Equipment and Resources

Photo of: LTQ Orbitrap XL™ ETD Hybrid Ion Trap-Orbitrap Mass Spectrometer coupled with Eksigent nanoLC 2D

Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer coupled with EASY-nLC 1000 Liquid Chromatograph

Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer coupled with EASY-nLC 1000 Liquid Chromatograph

High-Confidence Results, Quickly

  • HRAM and full-scan capabilities capture all sample data, all the time, enabling retrospective data analysis without need to re-run samples
  • Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices
  • Better than 1ppm mass accuracy in full-scan and all-ion fragmentation (AIF) modes ensures confident compound identification
  • Fast scanning at 12hz and spectral multiplexing suited to UHPLC applications
  • Rapid polarity switching maximizes information obtained
  • AIF and multiple dissociation techniques—in-source CID and HCD—aid in compound identification
  • Extended mass range to 6,000m/z enhances detection of singly charged small molecules and biomolecules
  • More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan

Greater Confidence for Drug Discovery and Metabolism Studies

  • Triple quadruple-equivalent ability to quantify parent compounds and metabolites along with identity confirmation provides greater throughput
  • Fast HRAM Orbitrap technology eliminates interferences for high-confidence metabolite structural identification and large-scale profiling of metabolomics and lipidomics samples
  • Fast scan-to-scan polarity switching in both MS and MS/MS modes maximizes metabolite detection and identification from a single injection

More Information for Superior Proteomics

  • HCD yields superior fragmentation and higher-quality MS/MS spectra compared to CID, improving identifications
  • High spectral quality and a wide dynamic range make it possible to identify and quantify proteins other instruments cannot find.
  • Quan/qual capability make it easier to transition from proteomic discovery experiments to targeted protein quantification

Highly Specific Environmental and Food Safety Analyses

  • Specificity exceeding triple quadruple Q-TOF or Q-Trap levels make this mass spectrometer the preferred quan/qual screening platform
  • Data-dependent, full-scan MS/MS capabilities and HRAM data ensure the highest possible confidence in every identification

High-Confidence Quanfirmation for Clinical Research and Forensic Toxicology

  • The combination of SRM and HRAM capabilities provides high-confidence quanfirmation of endogenous steroids, drugs of abuse and pain-management therapeutics with ease.

Application-Specific Software for Greater Throughput

EASY-nLC 1000 Liquid Chromatograph

  • For all proteomics core and research laboratories that are striving to identify more proteins and peptides while saving time and effort in the process.
  • If you have a well-established proteomics workflow that you need to speed-up — the EASY-nLC 1000 LC is your best choice.
  • The EASY-nLC 1000 LC supports a large selection of column lengths and particle sizes with flow pressures up to 1000 bar.
  • Combined with the innovative Thermo Scientific™ EASY-Spray™ source, it delivers exceptionally well separated peptides into your mass spectrometer.
  • The system is also recommended for researchers and scientists adopting nanoLC-/MS and UHPLC-/MS as a new technique in their laboratory.

Top Performance and Ease of Use:

  • Continuous 24/7 operation allows extended long run separations.
  • Enclosed and cooled autosampler protects your thermolabile samples.
  • 2D-LC capabilities can deliver more information from each sample.
  • Wizard-style programming and touch screen-driven, MS-independent control software simplify set up and operation.
  • Thermo Scientific™ nanoViper™ connection technology makes plumbing easy and reduces dead volume.
  • Easy access and intelligent maintenance help you keep your system working at peak performance.

Choose the Right Configuration for You: