PCORI: Broad Pragmatic Studies

If you are interested in the following opportunity, please contact Carole King at [email protected].

• LOI Due: September 8, 2026
• Amount: Up to $12,000,000 (plus 40% indirects)
• Project Period: Up to five years

This funding opportunity supports large-scale, high-impact patient-centered comparative clinical effectiveness research (CER) across a broad range of conditions, populations, and care settings. Projects must compare two or more existing interventions, treatments, or care delivery strategies to determine what works best in real-world practice.

Special areas of emphasis:

• Improving Mental Health and Substance Use Outcomes for Pregnant and Postpartum Populations
• Cancer Survivorship
• Diabetes Prevention, Care and Treatment
• Management of Neuropathic Pain
• Management of Pain in Individuals Living With Intellectual and Developmental Disabilities or Alzheimer’s Disease and Related Dementias

Applicants are strongly encouraged to propose individual- or cluster-randomized controlled trials; however, well-specified natural experiments and well-designed observational studies will also be considered. Patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making.