Faculty

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Andrew P. McMahon, PhD
W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine and Biological Sciences
Chair of Stem Cell Biology and Regenerative Medicine
Director, Eli and Edythe Broad Center For Regenerative Medicine and Stem Cell Research At Usc
Stem Cell Biology & Regenerative Medicine
BCC 312 1425 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 3056

Overview

McMahon Lab Website

Andrew P. McMahon is director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. He is Provost Professor and the inaugural holder of the W. M. Keck Professorship of Stem Cell Biology and Regenerative Medicine. In addition, he chairs the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC. McMahon also holds an appointment in the Department of Biological Sciences in the USC Dornsife College of Letters, Arts and Sciences.

Prior to joining USC, McMahon was the Frank B. Baird, Jr. Professor of Science in the Faculty of Arts and Sciences at Harvard University and served on the Executive Committee of the Harvard Stem Cell Institute. In 1993, he joined Harvard University as a full professor, and from 2001 to 2004, served as chair of its Department of Molecular and Cellular Biology. McMahon also served as professor in the Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology and principal faculty member in the Harvard Stem Cell Institute.

McMahon and his team study the mechanisms that underlie the assembly, repair and regeneration of critical organ systems, and have made enormous contributions to the understanding of the way the kidney matures during development. In building knowledge on these subjects, they seek to provide an informed, logic-based platform for translating basic research into practical applications in the area of regenerative medicine. This carries enormous potential for the treatment of human disease, as stem cell science offers a particularly broad reach. It can provide insights into normal and abnormal development in human cells, and holds the potential for the repair and replacement of human tissues and organs.

McMahon’s basic research has yielded important findings into the biology of mammalian signaling factors that have been translated into clinical medicine with the development of a novel anti-cancer drug, vismodegib, the first FDA-approved hedgehog pathway inhibitor, in a Curis/Genentech partnership.

Before arriving at Harvard, McMahon led the Department of Cell and Developmental Biology at the Roche Institute for Molecular Biology in Nutley, New Jersey. He previously held the position of staff scientist at the National Institute for Medical Research in London, where he started his independent research program.

While at the National Institute for Medical Research, McMahon worked closely with Brigid Hogan, George Barth Geller Professor and Chair, Department of Cell Biology at Duke University and director of the Duke University Stem Cell and Regenerative Medicine program. She lauded his innovative work in kidney development research.

McMahon received his bachelor’s degree from St. Peter’s College, Oxford University and his PhD from University College in London. He subsequently worked for three years as a postdoctoral fellow at the California Institute of Technology.

McMahon is an elected Fellow of the American Association for the Advancement of Science, the American Academy of Arts and Sciences, and the Royal Society (London), as well as an elected Associate Member of the European Molecular Biology Organization. He has served as an editor of the journals Development and Developmental Biology, and on the editorial boards of several other scientific journals, including Genes and Development and Current Biology.

Publications

Hedgehog Signaling: From Basic Biology to Cancer Therapy. Cell Chem Biol. 2017 Mar 16; 24(3):252-280. View in: PubMed

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 Mar 13; 40(5):439-452. e4. View in: PubMed

(Re)Building a Kidney. J Am Soc Nephrol. 2017 Jan 17. View in: PubMed

Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation. PLoS Genet. 2016 Dec; 12(12):e1006533. View in: PubMed

An Emerging Regulatory Landscape for Skeletal Development. Trends Genet. 2016 Nov 1. View in: PubMed

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development. 2016 Aug 15; 143(16):3012-23. View in: PubMed

Sonoelastography of the Achilles Tendon: Prevalence and Prognostic Value Among Asymptomatic Elite Australian Rules Football Players. Clin J Sport Med. 2016 Jul; 26(4):299-306. View in: PubMed

Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. Dev Cell. 2016 May 9; 37(3):238-53. View in: PubMed

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development. 2016 Feb 15; 143(4):595-608. View in: PubMed

An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1. Elife. 2016; 5. View in: PubMed

Stem cells for all ages, yet hostage to aging. Stem Cell Investig. 2016; 3:11. View in: PubMed

Development of the Mammalian Kidney. Curr Top Dev Biol. 2016; 117:31-64. View in: PubMed

Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. 2016 Jan 1; 340(1):43-52. View in: PubMed

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 9; 35(3):358-65. View in: PubMed

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors. Development. 2015 Oct 1; 142(19):3286-93. View in: PubMed

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney. Cell Rep. 2015 Aug 25; 12(8):1325-38. View in: PubMed

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep. 2015 Jul 14; 12(2):229-43. View in: PubMed

Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity. J Am Soc Nephrol. 2015 Jan; 26(1):81-94. View in: PubMed

Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity. Bone. 2014 Dec; 69:98-108. View in: PubMed

Induction and patterning of the metanephric nephron. Semin Cell Dev Biol. 2014 Dec; 36:31-8. View in: PubMed

A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning. Dev Cell. 2014 Nov 24; 31(4):448-60. View in: PubMed

Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 2014 Oct 23; 159(3):662-75. View in: PubMed

Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis. Stem Cell Reports. 2014 Oct 14; 3(4):650-62. View in: PubMed

Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct; 10(10):e1004604. View in: PubMed

Translational Profiles of Medullary Myofibroblasts during Kidney Fibrosis. J Am Soc Nephrol. 2014 Sep; 25(9):1979-90. View in: PubMed

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature. 2014 Jul 3; 511(7507):46-51. View in: PubMed

Defining the acute kidney injury and repair transcriptome. Semin Nephrol. 2014 Jul; 34(4):404-17. View in: PubMed

Global quantification of tissue dynamics in the developing mouse kidney. Dev Cell. 2014 Apr 28; 29(2):188-202. View in: PubMed

Defining kidney biology to understand renal disease. Clin J Am Soc Nephrol. 2014 Apr; 9(4):809-11. View in: PubMed

Cell-specific translational profiling in acute kidney injury. J Clin Invest. 2014 Mar 3; 124(3):1242-54. View in: PubMed

Gene regulatory networks mediating canonical wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells. 2013 Dec; 31(12):2667-79. View in: PubMed

Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19450-5. View in: PubMed

Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell. 2013 Sep 16; 26(5):469-82. View in: PubMed

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013 Sep 3; 123(9):4023-35. View in: PubMed

Wnt4/ß-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol. 2013 Sep; 24(9):1399-412. View in: PubMed

Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol. 2013 Sep; 231(1):44-52. View in: PubMed

Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug; 140(16):3423-34. View in: PubMed

Filopodia: the cellular quills of hedgehog signaling? Dev Cell. Filopodia: the cellular quills of hedgehog signaling? Dev Cell. 2013 May 28; 25(4):328-30. View in: PubMed

Progenitor programming in mammalian nephrogenesis. Nephrology (Carlton). 2013 Mar; 18(3):177-9. View in: PubMed

Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell. 2013 Feb 14; 152(4):691-702. View in: PubMed

A novel site comes into sight. Elife. 2013; 2(0):e01680. View in: PubMed

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun. 2013; 4:1367. View in: PubMed

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev. 2012 Dec 15; 26(24):2802-16. View in: PubMed

Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis. J Am Soc Nephrol. 2012 Oct; 23(10):1682-90. View in: PubMed

Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012 Sep 11; 23(3):637-51. View in: PubMed

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012 Aug 24; 19(8):972-82. View in: PubMed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12592-7. View in: PubMed

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15; 7(6):1040-8. View in: PubMed

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May; 139(10):1863-73. View in: PubMed

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers. Genesis. 2012 May; 50(5):443-50. View in: PubMed

Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol. 2012 May; 4(5). View in: PubMed

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1038-47. View in: PubMed

Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol. 2012 Apr; 180(4):1441-53. View in: PubMed

Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod. 2012 Feb; 86(2):37. View in: PubMed

Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn. 2012 Feb; 241(2):247-56. View in: PubMed

Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012; 7(10):e47238. View in: PubMed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci. 2012; 6:130. View in: PubMed

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development. 2011 Oct; 138(19):4245-54. View in: PubMed

The GUDMAP database--an online resource for genitourinary research. Development. 2011 Jul; 138(13):2845-53. View in: PubMed

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell. 2011 Jun 14; 20(6):788-801. View in: PubMed

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell. 2011 Jun 14; 20(6):775-87. View in: PubMed

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011 Feb; 79(3):317-30. View in: PubMed

A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec; 12(6):1027-41. View in: PubMed

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9736-41. View in: PubMed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. View in: PubMed

Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4194-9. View in: PubMed

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 1; 24(3):312-26. View in: PubMed

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010 Jan; 176(1):85-97. View in: PubMed

An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 1; 19(22):1912-7. View in: PubMed

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15; 333(2):312-23. View in: PubMed

Hedgehog signalling: Kif7 is not that fishy after all. Curr Biol. 2009 Sep 15; 19(17):R729-31. View in: PubMed

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15; 332(2):273-86. View in: PubMed

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):559-67. View in: PubMed

Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system. Biochim Biophys Acta. 2009 Apr; 1789(4):299-305. View in: PubMed

Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr; 16(4):600-6. View in: PubMed

Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 2009 Mar 12; 61(5):708-20. View in: PubMed

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2623-8. View in: PubMed

Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway. BMC Bioinformatics. 2009; 10:433. View in: PubMed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development. 2009 Jan; 136(1):161-71. View in: PubMed

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008 Dec 1; 324(1):88-98. View in: PubMed

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21; 322(5905):1247-50. View in: PubMed

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16976-81. View in: PubMed

Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell. 2008 Nov; 15(5):781-91. View in: PubMed

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 2008 Oct 1; 22(19):2651-63. View in: PubMed

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. View in: PubMed

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7; 3(2):169-81. View in: PubMed

Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol. 2008 Aug 1; 320(1):242-55. View in: PubMed

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development. 2008 Aug; 135(15):2489-503. View in: PubMed

An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. J Am Chem Soc. 2008 Jul 30; 130(30):9925-30. View in: PubMed

In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. J Biol Chem. 2008 Jul 25; 283(30):21002-10. View in: PubMed

Developmental biology. Grasping limb patterning. Science. 2008 Jul 18; 321(5887):350-2. View in: PubMed

Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol. 2008 Jul 15; 319(2):396-405. View in: PubMed

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76. View in: PubMed

Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol. 2008 May 15; 317(2):480-5. View in: PubMed

Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns. 2008 May; 8(5):297-306. View in: PubMed

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May; 135(9):1625-34. View in: PubMed

GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol. 2008 Apr; 19(4):667-71. View in: PubMed

Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008 Mar 6; 2(3):284-91. View in: PubMed

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development. 2008 Mar; 135(6):1097-106. View in: PubMed

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. View in: PubMed

Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol. 2008 Feb 1; 314(1):112-26. View in: PubMed

Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007 Dec 1; 312(1):312-20. View in: PubMed

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. View in: PubMed

The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet. 2007 Oct; 3(10):1922-38. View in: PubMed

Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct; 39(10):1225-34. View in: PubMed

Regulation of skeletogenic differentiation in cranial dermal bone. Development. 2007 Sep; 134(17):3133-44. View in: PubMed

Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007 Jul; 134(13):2533-9. View in: PubMed

A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns. 2007 Jun; 7(6):680-99. View in: PubMed

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007 May 15; 21(10):1244-57. View in: PubMed

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007 May; 134(10):1977-89. View in: PubMed

Shifting paradigms in Hedgehog signaling. Curr Opin Cell Biol. 2007 Apr; 19(2):159-65. View in: PubMed

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007 Feb; 134(4):801-11. View in: PubMed

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007 Jan; 12(1):113-27. View in: PubMed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell. 2007 Jan; 12(1):99-112. View in: PubMed

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res. 2006 Oct 15; 66(20):10171-8. View in: PubMed

Independent regulation of skeletal growth by Ihh and IGF signaling. Dev Biol. 2006 Oct 1; 298(1):327-33. View in: PubMed

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development. 2006 Aug; 133(16):3231-44. View in: PubMed

Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Res A Clin Mol Teratol. 2006 Aug; 76(8):574-9. View in: PubMed

Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein. J Am Chem Soc. 2006 Jul 12; 128(27):8939-46. View in: PubMed

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006 May; 10(5):647-56. View in: PubMed

Reproducible and inducible knockdown of gene expression in mice. Genesis. 2006 May; 44(5):252-61. View in: PubMed

BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. View in: PubMed

Retraction: Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development. 2005 Dec; 132(24):5615. View in: PubMed

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet. 2005 Dec; 37(12):1323-32. View in: PubMed

Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse. Dev Biol. 2005 Oct 1; 286(1):149-57. View in: PubMed

Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet. 2005 Oct; 37(10):1082-9. View in: PubMed

Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1. Infect Immun. 2005 Oct; 73(10):6981-9. View in: PubMed

Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation. Dev Biol. 2005 Sep 15; 285(2):490-5. View in: PubMed

WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005 Sep 15; 437(7057):417-21. View in: PubMed

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug; 9(2):283-92. View in: PubMed

Neural crest origins of the neck and shoulder. Nature. 2005 Jul 21; 436(7049):347-55. View in: PubMed

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul; 115(7):1734-42. View in: PubMed

Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development. 2005 Jun; 132(12):2809-23. View in: PubMed

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May; 8(5):751-64. View in: PubMed

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005 Feb; 8(2):229-39. View in: PubMed

Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development. 2005 Jan; 132(1):133-42. View in: PubMed

An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res. 2005; 33(18):e155. View in: PubMed

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. 2005 Jan; 132(1):143-54. View in: PubMed

Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. View in: PubMed

Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development. 2004 Oct; 131(20):5031-40. View in: PubMed

Recent genetic studies of mouse kidney development. Curr Opin Genet Dev. 2004 Oct; 14(5):550-7. View in: PubMed

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development. 2004 Sep; 131(17):4371-80. View in: PubMed

Hedgehog signaling: iguana debuts as a nuclear gatekeeper. Curr Biol. 2004 Aug 24; 14(16):R668-70. View in: PubMed

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20; 118(4):517-28. View in: PubMed

Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development. 2004 Aug; 131(16):4021-33. View in: PubMed

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science. 2004 Jul 16; 305(5682):396-9. View in: PubMed

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004 Jun 15; 270(2):393-410. View in: PubMed

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest. 2004 Jun; 113(12):1692-700. View in: PubMed

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15; 18(8):937-51. View in: PubMed

Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25; 350(13):1353-6. View in: PubMed

SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci. 2004 Mar-Aug; 26(2-4):148-65. View in: PubMed

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar; 131(6):1309-18. View in: PubMed

Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct; 130(20):4871-9. View in: PubMed

Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis. 2003 Oct; 37(2):51-3. View in: PubMed

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron. 2003 Sep 11; 39(6):937-50. View in: PubMed

Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest. 2003 Aug; 112(4):554-65. View in: PubMed

Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development. 2003 Jul; 130(14):3175-85. View in: PubMed

Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development. 2003 Jul; 130(13):2967-80. View in: PubMed

Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May; 130(10):2275-87. View in: PubMed

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003 Apr 15; 22(8):1811-23. View in: PubMed

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell. 2003 Apr 4; 113(1):11-23. View in: PubMed

Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb; 13(2):86-91. View in: PubMed

Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1; 17(3):394-409. View in: PubMed

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1; 17(3):342-7. View in: PubMed

Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol. 2003; 53:1-114. View in: PubMed

Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002 Dec; 129(23):5323-37. View in: PubMed

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev. 2002 Dec; 119 Suppl 1:S97-S101. View in: PubMed

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002 Nov 15; 16(22):2849-64. View in: PubMed

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns. 2002 Nov; 2(1-2):93-7. View in: PubMed

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002 Nov; 129(22):5301-12. View in: PubMed

Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development. 2002 Nov; 129(21):4963-74. View in: PubMed

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002 Oct; 129(20):4807-19. View in: PubMed

Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci. 2002 Sep; 5(9):831-2. View in: PubMed

Cholesterol modification of Hedgehog family proteins. J Clin Invest. 2002 Sep; 110(5):591-6. View in: PubMed

Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8084-9. View in: PubMed

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 2002 May; 129(9):2087-98. View in: PubMed

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol. 2002 Apr 15; 244(2):305-18. View in: PubMed

Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol. 2002 Apr; 32(4):967-71. View in: PubMed

Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev. 2002 Feb; 111(1-2):75-87. View in: PubMed

Hedgehog is required for murine yolk sac angiogenesis. Development. 2002 Jan; 129(2):361-72. View in: PubMed

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