Department of Surgery faculty members, both physicians and scientists, are world-renown in their subspecialties. Faculty members are passionate in their clinical care and research practices, as well as being mentors for medical students and trainees. The department also invests significant funds to provide protected time and lab space for junior faculty to perform research.

Frank Petrigliano

Frank Petrigliano

Associate Professor of Clinical Orthopaedic Surgery;Chief, USC Epstein Family Center for Sports Medicine;Head Team Physician Los Angeles Kings Hockey Team
Orthopaedic Surgery
HC2 - 1520 San Pablo Street, #2000 Health Sciences Campus Los Angeles

UCLA Department of Orthopaedic Surgery: Faculty Teaching Award, 2019

ASES Annual Open Meeting, New Orleans, LA: Charles Neer Award, 2018

UCLA Department of Orthopaedic Surgery: Physician of the Year, 2018

Castle Connolly: Best Doctors, 2018

AOSSM Meeting, Toronto, Canada: Bart Mann Award, 2017

Super Doctors: Rising Star, 2016

Lateral to medial fibro-adipogenic degeneration are greater in infraspinatus than supraspinatus following nerve and tendon injury of murine rotator cuff J Orthop Res. 2020 Sep 04. . View in PubMed

Novel in vivo mouse model of shoulder implant infection J Shoulder Elbow Surg. 2020 Jul; 29(7):1412-1424. . View in PubMed

Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis Arthritis Rheumatol. 2020 Apr 05. . View in PubMed

Continuous Peripheral Nerve Blocks Are Associated With Increased Rates of Emergency Department Visits After Arthroscopic Rotator Cuff Repair Surgery Orthopedics. 2020 Mar 01; 43(2):127-131. . View in PubMed

Stem Cell Treatment for Knee Articular Cartilage Defects and Osteoarthritis Curr Rev Musculoskelet Med. 2020 Feb; 13(1):20-27. . View in PubMed

Editorial Commentary: Bone Marrow Aspirate Concentrate Harvested From the Ilium During Acetabular Labral Repair: Is the Biologic Juice Worth the Squeeze? Arthroscopy. 2020 05; 36(5):1321-1322.. View in PubMed

Aged Mice Demonstrate Greater Muscle Degeneration of Chronically Injured Rotator Cuff J Orthop Res. 2020 02; 38(2):320-328. . View in PubMed

Infographic: we need minimum reporting standards for biologics Br J Sports Med. 2019 Aug; 53(15):974-975. . View in PubMed

Implant Engineering in the Age of Biologics J Am Acad Orthop Surg. 2019 Aug 01; 27(15):e685-e690. . View in PubMed

Preoperative Vitamin D Deficiency Is Associated With Higher Postoperative Complications in Arthroscopic Rotator Cuff Repair J Am Acad Orthop Surg Glob Res Rev. 2019 Jul; 3(7):e075. . View in PubMed

Rationale for Biologic Augmentation of Rotator Cuff Repairs J Am Acad Orthop Surg. 2019 Jul 01; 27(13):468-478. . View in PubMed

Rationale for Biologic Augmentation of Rotator Cuff Repairs J Am Acad Orthop Surg. 2019 Apr 16. . View in PubMed

Glenohumeral Dislocation Arthropathy: Etiology, Diagnosis, and Management J Am Acad Orthop Surg. 2019 Apr 01; 27(7):227-235. . View in PubMed

Cyclic testing of tibialis tendon allografts for anterior cruciate ligament reconstruction using suture-post versus spiked washer tibial fixation Clin Biomech (BristolAvon). 2019 12; 70:8-15. . View in PubMed

Trends and Complications in Open Versus Endoscopic Carpal Tunnel Release in Private Payer and Medicare Patient Populations Hand (N Y). 2019 07; 14(4):455-461. . View in PubMed

In vitro determination of the passive knee flexion axis: Effects of axis alignment on coupled tibiofemoral motions Med Eng Phys. 2019 05; 67:73-77. . View in PubMed

Non-fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle JCI Insight. 2019 12 19; 4(24). . View in PubMed

Nonarthroplasty Options for the Athlete or Active Individual with Shoulder Osteoarthritis Clin Sports Med. 2018 Oct; 37(4):517-526. . View in PubMed

Infographic: Reporting the right information for stem cell studies is important Bone Joint Res. 2018 Sep; 7(9):539-540. . View in PubMed

Neer Award 2018: Platelet-derived growth factor receptor a co-expression typifies a subset of platelet-derived growth factor receptor ß-positive progenitor cells that contribute to fatty degeneration and fibrosis of the murine rotator cuff J Shoulder Elbow Surg. 2018 Jul; 27(7):1149-1161. . View in PubMed

Marked pseudoepitheliomatous hyperplasia secondary to a red-pigmented tattoo: a case report J Eur Acad Dermatol Venereol. 2018 Jul; 32(7):e272-e273. . View in PubMed

Relative Complications and Trends of Outpatient Total Shoulder Arthroplasty Orthopedics. 2018 May 01; 41(3):e400-e409. . View in PubMed

Adipose-derived Human Perivascular Stem Cells May Improve Achilles Tendon Healing in Rats Clin Orthop Relat Res. 2018 10; 476(10):2091-2100. . View in PubMed

Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair Ann Rheum Dis. 2018 05; 77(5):760-769. . View in PubMed

Effects of Anterior Closing Wedge Tibial Osteotomy on Anterior Cruciate Ligament Force and Knee Kinematics Am J Sports Med. 2018 02; 46(2):370-377. . View in PubMed

Outpatient Total Knee Arthroplasty Is Associated with Higher Risk of Perioperative Complications J Bone Joint Surg Am. 2017 Dec 06; 99(23):1978-1986. . View in PubMed

MRI-Arthroscopy Correlation of the Rotator Cuff: A Case-based Review Sports Med Arthrosc Rev. 2017 Dec; 25(4):164-171. . View in PubMed

Evaluation of the Trends, Concomitant Procedures, and Complications With Open and Arthroscopic Rotator Cuff Repairs in the Medicare Population Orthop J Sports Med. 2017 Oct; 5(10):2325967117731310. . View in PubMed

Early complications of acromioclavicular joint reconstruction requiring reoperation Knee Surg Sports Traumatol Arthrosc. 2017 Jul; 25(7):2020-2024. . View in PubMed

Open shoulder stabilization: current trends and 1-year postoperative complications JSES Open Access. 2017 Jun; 1(2):72-78. . View in PubMed

Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells J Bone Joint Surg Am. 2017 May 17; 99(10):809-819. . View in PubMed

Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. . View in PubMed

Skeletal and cardiac muscle pericytes: Functions and therapeutic potential Pharmacol Ther. 2017 03; 171:65-74. . View in PubMed

Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration JCI Insight. 2017 01 12; 2(1):e88553. . View in PubMed

Injuries Sustained by the Mixed Martial Arts Athlete Sports Health. 2017 Jan/Feb; 9(1):64-69. . View in PubMed

Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 1: Biologics Overview, Ligament Injury, Tendinopathy Am J Sports Med. 2016 Dec; 44(12):3270-3283. . View in PubMed

Utilization of Platelet-Rich Plasma for Musculoskeletal Injuries: An Analysis of Current Treatment Trends in the United States Orthop J Sports Med. 2016 Dec; 4(12):2325967116676241. . View in PubMed

Location of the natural knee axis for internal-external tibial rotation Knee. 2016 Dec; 23(6):1083-1088. . View in PubMed

Plate Versus Intramedullary Nail Fixation of Anterior Tibial Stress Fractures: A Biomechanical Study Am J Sports Med. 2016 Jun; 44(6):1590-6. . View in PubMed

Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 3: Articular Cartilage Orthop J Sports Med. 2016 Apr; 4(4):2325967116642433. . View in PubMed

Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus J Biomech Eng. 2016 Apr; 138(4):044501. . View in PubMed

Trends associated with distal biceps tendon repair in the United States, 2007 to 2011 J Shoulder Elbow Surg. 2016 Apr; 25(4):676-80. . View in PubMed

Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 2: Rotator Cuff Orthop J Sports Med. 2016 Mar; 4(3):2325967116636586. . View in PubMed

Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells J Orthop Res. 2016 06; 34(6):985-94. . View in PubMed

Use of ultra-high molecular weight polycaprolactone scaffolds for ACL reconstruction J Orthop Res. 2016 05; 34(5):828-35. . View in PubMed

Utilization and Costs of Postoperative Physical Therapy After Rotator Cuff Repair: A Comparison of Privately Insured and Medicare PatientsArthroscopy. 2015 Dec; 31(12):2392-9. e1. . View in PubMed

Operative versus nonoperative treatment of acute Achilles tendon rupture: An analysis of 12,570 patients in a large healthcare database Foot Ankle Surg. 2015 Dec; 21(4):250-3. . View in PubMed

Rehabilitation Charges Associated With Anterior Cruciate Ligament Reconstruction Sports Health. 2015 Nov-Dec; 7(6):538-41. . View in PubMed

Response to Comment on: In Vivo Evaluation of Electrospun Polycaprolactone Graft for Anterior Cruciate Ligament EngineeringTissue Eng Part A. 2015;21(7-8):1228-1236. Tissue Eng Part A. 2015 Nov; 21(21-22):2776. . View in PubMed

Demographic Trends and Complication Rates in Arthroscopic Elbow Surgery Arthroscopy. 2015 Oct; 31(10):1928-32. . View in PubMed

Demographic trends in arthroscopic and open biceps tenodesis across the United States J Shoulder Elbow Surg. 2015 Oct; 24(10):e279-85. . View in PubMed

Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. . View in PubMed

Measurements of tibial rotation during a simulated pivot shift manoeuvre using a gyroscopic sensor Knee Surg Sports Traumatol Arthrosc. 2015 Aug; 23(8):2237-2243. . View in PubMed

Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra J Biophotonics. 2015 Jul; 8(7):555-66. . View in PubMed

Effect of Different Preconditioning Protocols on Anterior Knee Laxity After ACL Reconstruction with Four Commonly Used Grafts J Bone Joint Surg Am. 2015 Jul 01; 97(13):1059-66. . View in PubMed

Evaluation of polycaprolactone scaffold with basic fibroblast growth factor and fibroblasts in an athymic rat model for anterior cruciate ligament reconstruction Tissue Eng Part A. 2015 Jun; 21(11-12):1859-68. . View in PubMed

Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects Biomater Sci. 2015 May; 3(5):742-52. . View in PubMed

In vivo evaluation of electrospun polycaprolactone graft for anterior cruciate ligament engineering Tissue Eng Part A. 2015 Apr; 21(7-8):1228-36. . View in PubMed

Use of inertial sensors to predict pivot-shift grade and diagnose an ACL injury during preoperative testing Am J Sports Med. 2015 Apr; 43(4):857-64. . View in PubMed

Athymic rat model for evaluation of engineered anterior cruciate ligament grafts J Vis Exp. 2015 Mar 26; (97). . View in PubMed

Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis Osteoarthritis Cartilage. 2015 Feb; 23(2):308-18. . View in PubMed

In vitro and in vivo evaluation of heparin mediated growth factor release from tissue-engineered constructs for anterior cruciate ligament reconstruction J Orthop Res. 2015 Feb; 33(2):229-36. . View in PubMed

Outcome of chronic isolated anterior cruciate ligament reconstruction J Knee Surg. 2014 Oct; 27(5):383-92. . View in PubMed

Factors predicting complication and reoperation rates following surgical fixation of proximal humeral fractures J Bone Joint Surg Am. 2014 Sep 17; 96(18):1544-51. . View in PubMed

The changing demographics of knee dislocation: a retrospective database review Clin Orthop Relat Res. 2014 Sep; 472(9):2609-14. . View in PubMed

Trends in the surgical treatment of articular cartilage defects of the knee in the United States Knee Surg Sports Traumatol Arthrosc. 2014 Sep; 22(9):2070-5. . View in PubMed

Use of a gyroscope sensor to quantify tibial motions during a pivot shift test Knee Surg Sports Traumatol Arthrosc. 2014 Sep; 22(9):2064-9. . View in PubMed

Current tissue engineering strategies in anterior cruciate ligament reconstruction J Biomed Mater Res A. 2014 May; 102(5):1614-24. . View in PubMed

Recent insights into the identity of mesenchymal stem cells: Implications for orthopaedic applications Bone Joint J. 2014 Mar; 96-B(3):291-8. . View in PubMed

Incidence of acute postoperative infections requiring reoperation after arthroscopic shoulder surgery Am J Sports Med. 2014 Feb; 42(2):437-41. . View in PubMed

Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. . View in PubMed

The costs associated with the evaluation of rotator cuff tears before surgical repair J Shoulder Elbow Surg. 2013 Dec; 22(12):1662-6. . View in PubMed

Functional anatomy and biomechanics of shoulder stability in the athlete Clin Sports Med. 2013 Oct; 32(4):607-24. . View in PubMed

Hospital Charges and Practice Patterns for General and Regional Anesthesia in Arthroscopic Anterior Cruciate Ligament Repair Orthop J Sports Med. 2013 Oct; 1(5):2325967113505270. . View in PubMed

Incidence of postoperative infections requiring reoperation after arthroscopic knee surgery Arthroscopy. 2013 Aug; 29(8):1355-61. . View in PubMed

Surgical management of PCL injuries: indications, techniques, and outcomes Curr Rev Musculoskelet Med. 2013 Jun; 6(2):115-23. . View in PubMed

Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond Cell Biochem Funct. 2013 Jun; 31(4):271-80. . View in PubMed

Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells Stem Cell Reports. 2013; 1(6):575-89. . View in PubMed

Failed rotator cuff surgery, evaluation and decision making Clin Sports Med. 2012 Oct; 31(4):693-712. . View in PubMed

Effect of tibial slope on the stability of the anterior cruciate ligament-deficient knee Knee Surg Sports Traumatol Arthrosc. 2012 Aug; 20(8):1626-31. . View in PubMed

The effect of proximal tibial slope on dynamic stability testing of the posterior cruciate ligament- and posterolateral corner-deficient knee Am J Sports Med. 2012 Jun; 40(6):1322-8. . View in PubMed

Posterior cruciate ligament and posterolateral corner deficiency results in a reverse pivot shift Clin Orthop Relat Res. 2012 Mar; 470(3):815-23. . View in PubMed

Effect of meniscal loss on knee stability after single-bundle anterior cruciate ligament reconstruction Knee Surg Sports Traumatol Arthrosc. 2011 Dec; 19 Suppl 1:S86-93. . View in PubMed

Biologic augmentation of rotator cuff repair Curr Rev Musculoskelet Med. 2011 Dec; 4(4):221-30. . View in PubMed

Thermal shrinkage for shoulder instability HSS J. 2011 Jul; 7(2):108-14. . View in PubMed

Combined inhibition of the BMP pathway and the RANK-RANKL axis in a mixed lytic/blastic prostate cancer lesion Bone. 2011 Mar 01; 48(3):578-87. . View in PubMed

Targeting of prostate cancer cells by a cytotoxic lentiviral vector containing a prostate stem cell antigen (PSCA) promoter Prostate. 2009 Sep 15; 69(13):1422-34. . View in PubMed

Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside J Bone Joint Surg Am. 2009 May; 91(5):1073-83. . View in PubMed

Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in bone Bone. 2009 Jan; 44(1):160-7. . View in PubMed

Osteonecrosis of the hip: novel approaches to evaluation and treatment Clin Orthop Relat Res. 2007 Dec; 465:53-62. . View in PubMed

A novel dual-targeted lentiviral vector leads to specific transduction of prostate cancer bone metastases in vivo after systemic administration Mol Ther. 2007 Nov; 15(11):1973-81. . View in PubMed

The effects of local bFGF release and uniaxial strain on cellular adaptation and gene expression in a 3D environment: implications for ligament tissue engineering Tissue Eng. 2007 Nov; 13(11):2721-31. . View in PubMed

Diagnosis and treatment of posterior cruciate ligament injuries Curr Sports Med Rep. 2007 Oct; 6(5):293-9. . View in PubMed

Access to and quality of health and social care for rare diseases: patients' and caregivers' experiences Ann Ig. 2007 Mar-Apr; 19(2):153-60. . View in PubMed

MRI evaluation of isolated arthroscopic partial meniscectomy patients at a minimum five-year follow-up HSS J. 2007 Feb; 3(1):35-43. . View in PubMed

Isolated posterior cruciate ligament injuries of the knee Sports Med Arthrosc Rev. 2006 Dec; 14(4):206-12. . View in PubMed

Tissue engineering for anterior cruciate ligament reconstruction: a review of current strategies Arthroscopy. 2006 Apr; 22(4):441-51. . View in PubMed

Anterior cruciate ligament reconstruction with a four-strand hamstring tendon autograftSurgical technique. J Bone Joint Surg Am. 2005 Mar; 87 Suppl 1(Pt 1):51-66. . View in PubMed

Anterior cruciate ligament reconstruction with a four-strand hamstring tendon autograft J Bone Joint Surg Am. 2004 Feb; 86(2):225-32. . View in PubMed

Orbital fractures in sport: a review Sports Med. 2003; 33(4):317-22. . View in PubMed

Dr. Petrigliano is an Associate Professor of Clinical Orthopaedic Surgery and Chief of the Epstein Family Center for Sports Medicine at Keck Medicine of USC. He serves as the head team physician for the LA Kings hockey team and a team physician for USC Athletics. He specializes in the care of injuries of the shoulder, knee, and elbow. A native of New York, Dr. Petrigliano completed his undergraduate training at Cornell University where he graduated with honors. Dr. Petrigliano then attended the Rutgers Robert Wood Johnson Medical School for his medical training and his residency in Orthopaedic Surgery at UCLA. After residency, Dr. Petrigliano completed a fellowship in Sports Medicine and Shoulder Surgery at the prestigious Hospital for Special Surgery and Weill Cornell Medical College in New York City where he assisted in the care of the Brooklyn Nets and Iona College Athletics.

Dr. Petrigliano’s surgical interests include arthroscopic shoulder repair, knee ligament reconstruction, cartilage repair and transplantation, and elbow ligament reconstruction. Dr. Petrigliano also performs total shoulder replacements and reverse shoulder replacements. His research focuses on developing stem-cell based therapies for the treatment of muscle and cartilage injury, and he has received numerous accolades, including the Charles S. Neer Award from the American Shoulder and Elbow Surgeons, for his study of the role of fibrosis in rotator cuff muscle regeneration. Dr. Petrigliano has authored over one hundred articles, chapters, and peer-reviewed publications on shoulder, elbow, and knee injuries in athletes.
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