Faculty

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Peter Kuhn, PhD
Professor
Broad CIRM Center
TRF 114A University Park Campus Los Angeles
+1 213 821 3980

Publications

. View in: PubMed

Robotic salvage retroperitoneal and pelvic lymph node dissection for 'node-only' recurrent prostate cancer: technique and initial series. BJU Int. 2017 Sep; 120(3):401-408. View in: PubMed

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters. Clin Cancer Res. 2017 Apr 01; 23(7):1722-1732. View in: PubMed

Vasculogenic mimicry in small cell lung cancer. Nat Commun. 2016 Nov 09; 7:13322. View in: PubMed

The prothrombotic activity of cancer cells in the circulation. Blood Rev. 2016 Jan; 30(1):11-9. View in: PubMed

A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016 Jan 01; 22(1):61-8. View in: PubMed

A physical sciences network characterization of circulating tumor cell aggregate transport. Am J Physiol Cell Physiol. 2015 May 15; 308(10):C792-802. View in: PubMed

Fourier-ring descriptor to characterize rare circulating cells from images generated using immunofluorescence microscopy. Comput Med Imaging Graph. 2015 Mar; 40:70-87. View in: PubMed

The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation. Am J Physiol Cell Physiol. 2015 Feb 01; 308(3):C229-36. View in: PubMed

Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. Phys Biol. 2015 Jan 09; 12(1):016008. View in: PubMed

Spatiotemporal progression of metastatic breast cancer: a Markov chain model highlighting the role of early metastatic sites. NPJ Breast Cancer. 2015; 1:15018. View in: PubMed

Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PLoS One. 2015; 10(5):e0127081. View in: PubMed

Entropy, complexity, and Markov diagrams for random walk cancer models. Sci Rep. 2014 Dec 19; 4:7558. View in: PubMed

Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer. Drug Dev Res. 2014 Sep; 75(6):384-92. View in: PubMed

Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol. 2014 Aug; 9(8):1111-9. View in: PubMed

Adrenal metastases in lung cancer: clinical implications of a mathematical model. J Thorac Oncol. 2014 Apr; 9(4):442-6. View in: PubMed

Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Phys Biol. 2014 Feb; 11(1):016002. View in: PubMed

Physical biology in cancer. 2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol. 2014 Jan 15; 306(2):C80-8. View in: PubMed

Entropy, complexity, and Markov diagrams for random walk cancer models. Sci Rep. 2014; 4:7558. View in: PubMed

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PLoS One. 2014; 9(8):e101777. View in: PubMed

Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer Res. 2013 May 1; 73(9):2760-9. View in: PubMed

Spreaders and sponges define metastasis in lung cancer: a Markov chain Monte Carlo mathematical model. Cancer Res. 2013 May 01; 73(9):2760-9. View in: PubMed

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov. 2013 01; 12(1):25-34. View in: PubMed

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov. 2013 Jan; 12(1):25-34. View in: PubMed

An observational study of circulating tumor cells and (18)F-FDG PET uptake in patients with treatment-naive non-small cell lung cancer. PLoS One. 2013; 8(7):e67733. View in: PubMed

A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. View in: PubMed

Fluid biopsy for solid tumors: a patient's companion for lifelong characterization of their disease. Future Oncol. 2012 Aug; 8(8):989-98. View in: PubMed

Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med. 2012 Mar 21; 4(126):126ra33. View in: PubMed

Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3731-6. View in: PubMed

Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. 2012 Feb; 9(1):016001. View in: PubMed

Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol. 2012 Feb; 9(1):016003. View in: PubMed

A fluid biopsy as investigating technology for the fluid phase of solid tumors. Phys Biol. 2012 Feb; 9(1):010301. View in: PubMed

High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol. 2012 Feb; 9(1):016004. View in: PubMed

Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line. Phys Biol. 2012 Feb; 9(1):016002. View in: PubMed

Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol. 2012 Feb; 9(1):016005. View in: PubMed

Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Front Oncol. 2012; 2:72. View in: PubMed

A stochastic Markov chain model to describe lung cancer growth and metastasis. PLoS One. 2012; 7(4):e34637. View in: PubMed

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Front Oncol. 2012; 2:96. View in: PubMed

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19; 330(6007):1066-71. View in: PubMed

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10708-12. View in: PubMed

Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10708-12. View in: PubMed

Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family. J Virol. 2010 Mar; 84(6):3059-67. View in: PubMed

Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol. 2010; 2010:861341. View in: PubMed

Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3. J Virol. 2009 Dec; 83(24):12998-3008. View in: PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. View in: PubMed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. J Virol. 2009 Oct; 83(19):10314-8. View in: PubMed

Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet. 2009 Sep; 85(3):328-37. View in: PubMed

Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med. 2009 Sep; 133(9):1468-71. View in: PubMed

A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5252-7. View in: PubMed

Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J Virol. 2009 Feb; 83(4):1823-36. View in: PubMed

Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol. 2008 Jul 25; 380(5):828-43. View in: PubMed

Enthalpy array analysis of enzymatic and binding reactions. Anal Biochem. 2008 Jun 01; 377(1):33-9. View in: PubMed

A specific cholesterol binding site is established by the 2. 8 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. View in: PubMed

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol. 2008 Jun; 82(11):5279-94. View in: PubMed

Enthalpy array analysis of enzymatic and binding reactions. Anal Biochem. 2008 Jun 1; 377(1):33-9. View in: PubMed

C-ME: a 3D community-based, real-time collaboration tool for scientific research and training. PLoS One. 2008 Feb 20; 3(2):e1621. View in: PubMed

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. View in: PubMed

C-ME: a 3D community-based, real-time collaboration tool for scientific research and training. PLoS One. 2008; 3(2):e1621. View in: PubMed

Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem. 2007 Dec 14; 282(50):36505-13. View in: PubMed

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23; 318(5854):1258-65. View in: PubMed

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J Virol. 2007 Nov; 81(21):12049-60. View in: PubMed

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expr Purif. 2007 Nov; 56(1):85-92. View in: PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J Virol. 2007 Jun; 81(12):6700-8. View in: PubMed

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J Virol. 2007 Jun; 81(11):5637-48. View in: PubMed

Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex. Protein Expr Purif. 2007 May; 53(1):51-62. View in: PubMed

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. J Virol. 2007 Apr; 81(8):3913-21. View in: PubMed

Case study of the morphologic variation of circulating tumor cells. Hum Pathol. 2007 Mar; 38(3):514-9. View in: PubMed

Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem. 2006 Sep 22; 281(38):28185-92. View in: PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2. 06 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. View in: PubMed

Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol. 2006 Aug; 80(16):7918-28. View in: PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol. 2006 Aug; 80(16):7894-901. View in: PubMed

Crystal structure of TM1367 from Thermotoga maritima at 1. 90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. View in: PubMed

High speed detection of circulating tumor cells. Biosens Bioelectron. 2006 Apr 15; 21(10):1893-9. View in: PubMed

Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure. 2006 Feb; 14(2):321-30. View in: PubMed

In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr. 2005 Dec; 38(6):900-905. View in: PubMed

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure. 2005 Nov; 13(11):1665-75. View in: PubMed

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol. 2005 Oct; 79(20):12905-13. View in: PubMed

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol. 2005 Aug; 79(15):9665-76. View in: PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2. 80 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. View in: PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 1; 58(4):971-5. View in: PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. View in: PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1. 85 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. View in: PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2. 4 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. View in: PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2. 10 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. View in: PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2. 00-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. View in: PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1. 8 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. View in: PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1. 90 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. View in: PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1. 60 A resolution. Proteins. 2004 Jul 1; 56(1):167-70. View in: PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1. 60 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. View in: PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2. 50 A resolution. Proteins. 2004 May 15; 55(3):768-71. View in: PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1. 75 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. View in: PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2. 0 A resolution. Proteins. 2004 Jan 1; 54(1):157-61. View in: PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2. 0 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. View in: PubMed

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. View in: PubMed

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