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Hooman Allayee, PhD
Professor of Preventive Medicine
Preventive Medicine
CSC CSC202 Health Sciences Campus Los Angeles
+1 323 442 1736


Dr. Allayee is Professor of Preventive Medicine and Biochemistry & Molecular Medicine at the Keck School of Medicine of USC. His research program is focused on using multi-disciplinary genetics/genomics approaches to understand complex disorders, with an emphasis on cardiovascular, metabolic, and inflammatory diseases. In particular, his laboratory employs systems genetics strategies to dissect the architecture of complex diseases where a variety of intermediate phenotypes at the molecular, proteomic, and metabolomic levels are integrated into the genetic analyses. Current projects involve large-scale population studies in humans, gene-environment interactions, functional experiments using molecular genetics techniques, and the generation and characterization of mouse models. Dr. Allayee received his Ph.D. in Microbiology and Molecular Genetics in 1999 from the University of California, Los Angeles. Prior to joining USC, Dr. Allayee completed NIH Postdoctoral Fellowships at Harbor-UCLA Medical Center and the David Geffen School of Medicine UCLA.


The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities. Curr Atheroscler Rep. 2017 Feb; 19(2):6. View in: PubMed

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden. FASEB J. 2016 Dec 28. View in: PubMed

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. G3 (Bethesda). 2016 Oct 13; 6(10):3219-3228. View in: PubMed

Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. View in: PubMed

Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. Neurology. 2016 Aug 16; 87(7):699-708. View in: PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. J Am Heart Assoc. 2016 Aug; 5(8). View in: PubMed

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium. Diabetes. 2016 Jul; 65(7):2072-80. View in: PubMed

Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity. Obesity (Silver Spring). 2016 Jun; 24(6):1274-82. View in: PubMed

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Jun; 9(3):291-313. View in: PubMed

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 Jun; 57(6):925-42. View in: PubMed

Expanding role of gut microbiota in lipid metabolism. Curr Opin Lipidol. 2016 Apr; 27(2):141-7. View in: PubMed

Choline metabolites: gene by diet interactions. Curr Opin Lipidol. 2016 Feb; 27(1):33-9. View in: PubMed

Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2016 Feb; 11(1):1-3. View in: PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016; 9(1):12-27. View in: PubMed

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016; 17(1):171. View in: PubMed

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nat Commun. 2016; 7:10558. View in: PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016; 9(1):28-46. View in: PubMed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov; 47(11):1282-93. View in: PubMed

Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. 2015 Oct 9; 117(9):750-4. View in: PubMed

Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early Hum Dev. 2015 Aug; 91(8):483-9. View in: PubMed

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. View in: PubMed

Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. View in: PubMed

Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. View in: PubMed

Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. Obesity (Silver Spring). 2015 Feb 3. View in: PubMed

The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015; 5(11):2329-39. View in: PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia. 2014 Jul; 57(7):1391-9. View in: PubMed

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and l-Carnitine. Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. View in: PubMed

Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children. Obesity (Silver Spring). 2014 Jun; 22(6):1512-9. View in: PubMed

Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth. Obesity (Silver Spring). 2014 Feb; 22(2):474-81. View in: PubMed

Habitual Diets Rich in Dark-Green Vegetables Are Associated with an Increased Response to ?-3 Fatty Acid Supplementation in Americans of African Ancestry. J Nutr. 2014 Feb; 144(2):123-31. View in: PubMed

Adipose tissue 11ßHSD1 gene expression, ßcell function and ectopic fat in obese African Americans versus Hispanics. Obesity (Silver Spring). 2014 Jan; 22(1):14-8. View in: PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. View in: PubMed

Genetic and clinical markers of elevated liver fat content in overweight and obese hispanic children. Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. View in: PubMed

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013 Aug 15; 22(16):3381-93. View in: PubMed

Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circ Cardiovasc Genet. 2013 Aug; 6(4):372-80. View in: PubMed

ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. Clin Exp Allergy. 2013 May; 43(5):512-20. View in: PubMed

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2). J Biol Chem. 2013 Apr 26; 288(17):11940-8. View in: PubMed

Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol. 2013 Mar 5; 61(9):957-70. View in: PubMed

Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials. 2013 Mar; 34(2):326-35. View in: PubMed

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 8; 17(1):49-60. View in: PubMed

Seventy-five genetic loci influencing the human red blood cell. Nature. 2012 Dec 20; 492(7429):369-75. View in: PubMed

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2803-12. View in: PubMed

Metabolic Syndrome Is Linked to Chromosome 7q21 and Associated With Genetic Variants in CD36 and GNAT3 in Mexican Americans. Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. View in: PubMed

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. View in: PubMed

Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circ Cardiovasc Genet. 2012 Aug 1; 5(4):441-9. View in: PubMed

Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy african americans. J Nutr. 2012 Aug; 142(8):1417-28. View in: PubMed

Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. View in: PubMed

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr. 2012 Jul; 96(1):80-9. View in: PubMed

Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs. Am J Clin Nutr. 2012 Apr; 95(4):959-65. View in: PubMed

Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):516-22. View in: PubMed

CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults. Hum Genomics. 2012; 6:9. View in: PubMed

Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-?B stress pathway. Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-? B stress pathway. Diabetes. 2011 Nov; 60(11):2802-9. View in: PubMed

A novel g. -1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clin Genet. 2011 Sep; 80(3):265-72. View in: PubMed

Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology. 2011 Jul; 22(4):476-85. View in: PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet. 2011 Jun; 129(6):617-27. View in: PubMed

ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res. 2011 May; 52(5):991-1003. View in: PubMed

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 7; 472(7341):57-63. View in: PubMed

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Apr; 43(4):333-8. View in: PubMed

Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 2011 Feb 1; 123(4):374-80. View in: PubMed

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011 Jan 29; 377(9763):383-92. View in: PubMed

New gene functions in megakaryopoiesis and platelet formation. Nature. 2011; 480(7376):201-8. View in: PubMed

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 2011; 7(2):e1001300. View in: PubMed

Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load. Biodemography Soc Biol. 2011; 57(1):33-52. View in: PubMed

Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Med Genet. 2011; 12:127. View in: PubMed

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes. 2010 Dec; 59(12):3127-30. View in: PubMed

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. Am J Clin Nutr. 2010 Dec; 92(6):1522-7. View in: PubMed

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. J Lipid Res. 2010 Oct; 51(10):3055-61. View in: PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. Diabetes. 2009 Dec; 58(12):2946-53. View in: PubMed

Functional analysis of 5-lipoxygenase promoter repeat variants. Hum Mol Genet. 2009 Dec 1; 18(23):4521-9. View in: PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. View in: PubMed

Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay. Genet Test Mol Biomarkers. 2009 Jun; 13(3):361-5. View in: PubMed

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans. Obesity (Silver Spring). 2009 Apr; 17(4):729-36. View in: PubMed

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009 Feb 1; 18(3):569-79. View in: PubMed

Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics. J Nutrigenet Nutrigenomics. 2009; 2(3):140-8. View in: PubMed

Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr. 2008 Oct; 88(4):934-40. View in: PubMed

Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun; 51(6):978-88. View in: PubMed

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Hum Genet. 2008 May; 123(4):399-408. View in: PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans. Diabetes. 2008 Apr; 57(4):1048-56. View in: PubMed

Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa. Clin Genet. 2008 Apr; 73(4):385-7. View in: PubMed

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA. 2008 Mar 19; 299(11):1265-76. View in: PubMed

Non-conventional genetic risk factors for cardiovascular disease. World Rev Nutr Diet. 2008; 98:62-76. View in: PubMed

Prevalence of common disease-associated variants in Asian Indians. BMC Genet. 2008; 9:13. View in: PubMed

FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicol Sci. 2007 Dec; 100(2):474-85. View in: PubMed

The effect of montelukast and low-dose theophylline on cardiovascular dasease risk factgrs in asthmatics. Chest. 2007 Sep; 132(3):868-74. View in: PubMed

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest. 2007 Sep; 132(3):868-74. View in: PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes. Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. View in: PubMed

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. Diabetes. 2007 May; 56(5):1481-5. View in: PubMed

A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24. 3. Hum Genet. 2007 Jan; 120(5):653-62. View in: PubMed

Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma. 2006 Sep; 43(7):553-8. View in: PubMed

Nonconventional genetic risk factors for cardiovascular disease. Curr Atheroscler Rep. 2006 May; 8(3):184-92. View in: PubMed

Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med. 2006 Feb 15; 173(4):379-85. View in: PubMed

Using inbred mouse strains to identify genes for complex diseases. Front Biosci. 2006; 11:1216-26. View in: PubMed

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005 Nov; 37(11):1224-33. View in: PubMed

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics. 2005 Sep; 86(3):259-70. View in: PubMed

The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. View in: PubMed

Vascular cross-talk: a conversation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1748-9. View in: PubMed

Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1935-41. View in: PubMed

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res. 2004 Apr 16; 94(7):993-9. View in: PubMed

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004 Jan 1; 350(1):29-37. View in: PubMed

5-lipoxygenase and atherosclerosis. Curr Opin Lipidol. 2003 Oct; 14(5):447-57. View in: PubMed

Using mice to dissect genetic factors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Sep 1; 23(9):1501-9. View in: PubMed

Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Circ Res. 2003 Jun 13; 92(11):1262-7. View in: PubMed

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am J Hum Genet. 2003 Apr; 72(4):903-17. View in: PubMed

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res. 2002 Jul 26; 91(2):120-6. View in: PubMed

Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia. Circ Res. 2002 May 3; 90(8):926-31. View in: PubMed

Understanding atherosclerosis through mouse genetics. Curr Opin Lipidol. 2002 Apr; 13(2):181-9. View in: PubMed

Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension. 2001 Oct; 38(4):773-8. View in: PubMed

Biochemistry. An absorbing study of cholesterol. Science. 2000 Dec 1; 290(5497):1709-11. View in: PubMed

Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. Int J Obes Relat Metab Disord. 2000 Nov; 24(11):1381-91. View in: PubMed

Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia. Hum Mol Genet. 2000 Sep 1; 9(14):2067-74. View in: PubMed

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res. 2000 Apr; 41(4):573-82. View in: PubMed

Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J Lipid Res. 2000 Feb; 41(2):245-52. View in: PubMed

Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2730-6. View in: PubMed

A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11. Am J Hum Genet. 1999 Aug; 65(2):397-412. View in: PubMed

Novel genes for familial combined hyperlipidemia. Curr Opin Lipidol. 1999 Apr; 10(2):113-22. View in: PubMed

Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype. Am J Hum Genet. 1998 Aug; 63(2):577-85. View in: PubMed

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J Clin Invest. 1994 Aug; 94(2):877-84. View in: PubMed

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