Jesse Lee Berry, MD

Jesse L. Berry, MD, received her undergraduate and medical degree from Harvard University in Massachusetts. Following her ophthalmology residency at the University of Southern California, she was the assistant chief of service at the Los Angeles County Medical Center. She then completed a fellowship in Ocular Oncology at Children’s Hospital Los Angeles under the mentorship of Drs. Jonathan Kim and A. Linn Murphree. Dr. Berry is the founder of WOO, Women in Ocular Oncology.

Evaluation of the aqueous humor for tumor-derived genetic information and its application to prognosis and precision medicine for retinoblastoma patients. Investigating new methods of chemotherapy delivery for the treatment of Retinoblastoma. Evaluating treatment outcomes for Retinoblastoma eyes. This includes evaluation of treatment outcomes after systemic chemotherapy and the elucidation of factors present at diagnosis, which contribute to final visual outcome in eyes treated for retinoblastoma.

• University of Southern California Excellence in Resident Teaching Award, 2013-2014
• Society of Heed Fellows, 2013
• Department of Health Services Innovation Grant, 2012
• Starr Schulman Fellowship, 2012
• Doheny Eye Institute Medical Knowledge Award, 2011
• Center for Eye Research and Education McCleary Grant, 2007
• Harvard Medical International Initiatives in Research Grant, 2005
• Nevil & Louise Ford Scholarship Fund, 2004-2008
• David Rockefeller Center of Latin American Studies Grant, 2003
• Kappa Alpha Theta Foundation Scholarship, 2002
• Harvard College Scholarship: Elizabeth Cary Agassiz Scholar, 2000-2004
• Malcolm Kinsberg Scholarship, 2000-2004

• Retinoblastoma Outcomes in the Americas: A Prospective Analysis of 491 Children With Retinoblastoma From 23 American Countries Am J Ophthalmol. 2024 Apr; 260:91-101. . View in PubMed
• Cutaneous adverse effects induced by tebentafusp in patients with metastatic uveal melanoma: a case series and treatment insights Clin Exp Dermatol. 2024 Mar 21; 49(4):392-394. . View in PubMed
• Anterior plaque brachytherapy placement for treatment of iris and iridociliary melanomas – surgical procedure and institutional experience Indian J Ophthalmol. 2024 Jan 08. . View in PubMed
• Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma Br J Ophthalmol. 2024 02 21; 108(3):449-456. . View in PubMed
• Rare Tumors: Opportunities and challenges from the Children’s Oncology Group perspective EJC Paediatr Oncol. 2023 Dec; 2. . View in PubMed
• Aqueous Humor Liquid Biopsy as a Companion Diagnostic for Retinoblastoma: Implications for Diagnosis, Prognosis, and Therapeutic Options: Five Years of Progress Am J Ophthalmol. 2023 Nov 30; 263:188-205. . View in PubMed
• Multicentre analysis of nucleic acid quantification using aqueous humour liquid biopsy in uveal melanoma: implications for clinical testing Can J Ophthalmol. 2023 Nov 27. . View in PubMed
• A Multicenter Analysis of Nucleic Acid Quantification Using Aqueous Humor Liquid Biopsy in Retinoblastoma: Implications for Clinical Testing Ophthalmol Sci. 2023 Sep; 3(3):100289. . View in PubMed
• CD63/81 Small Extracellular Vesicles in the Aqueous Humor are Retinoblastoma Associated Invest Ophthalmol Vis Sci. 2023 Jul 03; 64(10):5. . View in PubMed
• Simultaneous Copy Number Alteration and Single-Nucleotide Variation Analysis in Matched Aqueous Humor and Tumor Samples in Children with Retinoblastoma Int J Mol Sci. 2023 May 11; 24(10). . View in PubMed
• Diagnostic Aqueous Humor Proteome Predicts Metastatic Potential in Uveal Melanoma Int J Mol Sci. 2023 Apr 06; 24(7). . View in PubMed
• Vision-related quality of life compared to generic measures in retinoblastoma survivors Qual Life Res. 2023 Apr; 32(4):1095-1105. . View in PubMed
• Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors NPJ Precis Oncol. 2023 Feb 20; 7(1):21. . View in PubMed
• Children’s Oncology Group’s 2023 blueprint for research: Rare tumors Pediatr Blood Cancer. 2023 09; 70 Suppl 6:e30574. . View in PubMed
• Non-synonymous, synonymous, and non-coding nucleotide variants contribute to recurrently altered biological processes during retinoblastoma progression Genes Chromosomes Cancer. 2023 05; 62(5):275-289. . View in PubMed
• The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study Eye (Lond). 2023 04; 37(5):966-970. . View in PubMed
• Benign Lobular Inner Nuclear Layer Proliferations of the Retina Associated with Congenital Hypertrophy of the Retinal Pigment Epithelium Ophthalmology. 2023 03; 130(3):265-273. . View in PubMed
• Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging Br J Ophthalmol. 2023 01; 107(1):127-132. . View in PubMed
• Intraocular Spread of Ocular Surface Squamous Neoplasia Presenting as a Postoperative Anterior Chamber Opacity after Excisional Biopsy Case Rep Ophthalmol. 2023 Jan-Dec; 14(1):194-202. . View in PubMed
• Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries Br J Ophthalmol. 2023 11 22; 107(12):1818-1822. . View in PubMed
• Potential of Aqueous Humor as a Liquid Biopsy for Uveal Melanoma Int J Mol Sci. 2022 Jun 02; 23(11). . View in PubMed
• Metastatic neuroendocrine tumors mimicking as primary ocular disease Am J Ophthalmol Case Rep. 2022 Jun; 26:101425. . View in PubMed
• Single vesicle analysis of aqueous humor in pediatric ocular diseases reveals eye specific CD63-dominant subpopulations J Extracell Biol. 2022 Apr; 1(4). . View in PubMed
• Chromosome 6p amplification detected in blood cell-free DNA in advanced intraocular retinoblastoma Ophthalmic Genet. 2022 12; 43(6):866-870. . View in PubMed
• Malignant teratoid intraocular ciliary body medulloepithelioma in a 5-year-old male with corresponding somatic copy number alteration profile of aqueous humor cell-free DNA Ophthalmic Genet. 2022 12; 43(6):855-861. . View in PubMed
• ALinn Murphree, MD: the Mississippi man who conquered retinoblastoma and changed the fate of patients and their families. Ophthalmic Genet. 2022 12; 43(6):729-730. . View in PubMed
• High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma: A Multicenter, International Data-Sharing American Joint Committee on Cancer Study Ophthalmology. 2022 08; 129(8):923-932. . View in PubMed
• Sex, gender, and retinoblastoma: analysis of 4351 patients from 153 countries Eye (Lond). 2022 08; 36(8):1571-1577. . View in PubMed
• Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma: A Multicenter Registry-Based Study Ophthalmology. 2022 08; 129(8):933-945. . View in PubMed
• Defining High-risk Retinoblastoma: A Multicenter Global Survey JAMA Ophthalmol. 2022 Jan 01; 140(1):30-36. . View in PubMed
• Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy Nat Commun. 2022 09 21; 13(1):5523. . View in PubMed
• Outpatient ocular brachytherapy: The USC Experience Adv Radiat Oncol. 2021 Sep-Oct; 6(5):100737. . View in PubMed
• Inter-eye genomic heterogeneity in bilateral retinoblastoma via aqueous humor liquid biopsy NPJ Precis Oncol. 2021 Jul 27; 5(1):73. . View in PubMed
• Comprehensive Somatic Copy Number Analysis Using Aqueous Humor Liquid Biopsy for Retinoblastoma Cancers (Basel). 2021 Jul 03; 13(13). . View in PubMed
• Establishing the Clinical Utility of ctDNA Analysis for Diagnosis, Prognosis, and Treatment Monitoring of Retinoblastoma: The Aqueous Humor Liquid Biopsy Cancers (Basel). 2021 Mar 13; 13(6). . View in PubMed
• Response criteria for intraocular retinoblastoma: RB-RECIST Pediatr Blood Cancer. 2021 05; 68(5):e28964. . View in PubMed
• A systematic review of ultrasound biomicroscopy use in pediatric ophthalmology Eye (Lond). 2021 01; 35(1):265-276. . View in PubMed
• The Effects of Breastfeeding on Retinoblastoma Development: Results from an International Multicenter Retinoblastoma Survey Cancers (Basel). 2021 09 24; 13(19):4773. . View in PubMed
• The Utility of Recycled Eyeglasses: A Pilot Study at the Los Angeles County Department of Health Services Int J Med Stud. 2021 Jan-Apr; 9(1):37-40. . View in PubMed
• Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic Analysis J Vis Exp. 2021 09 07; (175). . View in PubMed
• Intravitreal Melphalan for Retinoblastoma: The Impact of Toxicity on Recurrence and Ultimate Globe Salvage Ocul Oncol Pathol. 2020 Dec; 6(6):388-394. . View in PubMed
• Quantifying Subclinical and Longitudinal Microvascular Changes Following Episcleral Plaque Brachytherapy Using Spectral Domain-Optical Coherence Tomography Angiography J Vitreoretin Dis. 2020 Nov; 4(6):499-508. . View in PubMed
• Tumour size criteria for Group D and E eyes in the International Classification System for Retinoblastoma: effects on rates of globe salvage and high-risk histopathologic features Acta Ophthalmol. 2020 Feb; 98(1):e121-e125. . View in PubMed
• Simultaneous identification of clinically relevant RB1 mutations and copy number alterations in aqueous humor of retinoblastoma eyes Ophthalmic Genet. 2020 12; 41(6):526-532. . View in PubMed
• Variability in retinoblastoma genome stability is driven by age and not heritability Genes Chromosomes Cancer. 2020 10; 59(10):584-590. . View in PubMed
• Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients Transl Vis Sci Technol. 2020 09; 9(10):30. . View in PubMed
• Chromosome 6p Amplification in Aqueous Humor Cell-Free DNA Is a Prognostic Biomarker for Retinoblastoma Ocular Survival Mol Cancer Res. 2020 08; 18(8):1166-1175. . View in PubMed
• Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma Ophthalmology. 2020 04; 127(4):552-554. . View in PubMed
• Global Retinoblastoma Presentation and Analysis by National Income Level JAMA Oncol. 2020 05 01; 6(5):685-695. . View in PubMed
• Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma Int Ophthalmol Clin. 2020; 60(2):77-89. . View in PubMed
• Posterior Vitreous Detachment and the Associated Risk of Retinal Toxicity with Intravitreal Melphalan Treatment for Retinoblastoma Ocul Oncol Pathol. 2019 Jun; 5(4):238-244. . View in PubMed
• Aqueous Humor Markers in Retinoblastoma, a Review Transl Vis Sci Technol. 2019 Apr; 8(2):13. . View in PubMed
• Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007-2017 Br J Ophthalmol. 2019 09; 103(9):1272-1277. . View in PubMed
• Changes in Retinal Thickness on OCT from Intravitreal Melphalan Ophthalmol Retina. 2019 03; 3(3):288-289. . View in PubMed
• Extending far and wide: the role of biopsy and staging in the management of ocular surface squamous neoplasia Clin Exp Ophthalmol. 2019 03; 47(2):193-200. . View in PubMed
• A Review of Recurrent Retinoblastoma: Children’s Hospital Los Angeles Classification and Treatment Guidelines Int Ophthalmol Clin. 2019; 59(2):65-75. . View in PubMed
• Evaluation of an Intervention to Reduce Low-Value Preoperative Care for Patients Undergoing Cataract Surgery at a Safety-Net Health System JAMA Intern Med. 2019 05 01; 179(5):648-657. . View in PubMed
• Next-Generation Technologies and Strategies for the Management of Retinoblastoma Genes (Basel). 2019 12 11; 10(12). . View in PubMed
• Trends in Radiation Practices for Female Ocular Oncologists in North America: A Collaborative Study of the International Society of Ocular Oncology Ocul Oncol Pathol. 2019 Jan; 5(1):54-59. . View in PubMed
• The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene Genes (Basel). 2019 11 01; 10(11). . View in PubMed
• Lens Dose-Response Prediction Modeling and Cataract Incidence in Patients With Retinoblastoma After Lens-Sparing or Whole-Eye Radiation Therapy Int J Radiat Oncol Biol Phys. 2019 04 01; 103(5):1143-1150. . View in PubMed
• An Intraocular Pressure Predictive of High-risk Histopathologic Features in Group E Retinoblastoma Eyes Int Ophthalmol Clin. 2019; 59(2):77-86. . View in PubMed
• Porous orbital implant after enucleation in retinoblastoma patients: indications and complications Orbit. 2018 Dec; 37(6):438-443. . View in PubMed
• Outcomes of choroidal melanomas treated with eye physics plaques: A 25-year review Brachytherapy. 2018 Nov – Dec; 17(6):981-989. . View in PubMed
• Integrated Treatment during the Intravitreal Melphalan Era: Concurrent Intravitreal Melphalan and Systemic Chemoreduction Ocul Oncol Pathol. 2018 Nov; 4(6):335-340. . View in PubMed
• Conjunctival Squamous Neoplasia: Staging and Initial Treatment Cornea. 2018 Oct; 37(10):1287-1291. . View in PubMed
• Atypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation Ocul Oncol Pathol. 2018 Sep; 4(2):116-121. . View in PubMed
• Late Apical Recurrence of Choroidal Melanoma 10 Years after Successful Treatment with Brachytherapy Ocul Oncol Pathol. 2018 Jun; 4(4):225-229. . View in PubMed
• Iris Hypoplasia as the Presenting Sign of Retinoblastoma in a Child With a 13q Deletion J Pediatr Ophthalmol Strabismus. 2018 Apr 23; 55:e10-e13. . View in PubMed
• Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma Mol Cancer Res. 2018 11; 16(11):1701-1712. . View in PubMed
• Lurking below: massive choroidal invasion under a calcified tumor after attempted conservative therapy for retinoblastoma Ophthalmic Genet. 2018 10; 39(5):653-657. . View in PubMed
• Lack of correlation between age at diagnosis and RB1 mutations for unilateral retinoblastoma: the importance of genetic testing Ophthalmic Genet. 2018 06; 39(3):407-409. . View in PubMed
• Loss of fundus view as an indication for secondary enucleation in retinoblastoma Pediatr Blood Cancer. 2018 04; 65(4). . View in PubMed
• Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma-Reply JAMA Ophthalmol. 2018 05 01; 136(5):598. . View in PubMed
• Three presentations of CNS disease in patients with intraocular retinoblastoma at a tertiary medical center in the United States Ophthalmic Genet. 2018 Jan-Feb; 39(1):115-119. . View in PubMed
• Unilateral Multifocal Choroidal Melanoma Ocul Oncol Pathol. 2017 Dec; 4(1):48-51. . View in PubMed
• Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft Graefes Arch Clin Exp Ophthalmol. 2017 Dec; 255(12):2363-2373. . View in PubMed
• Long-term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era Pediatr Blood Cancer. 2017 Dec; 64(12). . View in PubMed
• Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion? Ocul Oncol Pathol. 2017 Nov; 3(4):283-291.. View in PubMed
• Treatment Outcomes of Focal Laser Consolidation during Chemoreduction for Group B Retinoblastoma Ophthalmol Retina. 2017 Sep – Oct; 1(5):361-368. . View in PubMed
• Clinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients Ophthalmol Retina. 2017 Sep – Oct; 1(5):369-374. . View in PubMed
• Acute Lymphoblastic Leukemia Relapse Presenting as Optic Nerve Infiltration JAMA Ophthalmol. 2017 Jan 12; 135(1):e164656. . View in PubMed
• Not All Seeds Are Created Equal: Seed Classification Is Predictive of Outcomes in Retinoblastoma Ophthalmology. 2017 12; 124(12):1817-1825. . View in PubMed
• Optical Coherence Tomography Imaging of a Large Spherical Seed in Retinoblastoma Ophthalmology. 2017 08; 124(8):1208. . View in PubMed
• Risk of metastasis and orbital recurrence in advanced retinoblastoma eyes treated with systemic chemoreduction versus primary enucleation Pediatr Blood Cancer. 2017 04; 64(4). . View in PubMed
• Acute Hemorrhagic Retinopathy following Intravitreal Melphalan Injection for Retinoblastoma: A Report of Two Cases and Technical Modifications to Enhance the Prevention of Retinal Toxicity Ocul Oncol Pathol. 2017 Jan; 3(1):34-40. . View in PubMed
• Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy JAMA Ophthalmol. 2017 12 01; 135(12):1426-1429. . View in PubMed
• Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma JAMA Ophthalmol. 2017 11 01; 135(11):1221-1230. . View in PubMed
• Detection and Intraretinal Localization of an ‘Invisible’ Retinoblastoma Using Optical Coherence Tomography Ocul Oncol Pathol. 2016 Apr; 2(3):148-52. . View in PubMed
• Patterns of subretinal fluid resolution in Group D eyes treated with chemoreduction: Experience from the Children’s Hospital Los Angeles/University of Southern California Ophthalmic Genet. 2016 12; 37(4):400-403. . View in PubMed
• Long-Term Outcomes of Group B Eyes in Patients with Retinoblastoma Treated with Short-Course Chemoreduction: Experience from Children’s Hospital Los Angeles/University of Southern California Ocul Oncol Pathol. 2015 Dec; 2(2):105-11. . View in PubMed
• Orbital Recurrence following Aggressive Laser Treatment for Recurrent Retinoblastoma Ocul Oncol Pathol. 2015 Dec; 2(2):76-9. . View in PubMed
• Use of the Toric Surgical Marker to Aid in Intraoperative Plaque Placement for the USC Eye Physics Plaques to Treat Uveal Melanoma: A New Surgical Technique Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):866-70. . View in PubMed
• Outcomes of medium choroidal melanomas treated with ruthenium brachytherapy guided by three-dimensional pretreatment modeling Brachytherapy. 2015 Sep-Oct; 14(5):718-25. . View in PubMed
• Low-Dose Chemoreduction for Infants Diagnosed with Retinoblastoma before 6 Months of Age Ocul Oncol Pathol. 2015 Feb; 1(2):103-10. . View in PubMed
• Methicillin-resistant Staphylococcus aureus dacryoadenitis JAMA Ophthalmol. 2014 Aug; 132(8):993-5. . View in PubMed
• Factors predictive of long-term visual outcomes of Group D eyes treated with chemoreduction and low-dose IMRT salvage: the Children’s Hospital Los Angeles experience Br J Ophthalmol. 2014 Aug; 98(8):1061-5. . View in PubMed
• Outcomes of choroidal melanomas treated with eye physics: a 20-year review JAMA Ophthalmol. 2013 Nov; 131(11):1435-42. . View in PubMed
• Long-term outcomes of Group D eyes in bilateral retinoblastoma patients treated with chemoreduction and low-dose IMRT salvage Pediatr Blood Cancer. 2013 Apr; 60(4):688-93. . View in PubMed
• Unmet need for corrective eyeglasses: results from a Los Angeles County Hospital survey Int Ophthalmol. 2012 Jun; 32(3):245-50. . View in PubMed
• Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3868-73. . View in PubMed
• Effect of saline conditions on the tensile strength of ophthalmic sutures Ophthalmic Surg Lasers Imaging. 2011 Mar-Apr; 42(2):148-51. . View in PubMed
• Histopathologic findings of eyes enucleated after treatment with chemosurgery for retinoblastoma Open Ophthalmol J. 2011 Jan 18; 5:1-5. . View in PubMed

• Jubran, Rima
• Cobrinik, David
• Rao, Narsing
• Belson, Paula
• Kuhn, Peter
• Xu, Liya
• Krailo, Mark
• Craft, Cheryl
• Nagiel, Aaron
• Shah, Rachana