Faculty

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Heinz-Josef Lenz, MD
Professor of Medicine
J. Terrence Lanni Chair in Gastrointestinal Cancer Research
Co Director, USC Center For Molecular Pathway and Drug Discovery
Medicine
NOR 3456 Health Sciences Campus Los Angeles
+1 323 865 3967

Overview

Heinz-Josef Lenz, M.D., FACP, is the Associate Director for Clinical Research and Co-Leader of the Gastrointestinal Cancers Program at the USC Norris Comprehensive Cancer Center. Dr. Lenz is Professor of Medicine and Preventive Medicine, Section Head of GI Oncology in the Division of Medical Oncology and Co-Director of the Colorectal Center at the Keck School of Medicine of the University of Southern California.

Dr. Lenz received his medical degree from Johannes-Gutenberg Universität in Mainz, Germany, in 1985. He completed a residency in Hematology and Oncology at the University Hospital Tübingen in Germany, a clerkship in Oncology at George Washington University in Washington, DC, and a clerkship in Hematology at Beth Israel Hospital of Harvard Medical School in Boston, Massachusetts. He served subsequent fellowships in Biochemistry and Molecular Biology at the USC Norris Comprehensive Cancer Center.

An active researcher, Dr. Lenz focuses on topics including the regulation of gene expression involved in drug resistance, patients at high risk of developing colorectal cancer, and determination of carcinogenesis, methods of early detection, and better surveillance of these cancers. He is a member of several professional societies, including the American Association for Cancer Research, the American Gastroenterology Association, and the National Society of Genetic Counselors. He also serves on the National Advisory Board of a number of professional organizations. Dr. Lenz is the author of numerous peer-reviewed publications and invited papers, reviews, and editorials. He also serves as Co-Chair of the GI Committee and Correlative Science Committee for SWOG. He is a member of the NCI Task Force for Gastroesophageal Cancer, the NCI Steering Committee and the NCI Translational Science Committee. In addition to having an NCI-funded laboratory, he was a recipient of the ASCO Young Investigator Award, the ASCO Career Development Award, and the STOP Cancer Career Development Award. He has been listed in the Best Doctors’ database (www.bestdoctors.com) since 2003.

As Associate Director for Clinical Research, Dr. Lenz oversees the programmatic activities of the Gastrointestinal Cancers, Genitourinary Cancers, Women’s Cancers, and Leukemia and Lymphoma Programs.

Awards

Western Society of Clinical Investigation: Outstanding Investigator Award, 2016

The WunderGlo Foundation: 1st Annual Cancer Warrior Award, 2012

2003 Annual Retreat on Cancer Research: The Gallo Award, 2003

USC: Bob Chandler Courage Award, 2003

Conquer Cancer Foundation: ASCO Career Development Award, 1995-1998

Conquer Cancer Foundation: ASCO Young Investigator Award, 1994

Publications

Mindfulness practice reduces cortisol blunting during chemotherapy: A randomized controlled study of colorectal cancer patients. Cancer. 2017 Apr 07. View in: PubMed

Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial. Int J Cancer. 2017 Apr 01. View in: PubMed

A Phase 1b Dose-Escalation Study of Encorafenib (LGX818) and Cetuximab With or Without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer. Cancer Discov. 2017 Mar 31. View in: PubMed

What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers? J Cell Commun Signal. What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers? J Cell Commun Signal. 2017 Feb 20. View in: PubMed

Comparative effectiveness of screening strategies for colorectal cancer. Cancer. 2017 Jan 24. View in: PubMed

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers. Clin Cancer Res. 2017 Jan 17. View in: PubMed

Metastatic Colorectal Cancer in Hispanics: Treatment Outcomes in a Treated Population. Clin Colorectal Cancer. 2016 Dec; 15(4):e221-e227. View in: PubMed

Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection. Mol Cancer Ther. 2016 Nov; 15(11):2814-2821. View in: PubMed

An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma. Clin Cancer Res. 2016 Nov 1; 22(21):5204-5210. View in: PubMed

Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials. JAMA Oncol. 2016 Oct 10. View in: PubMed

A Phase II Biomarker-Embedded Study of Lapatinib plus Capecitabine as First-line Therapy in Patients with Advanced or Metastatic Gastric Cancer. Mol Cancer Ther. 2016 Sep; 15(9):2251-8. View in: PubMed

Molecular Pathways: Cachexia Signaling-A Targeted Approach to Cancer Treatment. Clin Cancer Res. 2016 Aug 15; 22(16):3999-4004. View in: PubMed

Novel therapeutics in metastatic colorectal cancer: molecular insights and pharmacogenomic implications. Expert Rev Clin Pharmacol. 2016 Aug; 9(8):1091-108. View in: PubMed

Impact of sex, age, and ethnicity/race on the survival of patients with rectal cancer in the United States from 1988 to 2012. Oncotarget. 2016 Jul 19. View in: PubMed

Combined assessment of EGFR-related molecules to predict outcome of 1st-line cetuximab-containing chemotherapy for metastatic colorectal cancer. Cancer Biol Ther. 2016 Jul 2; 17(7):751-9. View in: PubMed

Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy. Clin Cancer Res. 2016 Jul 1; 22(13):3218-26. View in: PubMed

CDX2 as a Prognostic Biomarker in Colon Cancer. N Engl J Med. 2016 Jun 2; 374(22):2183. View in: PubMed

Genome-wide association study of colorectal cancer in Hispanics. Carcinogenesis. 2016 Jun; 37(6):547-56. View in: PubMed

TWIST1 Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy. Mol Cancer Ther. 2016 Jun; 15(6):1405-11. View in: PubMed

The safety of monoclonal antibodies for treatment of colorectal cancer. Expert Opin Drug Saf. 2016 Jun; 15(6):799-808. View in: PubMed

Clinical significance of <i>TLR1</i> I602S polymorphism for patients with metastatic colorectal cancer treated with FOLFIRI plus bevacizumab. Mol Cancer Ther. 2016 May 11. View in: PubMed

Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand? Nat Rev Gastroenterol Hepatol. Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand? Nat Rev Gastroenterol Hepatol. 2016 May; 13(5):258-9. View in: PubMed

Biomarker in Colorectal Cancer. Cancer J. 2016 May-Jun; 22(3):156-64. View in: PubMed

Understanding the FOLFOXIRI-regimen to optimize treatment for metastatic colorectal cancer. Crit Rev Oncol Hematol. 2016 Apr; 100:117-26. View in: PubMed

A novel antimetabolite: TAS-102 for metastatic colorectal cancer. Expert Rev Clin Pharmacol. 2016 Mar; 9(3):355-65. View in: PubMed

Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database. J Clin Oncol. 2016 Jan 10; 34(2):144-50. View in: PubMed

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016. ESMO Open. 2016; 1(5):e000097. View in: PubMed

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer. J Clin Oncol. 2015 Dec 20; 33(36):4284-92. View in: PubMed

Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor. Clin Cancer Res. 2015 Nov 15; 21(22):5002-7. View in: PubMed

Integrin beta-3 genetic variants and risk of venous thromboembolism in colorectal cancer patients. Thromb Res. 2015 Nov; 136(5):865-9. View in: PubMed

Pharmacodynamics (PD) and pharmacokinetics (PK) of E7389 (eribulin, halichondrin B analog) during a phase I trial in patients with advanced solid tumors: a California Cancer Consortium trial. Cancer Chemother Pharmacol. 2015 Nov; 76(5):897-907. View in: PubMed

TAS-102, a novel antitumor agent: A review of the mechanism of action. Cancer Treat Rev. 2015 Nov; 41(9):777-83. View in: PubMed

Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer. Mol Cancer Ther. 2015 Oct; 14(10):2374-81. View in: PubMed

Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach. Mol Cancer Ther. 2015 Oct; 14(10):2401-8. View in: PubMed

Response. J Natl Cancer Inst. 2015 Sep; 107(9). View in: PubMed

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial. Lancet Oncol. 2015 Aug; 16(8):937-48. View in: PubMed

Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases. Cancer. 2015 Jun 1; 121(11):1898-905. View in: PubMed

Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results. Int J Clin Oncol. 2015 Jun; 20(3):518-24. View in: PubMed

FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study. Gut. 2015 Jun; 64(6):921-8. View in: PubMed

Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer. N Engl J Med. 2015 May 14; 372(20):1909-19. View in: PubMed

IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):E2487-96. View in: PubMed

Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors. J Clin Oncol. 2015 May 10; 33(14):1551-6. View in: PubMed

Pharmacogenomics of fluorouracil -based chemotherapy toxicity. Expert Opin Drug Metab Toxicol. 2015 May; 11(5):811-21. View in: PubMed

Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation. Clin Cancer Res. 2015 Apr 1; 21(7):1583-90. View in: PubMed

Molecular classification of gastric adenocarcinoma: translating new insights from the cancer genome atlas research network. Curr Treat Options Oncol. 2015 Apr; 16(4):331. View in: PubMed

Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). 2015 Mar; 29(3). View in: PubMed

Primary tumor location as a prognostic factor in metastatic colorectal cancer. J Natl Cancer Inst. 2015 Mar; 107(3). View in: PubMed

Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer. J Clin Oncol. 2015 Mar 1; 33(7):692-700. View in: PubMed

A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine. Cancer Chemother Pharmacol. 2015 Mar; 75(3):537-46. View in: PubMed

Predictive and prognostic markers in the treatment of metastatic colorectal cancer (mCRC): personalized medicine at work. Hematol Oncol Clin North Am. 2015 Feb; 29(1):43-60. View in: PubMed

Non-coding RNAs derived from an alternatively spliced REST transcript (REST-003) regulate breast cancer invasiveness. Sci Rep. 2015; 5:11207. View in: PubMed

Genetic variants within obesity-related genes are associated with tumor recurrence in patients with stages II/III colon cancer. Pharmacogenet Genomics. 2015 Jan; 25(1):30-7. View in: PubMed

Impact of sex on the survival of patients with hepatocellular carcinoma: A Surveillance, Epidemiology, and End Results analysis. Cancer. 2014 Dec 1; 120(23):3707-16. View in: PubMed

Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients. Pharmacogenet Genomics. 2014 Dec; 24(12):588-96. View in: PubMed

Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent. Pharmacogenet Genomics. 2014 Nov; 24(11):539-47. View in: PubMed

Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer. 2014 Oct 1; 120(19):2980-5. View in: PubMed

So much effort, so little progress? J Natl Cancer Inst. So much effort, so little progress? J Natl Cancer Inst. 2014 Oct; 106(10). View in: PubMed

Safely targeting cancer stem cells via selective catenin coactivator antagonism. Cancer Sci. 2014 Sep; 105(9):1087-92. View in: PubMed

Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer. Invest New Drugs. 2014 Aug; 32(4):682-90. View in: PubMed

A randomized, phase II study of the anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody robatumumab (SCH 717454) in patients with advanced colorectal cancer. Cancer Med. 2014 Aug; 3(4):988-97. View in: PubMed

CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. Int J Cancer. 2014 Jul 1; 135(1):232-7. View in: PubMed

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer. Cell Rep. 2014 Jun 26; 7(6):1940-55. View in: PubMed

Molecular pathways: turning proteasomal protein degradation into a unique treatment approach. Clin Cancer Res. 2014 Jun 15; 20(12):3064-70. View in: PubMed

The potential of targeting Wnt/ß-catenin in colon cancer. Expert Opin Ther Targets. 2014 Jun; 18(6):611-5. View in: PubMed

Panitumumab safety for treating colorectal cancer. Expert Opin Drug Saf. 2014 Jun; 13(6):843-51. View in: PubMed

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy. Nat Rev Clin Oncol. 2014 May; 11(5):282-98. View in: PubMed

Panitumumab : leading to better overall survival in metastatic colorectal cancer? Expert Opin Biol Ther. Panitumumab : leading to better overall survival in metastatic colorectal cancer? Expert Opin Biol Ther. 2014 Apr; 14(4):535-48. View in: PubMed

Multi-drug inhibition of the HER pathway in metastatic colorectal cancer: Results of a phase I study of pertuzumab plus cetuximab in cetuximab-refractory patients. Invest New Drugs. 2014 Feb; 32(1):113-22. View in: PubMed

Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy. Mol Cancer Ther. 2014 Feb; 13(2):528-39. View in: PubMed

Testing for RAS Mutations in Patients With Metastatic Colorectal Cancer. Clin Adv Hematol Oncol. 2014 Jan; 12(1):48-9. View in: PubMed

The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin ß1. Sci Signal. 2014; 7(330):ra58. View in: PubMed

A Small Cog in a Big Wheel: PIK3CA Mutations in Colorectal Cancer. J Natl Cancer Inst. 2013 Dec 4; 105(23):1775-6. View in: PubMed

Timeliness of Adjuvant Chemotherapy for Stage III Adenocarcinoma of the Colon: A Measure of Quality of Care. Clin Colorectal Cancer. 2013 Dec; 12(4):275-9. View in: PubMed

RAS mutations in colorectal cancer. N Engl J Med. 2013 Nov 28; 369(22):2159. View in: PubMed

Role of cyclin polymorphisms in predicting outcome of 5-fluorouracil-based chemotherapy in colorectal cancer: one piece in a complex puzzle. Pharmacogenomics. 2013 Nov; 14(14):1671-4. View in: PubMed

Molecular pathways: estrogen pathway in colorectal cancer. Clin Cancer Res. 2013 Nov 1; 19(21):5842-8. View in: PubMed

Protein kinase inhibitors in metastatic colorectal cancer. Let's pick patients, tumors, and kinase inhibitors to piece the puzzle together! Expert Opin Pharmacother. 2013 Nov; 14(16):2203-20. View in: PubMed

Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States. Mol Cancer Ther. 2013 Oct; 12(10):2261-72. View in: PubMed

SWOG S0353: Phase II trial of intravesical gemcitabine in patients with nonmuscle invasive bladder cancer and recurrence after 2 prior courses of intravesical bacillus Calmette-Guérin. J Urol. 2013 Oct; 190(4):1200-4. View in: PubMed

Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation. Cancer. 2013 Aug 15; 119(16):3043-51. View in: PubMed

Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer. Invest New Drugs. 2013 Aug; 31(4):845-57. View in: PubMed

A phase I trial of oxaliplatin in combination with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Jul; 72(1):85-91. View in: PubMed

Phase I study of pazopanib in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study. Clin Cancer Res. 2013 Jul 1; 19(13):3631-9. View in: PubMed

MicroRNA-21 in colorectal cancer: "Just another brick in the wall"? J Natl Cancer Inst. MicroRNA-21 in colorectal cancer: "Just another brick in the wall"? J Natl Cancer Inst. 2013 Jun 19; 105(12):840-1. View in: PubMed

Markers of response for the antiangiogenic agent bevacizumab. J Clin Oncol. 2013 Mar 20; 31(9):1219-30. View in: PubMed

Reply to J. Zhang et al. J Clin Oncol. 2013 Feb 20; 31(6):816-7. View in: PubMed

Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement. HPB (Oxford). 2013 Feb; 15(2):106-15. View in: PubMed

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013 Jan 26; 381(9863):303-12. View in: PubMed

Listening in on difficult conversations: an observational, multi-center investigation of real-time conversations in medical oncology. BMC Cancer. 2013; 13(1):455. View in: PubMed

Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab. PLoS One. 2013; 8(7):e66774. View in: PubMed

Assessing the in vivo efficacy of biologic antiangiogenic therapies. Cancer Chemother Pharmacol. 2013 Jan; 71(1):1-12. View in: PubMed

Angiogenesis-related agents in esophageal cancer. Expert Opin Biol Ther. 2012 Oct; 12(10):1335-45. View in: PubMed

Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer. Clin Cancer Res. 2012 Oct 1; 18(19):5412-26. View in: PubMed

Targeted therapies: Cetuximab dosing by rash-is the scaling of EVEREST meaningful? Nat Rev Clin Oncol. Targeted therapies: Cetuximab dosing by rash-is the scaling of EVEREST meaningful? Nat Rev Clin Oncol. 2012 Aug 14; 9(10):554-6. View in: PubMed

A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma. Invest New Drugs. 2012 Aug; 30(4):1597-606. View in: PubMed

SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinoma. Invest New Drugs. 2012 Aug; 30(4):1646-51. View in: PubMed

Influence of sex on the survival of patients with esophageal cancer. J Clin Oncol. 2012 Jun 20; 30(18):2265-72. View in: PubMed

The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models. Mol Cancer Ther. 2012 Jun; 11(6):1353-64. View in: PubMed

Explaining the Unexplainable: EGFR Antibodies in Colorectal Cancer. J Clin Oncol. 2012 May 20; 30(15):1735-7. View in: PubMed

Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414). J Thorac Oncol. 2012 May; 7(5):906-12. View in: PubMed

Targeting IL-8 in colorectal cancer. Expert Opin Ther Targets. 2012 May; 16(5):491-7. View in: PubMed

LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome. Breast Cancer Res Treat. 2012 Apr; 132(2):537-44. View in: PubMed

Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium study. Invest New Drugs. 2012 Apr; 30(2):723-8. View in: PubMed

A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin Cancer Res. 2012 Mar 15; 18(6):1726-34. View in: PubMed

Pharmacogenomics and metastatic colorectal cancer: Current knowledge and perspectives. Scand J Gastroenterol. 2012 Mar; 47(3):325-39. View in: PubMed

A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study. Cancer Chemother Pharmacol. 2012 Mar; 69(3):835-43. View in: PubMed

Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2012 Mar; 11(3):616-28. View in: PubMed

Pancreatic cancer: medical management (novel chemotherapeutics). Gastroenterol Clin North Am. 2012 Mar; 41(1):189-209. View in: PubMed

"HER Majesty's a Pretty Nice Girl but She Changes From Day to Day". J Clin Oncol. 2012 Feb 1; 30(4):465-6. View in: PubMed

Cancer dormancy: a model of early dissemination and late cancer recurrence. Clin Cancer Res. 2012 Feb 1; 18(3):645-53. View in: PubMed

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer. Mol Cancer Ther. 2012 Jan; 11(1):119-31. View in: PubMed

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. Cancer Chemother Pharmacol. 2011 Dec; 68(6):1439-47. View in: PubMed

S0356: A Phase II Clinical and Prospective Molecular Trial With Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Before Surgery for Patients With Esophageal Adenocarcinoma. J Clin Oncol. 2011 Dec 1; 29(34):4555-60. View in: PubMed

A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma: Southwest Oncology Group study S0202. Cancer Chemother Pharmacol. 2011 Dec; 68(6):1595-602. View in: PubMed

Common cancer stem cell gene variants predict colon cancer recurrence. Clin Cancer Res. 2011 Nov 1; 17(21):6934-43. View in: PubMed

A review of excision repair cross-complementation group 1 in colorectal cancer. Clin Colorectal Cancer. 2011 Sep; 10(3):157-64. View in: PubMed

Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma. Int J Cancer. 2011 Sep 1; 129(5):1096-104. View in: PubMed

Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res. 2011 Sep 1; 17(17):5783-92. View in: PubMed

EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients. Clin Cancer Res. 2011 Aug 1; 17(15):5161-9. View in: PubMed

Predictive molecular classifiers in colorectal cancer. Semin Oncol. 2011 Aug; 38(4):576-87. View in: PubMed

Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity. J Gastrointest Oncol. 2011 Jun; 2(2):77-84. View in: PubMed

Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nat Med. 2011 Jun; 17(6):715-9. View in: PubMed

The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models. Cancer Res. 2011 May 15; 71(10):3635-48. View in: PubMed

Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer. Clin Cancer Res. 2011 May 15; 17(10):3469-77. View in: PubMed

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer. 2011 May 1; 128(9):2038-49. View in: PubMed

ERCC1 and ERCC2 polymorphisms predict clinical outcomes of oxaliplatin-based chemotherapies in gastric and colorectal cancer: a systemic review and meta-analysis. Clin Cancer Res. 2011 Mar 15; 17(6):1632-40. View in: PubMed

Molecular predictors of response to antiangiogenesis therapies. Cancer J. 2011 Mar-Apr; 17(2):134-41. View in: PubMed

Phase I clinical trial of pegylated liposomal Doxorubicin and docetaxel in patients with advanced solid tumors. Am J Clin Oncol. 2011 Feb; 34(1):27-31. View in: PubMed

Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin. Pharmacogenomics. 2011 Jan; 12(1):27-39. View in: PubMed

Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients. Clin Cancer Res. 2010 Nov 15; 16(22):5591-602. View in: PubMed

Molecular predictive and prognostic markers in colon cancer. Cancer Treat Rev. 2010 Nov; 36(7):550-6. View in: PubMed

Molecular predictors of combination targeted therapies (cetuximab, bevacizumab) in irinotecan-refractory colorectal cancer (BOND-2 study). Anticancer Res. 2010 Oct; 30(10):4209-17. View in: PubMed

Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415). J Thorac Oncol. 2010 Sep; 5(9):1472-6. View in: PubMed

Beyond KRAS: a new approach in metastatic colorectal cancer. Lancet Oncol. 2010 Aug; 11(8):706-7. View in: PubMed

Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer. Gastroenterology. 2010 Jun; 138(6):2163-76. View in: PubMed

Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. Ann Surg. 2010 May; 251(5):857-64. View in: PubMed

Molecular markers in the treatment of metastatic colorectal cancer. Cancer J. 2010 May-Jun; 16(3):262-72. View in: PubMed

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy. Cancer Chemother Pharmacol. 2010 Apr; 65(5):979-88. View in: PubMed

Colorectal cancer. Lancet. 2010 Mar 20; 375(9719):1030-47. View in: PubMed

Molecular response prediction in multimodality treatment for adenocarcinoma of the esophagus and esophagogastric junction. Recent Results Cancer Res. 2010; 182:179-91. View in: PubMed

Integrating biomarkers into clinical decision making for colorectal cancer. Clin Colorectal Cancer. 2010; 9 Suppl 1:S16-27. View in: PubMed

Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy. Oncologist. 2010; 15(8):836-44. View in: PubMed

The colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information. BMC Cancer. 2010; 10:687. View in: PubMed

The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38. Int J Cancer. 2009 Dec 15; 125(12):2957-69. View in: PubMed

Phase I trial of GTI-2040, oxaliplatin, and capecitabine in the treatment of advanced metastatic solid tumors: a California Cancer Consortium Study. Cancer Chemother Pharmacol. 2009 Nov; 64(6):1149-55. View in: PubMed

Gender disparities in metastatic colorectal cancer survival. Clin Cancer Res. 2009 Oct 15; 15(20):6391-7. View in: PubMed

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother Pharmacol. 2009 Sep; 64(4):777-83. View in: PubMed

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4. View in: PubMed

Japanese-US common-arm analysis of paclitaxel plus carboplatin in advanced non-small-cell lung cancer: a model for assessing population-related pharmacogenomics. J Clin Oncol. 2009 Jul 20; 27(21):3540-6. View in: PubMed

Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells. Int J Cancer. 2009 Jul 15; 125(2):463-73. View in: PubMed

Pharmacogenomics and -genetics in colorectal cancer. Adv Drug Deliv Rev. 2009 May 20; 61(5):375-80. View in: PubMed

Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer: clinical and pharmacogenomic results from SWOG S0124. J Clin Oncol. 2009 May 20; 27(15):2530-5. View in: PubMed

Phase II studies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer. J Clin Oncol. 2009 May 1; 27(13):2163-9. View in: PubMed

Chemotherapy with targeted agents for the treatment of metastatic colorectal cancer. Oncologist. 2009 May; 14(5):478-88. View in: PubMed

Thymidylate synthase gene variations: predictive and prognostic markers. Mol Cancer Ther. 2009 May; 8(5):1000-7. View in: PubMed

Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. Int J Oncol. 2009 Apr; 34(4):1147-53. View in: PubMed

Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. Pharmacogenet Genomics. 2009 Feb; 19(2):95-102. View in: PubMed

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan; 37(1):78-95. View in: PubMed

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines. BMC Med Genomics. 2009; 2:67. View in: PubMed

EGFR signaling and drug discovery. Oncology. 2009; 77(6):400-10. View in: PubMed

KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors. Clin Adv Hematol Oncol. 2008 Dec; 6(12):1-13, 14-6. View in: PubMed

Messenger RNA expression of TS and ERCC1 in colorectal cancer and matched liver metastasis. Int J Oncol. 2008 Dec; 33(6):1257-62. View in: PubMed

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Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine: a California Cancer Consortium Trial. Cancer Chemother Pharmacol. 2002 Nov; 50(5):353-9. View in: PubMed

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