Mark Masaru Urata, MD, DDS

Professor Of Clinical of Surgery

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Overview

Dr. Mark M. Urata is the Audrey Skirball-Kenis Chair and Chief of the Division of Plastic and Reconstructive Surgery of the Keck School of Medicine of USC. He is also Head of the Division of Plastic and Maxillofacial Surgery at Childrens Hospital Los Angeles and Director of Craniomaxillofacial Surgery at Cedars Sinai Medical Center. Dr. Urata is uniquely qualified with board certification in both Oral and Maxillofacial Surgery as well as Plastic Surgery and holds faculty appointments at both the Keck School of Medicine of USC and the USC School of Dentistry.
Dr. Urata trained for 18 years following his undergraduate education. He received his dental degree from the USC School of Dentistry and his medical degree from the USC Keck School of Medicine. He completed a residency in oral and maxillofacial surgery before matriculating to general surgery and then completing a residency in plastic and reconstructive surgery at USC. He then moved across town where he completed a fellowship in craniofacial surgery at the University of California, Los Angeles.

He specializes in the most complex craniofacial anomalies, including craniosynostosis, syndromic reconstruction, vascular anomalies, pediatric and adult craniomaxillofacial trauma, post-traumatic reconstruction, orthognathic surgery, aesthetic surgery of the head and neck and jaw deformities.

Dr. Urata has authored numerous scientific articles and book chapters and has been voted amongst the nation’s top surgeons according to multiple sources including U.S. News and World Report, Best Doctors and America’s Best Plastic Surgeons. He maintains NIH funded research within the Center for Craniofacial Molecular Biology related to defining TGF Beta signaling in palatogenesis. He is also interested in computerized planning of Le Fort III and orthognathic surgery and outcomes studies on cleft lip and palate.

Publications

From Bedside to Bench and Back: Advancing Our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future Cleft Palate Craniofac J. 2024 May; 61(5):759-773. . View in PubMed
A Single Institution 19 Year Comparison of Furlow and Straight Line Palatoplasty Techniques in Bilateral Cleft Lip and Palate Cleft Palate Craniofac J. 2024 Mar 17; 10556656241239203. . View in PubMed
A 10-Year Nationwide Analysis of Risk Factors of Readmission and the Implications of Same-Day Discharge Following Velopharyngeal Insufficiency Correcting Surgery Cleft Palate Craniofac J. 2024 Mar 15; 10556656241233248. . View in PubMed
Premaxillary Setback in Bilateral Cleft Lip and Palate Repair Cleft Palate Craniofac J. 2024 Mar; 61(3):416-421. . View in PubMed
A Calvarial Defect Model to Investigate the Osteogenic Potential of Umbilical Cord Stem Cells in Bone Regeneration Plast Reconstr Surg. 2024 Mar 01; 153(3):637-646. . View in PubMed
Comparing Outcomes of Traditional Lip Repair Versus Early Cleft Lip Repair on a National Scale Ann Plast Surg. 2024 Feb 01; 92(2):194-197. . View in PubMed
Dental Protraction Versus Surgery for Cleft Lip and Palate: A Budget Impact Analysis J Craniofac Surg. 2024 Jan-Feb 01; 35(1):129-132. . View in PubMed
Early Ophthalmology Findings in Nonsyndromic Craniosynostosis J Craniofac Surg. 2023 Jun 01; 34(4):1259-1261. . View in PubMed
Cleft Palate Craniofac J. 2023 04; 60(4):430-445. . View in PubMed
Rethinking the Rule of 10s: Early Cleft Lip Repair Improves Weight Gain Cleft Palate Craniofac J. 2023 03; 60(3):306-312. . View in PubMed
Orbital Foraminal Morphometrics in Nonsyndromic Unilateral Coronal Craniosynostosis Ann Plast Surg. 2023 06 01; 90(6S Suppl 5):S677-S680. . View in PubMed
Comparative Benefits of Open versus Closed Reduction of Condylar Fractures: A Systematic Review and Meta-Analysis Plast Reconstr Surg. 2023 04 01; 151(4):664e-672e. . View in PubMed
Craniofacial Dysmorphology in Infants With Non-Syndromic Unilateral Coronal Craniosynostosis J Craniofac Surg. 2022 Sep 01; 33(6):1903-1908. . View in PubMed
Syndromic Synostosis: Frontofacial Surgery Oral Maxillofac Surg Clin North Am. 2022 Aug; 34(3):459-466. . View in PubMed
Midface Growth Potential in Unoperated Clefts: A Systematic Review and Meta-Analysis J Craniofac Surg. 2022 May 01; 33(3):774-778. . View in PubMed
Establishing a Novel Treatment Algorithm for Pediatric Mandibular Tumor Reconstruction J Craniofac Surg. 2022 May 01; 33(3):744-749. . View in PubMed
Reconstructive Surgeons as Essential Operative Consultants: Quantifying the True Value of Plastic Surgeons to an Academic Medical Center Plast Reconstr Surg. 2022 Apr 01; 149(4):767e-773e. . View in PubMed
Increased Distraction Magnitude Leads to Greater Reduction in the Apnea-Hypopnea Index in Infants With Robin Sequence J Oral Maxillofac Surg. 2022 09; 80(9):1486-1492. . View in PubMed
Appropriateness of Computed Tomography Scanning in the Diagnosis of Craniosynostosis J Craniofac Surg. 2022 Jan-Feb 01; 33(1):222-225. . View in PubMed
Early Cleft Lip Repair: Demonstrating Efficacy in the First 100 Patients Plast Reconstr Surg. 2022 11 01; 150(5):1073-1080. . View in PubMed
The clinical manifestations, molecular mechanisms and treatment of craniosynostosis Dis Model Mech. 2022 04 01; 15(4). . View in PubMed
Orthognathic Surgery Rate in Cleft Care J Craniofac Surg. 2022 Jan-Feb 01; 33(1):87-92. . View in PubMed
Assessing the Safety of a Novel Neonatal Anesthesia Protocol: A Review of 101 Patients With Early Cleft Lip Repair J Craniofac Surg. 2021 Nov-Dec 01; 32(8):2682-2686. . View in PubMed
Sphenotemporal and Fronto-Orbital Dysmorphology in Unilateral Coronal Synostosis Using Geometric Morphometric Curve-Based Analysis J Craniofac Surg. 2021 Oct 01; 32(7):2449-2451. . View in PubMed
Cleft Lip and Palate: Le Fort I Distraction Using an Internal Device Clin Plast Surg. 2021 Jul; 48(3):407-417. . View in PubMed
Is Le Fort I Distraction Enough to Treat Severe Midface Hypoplasia? J Craniofac Surg. 2021 Jul-Aug 01; 32(5):1716-1720.. View in PubMed
Nasoalveolar Molding: Assessing the Burden of Care J Craniofac Surg. 2021 Mar-Apr 01; 32(2):574-577. . View in PubMed
Simultaneous LeFort III and LeFort I Osteotomies in Craniometaphyseal Dysplasia Cleft Palate Craniofac J. 2021 12; 58(12):1560-1568. . View in PubMed
Factors Associated With Delay in Cleft Surgery at a Tertiary Children’s Hospital in a Major US Metropolitan City Cleft Palate Craniofac J. 2021 12; 58(12):1508-1516. . View in PubMed
Postoperative helmet therapy following fronto-orbital advancement and cranial vault remodeling in patients with unilateral coronal synostosis Am J Med Genet A. 2021 09; 185(9):2670-2675. . View in PubMed
Mesenchymal stem cells and three-dimensional-osteoconductive scaffold regenerate calvarial bone in critical size defects in swine Stem Cells Transl Med. 2021 08; 10(8):1170-1183. . View in PubMed
Craniofacial Dysmorphology in Unilateral Coronal Synostosis Using Three-Dimensional Landmark-Based Analysis With Generalized Procrustes Superimposition J Craniofac Surg. 2021 Jan-Feb 01; 32(1):16-20. . View in PubMed
Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis Elife. 2021 01 22; 10. . View in PubMed
Reply: Simultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion Plast Reconstr Surg. 2021 09 01; 148(3):504e-505e. . View in PubMed
Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in CraniosynostosisCell. 2021 01 07; 184(1):243-256. e18. . View in PubMed
Rotation of the Ipsilateral Supraorbital Rim Around the Horizontal Axis in Unilateral Coronal Synostosis: A Craniometric Analysis of the Emergence Profile J Craniofac Surg. 2021 Jan-Feb 01; 32(1):168-172. . View in PubMed
Velopharyngeal Insufficiency Impact and Nasopharngoscopy Discomfort and Cooperation: Patient, Parent, and Provider Perspectives J Craniofac Surg. 2020 Sep; 31(6):1713-1716. . View in PubMed
Orthodontic Considerations for Cleft Orthognathic Surgery Oral Maxillofac Surg Clin North Am. 2020 May; 32(2):249-267. . View in PubMed
Temporal Fat Grafting in Children With Craniofacial Anomalies Ann Plast Surg. 2020 11; 85(5):505-510. . View in PubMed
Outcomes of Intracranial Versus Subcranial Approaches to the Frontofacial Skeleton J Oral Maxillofac Surg. 2020 09; 78(9):1609-1616. . View in PubMed
Simultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion Plast Reconstr Surg. 2020 06; 145(6):1067e-1072e. . View in PubMed
The Monobloc Distraction With Facial Bipartition: Outcomes of Simultaneous Multidimensional Facial Movement Compared With Monobloc Distraction or Facial Bipartition Alone Ann Plast Surg. 2020 05; 84(5S Suppl 4):S288-S294. . View in PubMed
Evaluation of Obstructive Sleep Apnea in Prone Versus Nonprone Body Positioning With Polysomnography in Infants With Robin Sequence Cleft Palate Craniofac J. 2020 02; 57(2):141-147. . View in PubMed
Sebaceous Nevus of the Scalp J Craniofac Surg. 2020 Jan/Feb; 31(1):257-260. . View in PubMed
Less Is More in Congenital and Pediatric Nasal Lesions J Craniofac Surg. 2019 Sep; 30(6):1777-1779. . View in PubMed
Cosmetically Challenging Congenital Melanocytic Nevi Ann Plast Surg. 2019 05; 82(5S Suppl 4):S306-S309. . View in PubMed
A Single Lab Test to Aid Pierre Robin Sequence Severity Diagnosis Cleft Palate Craniofac J. 2019 03; 56(3):298-306. . View in PubMed
Risk Factors for Preoperative Developmental Delay in Patients with Nonsyndromic Sagittal Craniosynostosis Plast Reconstr Surg. 2019 01; 143(1):133e-139e. . View in PubMed
Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars Elife. 2019 07 01; 8. . View in PubMed
Alternatives to Autologous Bone Graft in Alveolar Cleft Reconstruction: The State of Alveolar Tissue Engineering J Craniofac Surg. 2018 May; 29(3):584-593. . View in PubMed
Predictors of Failure in Infant Mandibular Distraction Osteogenesis J Oral Maxillofac Surg. 2018 09; 76(9):1955-1965. . View in PubMed
To Admit or Not to Admit: That is the Cleft Lip QuestionConfirming the Safety of Outpatient Cleft Lip Repair. Plast Reconstr Surg. 2018 07; 142(1):159-168. . View in PubMed
External Port Tissue Expansion in the Pediatric Population: Confirming Its Safety and Efficacy Plast Reconstr Surg. 2018 06; 141(6):883e-890e. . View in PubMed
Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care J Dent Res. 2018 04; 97(4):361-363. . View in PubMed
Impact of the Distance of Maxillary Advancement on Horizontal Relapse After Orthognathic Surgery Cleft Palate Craniofac J. 2018 04; 55(4):546-553. . View in PubMed
Is Postoperative Intensive Care Unit Care Necessary following Cranial Vault Remodeling for Sagittal Synostosis? Plast Reconstr Surg. 2017 Dec; 140(6):1235-1239.. View in PubMed
Proteus Syndrome With a Cranial Intraosseous Lipoma J Craniofac Surg. 2017 Nov; 28(8):e771-e773. . View in PubMed
Three-Dimensional Cone Beam Computed Tomography Volumetric Outcomes of rhBMP-2/Demineralized Bone Matrix versus Iliac Crest Bone Graft for Alveolar Cleft Reconstruction Plast Reconstr Surg. 2017 Oct; 140(4):767-774. . View in PubMed
A Comparative Analysis of Recombinant Human Bone Morphogenetic Protein-2 with a Demineralized Bone Matrix versus Iliac Crest Bone Graft for Secondary Alveolar Bone Grafts in Patients with Cleft Lip and Palate: Review of 501 Cases Plast Reconstr Surg. 2017 Aug; 140(2):318e-325e. . View in PubMed
Early Cleft Lip Repair Revisited: A Safe and Effective Approach Utilizing a Multidisciplinary Protocol Plast Reconstr Surg Glob Open. 2017 Jun; 5(6):e1340. . View in PubMed
Familial Recurrence of 3MC Syndrome in Consanguineous Families: A Clinical and Molecular Diagnostic Approach With Review of the Literature Cleft Palate Craniofac J. 2017 11; 54(6):739-748. . View in PubMed
Surgical Management of Obstructive Sleep Apnea Plast Reconstr Surg. 2016 Apr; 137(4):1263-1272. . View in PubMed
Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study Eur Heart J. 2016 Mar 14; 37(11):890-899. . View in PubMed
Focusing Quality Improvement Initiatives in Pediatric Plastic Surgery: A Descriptive Study Using the Pediatric National Surgical Quality Improvement Program J Craniofac Surg. 2016 Mar; 27(2):277-81. . View in PubMed
Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury Stem Cells Dev. 2016 12 01; 25(23):1801-1807. . View in PubMed
Intracranial hypertension after surgical correction for craniosynostosis: a systematic review Neurosurg Focus. 2015 May; 38(5):E6. . View in PubMed
The suture provides a niche for mesenchymal stem cells of craniofacial bones Nat Cell Biol. 2015 Apr; 17(4):386-96. . View in PubMed
Current Status of Surgical Planning for Orthognathic Surgery: Traditional Methods versus 3D Surgical Planning Plast Reconstr Surg Glob Open. 2015 Feb; 3(2):e307. . View in PubMed
Natural large-scale regeneration of rib cartilage in a mouse model J Bone Miner Res. 2015 Feb; 30(2):297-308. . View in PubMed
Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database Microsurgery. 2015 Jan; 35(1):6-12. . View in PubMed
A model for interprofessional health care: lessons learned from craniofacial teams J Calif Dent Assoc. 2014 Sep; 42(9):637-44. . View in PubMed
Assessment of three-dimensional high-definition visualization technology to perform microvascular anastomosis J Plast Reconstr Aesthet Surg. 2014 Jul; 67(7):967-72. . View in PubMed
Partial craniofacial duplication: a review of the literature and case report J Craniomaxillofac Surg. 2014 Jun; 42(4):290-6. . View in PubMed
Defining the role for submental intubation J Clin Anesth. 2014 May; 26(3):238-42. . View in PubMed
Freeman-Sheldon syndrome and respiratory obstruction: a novel use of distraction osteogenesis J Craniofac Surg. 2014 May; 25(3):e287-9. . View in PubMed
Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers J Plast Reconstr Aesthet Surg. 2014 Feb; 67(2):e42-8. . View in PubMed
TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate Development. 2014 Feb; 141(4):909-17. . View in PubMed
Injectable gel graft for bone defect repair Regen Med. 2014 Jan; 9(1):41-51. . View in PubMed
Incorporation of fresh tissue surgical simulation into plastic surgery education: maximizing extraclinical surgical experience J Surg Educ. 2013 Jul-Aug; 70(4):466-74. . View in PubMed
rhBMP-2 with a demineralized bone matrix scaffold versus autologous iliac crest bone graft for alveolar cleft reconstruction Plast Reconstr Surg. 2013 May; 131(5):1107-1115. . View in PubMed
Paediatric presentation and outcome of congenital protein C deficiency in Japan Haemophilia. 2013 May; 19(3):378-84. . View in PubMed
Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice Development. 2013 Mar; 140(6):1220-30. . View in PubMed
Scalp erosion in ankyloblepharon-ectodermal defect-cleft lip and/or palate (AEC syndrome): treatment with acellular dermal matrix J Craniofac Surg. 2013 Jan; 24(1):e28-30. . View in PubMed
Mandibular distraction instead of tracheostomy in Pierre Robin sequence patients: is it worth it? Plast Reconstr Surg. 2012 Nov; 130(5):766e-767e.. View in PubMed
Vector control in internal midface distraction using temporary anchorage devices J Craniofac Surg. 2012 Nov; 23(7 Suppl 1):2000-3. . View in PubMed
Multifocal lipoblastoma of the face J Craniofac Surg. 2012 Nov; 23(6):e585-7. . View in PubMed
The nance obturator, a new fixed obturator for patients with cleft palate and fistula J Prosthodont. 2012 Jul; 21(5):400-3. . View in PubMed
Solving convergent vector problems with internal maxillary distractors through the use of a fixed rapid palatal expander J Oral Maxillofac Surg. 2012 Jul; 70(7):e428-30. . View in PubMed
Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice J Clin Invest. 2012 Mar; 122(3):873-85. . View in PubMed
Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis J Biol Chem. 2012 Jan 20; 287(4):2353-63. . View in PubMed
Neonatal and infant mandibular distraction as an alternative to tracheostomy in severe obstructive sleep apnea Cleft Palate Craniofac J. 2012 Jan; 49(1):32-8. . View in PubMed
Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups Clin Epidemiol. 2012; 4:187-91. . View in PubMed
Nasofrontal heterotopic ossification following lymphangioma resection J Craniofac Surg. 2011 Nov; 22(6):2381-4. . View in PubMed
A mandibular mass in a pediatric patient J Oral Maxillofac Surg. 2011 Jun; 69(6):1661-7. . View in PubMed
Delayed middle cranial fossa perforation after autologous temporomandibular joint reconstruction J Oral Maxillofac Surg. 2011 Jun; 69(6):1613-6. . View in PubMed
Is presurgical nasoalveolar molding therapy more effective in unilateral or bilateral cleft lip-cleft palate patients? Plast Reconstr Surg. 2011 Mar; 127(3):1263-1269.. View in PubMed
Heteropagus (parasitic) twins: a review J Pediatr Surg. 2010 Dec; 45(12):2454-63. . View in PubMed
Adolescent orofacial injury: association with psychological symptoms Psychol Health Med. 2010 Oct; 15(5):574-83. . View in PubMed
Review of options for burned ear reconstruction J Craniofac Surg. 2010 Jul; 21(4):1165-9. . View in PubMed
TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis Dev Biol. 2010 May 01; 341(1):186-95. . View in PubMed
Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells J Biol Chem. 2010 Feb 12; 285(7):4975-82. . View in PubMed
Misleading presentation of an orbital lymphangioma Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb; 109(2):e82-5. . View in PubMed
Factors associated with orofacial injury and willingness to participate in interventions among adolescents treated in trauma centers J Oral Maxillofac Surg. 2009 Dec; 67(12):2627-35. . View in PubMed
Recurrent and refractory giant cell tumor of the jaw J Craniofac Surg. 2009 Nov; 20(6):2245-8. . View in PubMed
Epithelial-specific requirement of FGFR2 signaling during tooth and palate development J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):343-50. . View in PubMed
Bilateral complex odontomas: a rare complication of external mandibular distraction in the neonate J Craniofac Surg. 2009 May; 20(3):973-6. . View in PubMed
Clinical applications of orthodontic microimplant anchorage in craniofacial patients Cleft Palate Craniofac J. 2009 Mar; 46(2):136-46. . View in PubMed
Pneumosinus dilatans: a rare cause of frontal sinus expansion–case report and review of literature J Oral Maxillofac Surg. 2008 Nov; 66(11):2380-6. . View in PubMed
Amblyogenic anisometropia in the contralateral eye in unicoronal craniosynostosis J AAPOS. 2008 Oct; 12(5):471-6. . View in PubMed
Postoperative alopecia following orthognathic surgery J Oral Maxillofac Surg. 2008 Sep; 66(9):1957-8. . View in PubMed
Superior results using the islandized hemipalatal flap in palatoplasty: experience with 500 cases Plast Reconstr Surg. 2008 Jul; 122(1):232-239. . View in PubMed
TGF-beta signaling and aplasia cutis congenita: proposed animal model J Calif Dent Assoc. 2007 Dec; 35(12):865-9. . View in PubMed
Images in clinical medicineCocaine-induced palatal perforation. N Engl J Med. 2007 Nov 08; 357(19):1956. . View in PubMed
TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development Dev Biol. 2007 Oct 01; 310(1):140-53. . View in PubMed
A novel model surgery technique for LeFort III advancement J Craniofac Surg. 2007 Sep; 18(5):1230-5. . View in PubMed
Telogen effluvium following orthognathic surgery J Oral Maxillofac Surg. 2007 Jul; 65(7):1393-5. . View in PubMed
Facial nerve paralysis: a complication of distraction osteogenesis of the mandibular ramus in the treatment of temporomandibular joint ankylosis J Craniofac Surg. 2007 Jul; 18(4):844-8. . View in PubMed
Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion Dev Biol. 2006 Sep 01; 297(1):238-48. . View in PubMed
TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development Development. 2006 Jan; 133(2):371-81. . View in PubMed
Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing J Invest Dermatol. 2005 Dec; 125(6):1302-9. . View in PubMed
The separation of Guatemalan craniopagus twins Childs Nerv Syst. 2004 Aug; 20(8-9):593-600. . View in PubMed
Multifocal papillary apocrine adenoma arising in a systematized linear epidermal nevus Cutis. 2004 May; 73(5):348-52. . View in PubMed
Median clefts of the upper lip: a review and surgical management of a minor manifestation J Craniofac Surg. 2003 09; 14(5):749-55. . View in PubMed
Confocal microscopic analysis of scarless repair in the fetal rat: defining the transition Plast Reconstr Surg. 2002 Jan; 109(1):160-70. . View in PubMed
Comparative evaluation of screw configuration on the stability of the sagittal split osteotomy Oral Surg Oral Med Oral Pathol. 1989 Aug; 68(2):125-9. . View in PubMed
Monoclonal antibody to the streptococcal preparation OK-432: tissue OK-432 localization and analysis of interaction between OK-432 and macrophages or NK cells in human salivary adenocarcinoma-bearing nude mice given OK-432 J Biol Response Mod. 1988 Apr; 7(2):212-28. . View in PubMed
An odontogenic myxofibroma related to an embedded third molar of the mandibleReport of a case. Int J Oral Surg. 1982 Aug; 11(4):265-9. . View in PubMed

Mark Masaru Urata, MD, DDS

Overview

Publications

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