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Jaana Hartiala, PhD

Assistant Professor of Clinical Population and Public Health Sciences

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Overview

Jaana A. Hartiala, Ph.D., is an Assistant Professor of Clinical Preventive Medicine in the Department of Preventive Medicine at the University of Southern California. She earned her doctorate in Molecular Epidemiology from the University of Southern California. Dr. Hartiala received her post-doctoral training in Applied Statistical Genetics at the USC Keck School of Medicine, where she studied genome-wide associations of metabolite levels and cardiovascular disease. Dr. Hartiala’s research interests include systems genetics and computational biology approaches to identify genes and pathways for cardiovascular and pulmonary diseases; identification of environmental exposures that modulate susceptibility to cardiopulmonary diseases using epidemiological approaches; and study genome-wide gene-environment interactions for disease outcome and associated biomarkers. Dr. Hartiala’s more recent work include identifying a sex-specific genetic variant in the CPS1 gene that raises glycine levels and protects against cardiovascular disease among women. In another project, she showed that ambient air pollution is associated with the severity of coronary atherosclerosis and incident myocardial infarction among cardiac patients. Her current projects involve integrating large scale genetic, gene expression and metabolomic data to understand susceptibility to atherosclerosis and asthma.

Publications

  • Relationships and Mendelian Randomization of Gut Microbe-Derived Metabolites with Metabolic Syndrome Traits in the METSIM Cohort Metabolites. 2024 Mar 20; 14(3). . View in PubMed
  • Publisher Correction: A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk Nat Med. 2024 Mar 06. . View in PubMed
  • A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk Nat Med. 2024 Feb; 30(2):424-434. . View in PubMed
  • Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity J Allergy Clin Immunol. 2024 Jan 19. . View in PubMed
  • Effect of Genetic and Dietary Perturbation of Glycine Metabolism on Atherosclerosis in Humans and Mice medRxiv. 2023 Dec 11. . View in PubMed
  • Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial J Nutr. 2022 07 06; 152(7):1655-1665. . View in PubMed
  • Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women Clin Epigenetics. 2022 07 18; 14(1):90. . View in PubMed
  • Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis Front Physiol. 2022; 13:909870. . View in PubMed
  • Gene-Environment Interactions for Cardiovascular Disease Curr Atheroscler Rep. 2021 10 14; 23(12):75. . View in PubMed
  • Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality Eur Heart J. 2021 05 07; 42(18):1742-1756. . View in PubMed
  • Genome-wide analysis identifies novel susceptibility loci for myocardial infarction Eur Heart J. 2021 03 01; 42(9):919-933. . View in PubMed
  • Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection J Lipid Res. 2021; 62:100061. . View in PubMed
  • Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus Circ Genom Precis Med. 2020 12; 13(6):e002769. . View in PubMed
  • Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data Circulation. 2020 08 11; 142(6):546-555. . View in PubMed
  • Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma Nat Commun. 2020 04 15; 11(1):1776. . View in PubMed
  • A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity PLoS Genet. 2019 12; 15(12):e1008528. . View in PubMed
  • Subsequent Event Risk in Individuals With Established Coronary Heart Disease Circ Genom Precis Med. 2019 04; 12(4):e002470. . View in PubMed
  • Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events Circ Genom Precis Med. 2019 04; 12(4):e002471. . View in PubMed
  • Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease J Am Heart Assoc. 2019 05 21; 8(10):e011922. . View in PubMed
  • Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice Sci Rep. 2019 02 12; 9(1):1816. . View in PubMed
  • Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk JCI Insight. 2018 03 22; 3(6). . View in PubMed
  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent Nat Commun. 2018 11 28; 9(1):5052. . View in PubMed
  • Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions Circulation. 2017 Jun 13; 135(24):2336-2353. . View in PubMed
  • The Genetic Architecture of Coronary Artery Disease: Current Knowledge and Future Opportunities Curr Atheroscler Rep. 2017 Feb; 19(2):6. . View in PubMed
  • Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study Lancet Diabetes Endocrinol. 2017 07; 5(7):534-543. . View in PubMed
  • Proceedings of the 11th Congress of the International Society of Nutrigenetics and Nutrigenomics (ISNN 2017) J Nutrigenet Nutrigenomics. 2017; 10(5-6):155-162. . View in PubMed
  • Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. . View in PubMed
  • Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease Nat Commun. 2016 Jan 29; 7:10558. . View in PubMed
  • Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation J Am Heart Assoc. 2016 07 28; 5(8). . View in PubMed
  • The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. . View in PubMed
  • Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study Early Hum Dev. 2015 Aug; 91(8):483-9. . View in PubMed
  • The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice Stem Cell Reports. 2015 Jul 14; 5(1):125-38. . View in PubMed
  • Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2737-48. . View in PubMed
  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction Nature. 2015 Feb 05; 518(7537):102-6. . View in PubMed
  • Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation Nat Genet. 2015 11; 47(11):1282-1293. . View in PubMed
  • Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans Diabetologia. 2014 Jul; 57(7):1391-9. . View in PubMed
  • Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine Arterioscler Thromb Vasc Biol. 2014 Jun; 34(6):1307-13. . View in PubMed
  • Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q231. Hum Mol Genet. 2014 Apr 15; 23(8):2198-209. . View in PubMed
  • Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children Obesity (Silver Spring). 2013 Dec; 21(12):E790-7. . View in PubMed
  • Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia Hum Mol Genet. 2013 Aug 15; 22(16):3381-93. . View in PubMed
  • Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2) J Biol Chem. 2013 Apr 26; 288(17):11940-8. . View in PubMed
  • Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis J Am Coll Cardiol. 2013 Mar 05; 61(9):957-70. . View in PubMed
  • Seventy-five genetic loci influencing the human red blood cell Nature. 2012 Dec 20; 492(7429):369-75. . View in PubMed
  • A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site Blood. 2012 Dec 06; 120(24):4859-68. . View in PubMed
  • Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2803-12. . View in PubMed
  • Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography Circ Cardiovasc Genet. 2012 Aug 01; 5(4):441-9. . View in PubMed
  • Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans J Nutr. 2012 Aug; 142(8):1417-28. . View in PubMed
  • Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study Am J Clin Nutr. 2012 Jul; 96(1):80-9. . View in PubMed
  • Association of PLA2G4A with myocardial infarction is modulated by dietary PUFAs Am J Clin Nutr. 2012 Apr; 95(4):959-65. . View in PubMed
  • Clinical and genetic association of serum ceruloplasmin with cardiovascular risk Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):516-22. . View in PubMed
  • New gene functions in megakaryopoiesis and platelet formation Nature. 2011 Nov 30; 480(7376):201-8. . View in PubMed
  • A novel g-1258G>A mutation in a conserved putative regulatory element of PAX9 is associated with autosomal dominant molar hypodontia. Clin Genet. 2011 Sep; 80(3):265-72. . View in PubMed
  • Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism Epidemiology. 2011 Jul; 22(4):476-85. . View in PubMed
  • Genetic contribution of the leukotriene pathway to coronary artery disease Hum Genet. 2011 Jun; 129(6):617-27. . View in PubMed
  • ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation J Lipid Res. 2011 May; 52(5):991-1003. . View in PubMed
  • Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project PLoS Genet. 2011 Feb 10; 7(2):e1001300. . View in PubMed
  • Genetic risk score and risk of myocardial infarction in Hispanics Circulation. 2011 Feb 01; 123(4):374-80. . View in PubMed
  • Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies Lancet. 2011 Jan 29; 377(9763):383-92. . View in PubMed
  • Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy J Lipid Res. 2010 Oct; 51(10):3055-61. . View in PubMed
  • Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease Circulation. 2010 Aug 10; 122(6):603-13. . View in PubMed
  • Functional analysis of 5-lipoxygenase promoter repeat variants Hum Mol Genet. 2009 Dec 01; 18(23):4521-9. . View in PubMed
  • Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes. 2009 Dec; 58(12):2946-53. . View in PubMed
  • Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans J Clin Endocrinol Metab. 2009 Oct; 94(10):4094-102. . View in PubMed
  • Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans Obesity (Silver Spring). 2009 Apr; 17(4):729-36. . View in PubMed
  • A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus Hum Mol Genet. 2009 Feb 01; 18(3):569-79. . View in PubMed
  • Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction Am J Clin Nutr. 2008 Oct; 88(4):934-40. . View in PubMed
  • Identification of ALOX5 as a gene regulating adiposity and pancreatic function Diabetologia. 2008 Jun; 51(6):978-88. . View in PubMed
  • Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease Hum Genet. 2008 May; 123(4):399-408. . View in PubMed
  • Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans Diabetes. 2008 Apr; 57(4):1048-56. . View in PubMed
  • Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa Clin Genet. 2008 Apr; 73(4):385-7. . View in PubMed
  • The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics Chest. 2007 Sep; 132(3):868-74. . View in PubMed
  • Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican Americans Diabetes. 2007 May; 56(5):1481-5. . View in PubMed
  • A new locus for autosomal dominant amelogenesis imperfecta on chromosome 8q243. Hum Genet. 2007 Jan; 120(5):653-62. . View in PubMed
  • Nonconventional genetic risk factors for cardiovascular disease Curr Atheroscler Rep. 2006 May; 8(3):184-92. . View in PubMed
  • Rett syndrome in a 47,XXX patient with a de novo MECP2 mutation Am J Med Genet A. 2003 Oct 15; 122A(3):223-6. . View in PubMed
  • Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica Hum Genet. 2003 May; 112(5-6):534-41. . View in PubMed
  • Population-based twin study of the effects of migration from Finland to Sweden on endothelial function and intima-media thickness Arterioscler Thromb Vasc Biol. 2002 May 01; 22(5):832-7. . View in PubMed
  • A susceptibility locus for migraine with aura, on chromosome 4q24 Am J Hum Genet. 2002 Mar; 70(3):652-62. . View in PubMed
  • Coronary flow reserve: measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography Clin Physiol. 2001 Jan; 21(1):114-22. . View in PubMed
  • Reduced myocardial flow reserve does not impair exercise capacity in asymptomatic men Am J Cardiol. 1999 Nov 15; 84(10):1253-5A8. . View in PubMed
  • Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels Am J Hum Genet. 1999 May; 64(5):1453-63. . View in PubMed
  • Glucose uptake in the chronically dysfunctional but viable myocardium Circulation. 1996 May 01; 93(9):1658-66. . View in PubMed
  • Exercise echocardiography in the diagnosis of coronary artery disease Ann Med. 1996 Feb; 28(1):73-7. . View in PubMed
  • Exercise thallium-201 scintigraphy in the localization of myocardial ischaemia Clin Physiol. 1989 Dec; 9(6):555-65. . View in PubMed
  • Cigarette smoke affects lipolytic activity in isolated rat lungs Lipids. 1980 Jul; 15(7):539-43. . View in PubMed

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