Faculty

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Hooman Allayee, PhD
Professor of Preventive Medicine
Preventive Medicine
CSC CSC202 Health Sciences Campus Los Angeles
+1 323 442 1736

Publications

The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities. Curr Atheroscler Rep. 2017 Feb; 19(2):6. View in: PubMed

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden. FASEB J. 2016 Dec 28. View in: PubMed

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. G3 (Bethesda). 2016 Oct 13; 6(10):3219-3228. View in: PubMed

Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. View in: PubMed

Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. Neurology. 2016 Aug 16; 87(7):699-708. View in: PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. J Am Heart Assoc. 2016 Aug; 5(8). View in: PubMed

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium. Diabetes. 2016 Jul; 65(7):2072-80. View in: PubMed

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 Jun; 57(6):925-42. View in: PubMed

Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2016 Jun; 9(3):291-313. View in: PubMed

Lower omental t-regulatory cell count is associated with higher fasting glucose and lower ß-cell function in adults with obesity. Obesity (Silver Spring). 2016 Jun; 24(6):1274-82. View in: PubMed

Expanding role of gut microbiota in lipid metabolism. Curr Opin Lipidol. 2016 Apr; 27(2):141-7. View in: PubMed

Choline metabolites: gene by diet interactions. Curr Opin Lipidol. 2016 Feb; 27(1):33-9. View in: PubMed

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016; 17(1):171. View in: PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016; 9(1):12-27. View in: PubMed

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016; 9(1):28-46. View in: PubMed

Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease. Nat Commun. 2016; 7:10558. View in: PubMed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov; 47(11):1282-93. View in: PubMed

Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. Contribution of Gut Bacteria to Lipid Levels: Another Metabolic Role for Microbes? Circ Res. 2015 Oct 9; 117(9):750-4. View in: PubMed

Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Early Hum Dev. 2015 Aug; 91(8):483-9. View in: PubMed

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. View in: PubMed

Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. View in: PubMed

Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. View in: PubMed

Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. Obesity (Silver Spring). 2015 Feb 3. View in: PubMed

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb 2; 518(7537):102-6. View in: PubMed

The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015; 5(11):2329-39. View in: PubMed

Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia. 2014 Jul; 57(7):1391-9. View in: PubMed

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and l-Carnitine. Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. View in: PubMed

Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children. Obesity (Silver Spring). 2014 Jun; 22(6):1512-9. View in: PubMed

Habitual Diets Rich in Dark-Green Vegetables Are Associated with an Increased Response to ?-3 Fatty Acid Supplementation in Americans of African Ancestry. J Nutr. 2014 Feb; 144(2):123-31. View in: PubMed

Modifying influence of dietary sugar in the relationship between cortisol and visceral adipose tissue in minority youth. Obesity (Silver Spring). 2014 Feb; 22(2):474-81. View in: PubMed

Adipose tissue 11ßHSD1 gene expression, ßcell function and ectopic fat in obese African Americans versus Hispanics. Obesity (Silver Spring). 2014 Jan; 22(1):14-8. View in: PubMed

Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. View in: PubMed

Genetic and clinical markers of elevated liver fat content in overweight and obese hispanic children. Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. View in: PubMed

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013 Aug 15; 22(16):3381-93. View in: PubMed

Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circ Cardiovasc Genet. 2013 Aug; 6(4):372-80. View in: PubMed

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2). J Biol Chem. 2013 Apr 26; 288(17):11940-8. View in: PubMed

Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol. 2013 Mar 5; 61(9):957-70. View in: PubMed

Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. Contemp Clin Trials. 2013 Mar; 34(2):326-35. View in: PubMed

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 8; 17(1):49-60. View in: PubMed

Seventy-five genetic loci influencing the human red blood cell. Nature. 2012 Dec 20; 492(7429):369-75. View in: PubMed

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2803-12. View in: PubMed

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. View in: PubMed

Metabolic Syndrome Is Linked to Chromosome 7q21 and Associated With Genetic Variants in CD36 and GNAT3 in Mexican Americans. Obesity (Silver Spring). 2012 Oct; 20(10):2083-92. View in: PubMed

Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy african americans. J Nutr. 2012 Aug; 142(8):1417-28. View in: PubMed

Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography. Circ Cardiovasc Genet. 2012 Aug 1; 5(4):441-9. View in: PubMed

Genetic-related and carbohydrate-related factors affecting liver fat accumulation. Curr Opin Clin Nutr Metab Care. 2012 Jul; 15(4):392-6. View in: PubMed

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr. 2012 Jul; 96(1):80-9. View in: PubMed

Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs. Am J Clin Nutr. 2012 Apr; 95(4):959-65. View in: PubMed

Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):516-22. View in: PubMed

CXCL5 polymorphisms are associated with variable blood pressure in cardiovascular disease-free adults. Hum Genomics. 2012; 6:9. View in: PubMed

Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-?B stress pathway. Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-? B stress pathway. Diabetes. 2011 Nov; 60(11):2802-9. View in: PubMed

Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology. 2011 Jul; 22(4):476-85. View in: PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet. 2011 Jun; 129(6):617-27. View in: PubMed

ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. J Lipid Res. 2011 May; 52(5):991-1003. View in: PubMed

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011 Apr 7; 472(7341):57-63. View in: PubMed

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Apr; 43(4):333-8. View in: PubMed

Genetic risk score and risk of myocardial infarction in Hispanics. Circulation. 2011 Feb 1; 123(4):374-80. View in: PubMed

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011 Jan 29; 377(9763):383-92. View in: PubMed

Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load. Biodemography Soc Biol. 2011; 57(1):33-52. View in: PubMed

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet. 2011; 7(2):e1001300. View in: PubMed

Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Med Genet. 2011; 12:127. View in: PubMed

New gene functions in megakaryopoiesis and platelet formation. Nature. 2011; 480(7376):201-8. View in: PubMed

Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents. Diabetes. 2010 Dec; 59(12):3127-30. View in: PubMed

Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. Am J Clin Nutr. 2010 Dec; 92(6):1522-7. View in: PubMed

Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy. J Lipid Res. 2010 Oct; 51(10):3055-61. View in: PubMed

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose. Diabetes. 2009 Dec; 58(12):2946-53. View in: PubMed

Functional analysis of 5-lipoxygenase promoter repeat variants. Hum Mol Genet. 2009 Dec 1; 18(23):4521-9. View in: PubMed

Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. View in: PubMed

Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay. Genet Test Mol Biomarkers. 2009 Jun; 13(3):361-5. View in: PubMed

Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans. Obesity (Silver Spring). 2009 Apr; 17(4):729-36. View in: PubMed

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet. 2009 Feb 1; 18(3):569-79. View in: PubMed

Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics. J Nutrigenet Nutrigenomics. 2009; 2(3):140-8. View in: PubMed

Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. Am J Clin Nutr. 2008 Oct; 88(4):934-40. View in: PubMed

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Hum Genet. 2008 May; 123(4):399-408. View in: PubMed

Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans. Diabetes. 2008 Apr; 57(4):1048-56. View in: PubMed

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA. 2008 Mar 19; 299(11):1265-76. View in: PubMed

Non-conventional genetic risk factors for cardiovascular disease. World Rev Nutr Diet. 2008; 98:62-76. View in: PubMed

Prevalence of common disease-associated variants in Asian Indians. BMC Genet. 2008; 9:13. View in: PubMed

FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicol Sci. 2007 Dec; 100(2):474-85. View in: PubMed

The effect of montelukast and low-dose theophylline on cardiovascular dasease risk factgrs in asthmatics. Chest. 2007 Sep; 132(3):868-74. View in: PubMed

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest. 2007 Sep; 132(3):868-74. View in: PubMed

Genetics of gestational diabetes mellitus and type 2 diabetes. Diabetes Care. 2007 Jul; 30 Suppl 2:S134-40. View in: PubMed

Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans. Diabetes. 2007 May; 56(5):1481-5. View in: PubMed

A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q24. 3. Hum Genet. 2007 Jan; 120(5):653-62. View in: PubMed

Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma. 2006 Sep; 43(7):553-8. View in: PubMed

Nonconventional genetic risk factors for cardiovascular disease. Curr Atheroscler Rep. 2006 May; 8(3):184-92. View in: PubMed

Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med. 2006 Feb 15; 173(4):379-85. View in: PubMed

Using inbred mouse strains to identify genes for complex diseases. Front Biosci. 2006; 11:1216-26. View in: PubMed

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005 Nov; 37(11):1224-33. View in: PubMed

A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics. 2005 Sep; 86(3):259-70. View in: PubMed

The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. View in: PubMed

Vascular cross-talk: a conversation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1748-9. View in: PubMed

Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1935-41. View in: PubMed

Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Circ Res. 2004 Apr 16; 94(7):993-9. View in: PubMed

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med. 2004 Jan 1; 350(1):29-37. View in: PubMed

5-lipoxygenase and atherosclerosis. Curr Opin Lipidol. 2003 Oct; 14(5):447-57. View in: PubMed

Using mice to dissect genetic factors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Sep 1; 23(9):1501-9. View in: PubMed

Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia. Circ Res. 2003 Jun 13; 92(11):1262-7. View in: PubMed

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am J Hum Genet. 2003 Apr; 72(4):903-17. View in: PubMed

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res. 2002 Jul 26; 91(2):120-6. View in: PubMed

Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia. Circ Res. 2002 May 3; 90(8):926-31. View in: PubMed

Understanding atherosclerosis through mouse genetics. Curr Opin Lipidol. 2002 Apr; 13(2):181-9. View in: PubMed

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