Department of Surgery faculty members, both physicians and scientists, are world-renown in their subspecialties. Faculty members are passionate in their clinical care and research practices, as well as being mentors for medical students and trainees. The department also invests significant funds to provide protected time and lab space for junior faculty to perform research.

Crystal Nicole Marconett

Crystal Nicole Marconett

Assistant Professor of Research Surgery
6418A Norris Topping Tower Health Sciences Campus Los Angeles

STOP Cancer: Howard and Andree Shore Seed Grant, 2017-2018

American Journal of Respiratory Cell Biology: Featured Researcher 2017, 2017-2017

American Cancer Society: ACS/Canary Foundation Postdoctoral Fellow, 2010-2013

California Breast Cancer Research Program: CBCRP Dissertation Fellowship, 2007-2009

UC Berkeley: Chancellors Predoctoral Award, 2005-2007

TENET 20: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 Sep; 16(9):e1009023. . View in PubMed

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women Genomics. 2020 03; 112(2):1223-1232. . View in PubMed

Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells . 2020 07 01; 319(1):L173-L184. . View in PubMed

LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response Cancer Res. 2019 Jun 15; 79(12):3050-3062. . View in PubMed

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes Epigenomics. 2018 09; 10(9):1167-1187. . View in PubMed

CLDN181 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications Oncotarget. 2017 Oct 06; 8(46):81538-81557. . View in PubMed

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. . View in PubMed

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations Hum Mol Genet. 2017 01 15; 26(2):454-465. . View in PubMed

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers Hum Mol Genet. 2017 08 01; 26(15):3014-3027. . View in PubMed

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study PLoS Med. 2016 Dec; 13(12):e1002162. . View in PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung . 2016 Jan 15; 310(2):L114-20. . View in PubMed

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides J Natl Cancer Inst. 2016 12; 108(12). . View in PubMed

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. . View in PubMed

The importance of detailed epigenomic profiling of different cell types within organs Epigenomics. 2016 06; 8(6):817-29. . View in PubMed

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat Genom Data. 2014 Dec 01; 2:105-109. . View in PubMed

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury . 2014 Oct 01; 307(7):L524-36. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nat Commun. 2014 Feb 27; 5:3365. . View in PubMed

CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer J Thorac Oncol. 2013 Nov; 8(11):1378-88. . View in PubMed

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation PLoS Genet. 2013 Jun; 9(6):e1003513. . View in PubMed

Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):74-84. . View in PubMed

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells Carcinogenesis. 2011 Sep; 32(9):1315-23. . View in PubMed

BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype . 2010 Aug 15; 10(4):397-405. . View in PubMed

1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells Chem Biol Interact. 2010 Aug 05; 186(3):255-66. . View in PubMed

Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop Mol Biol Cell. 2010 Apr 01; 21(7):1166-77. . View in PubMed

Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells Carcinogenesis. 2008 Dec; 29(12):2252-8. . View in PubMed

Our lab focuses on lung cancer research. We utilize bioinformatic and computational science alongside in vitro experimentation to understand fundamental mechanisms of lung adenocarcinoma disease progression. As an associate member of the Norris Cancer Center and junior faculty member in the Departments of Surgery, and Biochemistry/Molecular Medicine, my labs focus is on understanding the contribution long non-coding RNAs play in the development of lung cancers. We have characterized a novel role for lncRNAs in mediation of the DNA damage response, and are keen on translating these basic mechanistic understandings into actionable therapeutic options.
Powered by SC CTSI