PCORI: Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research

If you are interested in the following opportunity, please contact Carole King at carole.king@med.usc.edu.

• LOI due: January 6, 2026
• Budget: up to $750,000 (plus 40% indirects)
• Project period:  up to three years

PCORI seeks to fund projects that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies.   

Program priorities:   

• Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in CER.
• Methods To Improve Study Design.
• Methods To Support Data Research Networks.
• Methods Related to Ethical and Human Subjects Protections Issues in CER. 

PCORI has established the Patient-Centered Outcomes Data Repository (PCODR) at the Inter-university Consortium for Political and Social Research (ICPSR), based at the University of Michigan. The repository contains a growing number of patient-centered CER datasets that applicants may find useful for the conduct of their proposed methodological research (e.g., for use cases). Use of these datasets is encouraged but not required.