2006 Jan; 78(1):15-27. . View in PubMed

Childhood asthma and exposure to traffic and nitrogen dioxide Epidemiology. 2005 Nov; 16(6):737-43. . View in PubMed

Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study Arch Environ Health. 2004 Oct; 59(10):505-14. . View in PubMed

Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am J Epidemiol. 2004 Jan 15; 159(2):140-7.. View in PubMed

Candidate gene association analysis for a quantitative trait, using parent-offspring trios Genet Epidemiol. 2003 Dec; 25(4):327-38. . View in PubMed

Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake Am J Epidemiol. 2003 Sep 15; 158(6):576-84. . View in PubMed

Environmental tobacco smoke and absenteeism related to respiratory illness in schoolchildren Am J Epidemiol. 2003 May 15; 157(10):861-9. . View in PubMed

Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6. . View in PubMed

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. . View in PubMed

Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. . View in PubMed

Association between air pollution and lung function growth in southern California children: results from a second cohort Am J Respir Crit Care Med. 2002 Jul 01; 166(1):76-84. . View in PubMed

Asthma in exercising children exposed to ozone: a cohort study Lancet. 2002 Feb 02; 359(9304):386-91. . View in PubMed

Association tests in nuclear families Hum Hered. 2001; 52(2):66-76. . View in PubMed

Combined linkage and association analysis in pedigrees Genet Epidemiol. 2001; 21 Suppl 1:S358-63. . View in PubMed

Gene-environment interaction and affected sib pair linkage analysis Hum Hered. 2001; 52(1):34-46. . View in PubMed

Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma Am J Respir Crit Care Med. 2000 Dec; 162(6):2097-104. . View in PubMed

Association between air pollution and lung function growth in southern California children Am J Respir Crit Care Med. 2000 Oct; 162(4 Pt 1):1383-90. . View in PubMed

Evidence for age-specific genetic relative risks in lung cancer Am J Epidemiol. 2000 Jan 01; 151(1):41-9. . View in PubMed

Air pollution and bronchitic symptoms in Southern California children with asthma Environ Health Perspect. 1999 Sep; 107(9):757-60. . View in PubMed

Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs Am J Epidemiol. 1999 Apr 15; 149(8):693-705. . View in PubMed

A study of twelve Southern California communities with differing levels and types of air pollutionII. Effects on pulmonary function. Am J Respir Crit Care Med. 1999 Mar; 159(3):768-75. . View in PubMed

A study of twelve Southern California communities with differing levels and types of air pollutionI. Prevalence of respiratory morbidity. Am J Respir Crit Care Med. 1999 Mar; 159(3):760-7. . View in PubMed

A generalized estimating equations approach to linkage analysis in sibships in relation to multiple markers and exposure factors Genet Epidemiol. 1999; 17 Suppl 1:S737-42. . View in PubMed

A joint test of linkage and gene x environment interaction, with affected sib pairs Genet Epidemiol. 1999; 17 Suppl 1:S563-8. . View in PubMed

Family-based association studies J Natl Cancer Inst Monogr. 1999; (26):31-7. . View in PubMed

Association tests using unaffected-sibling versus pseudo-sibling controls Genet Epidemiol. 1999; 17 Suppl 1:S731-6. . View in PubMed

Detection of gene-environment interactions in joint segregation and linkage analysis Am J Hum Genet. 1997 Nov; 61(5):1189-99. . View in PubMed

Analysis of gene-smoking interaction in lung cancer Genet Epidemiol. 1997; 14(2):199-214. . View in PubMed

Association between the Rfp-Y haplotype and the incidence of Marek's disease in chickens Immunogenetics. 1996; 44(4):242-5. . View in PubMed

Genetic epidemiologic analysis of quantitative phenotypes using Gibbs sampling Genet Epidemiol. 1995; 12(6):753-8. . View in PubMed

Censored survival models for genetic epidemiology: a Gibbs sampling approach Genet Epidemiol. 1994; 11(2):171-88. . View in PubMed

A bivariate genetic analysis of HDL- and LDL-cholesterol incorporating measured covariates: a Gibbs sampling application Genet Epidemiol. 1993; 10(6):623-8. . View in PubMed

Combined segregation and linkage analysis of late-onset Alzheimer's disease in Duke families using Gibbs sampling Genet Epidemiol. 1993; 10(6):489-94. . View in PubMed

Community care of corneal ulcers Am J Ophthalmol. 1992 Nov 15; 114(5):531-8. . View in PubMed

Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis Cornea. 1992 Sep; 11(5):398-403. . View in PubMed

Diurnal variation of corneal topography after radial keratotomy Arch Ophthalmol. 1992 Mar; 110(3):351-6. . View in PubMed

Computer-assisted study of diurnal variation in corneal topography after penetrating keratoplasty Ophthalmic Surg. 1992 Jan; 23(1):10-6. . View in PubMed

Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis Int Ophthalmol. 1992 Jan; 16(1):27-32. . View in PubMed

Clearance rate of macrophages from the vitreous in rabbits Curr Eye Res. 1990 Jul; 9(7):683-6. . View in PubMed

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