Department of Surgery faculty members, both physicians and scientists, are world-renown in their subspecialties. Faculty members are passionate in their clinical care and research practices, as well as being mentors for medical students and trainees. The department also invests significant funds to provide protected time and lab space for junior faculty to perform research.

Burton Eisenberg

Burton Eisenberg

Professor of Clinical Surgery;Director, Hoag/USC Cancer Program
1 Hoag Dr. Health Sciences Campus Newport Beach

Molecular profiling of melanoma brain metastases compared to primary cutaneous melanoma and to extracranial metastases Oncotarget. 2020 Aug 18; 11(33):3118-3128. . View in PubMed

Complete response with talimogene laherparepvec in recurrent melanoma of the ear: A case report Oral Oncol. 2020 Jul 11; 104899. . View in PubMed

The current state of molecular testing in the treatment of patients with solid tumors, 2019 CA Cancer J Clin. 2019 07; 69(4):305-343. . View in PubMed

The role of margins in extremity soft tissue sarcoma J Surg Oncol. 2016 Mar; 113(3):333-8. . View in PubMed

Upfront boost Gamma Knife "leading-edge" radiosurgery to FLAIR MRI-defined tumor migration pathways in 174 patients with glioblastoma multiforme: a 15-year assessment of a novel therapy J Neurosurg. 2016 12; 125(Suppl 1):40-49. . View in PubMed

Recent advances in the management of liposarcoma F1000Res. 2016; 5:2907. . View in PubMed

Contemporary Management of Retroperitoneal Soft Tissue Sarcomas Curr Oncol Rep. 2015 Aug; 17(8):39. . View in PubMed

Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial J Clin Oncol. 2015 Jul 10; 33(20):2231-8. . View in PubMed

The SSG XVIII/AIO trial: results change the current adjuvant treatment recommendations for gastrointestinal stromal tumors Am J Clin Oncol. 2013 Feb; 36(1):89-90. . View in PubMed

A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue Breast Cancer Res Treat. 2013 Feb; 138(1):175-83. . View in PubMed

Gastrointestinal stromal tumor--background, pathology, treatment Hematol Oncol Clin North Am. 2012 Dec; 26(6):1239-59. . View in PubMed

ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression J Nucl Med. 2012 Apr; 53(4):567-74. . View in PubMed

Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132 Ann Surg Oncol. 2012 Apr; 19(4):1074-80. . View in PubMed

Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330 Sarcoma. 2012; 2012:659485. . View in PubMed

Adjuvant and neoadjuvant imatinib therapy: current role in the management of gastrointestinal stromal tumors Int J Cancer. 2011 Dec 01; 129(11):2533-42. . View in PubMed

Adjuvant and neoadjuvant therapy for primary GIST Cancer Chemother Pharmacol. 2011 Jan; 67 Suppl 1:S3-8. . View in PubMed

Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514 Cancer. 2010 Oct 01; 116(19):4613-21. . View in PubMed

High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors Genes Chromosomes Cancer. 2009 Oct; 48(10):886-96. . View in PubMed

Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor . 2009 Aug; 8(8):2172-82. . View in PubMed

Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells Nutr Cancer. 2009; 61(1):114-22. . View in PubMed

Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665 J Surg Oncol. 2009 Jan 01; 99(1):42-7. . View in PubMed

The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors . 2008 Oct; 7(19):2949-55. . View in PubMed

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8387-92. . View in PubMed

The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells Cancer Invest. 2008 Mar; 26(2):118-27. . View in PubMed

Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT J Clin Oncol. 2008 Feb 01; 26(4):620-5. . View in PubMed

Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology J Clin Oncol. 2007 Jan 01; 25(1):146-62. . View in PubMed

Combined-modality strategy for gastrointestinal stromal tumors Semin Oncol. 2006 Dec; 33(6 Suppl 11):S75-8. . View in PubMed

Combining imatinib with surgery in gastrointestinal stromal tumors: rationale and ongoing trials Clin Colorectal Cancer. 2006 Nov; 6 Suppl 1:S24-9. . View in PubMed

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors J Clin Oncol. 2006 Oct 10; 24(29):4764-74. . View in PubMed

Phase II trial of preoperative chemoradiation with a hyperfractionated radiation boost in locally advanced rectal cancer Am J Clin Oncol. 2006 Oct; 29(5):435-41. . View in PubMed

Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms Cancer Res. 2006 May 15; 66(10):5477-86. . View in PubMed

Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514 J Clin Oncol. 2006 Feb 01; 24(4):619-25. . View in PubMed

Management of gastrointestinal stromal tumors in the imatinib era: selected case studies Oncologist. 2006 Jan; 11(1):9-20. . View in PubMed

Soft tissue sarcomas: opportunities for defining the molecular phenotype of a solid tumor malignancy Curr Opin Oncol. 2005 Jul; 17(4):355-6. . View in PubMed

Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling Clin Cancer Res. 2005 May 15; 11(10):3668-77. . View in PubMed

Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients Cancer Res. 2004 Sep 15; 64(18):6476-81. . View in PubMed

Soft tissue sarcomas treated with postoperative external beam radiotherapy with and without low-dose-rate brachytherapy Int J Radiat Oncol Biol Phys. 2004 Jun 01; 59(2):475-80. . View in PubMed

NCCN Task Force report: optimal management of patients with gastrointestinal stromal tumor (GIST)--expansion and update of NCCN clinical practice guidelines J Natl Compr Canc Netw. 2004 May; 2 Suppl 1:S-1-26; quiz 27-30. . View in PubMed

Surgery and imatinib in the management of GIST: emerging approaches to adjuvant and neoadjuvant therapy Ann Surg Oncol. 2004 May; 11(5):465-75. . View in PubMed

Is reporting of recurrence data important in pancreatic cancer? Ann Surg Oncol. 2004 Mar; 11(3):304-9.. View in PubMed

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor J Clin Oncol. 2003 Dec 01; 21(23):4342-9. . View in PubMed

Imatinib mesylate: a molecularly targeted therapy for gastrointestinal stromal tumors Oncology (Williston Park). 2003 Nov; 17(11):1615-20; discussion 162016231626 passim. . View in PubMed

Intraoperative radiotherapy in the multimodality approach to bone and soft tissue cancers Surg Oncol Clin N Am. 2003 Oct; 12(4):1015-29. . View in PubMed

Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors . 2003 Aug; 2(8):699-709. . View in PubMed

Pharmacotherapy of gastrointestinal stromal tumours Expert Opin Pharmacother. 2003 Jun; 4(6):869-74. . View in PubMed

Soft tissue sarcomas of adults: state of the translational science Clin Cancer Res. 2003 Jun; 9(6):1941-56. . View in PubMed

Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome Int J Gastrointest Cancer. 2003; 34(2-3):121-8. . View in PubMed

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors N Engl J Med. 2002 Aug 15; 347(7):472-80. . View in PubMed

2002 Mar-Apr; 6(2):147-57; discussion 157-8. . View in PubMed

Gastrointestinal stromal tumors Curr Treat Options Oncol. 2001 Dec; 2(6):485-91. . View in PubMed

Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation Cancer. 2001 May 15; 91(10):1862-9. . View in PubMed

Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade Ann Surg Oncol. 2001 Apr; 8(3):260-7. . View in PubMed

Trimodality therapy for advanced gallbladder cancer Am Surg. 2001 Mar; 67(3):277-83; discussion 284. . View in PubMed

Local recurrence of breast cancer in the stereotactic core needle biopsy site: case reports and review of the literature Breast J. 2001 Mar-Apr; 7(2):124-7. . View in PubMed

Effect of preoperative chemoradiotherapy on surgical margin status of resected adenocarcinoma of the head of the pancreas J Gastrointest Surg. 2001 Mar-Apr; 5(2):121-30. . View in PubMed

Radiation Therapy Oncology GroupResearch Plan 2002-2006. Tumor Utilization Committee. Int J Radiat Oncol Biol Phys. 2001; 51(3 Suppl 2):103-9. . View in PubMed

Radiation Therapy Oncology GroupResearch Plan 2002-2006. Surgical Oncology Committee. Int J Radiat Oncol Biol Phys. 2001; 51(3 Suppl 2):92-5. . View in PubMed

Pancreatic carcinoma deemed unresectable at exploration may be resected for cure: an institutional experience Am Surg. 2000 Apr; 66(4):378-85; discussion 386. . View in PubMed

Local excision and chemoradiation for low rectal T1 and T2 cancers is an effective treatment Am Surg. 1999 Jul; 65(7):625-30; discussion 630-1. . View in PubMed

Phase I dose escalating trial of hyperfractionated pre-operative chemoradiation for locally advanced rectal cancer Int J Radiat Oncol Biol Phys. 1998 Aug 01; 42(1):43-50. . View in PubMed

Preoperative versus postoperative chemoradiation for patients with resected pancreatic adenocarcinoma Am Surg. 1998 Jul; 64(7):686-92. . View in PubMed

A close or positive margin after mastectomy is not an indication for chest wall irradiation except in women aged fifty or younger Int J Radiat Oncol Biol Phys. 1998 Jun 01; 41(3):599-605. . View in PubMed

Comparison of liver function tests after hepatic lobectomy and hepatic wedge resection Am Surg. 1998 May; 64(5):408-14. . View in PubMed

Use of saline-filled tissue expanders to protect the small bowel from radiation Oncology (Williston Park). 1998 Jan; 12(1):51-4; discussion 546062passim. . View in PubMed

Biliary CA 19-9 values correlate with the risk of hepatic metastases in patients with adenocarcinoma of the pancreas J Gastrointest Surg. 1998 Jan-Feb; 2(1):28-35. . View in PubMed

Prediction of recurrence and survival by post-resection CA 19-9 values in patients with adenocarcinoma of the pancreas Ann Surg Oncol. 1997 Oct-Nov; 4(7):551-6. . View in PubMed

Implications of fine-needle aspiration in patients with resectable pancreatic cancer Am Surg. 1997 Aug; 63(8):675-9; discussion 679-80. . View in PubMed

Identification of women with T1-T2 breast cancer at low risk of positive axillary nodes J Surg Oncol. 1997 May; 65(1):34-9. . View in PubMed

Permeation through an open channel: Poisson-Nernst-Planck theory of a synthetic ionic channel Biophys J. 1997 Jan; 72(1):97-116. . View in PubMed

Cryosurgical ablation of hepatic metastases from colorectal carcinomas Am Surg. 1997 Jan; 63(1):63-8. . View in PubMed

Metabolic characterization of human soft tissue sarcomas in vivo and in vitro using proton-decoupled phosphorus magnetic resonance spectroscopy Cancer Res. 1996 Jul 01; 56(13):2964-72. . View in PubMed

The impact of tamoxifen on breast recurrence, cosmesis, complications, and survival in estrogen receptor-positive early-stage breast cancer Int J Radiat Oncol Biol Phys. 1996 Jul 01; 35(4):669-77. . View in PubMed

Atraumatic method of intraoperative retrograde transhepatic biliary stent insertion J Surg Oncol. 1996 May; 62(1):10-4. . View in PubMed

Palliative pelvic exenteration: patient selection and results Oncology (Williston Park). 1996 Apr; 10(4):479-84; discussion 484-6490493. . View in PubMed

Does the placement of surgical clips within the excision cavity influence local control for patients treated with breast-conserving surgery and irradiation Int J Radiat Oncol Biol Phys. 1996 Mar 15; 34(5):1009-17. . View in PubMed

Wound complications after resection and immediate postoperative brachytherapy in the management of soft-tissue sarcomas Ann Surg Oncol. 1996 Jan; 3(1):51-6. . View in PubMed

Long-term follow-up of local excision and radiation therapy for invasive rectal cancer Dis Colon Rectum. 1995 Nov; 38(11):1193-9. . View in PubMed

Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control? Int J Radiat Oncol Biol Phys. 1995 Jul 15; 32(4):969-76.. View in PubMed

Routine bone scanning in patients with T1 and T2 breast cancer: a waste of money Ann Surg Oncol. 1995 Jul; 2(4):319-24. . View in PubMed

Reconstruction with myocutaneous flaps following resection of locally recurrent rectal cancer Am Surg. 1995 Jul; 61(7):581-9. . View in PubMed

Is CT portography (CTAP) really useful in patients with liver tumors who undergo intraoperative ultrasonography (IOUS)? Am Surg. 1995 Jul; 61(7):560-5.. View in PubMed

A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas Am J Surg. 1995 Jan; 169(1):71-7; discussion 77-8. . View in PubMed

Preoperative chemoradiation for adenocarcinoma of the pancreas and duodenum Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):161-7. . View in PubMed

Morbidity after intraperitoneal insertion of saline-filled tissue expanders for small bowel exclusion from radiotherapy treatment fields: a prospective four year experience with 34 patients Am Surg. 1994 Jul; 60(7):473-82; discussion 482-3. . View in PubMed

A single institutional experience with preoperative chemoradiotherapy for stage I-III pancreatic adenocarcinoma Am Surg. 1993 Nov; 59(11):772-80; discussion 780-1. . View in PubMed

Neoadjuvant chemoradiation in pancreatic and duodenal carcinomaA Phase II Study. Cancer. 1993 Oct 01; 72(7):2124-33. . View in PubMed

Surgical management of recurrent liver tumors Semin Oncol. 1993 Oct; 20(5):493-505. . View in PubMed

Diagnosis and surgical management of locally recurrent soft-tissue sarcomas of the extremity Semin Oncol. 1993 Oct; 20(5):451-5. . View in PubMed

The influence of surgical margins on advanced cancer treated with intraoperative radiation therapy (IORT) and surgical resection J Surg Oncol. 1993 May; 53(1):30-5. . View in PubMed

Hepatic resection following systemic chemotherapy for metastatic colorectal carcinoma J Surg Oncol. 1992 Oct; 51(2):122-5. . View in PubMed

Comparison of infections in Hickman and implanted port catheters in adult solid tumor patients J Surg Oncol. 1992 Mar; 49(3):156-62. . View in PubMed

Conservative management of extensive low-lying rectal carcinomas with transanal local excision and combined preoperative and postoperative radiation therapyA report of a phase I-II trial. Cancer. 1992 Jan 15; 69(2):335-41. . View in PubMed

Risk factors for immediate prosthetic postmastectomy reconstruction Am Surg. 1991 Aug; 57(8):514-21; discussion 522. . View in PubMed

Renal vein leiomyosarcoma J Surg Oncol. 1990 Oct; 45(2):131-3. . View in PubMed

Retrotracheal goiter South Med J. 1990 Feb; 83(2):239-40. . View in PubMed

Histiocytoid carcinoma: a variant of breast cancer J Surg Oncol. 1986 Apr; 31(4):271-4. . View in PubMed

The diagnosis and treatment of obstructive jaundice secondary to malignant lymphoma: a problem in multidisciplinary management J Surg Oncol. 1980; 14(2):111-23. . View in PubMed

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