PCORI: Broad Pragmatic Studies

If you are interested in the following opportunity, please contact Carole King at carole.king@med.usc.edu.

• LOI due: January 6, 2026
• Budget: up to $12,000,000 (plus 40% indirects)
• Project period: five years

PCORI seeks patient-centered comparative clinical effectiveness research (CER) projects comparing two or more widely used interventions to fill evidence gaps that inform healthcare decisions for patients, caregivers, clinicians, and policymakers. Strongly encouraged are individual- or cluster-randomized trials, though well-designed observational studies or natural experiments are also eligible. Hybrid effectiveness-implementation approaches are encouraged, but studies solely focused on implementation, dissemination, or methods development are non-responsive.

Meaningful patient and stakeholder engagement is required.  Patient care costs may be requested but are not guaranteed.

Special Areas of Emphasis:

• Obesity: Comparative effectiveness of lifestyle, pharmacologic, procedural, or combination interventions with clinically meaningful obesity outcomes.
• Menopausal Symptoms: CER on hormonal, non-hormonal, or system-level interventions to improve health and quality of life for peri- and post-menopausal women.
• Care for Individuals with Intellectual and Developmental Disabilities (IDD): CER on systems-level care strategies to improve access, quality, navigation, and patient-centered outcomes.