Collaborate Information

For people interest in collaborating with this Division, the research liaison Amy Ryan (Firth) (pre-clinical) and Janice Liebler (clinical/translational).

The Division of Pulmonary, Critical Care and Sleep Medicine (PCCSM) strives towards excellence in all three academic missions, providing exceptional clinical care, robust basic and clinical research programs and outstanding opportunities for training of the next generation of clinicians in our highly sought after fellowship programs. Division faculty and fellows provide services in seven Intensive Care Units, two at LAC+USC, four at KH, and one at Norris.

Research areas in the Division include airway and alveolar epithelial cell biology, gene regulation in lung injury and repair, lung cancer, nanoparticle trafficking across the alveolar epithelium, pulmonary fibrosis, stem cell biology and regenerative medicine, outcomes in critical care, cystic fibrosis, pulmonary hypertension and sleep.

Faculty Engaged in Scholarly Work

Ahmet Baydur, MD

  • Mechanical properties and breathing patterns of the respiratory system in health and disease.
  • Disorders involving the nerves and muscles and how they affect breathing.
  • Exercise testing in respiratory and cardiovascular conditions, and its use in the evaluation of the mechanisms of shortness of breath.

Zea Borok, MD

  • Transcriptional and epigenetic mechanisms regulating alveolar epithelial stem cell function and differentiation
  • Lung alveolar epithelial cell plasticity and epithelial-mesenchymal transitions
  • Transport and barrier properties of lung alveolar epithelium
  • Functional and phenotypic characterization of alveolar epithelial type I cells

Richard Castriotta, MD

  • Non-apneic breathing problems in obesity
  • The connection between heart rhythm problems (atrial fibrillation) and breathing problems during sleep
  • Dream enactment (REM sleep behavior disorder) and early detection of Parkinson’s disease
  • Treatment of complex sleep apnea, central sleep apnea and obstructive sleep apnea
  • Body temperature and sleep

Ching-Fei Chang, MD

  • Lung cancer in women
  • Lung cancer in Asian patients
  • Cost-effectiveness of new bronchoscopic and pleural techniques (EBUS, EMN, IPC, BT, endobronchial valves) in ethically- and economically-diverse populations

Ya-Wen Chen, PhD

  • Stem cell
  • Lung
  • Regenerative medicine
  • Development

Edward Crandall, PhD, MD

  • Imaging approaches
  • Mathematical modelling
  • Environmental impact
  • Mechanisms of chronic lung diseases

Sivagini Ganesh, MD

  • New treatments for patients with pulmonary hypertension
  • Outcomes in patients who have undergone lung transplantation

Aarya Kafi, MD

  • Immunosuppression in lung transplant recipients
  • Treatment of pulmonary fibrosis

Santhi Iyer-Kumar, MD

  • Quality
  • Safety
  • Critical care
  • Teamwork and communication

Kwang Jin Kim, PhD

  • Transport of water, small solutes and proteins across mammalian lung alveoli epithelial cells
  • Nanoparticle interaction/processing with/in mammalian lung alveolar epithelial cells
  • Mechanisms and pathways of pulmonary drug delivery

May Lee, MD

  • Exploring and implementing best practices and innovative curricula in graduate medical education
  • Use of social media in graduate medical education
  • Exploring hypoxemia in non-ARDS patients

Janice Liebler, MD

  • Critical care medicine
  • Lung injury, repair after lung injury and the pathogenesis of pulmonary fibrosis
  • Lung transplant outcomes

Brett Lindgren, DO

  • Management of patients receiving mechanical ventilation
  • Outcomes of patients with the adult respiratory distress syndrome (ARDS)
  • Extracorporeal mechanical support (ECMO) procedures
  • Advanced Bronchoscopy

Adupa Purush Rao, MD

  • Novel drug treatments for cystic fibrosis patients
  • Optimization of care for patients with advanced lung disease

Amy Ryan (Firth), PhD

  • Cystic Fibrosis: Gene correction and epithelial repair
  • Rare lung diseases: Lymphangioleiomyomatosis (LAM), Primary Ciliary Dyskinesia (PCD)
  • Mechanisms of mucociliary transport
  • Stem cell models of disease: pluripotent, induced and adult stem cells and tissue regeneration

Arnold Sipos, PhD, MD

  • Interaction of the alveolar epithelial cells and nanoparticles
  • Studying the biological effects of nanoparticle exposure on airway epithelial cells.
  • Identifying the molecular link between nanoparticle exposure and chronic lung diseases (e.g., chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis)
  • Exploring the involvement of autophagy in response to nanoparticle exposure

Bassam Yaghmour, MD

  • Physiologic abnormalities and innovative medical treatments in pulmonary arterial hypertension
  • Clinical assessment of endothelial dysfunction in pulmonary vascular disease.
  • Interventional pulmonology
  • Critical care medicine and quality improvement in intensive care medicine

Beiyun Zhou, PhD

  • Role of endoplasmic reticulum stress in alveolar epithelial abnormalities during development and in pulmonary fibrosis
  • Transcriptional and epigenetic regulation of pulmonary alveolar epithelial cell differentiation and plasticity
  • Epithelial plasticity and epithelial-mesenchymal cross-talk in the context of lung injury, repair and fibrosis
  • Hippo-YAP signaling in regulation of pulmonary stem/progenitor cell proliferation/differentiation