Faculty

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Rema Raman, PhD
Professor of Neurology
Director, Biostatistics Core
Neurology
ATR 9860 Mesa Rim Road Health Sciences Campus San Diego
+1 858 964 0673

Overview

Rema Raman, PhD, is a tenured Professor of Neurology at the Keck School of Medicine of the University of Southern California (USC) and the Director of Biostatistics of USC’s Alzheimer’s Therapeutic Research Institute (ATRI). She received her training in biostatistics from the School of Public Health at the University of Illinois at Chicago. Her statistical research interests are in efficient clinical trial design and monitoring approaches (risk-based monitoring, data visualization), and correlated data analysis topics (impact of missing data, analysis of ordinal data). Dr. Raman has extensive experience as a biostatistician in biomedical research projects, providing biostatistics and data management leadership to the design, coordination, conduct and analyses of clinical trials and large observational studies. She has served or currently serves as the primary statistician for several, multi-center clinical trials in Alzheimer’s disease, acute stroke, post-traumatic stress disorder, and traumatic brain injury. She is a regular member of two NIH study sections, an ad-hoc member on several others and serves as the Biostatistician on several Data and Safety Monitoring Boards.

Publications

Accuracy of Stroke Diagnosis in Telestroke-Guided Tissue Plasminogen Activator Patients. J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2942-2946. View in: PubMed

Visual Determination of Conjugate Eye Deviation on Computed Tomography Scan Predicts Diagnosis of Stroke Code Patients. J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2809-2813. View in: PubMed

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2). Stroke. 2016 Nov 10. View in: PubMed

Telephone Problem Solving for Service Members with Mild Traumatic Brain Injury: A Randomized, Clinical Trial. J Neurotrauma. 2016 Oct 13. View in: PubMed

Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016 Aug 10; 54(1):373-81. View in: PubMed

Randomized Controlled Trial of Acceptance and Commitment Therapy for Distress and Impairment in OEF/OIF/OND Veterans. Psychol Trauma. 2016 Jun 20. View in: PubMed

Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology. 2016 Apr; 41(5):1191-8. View in: PubMed

Feasibility and Safety of Using External Counterpulsation to Augment Cerebral Blood Flow in Acute Ischemic Stroke-The Counterpulsation to Upgrade Forward Flow in Stroke (CUFFS) Trial. J Stroke Cerebrovasc Dis. 2015 Nov; 24(11):2596-604. View in: PubMed

Accuracy of First Recorded "Last Known Normal" Times of Stroke Code Patients. J Stroke Cerebrovasc Dis. 2015 Nov; 24(11):2467-73. View in: PubMed

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. View in: PubMed

Defining mild stroke: outcomes analysis of treated and untreated mild stroke patients. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1276-81. View in: PubMed

The "DeyeCOM Sign": Predictive Value in Acute Stroke Code Evaluations. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1299-304. View in: PubMed

Mental Disorders, Comorbidity, and Pre-enlistment Suicidal Behavior Among New Soldiers in the U. S. Army: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Suicide Life Threat Behav. 2015 Jan 26. View in: PubMed

Peripheral and central effects of ?-secretase inhibition by semagacestat in Alzheimer's disease. Alzheimers Res Ther. 2015; 7(1):36. View in: PubMed

Prevalence and correlates of suicidal behavior among new soldiers in the u. s. Army: results from the army study to assess risk and resilience in servicemembers (army starrs). Depress Anxiety. 2015 Jan; 32(1):3-12. View in: PubMed

Association of Hispanic ethnicity with acute ischemic stroke care processes and outcomes. Ethn Dis. 2015; 25(1):19-23. View in: PubMed

Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials. Alzheimers Res Ther. 2015; 7(1):39. View in: PubMed

Alzheimer's disease progression by geographical region in a clinical trial setting. Alzheimers Res Ther. 2015; 7(1):43. View in: PubMed

Concussion treatment after combat trauma: Development of a telephone based, problem solving intervention for service members. Contemp Clin Trials. 2015 Jan; 40:54-62. View in: PubMed

Estimating long-term multivariate progression from short-term data. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S400-10. View in: PubMed

Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines. Clin Infect Dis. 2014 Oct; 59(7):962-8. View in: PubMed

Banks SJ, Raman R, He F, Salmon DP, Ferris S, Aisen P, Cummings J. The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline. Dement Geriatr Cogn Dis Extra. 2014 Sep-Dec; 4(3):509-16. View in: PubMed

Banks SJ, Raman R, He F, Salmon DP, Ferris S, Aisen P, Cummings J. The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline. Dement Geriatr Cogn Dis Extra. 2014 Sep-Dec; 4(3):509-16. View in: PubMed

Individuals with chronic traumatic brain injury improve walking speed and mobility with intensive mobility training. Arch Phys Med Rehabil. 2014 Aug; 95(8):1454-60. View in: PubMed

The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol. 2014 Aug; 71(8):961-70. View in: PubMed

Self-reported smoking and musculoskeletal overuse injury among male and female U. S. Marine Corps recruits. Mil Med. 2014 Jul; 179(7):735-43. View in: PubMed

A two-site pilot randomized 3 day trial of high dose left prefrontal repetitive transcranial magnetic stimulation (rTMS) for suicidal inpatients. Brain Stimul. 2014 May-Jun; 7(3):421-31. View in: PubMed

Imaging negative stroke: diagnoses and outcomes in intravenous tissue plasminogen activator-treated patients. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):1046-50. View in: PubMed

Does symptom onset to primary stroke center time goals affect stroke outcome? J Stroke Cerebrovasc Dis. Does symptom onset to primary stroke center time goals affect stroke outcome? J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):993-1000. View in: PubMed

Pooled assessment of computed tomography interpretation by vascular neurologists in the STRokE DOC telestroke network. J Stroke Cerebrovasc Dis. 2014 Mar; 23(3):511-5. View in: PubMed

Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition. Alzheimers Dement. 2014 Mar; 10(2):171-8. View in: PubMed

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23; 370(4):311-21. View in: PubMed

Effect of head impacts on diffusivity measures in a cohort of collegiate contact sport athletes. Neurology. 2014 Jan 7; 82(1):63-9. View in: PubMed

Weight patterns before and after total joint arthroplasty and characteristics associated with weight change. Perm J. 2014; 18(1):25-31. View in: PubMed

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol. Int J Stroke. 2014 Jan; 9(1):117-25. View in: PubMed

Epidemiology of pathogen-specific respiratory infections among three US populations. PLoS One. 2014; 9(12):e114871. View in: PubMed

Parametric comparisons of intracranial mechanical responses from three validated finite element models of the human head. Ann Biomed Eng. 2014 Jan; 42(1):11-24. View in: PubMed

Trends in antihypertensive drug prescription patterns among ambulatory stroke patients in the United States, 2000-2009. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):e568-75. View in: PubMed

Diffusion-weighted imaging-fluid attenuated inversion recovery mismatch in nocturnal stroke patients with unknown time of onset. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):972-7. View in: PubMed

A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med. 2013 Jul 25; 369(4):341-50. View in: PubMed

Determinants of Pneumonia Risk During Endovascular Hypothermia. Ther Hypothermia Temp Manag. 2013 Mar; 3(1):24-27. View in: PubMed

Effect of study partner on the conduct of Alzheimer disease clinical trials. Neurology. 2013 Jan 15; 80(3):282-8. View in: PubMed

Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis. J Ther Ultrasound. 2013; 1:18. View in: PubMed

The association of self-reported measures with poor training outcomes among male and female U. S. Navy recruits. Mil Med. 2013 Jan; 178(1):43-9. View in: PubMed

Intravenous tissue plasminogen activator for patients with minor ischemic stroke. J Stroke Cerebrovasc Dis. 2012 Nov; 21(8):732-6. View in: PubMed

CT interpretation in a telestroke network: agreement among a spoke radiologist, hub vascular neurologist, and hub neuroradiologist. Stroke. 2012 Nov; 43(11):3095-7. View in: PubMed

Late night activity regarding stroke codes: LuNAR strokes. Int J Stroke. 2012 Aug; 7(6):473-6. View in: PubMed

Age and rate of cognitive decline in Alzheimer disease: implications for clinical trials. Arch Neurol. 2012 Jul; 69(7):901-5. View in: PubMed

Determinants of effective cooling during endovascular hypothermia. Neurocrit Care. 2012 Jun; 16(3):413-20. View in: PubMed

Assessment of long-term outcomes for the STRokE DOC telemedicine trial. J Stroke Cerebrovasc Dis. 2012 May; 21(4):259-64. View in: PubMed

Efficacy of telemedicine for stroke: pooled analysis of the Stroke Team Remote Evaluation Using a Digital Observation Camera (STRokE DOC) and STRokE DOC Arizona telestroke trials. Telemed J E Health. 2012 Apr; 18(3):230-7. View in: PubMed

Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol. 2012 Mar; 69(3):368-72. View in: PubMed

Evaluating transdiagnostic treatment for distress and impairment in veterans: a multi-site randomized controlled trial of Acceptance and Commitment Therapy. Contemp Clin Trials. 2012 Jan; 33(1):116-23. View in: PubMed

Comprehensive stroke centers and the 'weekend effect': the SPOTRIAS experience. Cerebrovasc Dis. 2012; 34(5-6):424-9. View in: PubMed

Two-hour improvement of patients in the National Institute of Neurological Disorders and Stroke trials and prediction of final outcome. Stroke. 2011 Nov; 42(11):3163-7. View in: PubMed

Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry. 2011 Aug; 68(8):853-61. View in: PubMed

Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease. Alzheimer Dis Assoc Disord. 2011 Apr-Jun; 25(2):122-7. View in: PubMed

Therapeutic hypothermia is associated with a decrease in urine output in acute stroke patients. Resuscitation. 2010 Dec; 81(12):1642-7. View in: PubMed

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial. JAMA. 2010 Nov 3; 304(17):1903-11. View in: PubMed

Alberta Stroke Program Early CT Score (ASPECTS) in patients with wake-up stroke. J Stroke Cerebrovasc Dis. 2010 Nov-Dec; 19(6):475-9. View in: PubMed

Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke. 2010 Oct; 41(10):2265-70. View in: PubMed

Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment. Alzheimers Dement. 2010 Sep; 6(5):412-9. View in: PubMed

Gender differences in acute stroke treatment: the University of California San Diego experience. Stroke. 2010 Aug; 41(8):1755-7. View in: PubMed

Analysis of the National Institute of Neurological Disorders and Stroke tissue plasminogen activator studies following European Cooperative Acute Stroke Study III patient selection criteria. J Stroke Cerebrovasc Dis. 2010 Jul-Aug; 19(4):290-3. View in: PubMed

Stroke team remote evaluation using a digital observation camera in Arizona: the initial mayo clinic experience trial. Stroke. 2010 Jun; 41(6):1251-8. View in: PubMed

Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement. 2010 May; 6(3):239-46. View in: PubMed

MRI substudy participation in Alzheimer disease (AD) clinical trials: baseline comparability of a substudy sample to entire study population. Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):333-6. View in: PubMed

Injury-specific predictors of posttraumatic stress disorder. Injury. 2009 Sep; 40(9):1004-10. View in: PubMed

Characteristics and performance of a modified version of the ADCS-CGIC CIBIC+ for mild cognitive impairment clinical trials. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):260-7. View in: PubMed

National Institutes of Health Stroke Scale certification is reliable across multiple venues. Stroke. 2009 Jul; 40(7):2507-11. View in: PubMed

Clinical interview assessment of financial capacity in older adults with mild cognitive impairment and Alzheimer's disease. J Am Geriatr Soc. 2009 May; 57(5):806-14. View in: PubMed

Plasma urate and progression of mild cognitive impairment. Neurodegener Dis. 2009; 6(1-2):23-8. View in: PubMed

In vitro sonothrombolysis with duplex ultrasound: first results using a simplified model. Cerebrovasc Dis. 2009; 28(4):365-70. View in: PubMed

Can comprehensive stroke centers erase the 'weekend effect'? Cerebrovasc Dis. Can comprehensive stroke centers erase the 'weekend effect'? Cerebrovasc Dis. 2009; 27(2):107-13. View in: PubMed

Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study. Lancet Neurol. 2008 Sep; 7(9):787-95. View in: PubMed

Awareness of deficits in financial abilities in patients with mild cognitive impairment: going beyond self-informant discrepancy. Am J Geriatr Psychiatry. 2008 Aug; 16(8):650-9. View in: PubMed

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol. 2008 Aug; 65(8):1031-8. View in: PubMed

Reliability of site-independent telemedicine when assessed by telemedicine-naive stroke practitioners. J Stroke Cerebrovasc Dis. 2008 Jul-Aug; 17(4):181-6. View in: PubMed

The first puff: forces in smoking initiation among Californians of Korean descent. Nicotine Tob Res. 2007 Dec; 9(12):1277-86. View in: PubMed

Quetiapine for agitation or psychosis in patients with dementia and parkinsonism. Neurology. 2007 Apr 24; 68(17):1356-63. View in: PubMed

An expedited code stroke protocol is feasible and safe. Stroke. 2006 Dec; 37(12):2935-9. View in: PubMed

ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S124-38. View in: PubMed

ADCS Prevention Instrument Project: behavioral measures in primary prevention trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S147-51. View in: PubMed

ADCS Prevention Instrument Project: the Mail-In Cognitive Function Screening Instrument (MCFSI). Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S170-8. View in: PubMed

NIHSS training and certification using a new digital video disk is reliable. Stroke. 2005 Nov; 36(11):2446-9. View in: PubMed

Divalproex sodium in nursing home residents with possible or probable Alzheimer Disease complicated by agitation: a randomized, controlled trial. Am J Geriatr Psychiatry. 2005 Nov; 13(11):942-9. View in: PubMed

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25; 307(5713):1282-8. View in: PubMed

Are there differences in risk factor profiles and frequency of CT/MRI-based infarcts among African American stroke patients with and without hypertension? A report from the African American Antiplatelet Stroke Prevention Study (AAASPS). J Natl Med Assoc. 2003 Jun; 95(6):423-32. View in: PubMed

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