Faculty

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Edward David Crandall, PhD, MD
Chair and Professor of Medicine
Kenneth T. Norris, Jr., Chair in Medicine
Hastings Foundation Professorship in Medicine
Medicine
IRD 620 Off Campus Los Angeles
+1 323 226 7593

Overview

Dr. Crandall's research is focused on the following topics: markers of alveolar epithelial cell development and differentiation, regulation of pulmonary epithelial cell differentiation, acute and chronic lung injury and the factors that influence recovery, transport properties of pulmonary alveolar epithelium, cell pathophysiology of alveolar epithelium (e.g., lung injury and pathogenesis of alveolar pulmonary edema, and stem cell biology in lung injury.

Dr. Crandall received his B.Ch.E. from Cooper Union, his M.S. and Ph.D. in chemical engineering from Northwestern University, and his M.D. from the University of Pennsylvania. His training in internal medicine and pulmonary/critical care medicine was undertaken at the Hospital of the University of Pennsylvania.

Awards

National Institutes of Health: Person ID, 1975-1980

Person ID

National Institutes of Health: Person ID, 1987-1997

end date

National Institutes of Health: end date, 1987-1997

National Institutes of Health: end date, 1975-1980

National Institutes of Health: Keck School of Medicine of USC, 1975-1980

National Institutes of Health: Keck School of Medicine of USC, 1987-1997

Keck School of Medicine of USC

workplace homepage

National Institutes of Health: workplace homepage, 1975-1980

National Institutes of Health: workplace homepage, 1987-1997

National Institutes of Health: Professor, 1975-1980

Professor

National Institutes of Health: Professor, 1987-1997

position in organization

National Institutes of Health: position in organization, 1975-1980

National Institutes of Health: position in organization, 1987-1997

Faculty Rank

National Institutes of Health: award conferred by, 1975-1980

National Institutes of Health: award conferred by, 1987-1997

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National Institutes of Health: Faculty Rank, 1987-1997

National Institutes of Health: Faculty Rank, 1975-1980

National Institutes of Health: Research Career Development Award, 1975-1980

is primary position

National Institutes of Health: is primary position, 1987-1997

National Institutes of Health: Organization, 1975-1980

National Institutes of Health: Organization, 1987-1997

Organization

last name

National Institutes of Health: MERIT Award, 1987-1997

award or honor for

National Institutes of Health: award or honor for, 1975-1980

National Institutes of Health: person in primary position, 1975-1980

National Institutes of Health: person in primary position, 1987-1997

person in primary position

Person

National Institutes of Health: Person, 1987-1997

National Institutes of Health: Person, 1975-1980

preferred title

National Institutes of Health: preferred title, 1975-1980

National Institutes of Health: first name, 1987-1997

first name

National Institutes of Health: first name, 1975-1980

Crandall, Edward

Best Doctors of America

Department

National Institutes of Health: Department, 1975-1980

National Institutes of Health: Department, 1987-1997

National Institutes of Health: start date, 1975-1980

start date

National Institutes of Health: type, 1975-1980

email address

National Institutes of Health: email address, 1975-1980

National Institutes of Health: email address, 1987-1997

type

National Institutes of Health: type, 1987-1997

National Institutes of Health: Medicine, 1975-1980

Medicine

National Institutes of Health: Medicine, 1987-1997

National Institutes of Health: Award or Honor Receipt, 1975-1980

National Institutes of Health: Award or Honor Receipt, 1987-1997

Award or Honor Receipt

has faculty rank

National Institutes of Health: has faculty rank, 1987-1997

National Institutes of Health: full name, 1987-1997

National Institutes of Health: full name, 1975-1980

full name

National Institutes of Health: Chair and Professor of Medicine, 1987-1997

National Institutes of Health: Chair and Professor of Medicine, 1975-1980

Chair and Professor of Medicine

National Institutes of Health: start date, 1987-1997

National Institutes of Health: preferred title, 1987-1997

National Institutes of Health: is primary position, 1975-1980

Agent

National Institutes of Health: Agent, 1987-1997

National Institutes of Health: Agent, 1975-1980

photo

National Institutes of Health: photo, 1975-1980

National Institutes of Health: photo, 1987-1997

National Institutes of Health: position in department, 1975-1980

National Institutes of Health: position in department, 1987-1997

position in department

HR job title

National Institutes of Health: HR job title, 1987-1997

National Institutes of Health: HR job title, 1975-1980

National Institutes of Health: has faculty rank, 1975-1980

National Institutes of Health: sort order, 1987-1997

National Institutes of Health: sort order, 1975-1980

National Institutes of Health: award or honor for, 1987-1997

Publications

IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 Nov; 46(11):2531-2541. View in: PubMed

Cross-species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-specific Genes. Am J Respir Cell Mol Biol. 2016 Oct 17. View in: PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):395-406. View in: PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. View in: PubMed

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. View in: PubMed

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1; 307(7):L524-36. View in: PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. View in: PubMed

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. View in: PubMed

Polystyrene nanoparticle exposure induces ion-selective pores in lipid bilayers. Biochim Biophys Acta. 2013 Sep; 1828(9):2215-22. View in: PubMed

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. View in: PubMed

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium. Environ Health Perspect. 2013 Jun; 121(6):683-90. View in: PubMed

Interactions Between ß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). J Biol Chem. 2012 Mar 2; 287(10):7026-38. View in: PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. View in: PubMed

Troglitazone Attenuates TGF-ß1-Induced EMT in Alveolar Epithelial Cells via a PPAR?-Independent Mechanism. Troglitazone Attenuates TGF-ß1-Induced EMT in Alveolar Epithelial Cells via a PPAR? -Independent Mechanism. PLoS One. 2012; 7(6):e38827. View in: PubMed

Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. View in: PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. View in: PubMed

Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Qual Atmos Health. 2011 Mar 1; 4(1):65-78. View in: PubMed

Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. View in: PubMed

Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 1; 182(11):1398-409. View in: PubMed

Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. View in: PubMed

Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. View in: PubMed

More life for a "terminal" cell. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. View in: PubMed

Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. View in: PubMed

Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm. 2009 Mar-Apr; 6(2):492-503. View in: PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. View in: PubMed

Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. View in: PubMed

Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. View in: PubMed

Rat aquaporin-5 4. 3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. View in: PubMed

Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci. 2008 Jun; 97(6):2340-9. View in: PubMed

Foxp2 inhibits Nkx2. 1-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. View in: PubMed

Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. View in: PubMed

Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. J Cell Physiol. 2008 Mar; 214(3):645-54. View in: PubMed

Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. View in: PubMed

Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. View in: PubMed

Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro. 2007 Dec; 21(8):1373-81. View in: PubMed

Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharm Res. 2007 Sep; 24(9):1713-9. View in: PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. View in: PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. View in: PubMed

SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May; 168(5):1452-63. View in: PubMed

Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 2005 May; 166(5):1321-32. View in: PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol. 2005 Jan; 98(1):322-8. View in: PubMed

Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol. 2005 Jan; 98(1):138-43. View in: PubMed

Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respir Res. 2005; 6:40. View in: PubMed

Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. View in: PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. View in: PubMed

Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. View in: PubMed

The critical care crisis in the United States: a report from the profession. Chest. 2004 Apr; 125(4):1514-7. View in: PubMed

Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. View in: PubMed

Transcytosis of GCSF-transferrin across rat alveolar epithelial cell monolayers. Pharm Res. 2003 Aug; 20(8):1231-8. View in: PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. View in: PubMed

Absorption of intact albumin across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Mar; 284(3):L458-65. View in: PubMed

Historical perspectives on lung edema clearance. J Appl Physiol. 2002 Oct; 93(4):1527-32. View in: PubMed

Polarity of alveolar epithelial cell acid-base permeability. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L675-83. View in: PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. View in: PubMed

Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. View in: PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 18; ajplung. 00005. 2015. View in: PubMed

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