ARPA-H: Treating Hereditary Rare Diseases with In Vivo Precision Genetic Medicines – THRIVE

October 01, 2025

Deadline

12/19/2025

Sponsor

Advanced Research Projects Agency for Health (ARPA-H)

Research Area

Genetics, Disease Prevention, Manufacturing

Funder Url

https://arpa-h.gov/explore-funding/programs/give?utm_medium=email&_hsenc=p2ANqtz-9tq1bxyRdqd__-2iSqqfD450LG59rxcP2q3r-Y5W_amze3rF9TDA5fiVLRKqSiNB6VMkz68UezNkVVn3U2ZcVS7KL2aQ&_hsmi=382325863&utm_content=382325863&utm_source=hs_email

Solution summary deadline: December 19, 2025

Award amount: Based on project’s needs

It’s GIVE-ing more treatments for patients. The GIVE program, or Genetic Medicines and Individualized Manufacturing for Everyone, aims to leverage cutting-edge production technologies to establish the U.S. as a frontrunner in advanced manufacturing methods for high-quality medicines.

Why it’s needed: Genetic medicines hold promise to make treatments in different formats. However, their development is often hindered by the high cost and complexity of manufacturing and quality testing, centralized facilities with specialized equipment needs, and ultracold shipping requirements.

From the Program Manager: “Our vision is to rapidly produce multiple kinds of genetic medicines so that breakthrough treatments are accessible, affordable, and ready to dose within a week of diagnosis,” said GIVE Program Manager John Schiel, Ph.D. “Individualized domestic biomanufacturing will give the U.S. an advantage and ensure that researchers and patients alike have access to the latest therapeutic capabilities.”

How to engage: For more information about the GIVE program, including solicitation details and Proposers’ Day registration, visit the GIVE program page.