USC Cancer Epidemiology Seminar Series: The Mutagenic Forces Shaping the Genomic Landscape of Lung Cancer

The Mutagenic Forces Shaping the Genomic Landscape of Lung Cancer

We are excited to announce this USC Cancer Epidemiology Seminar Series talk from Dr. Maria Teresa Landi. Dr. Landi is an M.D., Ph.D. with training in clinical oncology and molecular epidemiology. She is Senior Investigator in the NCI Division of Cancer Epidemiology and Genetics. She focuses her research on the genetic and environmental determinants of lung cancer and melanoma, and on the genomic characterization of these tumors. She is PI of both EAGLE and Sherlock-Lung, two landmark studies of lung cancer in smokers and never smokers, respectively, which identified subtypes with distinct genomic features, mutational signatures, and evolutionary trajectories.

Talk Summary: In this talk, Dr. Landi will briefly describe the Sherlock-Lung study, and report on the mutational signatures identified in lung cancer from never smokers and their implications for understanding cancer etiology. Dr. Landi will then describe how even a mutational signature of a previously unknown mutational process was key to identify a new mechanism shaping lung cancer tumor evolution.

Zoom link: https://usc.zoom.us/j/95873416446?pwd=KKg9M4RHaMzeUOJba6L8yow63PNv4V.1