Principal Investigators
Zhongwei Li
Contact
NIH: NIH Director's New Innovator Award, 2022
University of Southern California: "Heros Among Us" Medal, 2022
School of Life Sciences of Tsinghua University: Representative Alumni Award, 2021
Keck School of Medicine of USC: Dean's Pilot Award, 2019
Wright Foundation: Wright Foundation Pilot Award, 2018
Institute of Scientific and Technical Information of China (ISTIC): Top 100 Influential Research Articles in China (2012), 2013
Johnson & Johnson: "Johnson & Johnson Asia Outstanding Thesis Award in Bio-tech", 1st Prize, 2012
Ray Wu Memorial Fund: Ray Wu Prize, 2012
City of Beijing: Outstanding Ph.D. Graduate Award, 2012
Tsinghua University: Outstanding Ph.D. Graduate Award, 2012
Tsinghua University: Outstanding Ph.D. Thesis Award, 2012
Sichuan University: Outstanding Undergraduate Award, 2007
Sichuan University: Outstanding Undergraduate Thesis Award, 2007
Approaches to kidney replacement therapies-opportunities and challenges Front Cell Dev Biol. 2022; 10:953408. . View in PubMed
Building a kidney tree: Functional collecting duct from human pluripotent stem cells Dev Cell. 2022 10 10; 57(19):2251-2253. . View in PubMed
Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing Nat Commun. 2022 06 25; 13(1):3646. . View in PubMed
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors Nat Commun. 2021 06 15; 12(1):3641. . View in PubMed
Epigenetic regulation of kidney progenitor cells Stem Cells Transl Med. 2020 Jun; 9(6):655-660. . View in PubMed
A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells Cell Rep. 2020 04 07; 31(1):107476. . View in PubMed
Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates J Tissue Eng Regen Med. 2019 09; 13(9):1724-1731. . View in PubMed
Gene Editing in 3D Cultured Nephron Progenitor Cell Lines Methods Mol Biol. 2019; 1926:151-159. . View in PubMed
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic PotencyCell. 2017 04 06; 169(2):243-257. e25. . View in PubMed
Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells J Biol Chem. 2017 01 27; 292(4):1339-1350. . View in PubMed
3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors Cell Stem Cell. 2016 10 06; 19(4):516-529. . View in PubMed
Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor J Biol Chem. 2015 Sep 04; 290(36):22019-29. . View in PubMed
An alternative pluripotent state confers interspecies chimaeric competency Nature. 2015 May 21; 521(7552):316-21. . View in PubMed
BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells J Biol Chem. 2013 Mar 22; 288(12):8053-8060. . View in PubMed
Functions of BMP signaling in embryonic stem cell fate determination Exp Cell Res. 2013 Jan 15; 319(2):113-9. . View in PubMed
TGF-ß in Human Disease (Chapter 2) 2013. . View in PubMed
Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells Protein Cell. 2012 Jun; 3(6):401-4. . View in PubMed
Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate Cell Stem Cell. 2012 Mar 02; 10(3):231-2. . View in PubMed
BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells Cell Stem Cell. 2012 Feb 03; 10(2):171-82. . View in PubMed
Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells Cell Res. 2010 Dec; 20(12):1306-18. . View in PubMed
Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination Genome Res. 2010 Jan; 20(1):36-44. . View in PubMed
