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Hussein Yassine, MD
Assistant Professor of Medicine
Medicine
CSC 210 Health Sciences Campus Los Angeles
+1 323 442 1909

Overview

Dr. Yassine is an Assistant Professor of Medicine-Endocrinology at the University of Southern California and was mentored by Dr. Serrine Lau. Dr. Yassine graduated from Beirut Arab University in June 2003 with his MD. He completed residency training in Internal Medicine at Case Western Reserve University, and graduated in June 2007. Dr. Yassine was awarded the prestigious “Resident Teacher of the Year” at graduation. Dr. Yassine was awarded the “Presidential Poster Award” (2009) from the Endocrine Society for research on platelet function in diabetes. Dr. Yassine was co-mentored by additional SWEHSC members including Drs. Craig Stump (Endocrinology, clinical expertise), Dean Billheimer (Biostatistics, proteomics and population analysis) and Donata Vercelli (Advisor, clinical and genetics expertise).

Dr. Yassine's long term research program focuses on the contribution of dyslipidemia to atherosclerosis. He completed his post-doctoral training in the Lau Lab (2010) in the application of mass spectrometry to study proteins and protein modifications relevant to diabetes and cardiovascular disease. He joined the faculty at the University of Arizona and established the lipid clinic. With this exposure, he developed an understanding of the unmet clinical needs in lipids and cardiovascular disease. To that end, he obtained a career development award from NIH K23 grant HL107389, entitled "Effect of Saturated Fat on HDL Proteome, " with Dr. Serrine Lau as his main mentor. and an AHA clinical research award to study HDL protein composition by mass spectrometry in diabetes.

In 2009 Dr. Yassine served as a key personnel on a SWEHSC Pilot project grant (PI-Stump) to study the role of arsenic exposure on diabetes development and complications. Dr. Yassine was mentored by Drs. Lau and Tsaprailis on the utilization of mass spectrometry-based proteomics approaches in determining protein biomarkers associated with Type 2 Diabetes and the association of arsenic exposure and diabetes development. In addition to providing mentors from all disciplines, secretarial, and computer support, the SWEHSC was a platform for promoting interactions with Drs. Randy Nelson and Peter Reaven, established investigators in diabetes projects at the Biodesign Institute of ASU, and the Phoenix VA Medical Center, respectively. These interactions resulted in Dr. Yassine serving as a co-Investigator on a NIH R01 application titled “Population Proteomics of Type 2 Diabetes” led by Dr. Nelson. He moved to the University of Southern California in September 2012 to establish his own laboratory.

Awards

Beirut Arab University, Beirut, Lebanon: Dean's Distinguished Student Medicine Day Award, 2002

Beirut Arab University, Beirut, Lebanon: Dean's Honor List on graduation, 2003

Case Western Reserve University, Cleveland, OH: Resident Teacher of the Year Award, 2007

Department of Veterans Affairs VISN 18 Outstanding Research Award

Presidential Poster Award, Endocrine Society

Beirut Arab University, Beirut, Lebanon : Dean's Distinguished Student Medicine Day Award, 2002

Beirut Arab University, Beirut, Lebanon : Dean's Honor List on graduation, 2003

Case Western Reserve University, Cleveland, OH : Resident Teacher of the Year Award, 2007

Department of Veterans Affairs VISN 18 Outstanding Research Award

Presidential Poster Award, Endocrine Society

Beirut Arab University, Beirut, Lebanon : award conferred by, 2003

Case Western Reserve University, Cleveland, OH : award conferred by, 2007

is primary position

Beirut Arab University, Beirut, Lebanon : award conferred by, 2002

ORNG Application Instance for Person

Beirut Arab University, Beirut, Lebanon : ORNG Application Instance for Person, 2003

Beirut Arab University, Beirut, Lebanon : ORNG Application Instance for Person, 2002

Beirut Arab University, Beirut, Lebanon : start date, 2002

Beirut Arab University, Beirut, Lebanon : start date, 2003

start date

Case Western Reserve University, Cleveland, OH : start date, 2007

full name

Beirut Arab University, Beirut, Lebanon : full name, 2003

Beirut Arab University, Beirut, Lebanon : full name, 2002

Case Western Reserve University, Cleveland, OH : full name, 2007

Required Scholarly Project Mentor

Case Western Reserve University, Cleveland, OH : Required Scholarly Project Mentor, 2007

Beirut Arab University, Beirut, Lebanon : Required Scholarly Project Mentor, 2002

Beirut Arab University, Beirut, Lebanon : Required Scholarly Project Mentor, 2003

Case Western Reserve University, Cleveland, OH : person in primary position, 2007

Beirut Arab University, Beirut, Lebanon : person in primary position, 2003

Beirut Arab University, Beirut, Lebanon : person in primary position, 2002

person in primary position

Beirut Arab University, Beirut, Lebanon : is primary position, 2003

Case Western Reserve University, Cleveland, OH : is primary position, 2007

Beirut Arab University, Beirut, Lebanon : is primary position, 2002

Beirut Arab University, Beirut, Lebanon : last name, 2002

Case Western Reserve University, Cleveland, OH : last name, 2007

Beirut Arab University, Beirut, Lebanon : last name, 2003

last name

ORNG Application URL

Case Western Reserve University, Cleveland, OH : ORNG Application URL, 2007

Beirut Arab University, Beirut, Lebanon : ORNG Application URL, 2003

Beirut Arab University, Beirut, Lebanon : ORNG Application URL, 2002

Beirut Arab University, Beirut, Lebanon : HR job title, 2002

Beirut Arab University, Beirut, Lebanon : HR job title, 2003

Case Western Reserve University, Cleveland, OH : HR job title, 2007

HR job title

Case Western Reserve University, Cleveland, OH : Department, 2007

Department

Beirut Arab University, Beirut, Lebanon : Department, 2002

Beirut Arab University, Beirut, Lebanon : Department, 2003

Beirut Arab University, Beirut, Lebanon : Assistant Professor of Medicine, 2003

Case Western Reserve University, Cleveland, OH : Assistant Professor of Medicine, 2007

Assistant Professor of Medicine

Beirut Arab University, Beirut, Lebanon : Assistant Professor of Medicine, 2002

sort order

Beirut Arab University, Beirut, Lebanon : sort order, 2002

Beirut Arab University, Beirut, Lebanon : sort order, 2003

Case Western Reserve University, Cleveland, OH : sort order, 2007

Person

Beirut Arab University, Beirut, Lebanon : Person, 2002

Case Western Reserve University, Cleveland, OH : Person, 2007

Beirut Arab University, Beirut, Lebanon : Person, 2003

Assistant Professor

Beirut Arab University, Beirut, Lebanon : Assistant Professor, 2002

Beirut Arab University, Beirut, Lebanon : Assistant Professor, 2003

Case Western Reserve University, Cleveland, OH : Assistant Professor, 2007

Beirut Arab University, Beirut, Lebanon : email address, 2002

email address

Beirut Arab University, Beirut, Lebanon : email address, 2003

Case Western Reserve University, Cleveland, OH : email address, 2007

Beirut Arab University, Beirut, Lebanon : Person ID, 2003

Beirut Arab University, Beirut, Lebanon : Person ID, 2002

Person ID

Case Western Reserve University, Cleveland, OH : Person ID, 2007

Beirut Arab University, Beirut, Lebanon : label, 2002

label

Case Western Reserve University, Cleveland, OH : label, 2007

Beirut Arab University, Beirut, Lebanon : label, 2003

Beirut Arab University, Beirut, Lebanon : position in organization, 2003

Case Western Reserve University, Cleveland, OH : position in organization, 2007

Beirut Arab University, Beirut, Lebanon : position in organization, 2002

position in organization

Faculty Rank

Organization

Beirut Arab University, Beirut, Lebanon : Organization, 2003

Case Western Reserve University, Cleveland, OH : Organization, 2007

Beirut Arab University, Beirut, Lebanon : Organization, 2002

Beirut Arab University, Beirut, Lebanon : first name, 2002

Beirut Arab University, Beirut, Lebanon : first name, 2003

first name

Case Western Reserve University, Cleveland, OH : first name, 2007

Beirut Arab University, Beirut, Lebanon : preferred title, 2003

Case Western Reserve University, Cleveland, OH : preferred title, 2007

preferred title

Case Western Reserve University, Cleveland, OH : ORNG Application Instance for Person, 2007

Agent

Beirut Arab University, Beirut, Lebanon : Agent, 2003

Beirut Arab University, Beirut, Lebanon : Agent, 2002

Case Western Reserve University, Cleveland, OH : Agent, 2007

RequiredScholarlyProjectMentor

Beirut Arab University, Beirut, Lebanon : RequiredScholarlyProjectMentor, 2003

Case Western Reserve University, Cleveland, OH : RequiredScholarlyProjectMentor, 2007

Beirut Arab University, Beirut, Lebanon : RequiredScholarlyProjectMentor, 2002

Yassine, Hussein

Beirut Arab University, Beirut, Lebanon : Yassine, Hussein, 2002

Case Western Reserve University, Cleveland, OH : Yassine, Hussein, 2007

Beirut Arab University, Beirut, Lebanon : Yassine, Hussein, 2003

has faculty rank

Case Western Reserve University, Cleveland, OH : has faculty rank, 2007

Beirut Arab University, Beirut, Lebanon : has faculty rank, 2003

Beirut Arab University, Beirut, Lebanon : preferred title, 2002

Beirut Arab University, Beirut, Lebanon : Keck School of Medicine of USC, 2002

Beirut Arab University, Beirut, Lebanon : Keck School of Medicine of USC, 2003

Keck School of Medicine of USC

Case Western Reserve University, Cleveland, OH : Keck School of Medicine of USC, 2007

Beirut Arab University, Beirut, Lebanon : Medicine, 2003

Beirut Arab University, Beirut, Lebanon : Medicine, 2002

Medicine

Case Western Reserve University, Cleveland, OH : Medicine, 2007

Beirut Arab University, Beirut, Lebanon : http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10112-123, 2002

http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10112-123

Case Western Reserve University, Cleveland, OH : http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10112-123, 2007

Case Western Reserve University, Cleveland, OH : Position, 2007

Position

Beirut Arab University, Beirut, Lebanon : Position, 2003

Beirut Arab University, Beirut, Lebanon : Position, 2002

position in department

Beirut Arab University, Beirut, Lebanon : position in department, 2002

Beirut Arab University, Beirut, Lebanon : position in department, 2003

Beirut Arab University, Beirut, Lebanon : http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10112-123, 2003

Beirut Arab University, Beirut, Lebanon : has faculty rank, 2002

Case Western Reserve University, Cleveland, OH : position in department, 2007

Publications

DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA. Alzheimers Res Ther. 2017 Mar 23; 9(1):23. View in: PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review. JAMA Neurol. 2017 Jan 17. View in: PubMed

Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions. J Clin Lipidol. 2017 Jan - Feb; 11(1):224-233. e2. View in: PubMed

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis. JAMA Neurol. 2016 Oct 1; 73(10):1208-1216. View in: PubMed

Development of quantitative mass spectrometric immunoassay for serum amyloid A. Biomarkers. 2016 Jul 22; 1-9. View in: PubMed

Posttranslational modifications of apolipoprotein A-II proteoforms in type 2 diabetes. J Clin Lipidol. 2016 Jul-Aug; 10(4):808-15. View in: PubMed

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Am Heart Assoc. 2016; 5(2). View in: PubMed

The association of plasma cystatin C proteoforms with diabetic chronic kidney disease. Proteome Sci. 2016; 14:7. View in: PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimers Res Ther. 2016; 8:25. View in: PubMed

Site specific modification of the human plasma proteome by methylglyoxal. Toxicol Appl Pharmacol. 2015 Dec 1; 289(2):155-62. View in: PubMed

The Association of Human Apolipoprotein C-III Sialylation Proteoforms with Plasma Triglycerides. PLoS One. 2015; 10(12):e0144138. View in: PubMed

Serum amyloid a truncations in type 2 diabetes mellitus. PLoS One. 2015; 10(1):e0115320. View in: PubMed

The Application of Multiple Reaction Monitoring to Assess Apo A-I Methionine Oxidations in Diabetes and Cardiovascular Disease. Transl Proteom. 2014 Dec 1; 4-5:18-24. View in: PubMed

Elevated Plasma Albumin and Apolipoprotein A-I Oxidation under Suboptimal Specimen Storage Conditions. Mol Cell Proteomics. 2014 Jul; 13(7):1890-9. View in: PubMed

Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes. Metabolism. 2014 May; 63(5):727-34. View in: PubMed

The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins. Lipids Health Dis. 2014; 13(1):8. View in: PubMed

Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: potential applications to cardiovascular disease and diabetes. Proteomics Clin Appl. 2013 Aug; 7(7-8):528-40. View in: PubMed

Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade. Endocr Pract. 2012 Sep-Oct; 18(5):e111-3. View in: PubMed

Adjusting for Urinary Creatinine Overestimates Arsenic Concentrations in Diabetics. Cardiorenal Med. 2012 Feb; 2(1):26-32. View in: PubMed

New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chem Biol Interact. 2011 Jun 30; 192(1-2):122-8. View in: PubMed

Clinical determinants of aspirin resistance in diabetes. Diabetes Res Clin Pract. 2010 Oct; 90(1):e19-21. View in: PubMed

Effect of glucose or fat challenge on aspirin resistance in diabetes. Int J Endocrinol. 2010; 2010:820876. View in: PubMed

Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):90-5. View in: PubMed

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