PCORI: Partnering Research and Community Organizations for Comparative Clinical Effectiveness Research Across the Cancer Care Continuum (The Cancer Partner PFA)

If you are interested in the following opportunity, please contact Carole King at carole.king@med.usc.edu.

• LOI due: January 6, 2026
• Budget: up to $12,000,000 (plus 40% indirects)
• Project period: up to five years

Special areas of interest:

1. Barriers to cancer screening: CER studies testing strategies to improve screening and timely follow-up, especially in populations with low uptake. Focus areas: access, communication, health literacy, cultural factors, systematic screening, and genetic testing for high-risk individuals.
2. Evidence-based treatment delivery: CER studies comparing strategies to enhance cancer care delivery and outcomes, particularly for underserved groups. Priorities: timely, evidence-based treatment, managing toxicity/burden, mental health support, healthcare coordination, and caregiver support, especially for metastatic patients.
3. Post-treatment follow-up care: CER studies comparing follow-up models for survivors, including risk-based/stratified approaches. Focus: adolescent/young adult survivors, rural access via telehealth or multidisciplinary teams, care transitions, older survivors with chronic conditions, and long-term survivors (5+ years post-diagnosis).

Dual PIs required—one from a research organization, one from a community organization. Only individual-level or cluster-RCTs are eligible; observational studies are excluded. Studies solely on patient navigators or educators are non-responsive, but integrating navigation into routine care is of interest.