PCORI: Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research

If you are interested in the following opportunity, please contact Carole King at [email protected].

• LOI Due: September 8, 2026
• Amount: Up to $750,000 (plus 40% indirects)
• Project Period: Up to three years

Funds studies that address high-impact methodological gaps in patient-centered comparative clinical effectiveness research (CER). Research should address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies.

For the Cycle 3 2026 Methods PFA, PCORI has identified the following areas as program priorities:

• Methods To Support the Use of Patient-Centered Measurement in Patient-Centered CER
• Methods To Support the Use of Real-World Data (RWD) in Multi-Site Patient-Centered CER
• Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER
• Methods To Improve Study Design in Patient-Centered CER