Department of Surgery faculty members, both physicians and scientists, are world-renown in their subspecialties. Faculty members are passionate in their clinical care and research practices, as well as being mentors for medical students and trainees. The department also invests significant funds to provide protected time and lab space for junior faculty to perform research.

Alex K. Wong

Alex K. Wong

Associate Professor Of Clinical Surgery
1510 San Pablo St. Health Sciences Campus Los Angeles

USC: SuperDoctors Rising Star , 2013-2016

USC: SC-CTSI KL2 Mentored Research Award, 2013-2016

USC: Pasadena Magazine Top Doctor, 2010-2016

USC: Robert E. and May R. Wright Foundation Award , 2010-2012

Harvard Medical School: Howard Hughes Medical Institute Fellowship, 1999-2000

The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus Cancer Res. 2020 Aug 01; 80(15):3130-3144. . View in PubMed

Role of stem cell therapies in treating chronic wounds: A systematic review World J Stem Cells. 2020 Jul 26; 12(7):659-675. . View in PubMed

Patient Characteristics Associated with Free Nipple Graft Reduction Mammoplasty Cureus. 2020 Jul 08; 12(7):e9063. . View in PubMed

Supercharged Free Transverse Rectus Abdominis Myocutaneous Flap: An Autologous Reconstructive Option for the Thin Breast Reconstruction Patient Cureus. 2020 Jun 22; 12(6):e8776. . View in PubMed

Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps PLoS One. 2020; 15(1):e0227599. . View in PubMed

Analysis of Trends in the Selection and Production of US. Academic Plastic Surgery Faculty. Plast Reconstr Surg Glob Open. 2020 Jan; 8(1):e2607. . View in PubMed

Prevention of postsurgical lymphedema via immediate delivery of sustained-release 9-cis retinoic acid to the lymphedenectomy site J Surg Oncol. 2020 Jan; 121(1):100-108. . View in PubMed

Analysis of the Microsurgery Match from 2014 to 2018 Reveals Increased Competition for Microsurgery Fellowship Positions J Reconstr Microsurg. 2019 Nov; 35(9):662-668. . View in PubMed

Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis Lymphat Res Biol. 2019 Feb; 17(1):19-29. . View in PubMed

Complex Reconstruction of the Knee with a Free Vertical Rectus Abdominis Flap after Periprosthetic Soft Tissue Necrosis Cureus. 2019 Jan 28; 11(1):e3969. . View in PubMed

Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation Stem Cells Transl Med. 2019 09; 8(9):925-934. . View in PubMed

Trochanteric pressure ulcers: preoperative management and reconstructive considerations Ann Transl Med. 2019 Jan; 7(1):22. . View in PubMed

A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema Sci Rep. 2019 12 04; 9(1):18264. . View in PubMed

Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance JCI Insight. 2019 03 07; 4(5). . View in PubMed

Risk Factors Associated with Reconstructive Complications Following Sacrectomy Plast Reconstr Surg Glob Open. 2018 Nov; 6(11):e2002. . View in PubMed

Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model Plast Reconstr Surg. 2018 09; 142(3):679-686. . View in PubMed

Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing Ann Plast Surg. 2018 05; 80(5S Suppl 5):S317-S321. . View in PubMed

Porcine Mesothelium-Wrapped Diced Cartilage Grafts for Nasal Reconstruction Tissue Eng Part A. 2018 04; 24(7-8):672-681. . View in PubMed

Updates on the Management of Non-Melanoma Skin Cancer (NMSC) Healthcare (Basel). 2017 Nov 01; 5(4). . View in PubMed

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4 Circ Res. 2017 Apr 28; 120(9):1426-1439. . View in PubMed

Laminar flow downregulates Notch activity to promote lymphatic sprouting J Clin Invest. 2017 Apr 03; 127(4):1225-1240. . View in PubMed

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat Sci Rep. 2017 07 17; 7(1):5577. . View in PubMed

Topical Fibronectin Improves Wound Healing of Irradiated Skin Sci Rep. 2017 06 20; 7(1):3876. . View in PubMed

Radiomics-based Prognosis Analysis for Non-Small Cell Lung Cancer Sci Rep. 2017 04 18; 7:46349. . View in PubMed

Spinning Out of Control: A 19-Year-Old Female with Spinning-Related Exertional Thigh Compartment Syndrome Cureus. 2016 Dec 24; 8(12):e939. . View in PubMed

An update and review of cell-based wound dressings and their integration into clinical practice Ann Transl Med. 2016 Dec; 4(23):457. . View in PubMed

Integra-based Reconstruction of Large Scalp Wounds: A Case Report and Systematic Review of the Literature Plast Reconstr Surg Glob Open. 2016 Oct; 4(10):e1074. . View in PubMed

Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid Ann Surg. 2016 08; 264(2):353-61. . View in PubMed

Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells PLoS One. 2016; 11(6):e0157126. . View in PubMed

Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database Microsurgery. 2015 Jan; 35(1):6-12. . View in PubMed

Determination of a perfusion threshold in experimental perforator flap surgery using indocyanine green angiography Ann Plast Surg. 2014 Nov; 73(5):602-6. . View in PubMed

Assessment of three-dimensional high-definition visualization technology to perform microvascular anastomosis J Plast Reconstr Aesthet Surg. 2014 Jul; 67(7):967-72. . View in PubMed

Update and Review on the Surgical Management of Primary Cutaneous Melanoma Healthcare (Basel). 2014 Jun 10; 2(2):234-49. . View in PubMed

Abstract 31: DNA methylation analysis of radiated skin reveals chonic inflammation with a predominance of polymorphonuclear granulocytes Plast Reconstr Surg. 2014 Mar; 133(3 Suppl):42. . View in PubMed

Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers J Plast Reconstr Aesthet Surg. 2014 Feb; 67(2):e42-8. . View in PubMed

Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models PLoS One. 2014; 9(12):e113956. . View in PubMed

Metastasis of hepatocellular and renal cell carcinoma to the hand Plast Reconstr Surg Glob Open. 2013 Dec; 1(9):e83. . View in PubMed

Risk factors associated with venous thromboembolism in 49,028 mastectomy patients Breast. 2013 Aug; 22(4):444-8. . View in PubMed

Incidence of surgical-site infection is not affected by method of immediate breast reconstruction Plast Reconstr Surg. 2013 Jul; 132(1):20e-9e. . View in PubMed

Identifying risk factors for surgical site infections in mastectomy patients using the National Surgical Quality Improvement Program database Am J Surg. 2013 Feb; 205(2):194-9. . View in PubMed

Novel biomarkers of arterial and venous ischemia in microvascular flaps PLoS One. 2013; 8(8):e71628. . View in PubMed

Effect of immediate reconstruction on postmastectomy surgical site infection Ann Surg. 2012 Aug; 256(2):326-33. . View in PubMed

Breast implants and minimally invasive cardiac surgery: a case series Ann Plast Surg. 2012 Jul; 69(1):10-3. . View in PubMed

A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction Ann Plast Surg. 2012 Apr; 68(4):346-56. . View in PubMed

9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema Circulation. 2012 Feb 21; 125(7):872-82. . View in PubMed

The variation in the absence of the palmaris longus in a multiethnic population of the United States: an epidemiological study Plast Surg Int. 2012; 2012:282959. . View in PubMed

Use of human acellular dermal matrix in implant- based breast reconstruction: evaluating the evidence J Plast Reconstr Aesthet Surg. 2011 Dec; 64(12):1553-61. . View in PubMed

Radioprotection of osteoblasts by a fractionated dose regimen and amifostine Plast Reconstr Surg. 2009 Feb; 123(2 Suppl):104S-13S. . View in PubMed

Ionizing radiation of mesenchymal stem cells results in diminution of the precursor pool and limits potential for multilineage differentiation Plast Reconstr Surg. 2008 Jul; 122(1):64-76. . View in PubMed

Hyperbaric oxygen inhibits growth but not differentiation of normal and irradiated osteoblasts J Craniofac Surg. 2008 May; 19(3):757-65. . View in PubMed

Histologic analysis of angiogenesis and lymphangiogenesis in acellular human dermis Plast Reconstr Surg. 2008 Apr; 121(4):1144-52. . View in PubMed

Treatment of hydroxyapatite scaffolds with fibronectin and fetal calf serum increases osteoblast adhesion and proliferation in vitro Plast Reconstr Surg. 2008 Mar; 121(3):751-62. . View in PubMed

Soft-tissue coverage of the hand following sarcoma resection Plast Reconstr Surg. 2008 Feb; 121(2):534-43. . View in PubMed

The effect of hyperbaric oxygen treatment on squamous cell cancer growth and tumor hypoxia Ann Plast Surg. 2008 Jan; 60(1):81-8. . View in PubMed

Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7481-6. . View in PubMed

An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis Cancer Metastasis Rev. 2000; 19(1-2):121-9. . View in PubMed

Dr. Alex K. Wong is an Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery. He is the Director of our Microvascular Surgery Fellowship Program, Director of Basic, Translation, and Clinical Research, and Director for Medical Student Education.

Dr. Wong performs aesthetic surgery of the face, breast, and body. He has a special interest in breast augmentation with implants and autologous fat grafting. His reconstructive practice is focused on microsurgical free tissue transfer for the management of complex wounds, post-oncologic reconstruction, abdominal wall reconstruction, and lymphedema surgery. Dr. Wong has attending staff appointments at Keck University Hospital of USC, LAC+USC Medical Center, Huntington Memorial Hospital, and Garfield Medical Center.

Some of Dr. Wong's many qualifications include: Member of the Society of University Surgeons, American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, World Society for Reconstructive Microsurgery, and Plastic Surgery Research Council. He is a Diplomat of the American Board of Plastic Surgery and Fellow of the American College of Surgeons. Dr. Wong has been named one of Pasadena Magazine's Top Doctors for every year since 2010, and is on the list of SuperDoctors/Los Angeles Magazine.

As a member of the full time Keck School of Medicine USC faculty, Dr. Wong teaches and mentors the next generation of doctors and plastic surgeons. He serves as the Director of Plastic Surgery Visiting Clerkship at the Keck School of Medicine.

In addition to his clinical practice, Dr. Wong directs a research laboratory with focus areas in lymphedema, adult-derived stem cells and novel biologics for wound healing, molecular pathogenesis of silicone breast implant capsular contracture, and microvascular flap physiology. Dr. Wong has received multiple grants and awards from organizations such as the National Institutes of Health, Howard Hughes Medical Institute, Plastic Surgery Educational Foundation, American Society for Maxillofacial Surgery, Wright Foundation, Whittier Foundation, American Cancer Society, and Southern California-Clinical Translational Science Institute (SC-CTSI). His work has been published in a variety of high impact peer reviewed journals.

Prior to joining the faculty at USC, Dr. Wong completed his Fellowship training at the NYU Institute of Reconstructive Plastic Surgery and completed his formal Plastic Surgery residency at the University of Pittsburgh. Dr. Wong received his medical degree from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology and is an honors graduate of the College of Arts and Sciences of Cornell University.
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